Antibody by dendritic cells. Medical search. Frequent questions

We have developed a DC enrichment platform, which uses the CMRF-44 (IgM) or CMRF-56 (IgG) monoclonal antibodies (mAb) to select BDC that express these antigens after a short overnight incubation. (nih.gov)
While anti-HIV-1 neutralizing antibodies have been difficult to elicit by immunization, there are several human monoclonal antibodies (MAbs) that effectively neutralize virus infection of activated T cells. (usuhs.edu)
Through screening of 455 monoclonal antibodies for SARS-CoV-2 variant binding and virus neutralization, we identified a cluster of activated B cells highly enriched for SARS-CoV-2 neutralizing antibodies. (bvsalud.org)

These subtypes include conventional dendritic cells (cDC1 and cDC2), plasmacytoid dendritic cells (pDCs), monocyte-derived dendritic cells (moDCs), and Langerhans cells (LCs). (origene.com)
Plasmacytoid dendritic cells (pDCs), are round plasma-shaped cells specialized for the production of large amounts of type I and type III interferon in response to viral infection. (origene.com)
This was shown to be dependent on efficient MHC II presentation by minor Clec9A-expressing DC subtypes in the environment of the Batf3 -/- mice, namely early cells of the CD8 DC lineage and the plasmacytoid-related CD8 + DC subset, but not by plasmacytoid cells themselves. (monash.edu)
Importantly, activated MDMs in turn mediate strong activation of plasmacytoid dendritic cells (pDCs), leading to the secretion of high levels of IFN-α and TNF. (nature.com)
Blastic Plasmacytoid Dendritic Cell Neoplasm: State of the Art and Prospects. (ncbcs.org)
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an especially uncommon tumour, which often impacts aged males and presents within the pores and skin with frequent involvement of the bone-marrow, peripheral blood and lymph nodes. (ncbcs.org)
They discovered that both vaccines could activate a particular kind of dendritic cell (plasmacytoid), but only the trivalent vaccine could induce antiviral interferon responses in other types of dendritic cells. (jax.org)
The Company is advancing PVEK in clinical trials for patients with blastic plasmacytoid dendritic cell neoplasm (BPDCN) and acute myeloid leukemia (AML). (stockhouse.com)

First discovered by Ralph Steinman and Zanvil A. Cohn in the 1970s, named for their tree-like branches or "dendrites", these cells patrol our bodies, ingest pathogens, process them, and present fragments (antigens) to T-cells, thus initiating a targeted immune response [2]. (origene.com)
cDC1: These cells are very effective at presenting antigens to CD8+ T cells, a type of cytotoxic T cell that can kill infected or cancerous cells. (origene.com)
cDC2: These cells are specialized in presenting antigens to CD4+ T cells, a type of helper T cell that helps coordinate the immune response. (origene.com)
Injection of antigens coupled to antibodies against the dendritic cell (DC) surface molecule Clec9A has been shown to produce strongly enhanced antibody responses even without co-administration of adjuvants, via antigen presentation by DC on MHC class II and consequent production of follicular helper T cells. (monash.edu)
As a Ph.D. student, Nussenzweig was the first to show that dendritic cells present foreign antigens to initiate T cell immunity. (wikipedia.org)
The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Here, we present a new generation of subunit vaccines targeting viral antigens to CD40-expressing antigen-presenting cells. (nature.com)
Dendritic cells can be used as a vaccine by preparing together with either peptides or small portions of tumor antigens and they can then be injected into the body. (moffitt.org)
The human immune system is capable of producing up to 10 9 different antibody species to interact with a wide range of antigens. (medscape.com)
Anti-ICRC antibody raised by intradermal inoculation of sonicated ICRC bacilli in rabbits reacted with both human immunoglobulin G (IgG) and antigens of ICRC. (scirp.org)
Anti-ICRC rabbit antibody absorbed with anti human IgG was also tested against soluble antigens of ICRC and human IgG by the agarose gel diffusion method. (scirp.org)
Notably, vaccination with DREP-GP and DREP-VP40, which produces both GP and VP40 antigens, induced a significantly higher level of anti-GP IgG2a antibody and increased IFN-γ secreting CD8 + T-cell responses relative to vaccination with DREP-GP or DREP-VP40 vector alone. (frontiersin.org)
To keep away from such measure impedance, antigens can be introduced utilizing dendritic cells, permitting the overall antigenicity of various prompts be analyzed straightforwardly. (phrconference.org)
These cells report information (in the form of antigens) about the invaders to the warriors, or T cells, of the immune system. (eurekalert.org)
Normally, only the T cells that learn to ignore the body's own antigens (self-antigens) are allowed to mature and leave the thymus. (msdmanuals.com)
T cells can potentially recognize an almost limitless number of different antigens. (msdmanuals.com)
Antigens are the molecules that are recognized and stimulate the cells of immune system. (medscape.com)
The antibodies then specifically bind to only those particular antigens. (medscape.com)
Variable region constitutes the antibody binding region of the molecule to the different antigens as it consists of about 110 amino acids that vary widely among the different antibody molecules. (medscape.com)

In humans, pDCs can be identified by the expression of several specific cell surface proteins, including CD123 (the IL-3 receptor alpha chain), BDCA-2, and BDCA-4. (origene.com)
The intracellular domain of activated M-CSF R binds more than 150 proteins that affect cell proliferation, survival, differentiation and cytoskeletal reorganization. (rndsystems.com)
For the next week or so, the bacteria will insert its genetic information into the plants, triggering the production of millions of spike proteins in every cell of the infected leaves. (readersdigest.ca)
After that, the adaptive immune system kicks in: B cells (a type of white blood cell) begin making antibodies, the proteins that can subdue a virus by blocking its ability to get into the body's cells. (readersdigest.ca)
The exceptionally touchy and adaptable DC-T cell examine measures assuming competitor proteins initiate partner CD4+ T cell multiplication that might prompt enemy of medication neutralizer reactions or other undesirable immunogenicity. (phrconference.org)
The Dendritic Cell (DC)- T cell measure for screening entire proteins has wide-running applications. (phrconference.org)
These may be different molecules within the cells like proteins, polysaccharides, or nucleoproteins and may also be the whole cell, like a tumor cell or organisms like bacteria, viruses, fungi, parasites, or agents containing genetic material such as nucleic acids or lipids. (medscape.com)
GEFs turn on (activate) proteins called GTPases, which play an important role in chemical signaling within cells. (medlineplus.gov)
Signaling stimulated by DOCK family proteins are typically involved in the arrangement of the structural framework inside cells (the cytoskeleton). (medlineplus.gov)
By controlling the shape of the cytoskeleton, DOCK family proteins play a role in cell structure and movement (migration). (medlineplus.gov)
B cells produce proteins called antibodies, which attach to foreign particles and germs and mark them for destruction. (medlineplus.gov)

Work on adaptive immunity focuses on B lymphocytes and antibodies to HIV-1, while work on innate immunity focuses on dendritic cells. (wikipedia.org)
Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity. (rochester.edu)
Different vaccines trigger immunity through different mechanisms, and that the ability of a vaccine to induce a specific immune response in dendritic cells may compensate for the absence of adjuvants and increase the vaccine's efficacy. (jax.org)
Initial results from the study were reported in 2020, and demonstrated that vaccination with Th17-inducing folate-receptor alpha (FRα)-loaded dendritic cells was safe, generated antigen-specific immunity, and was associated with increased remission, Cannon reports. (onclive.com)
Another important finding from the study was the role played by CD4+ T cells in retaining immune memory-the authors believe that these cells are responsible for a long-lasting immunity to cancer throughout the body. (ajmc.com)
Our research group uses chemistry, molecular biology, chemical biology and immunology to design and synthesize tools and reagents to gain insight in how to (i) most efficiently 'educate' and boost the patient's immune system to recognize the tumor and to (ii) eliminate or "re-educate" major immunosuppressive cells from the tumor microenvironment to tip the balance towards anticancer immunity. (irbbarcelona.org)
Deficiencies are highly variable with regard to symptoms, phenotype, genotype, severity, etc, because many cells and molecules are required for both natural and adaptive immunity . (lu.se)
The cells that have the inherent property of innate and adaptive immunity within the body are present at different sites including the blood, lymphatic system (lymph, lymphoid nodules and lymphoid organs), epithelium, and connective tissues. (medscape.com)
The adaptive immune response, in turn, albeit with different mechanisms of action, is closely related to the innate response, so that their activation occurs mainly by dendritic cells participating in the natural immunity. (bvsalud.org)

The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)
2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
It is also weakly expressed on B lymphocytes, but is absent from T lymphocytes, NK cells, red blood cells and platelets. (beckman.com)
Building on his seminal discovery of the function of the thymus, he discovered that T lymphocytes derived from the thymus helped B lymphocytes create antibodies. (edu.au)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
[ 11 ] A negative crossmatch (no reaction against donor lymphocytes when incubated with recipient serum) indicated that no antibody was present in the recipient, directed against the donor's organ. (medscape.com)
Molecular sites on or in B-lymphocytes, follicular dendritic cells, lymphoid cells, and epithelial cells that recognize and combine with COMPLEMENT C3D. (bvsalud.org)
The immune system can remember every antigen encountered because after an encounter, some lymphocytes develop into memory cells. (msdmanuals.com)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)
Immunoglobulins (Igs), the term is sometimes used interchangeably with "antibodies," are glycoprotein molecules produced by B lymphocytes and plasma cells in response to an immunogen or after recognition of specific epitopes on the antigen. (medscape.com)
Antibodies can be found on the surface of lymphocytes as an integral part of the cell membrane protein or can be freely circulating in the blood or be part of one of the body's gland secretion. (medscape.com)

We previously demonstrated that the combination of an allogeneic tumour-lysate dendritic cell (DC) vaccine with an anti-CD40 agonistic antibody resulted in robust antitumour responses with survival benefit in a murine PDAC model. (iozk.de)
Prevention of the initial infection of mucosal dendritic cells (DC) and interruption of the subsequent transmission of HIV-1 from DC to T cells are likely to be important attributes of an effective human immunodeficiency virus type 1 (HIV-1) vaccine. (usuhs.edu)
Additionally, we demonstrate that a single dose of the αCD40.RBD vaccine, injected without adjuvant, is sufficient to boost a rapid increase in neutralizing antibodies in convalescent non-human primates (NHPs) exposed six months previously to SARS-CoV-2. (nature.com)
Vaccine-elicited antibodies cross-neutralize different SARS-CoV-2 variants, including D614G, B1.1.7 and to a lesser extent B1.351. (nature.com)
The latest addition to oncotherapy is the use of dendritic cell (DC) vaccine therapy. (moffitt.org)
A dendritic cell vaccine is a cross between a vaccine and a cell therapy. (moffitt.org)
Now researchers at Moffitt are working to develop a dendritic cell vaccine targeting HER3, a protein involved in the growth and spread of many different cancer types. (moffitt.org)
The enzymes work to break apart the cell walls, releasing the virus-like particles so they can be collected, purified and converted into a yellowish vaccine. (readersdigest.ca)
Martin Cannon, PhD, discusses the phase 1 investigation of the Th17 dendritic cell vaccine in ovarian cancer, and how it could potentially improve suboptimal responses when treated with immunotherapy alone in this population. (onclive.com)
Martin Cannon, PhD, professor, Department of Microbiology and Immunology, University of Arkansas for Medical Sciences (UAMS) College of Medicine, discusses the phase 1 investigation of the Th17 dendritic cell vaccine in ovarian cancer, and how it could potentially improve suboptimal responses when treated with immunotherapy alone in this population. (onclive.com)
Accordingly, a Th17-stimulating dendritic cell vaccine was developed to potentially improve immune responses and clinical outcomes in this space, Cannon begins. (onclive.com)
The immunogenicity and safety of the Th17-stimulating dendritic cell vaccine in patients with stage IIIC-IV ovarian cancer was evaluated in a single-arm, open-label, phase 1 clinical trial (NCT02111941), Cannon details. (onclive.com)
Patients received the dendritic cell vaccine in the maintenance setting following the completion of upfront surgery and chemotherapy, he says. (onclive.com)
A comparison of T-cell frequency before and after vaccination showed that the vaccine successfully stimulated Th1, Th17, and antibody responses to FRα in most patients with ovarian cancer. (onclive.com)
Baxalta, the biopharmaceutical spinoff of Baxter, entered into a $1.7 B deal with Precision BioSceinces for 6 CAR-T (Chimeric Antigen Receptor T-cell) projects, and Saronic Biotechnology announced positive data in preclinical studies of its autologous dendritic cell vaccine for hepatocellular carcinoma. (shu.edu)
Despite development of effective SARS-CoV-2 vaccines, a sub-group of vaccine non-responders depends on therapeutic antibodies or small-molecule drugs in cases of severe disease. (bvsalud.org)

NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
It plays a role in antigen capture, phagocytosis of IgG/antigen complexes, and antibody-dependent cellular cytotoxicity (ADCC). (biolegend.com)
Binding of the Fc portion of the antibodies to FcR leads to activation of effector cells and further release of proinflammatory cytokines and proteolytic enzymes, mediators of antibody-dependent cell-mediated cytotoxicity (ADCC). (hindawi.com)
The aim of this study was to compare the effects of cationic micelle and liposome drug delivery systems on liver and lung cells in a toxicological in vitro screening model, with observations on cytotoxicity and genotoxicity. (bvsalud.org)

Dendritic cells (DC) for cancer immunotherapy protocols are generated most commonly by in vitro differentiation of monocytes with exogenous cytokines (Mo-DC). (nih.gov)
However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
CD64 is a 72 kD single chain type I glycoprotein also known as FcγRI and FcR I. CD64 is a member of the immunoglobulin superfamily and is expressed on monocytes/macrophages, dendritic cells, and activated granulocytes. (biolegend.com)
Human rheumatoid synovial fluid cells and fibronectin-purified monocytes. (biolegend.com)
Antigen Presenting Cells (APc's - dendritic cells, monocytes, and macrophages) are the key to provoking a robust adaptive immune response. (shu.edu)
Giver PBMC are utilized as a wellspring of monocytes that are refined in characterized media to produce juvenile dendritic cells. (phrconference.org)

Likewise B cells function as crucial antigen presenting cells in autoimmune diseases that are traditionally viewed as T cell mediated. (hindawi.com)
Independent of antibody secretion B cells secrete proinflammatory cytokines, support the formation of ectopic GCs, and serve as antigen presenting cells. (hindawi.com)
Secondary lymphopoiesis (SL) begins when mature B cells enter the extrafollicular area of lymphoid tissue and differentiate into short-lived plasma cells and memory cells after being stimulated by antigen-presenting cells. (medscape.com)
Janssen Biotech acquired a worldwide license to Alligator Bioscience's Phase I immunotherapy ADC-1013 , an agonistic monoclonal antibody that targets CD40, an immuno-stimulatory receptor found on antigen-presenting cells, which can spur an increase in T cells attacking a tumor. (shu.edu)
DCs are now activated and transform into antigen-presenting cells (APCs). (eurekalert.org)

Flu vaccines trigger the development of antibodies in key immune cells known as dendritic cells. (jax.org)
Now, the immune system has messenger cells known as dendritic cells (DCs). (eurekalert.org)

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The laboratory has isolated and cloned human antibodies to HIV-1 and explored their roles in prevention and therapy. (wikipedia.org)

Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
Moffitt Cancer Center continues to distinguish itself as a world leader in the development of novel immunotherapy treatments, capitalizing on the natural power of the body's immune system to defend itself against the growth and spread of cancerous cells. (moffitt.org)
It is a phase 2b randomized trial of autologous dendritic cell immunotherapy (CMN-001) plus standard treatment for advanced renal cell carcinoma after a nephrectomy ( MCC 21083 ). (moffitt.org)
This CMN-001 is an autologous, tumor antigen-loaded dendritic cell immunotherapy. (moffitt.org)
A system-wide immune response, not just a local response limited to the tumor, is what determines successful remission following cancer immunotherapy, according to a new study published in the journal Cell . (ajmc.com)

He also produced the first dendritic cell-specific monoclonal antibody and cloned the first dendritic cell receptor. (wikipedia.org)
The intracellular tyrosine kinase Lyn mediates inhibitory receptor function in B cells and myeloid cells, and Lyn(-/-) mice spontaneously develop an autoimmune and inflammatory disease that closely resembles human systemic lupus erythematosus. (univr.it)
M-CSF receptor is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta (1). (rndsystems.com)
It is heterodimeric cell surface receptor expressed on all leukocytes. (biolegend.com)
The antibody can be used as a reporter of the activation state of the integrin receptor in response to exposure to Mg 2+ or Mn 2+ . (biolegend.com)
We demonstrate that targeting the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein to CD40 (αCD40.RBD) induces significant levels of specific T and B cells, with long-term memory phenotypes, in a humanized mouse model. (nature.com)
Immunotherapies include checkpoint inhibitory antibodies, chimeric antigen receptor (CAR) T-cells, cancer vaccines, and oncolytic viruses. (moffitt.org)
Following B-cell receptor activation, 2 waves of tyrosine kinase phosphorylation occur. (medscape.com)
X-linked agammaglobulinemia (XLA), also known as Bruton agammaglobulinemia, results from a mutation of the BTK gene, which encodes the pre-B-cell receptor (Pre-BCR) and BCR. (medscape.com)
Its ELAHERE (Mirvetuximab Soravtansine) is a first-in-class ADC targeting folate receptor alpha (FRa), a cell-surface protein over-expressed in a number of epithelial tumors, including ovarian, endometrial, and non-small-cell lung cancers. (stockhouse.com)
Epitope binning and Cryo-EM structure analysis identified the majority of neutralizing antibodies having epitopes overlapping with the ACE2 receptor binding motif (class 1 binders). (bvsalud.org)
Human complement receptor 2 (CR2) serves as a receptor for both C3dg and the gp350/220 glycoprotein of HERPESVIRUS 4, HUMAN, and binds the monoclonal antibody OKB7, which blocks binding of both ligands to the receptor. (bvsalud.org)
Studies reported in the literature demonstrates the involvement of the innate immune system in PD in several ways: activation and signaling Toll Like Receptor (TLRs), production of antimicrobial peptides such as defensins and cathelicidins and the important role of dendritic cells in mediating between the two immunologic responses. (bvsalud.org)

The tyrosine kinase receptors Tyro3, Axl and Mer (TAMs) and their ligands protein S and Gas6 are involved in the uptake of PS-exposing apoptotic cells in macrophages and dendritic cells. (lu.se)

Right panel: antigen binds to the BCR of antigen-specific B cells and is internalized. (hindawi.com)
The experimental treatment uses a tumor-binding antibody that binds the tumor and also evokes a dendritic cell response. (ajmc.com)
An ADC with the Company's technology comprises an antibody that binds to a target found on tumor cells and is conjugated to one of its potent anti-cancer agents as a payload to kill the tumor cell once. (stockhouse.com)
The constant region at the carboxyl-terminal end of the heavy chain, called the Fc region, binds to the Fc receptors of neutrophils, eosinophils, macrophages, dendritic cells, B cells, and the natural killer (NK) cells. (medscape.com)

These antibodies are capable of fighting infection by the specific viruses that are the vaccines' targets. (jax.org)
Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets. (jax.org)
Dendritic cell vaccines can potentially be used to treat different cancer types. (moffitt.org)
This enables us to synthesize molecularly defined multifunctional dendritic cell targeted vaccines, as well as immune checkpoint targeting molecules. (irbbarcelona.org)

He earned a Ph.D. from The Rockefeller University in 1981 in cellular immunology, working in Zanvil A. Cohn's laboratory with Ralph M. Steinman on groundbreaking studies of mouse dendritic cells. (wikipedia.org)

Antibody drug conjugates (ADCs) are emerging as powerful treatment strategies with outstanding target specificity and high therapeutic activity in cancer patients. (biomedcentral.com)
Intravenous immunoglobulin (IVIG) is a therapeutic preparation of polyspecific antibodies isolated from pools of plasma obtained from several thousand healthy blood donors [1]. (academie-medecine.fr)
This new understanding of the role of B cells opened up novel therapeutic options for the treatment of autoimmune diseases. (hindawi.com)
and current B-cell-based therapeutic treatments. (hindawi.com)
Dendritic cells-based therapeutic approach may be a potential strategy for SARS-CoV-2 infection. (medsci.org)
However, perpetual viral evolution has required continuous efficacy monitoring as well as exploration of new therapeutic antibodies, to circumvent resistance mutations arising in the viral population. (bvsalud.org)
The transcriptomic signature of activated B cells harboring broadly binding neutralizing antibodies with therapeutic potential identified here, may be a guide in future efforts of rapid therapeutic antibody discovery. (bvsalud.org)
Discovery of therapeutic antibodies is a field of intense development, where immunization of rodents remains a major source of antibody candidates. (bvsalud.org)

Immunohistochemistry-Paraffin: SAMHD1 Antibody (OTI3F5) [NBP2-03285] - Staining of Human tonsil using anti-SAMHD1 mouse monoclonal antibody. (novusbio.com)

The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
It drives a significant immune response in the breast and helps the Herceptin and Perjeta antibodies to create a more complete response. (moffitt.org)
The new treatment triggered a coordinated immune response across many different tissues-sustained activation of peripheral immune cells—even after the response within the tumor died down. (ajmc.com)
To test this hypothesis, the researchers transplanted CD4+ T cells from successfully treated mice into other mice and found that these activated T cells triggered an immune response against tumors in the transplanted mice. (ajmc.com)
Although the authors were surprised with the impact of CD4+ T cells-since CD8+ T cells are thought to play a more important role in recognizing dangerous foreign cells in the body—they believe that the important role of CD4+ T cells in other settings also means that they can coordinate an immune response against tumors. (ajmc.com)
A similar CD4+ T cell activation signature was observed in the blood of patients who had responded well to treatment with a PD-1 inhibitor for their melanoma, which confirmed the hypothesis of the importance of a system-wide immune response in ensuring a sustained treatment response. (ajmc.com)
Furthermore, TLR signaling induces dendritic cell maturation and contributes consequently to the adaptive immune response. (antibodies-online.com)
A shortage of T cells impairs the immune response to foreign invaders, accounting for the severe skin infections common in DOCK8 immunodeficiency syndrome. (medlineplus.gov)

PEG Spacer Length Substantially Affects Antibody-Based Nanocarrier Targeting of Dendritic Cell Subsets. (mpg.de)

Here, we demonstrate that upon phagocytosis of SARS-CoV-2-infected cells, MDMs are activated and secrete IL-6 and TNF. (nature.com)
Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)
Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)

In addition to the direct cytotoxic effect on tumour cells, dolastatins efficiently promoted antigen uptake and migration of tumour-resident DCs to tumour-draining lymph nodes. (biomedcentral.com)
APCs then migrate to the lymph nodes where T cells reside to report this information. (eurekalert.org)
Instillation studies with fluorescein-conjugated isothiocyanate and TDI suggested that TNF-alpha deficiency also resulted in a significant reduction in the migration of airway dendritic cells to the draining lymph nodes. (cdc.gov)
Mature T cells are stored in secondary lymphoid organs (lymph nodes, spleen, tonsils, appendix, and Peyer patches in the small intestine). (msdmanuals.com)

Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)

This study will determine the safety of DC/anti-CD40 agonistic antibody combination treatment, and treatment-induced tumour-specific immunological responses. (iozk.de)
They are known to secrete interleukin-12, as well as type I and type III interferons, and are believed to promote Th1 helper T cell and natural killer responses. (origene.com)
However targeting of antigen to Clec9A in batf3 null mice produced enhanced antibody responses despite the marked reduction in CD8 + DC, the major Clec9A-expressing DC subtype. (monash.edu)
The reduced autoantibody production in mice lacking MyD88 in B cells or DCs was accompanied by a dramatic decrease in the spontaneous germinal center (GC) response, suggesting that autoantibodies in Lyn(-/-) mice may depend on GC responses. (univr.it)
Consistent with this view, IgG anti-nuclear Abs were absent if T cells were deleted (TCRβ(-/-) TCRδ(-/-) mice) or if T cells were unable to contribute to GC responses as the result of mutation of the adaptor molecule SAP. (univr.it)
Reciprocal roles of T-cell help for B cells during adaptive immune responses and B-cell help in CD4+ T-cell activation are being increasingly recognized. (hindawi.com)
Moreover, Th1 and FRα antibody responses were associated with high RFS, Cannon says. (onclive.com)
Considering the strength of positive contributor cell responses is likewise significant. (phrconference.org)

these mice did not give enhanced antibody production, confirming the response was dependent on Clec9A-expressing DC. (monash.edu)

Conventional dendritic cells (cDCs), also known as myeloid dendritic cells or classical dendritic cells, are a type of antigen-presenting cell (APC), cDCs originate from hematopoietic stem cells, specifically from the common myeloid progenitor in the bone marrow. (origene.com)
Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. (frontiersin.org)
In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
Nevertheless, the majority of scientific discoveries points toward a more tumor-supporting role for myeloid cells in the TME. (frontiersin.org)
PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)

It is found on Langerhans cells, follicular dendritic cells and histiocytes. (beckman.com)

Be that as it may, since polyclonal antibodies can perceive numerous epitopes, the foundation and the cross reactivity in the measures is typically high, making the outcomes hard to interpret. (phrconference.org)
To limit the foundation and cross reactivity and work on the parcel to-part consistency, a one of a kind GenScript Mouse Anti-Human IgG Fc Antibody (50B4A9)[HRP], mAb has been created to be utilized as an auxiliary counter acting agent. (phrconference.org)
Airway inflammation, goblet cell metaplasia, epithelial cell damage, and nonspecific airway reactivity to methacholine challenge, measured 24 h following the last challenge, were reduced to baseline levels in TNF-alpha null mice and athymic mice. (cdc.gov)

B-cell disorders are divided into defects of B-cell development/immunoglobulin production ( immunodeficiencies ) and excessive/uncontrolled proliferation ( lymphomas , leukemias ). (medscape.com)
Memory cells travel to the primary follicle, where, after exposure to dendritic cells, they differentiate into centroblasts (immunoglobulin class-switch). (medscape.com)
Since chickens generate antibodies from a restricted set of germline genes, the possibility of adapting the Symplex antibody discovery platform to chicken immunoglobulin genes and combining it with high-throughput humanization of antibody frameworks by "mass complementarity-determining region grafting" was explored. (bvsalud.org)
1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)
Antibody deficiencies are treated with intravenous immunoglobulin substitution therapy. (lu.se)
Antibodies belong to immunoglobulin family of protein and have 5 isotypes (G, A, M, E, D) with further subclasses of G and A. The classes are differentiated with the characteristics of the Ig heavy chain of the antibody. (medscape.com)

The Company is focused on developing and commercializing of antibody- drug conjugates (ADCs) to improve outcomes for cancer patients. (stockhouse.com)

Thus, neutralizing antibodies can block HIV-1 infection of DC and the cell-to-cell transmission of virus from infected DC to T cells. (usuhs.edu)
These data suggest that neutralizing antibodies could interrupt the initial events associated with mucosal transmission and regional spread of HIV-1. (usuhs.edu)
Extensive functional antibody characterization identified two potent neutralizing antibodies, one retaining SARS-CoV-1 neutralizing capability, while both bind major common variants of concern and display prophylactic efficacy in vivo. (bvsalud.org)

More information to SARS-CoV-2 Interferon Antagonism and antibodies for key actors and inhibitors. (antibodies-online.com)

The active components of CMN-001 are autologous, matured dendritic cells, which have been co-electroporated with both in vitro transcribed (IVT) RNA from an autologous tumor specimen and CD40L RNA. (moffitt.org)
Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)

The fluorescence histogram showing Dendritic Cells antigen expression (or Ig Isotype control staining) were derived from either CD11b+ CD11c- (Left Panel) or CD11b [intermediate] CD11c+ (Right Panel) gated events, as indicated, with the forward and side light-scatter characteristics of intact leucocytes. (bdbiosciences.com)

Pancreatic cancer spatial transcriptomics The lethality and treatment-refractory nature of pancreatic cancer are largely mediated by collaborative interactions between cancer cells and other cell types in the tumor microenvironment, including cancer-associated fibroblasts and immune cells. (harvard.edu)

In fact, I would recommend making chicken antibodies. (bio.net)
The PD1 antibody repertoire was successfully humanized, and we found that most humanized antibodies retained affinity largely similar to that of the parental chicken antibodies. (bvsalud.org)

In clinical trials, a broadly neutralizing antibody isolated from an HIV-infected patient was shown to be safe and effective and to interfere with chronic infection in a way that traditional antiretroviral therapy does not. (wikipedia.org)
The MAbs prevented viral entry into purified DC and the ensuing productive infection in DC/T-cell cultures. (usuhs.edu)
Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture. (mpg.de)
If the infection is cleared, many of the body's B and T cells then die off themselves. (readersdigest.ca)
Induction of IDO by DCs is a cell-autonomous response to Listeria monocytogenes infection and was also observed in other granulomatous infections with intracellular bacteria, such as Bartonella henselae. (jci.org)
The model showed that at the onset of infection, DCs from infected tissues were activated and then antibodies to neutralize SARS-CoV-2 gradually started building. (eurekalert.org)
Interferons are chemical messengers that warn neighboring cells of a viral infection. (eurekalert.org)
We focus on the essential functions of dendritic cell in severe SARS-CoV-2 infection. (medsci.org)
T cells and NK cells recognize and attack foreign invaders, such as viruses, to prevent infection. (medlineplus.gov)
It also aids in the movement of these immune system cells to sites of infection, particularly the skin. (medlineplus.gov)

Conceived initially for antibody replacement therapy in patients with primary and secondary immunodeficiencies, IVIG is now used in several autoimmune and inflammatory diseases. (academie-medecine.fr)
CMN-001 is indicated for the treatment of intermediate/poor-risk patients with advanced renal cell carcinoma (RCC) in combination with nivolumab plus ipilimumab as first-line therapy and in combination with lenvatinib plus everolimus as 2nd line therapy post-first-line failure. (moffitt.org)

In this open-label, single-centre (Erasmus Univsersity Medical Center, Rotterdam, Netherlands), single-arm, phase I dose finding study, adult patients with metastatic pancreatic cancer with progressive disease after FOLFIRINOX chemotherapy will receive monocyte-derived DCs loaded with an allogeneic tumour lysate in conjunction with a CD40 agonistic antibody. (iozk.de)

Deposited immune complexes can activate complement and effector cells. (hindawi.com)
The Fc portion of antibodies in immune complexes can be bound by C1q of the classical complement pathway, which eventually leads to the release of C5a and C3a. (hindawi.com)
Likewise, antigen/antibody complexes are bound by the FcR of APCs and processed in a unique fashion dependent on the epitope specificity of the bound antibody. (hindawi.com)
Lysates were clarified from sonicated nuclei and histone-DNA complexes were isolated with antibody. (nih.gov)

Internalization of bim Bm or bim Bp isolates by CD11c + dendritic cells and F4/80 + macrophages was comparable (not shown). (cdc.gov)

This kind of pDC activation was dependent on direct integrin-mediated cell‒cell contacts and involved stimulation of the TLR7 and STING signaling pathways. (nature.com)
Different pathways regulate different immune cells to help the body differentiate the bodies own healthy cells from disease-causing agents including bacteria, viruses, fungi, parasites, cancerous cells, and many more. (medscape.com)
The DOCK8 protein is also involved in chemical signaling pathways that stimulate B cells to mature and produce antibodies. (medlineplus.gov)

The maturation pathway involves several stages, with differentiating cells passing through a monocyte-like stage before fully maturing into dendritic cells. (origene.com)
A lack of DOCK8 protein also impairs B cell maturation and the production of certain antibodies. (medlineplus.gov)

These dendritic cells are like immune system factories and make other molecules that activate critical parts of the innate and adaptive immune system. (moffitt.org)
Tumors however, evade the immune system by generating immunosuppressive tumor-microenvironments to enable unhampered growth, by attracting suppressor immune cells and the expression of surface molecules that inactivate cytotoxic immune cells. (irbbarcelona.org)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)
The immune system is an inherent self-defense system consisting of cells that helps the body distinguish between self and non-self molecules. (medscape.com)

These anaphylatoxins promote release of proinflammatory cytokines and serve as chemoattractants for effector cells. (hindawi.com)

Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
Dendritic cells and the immune system: Dendritic cells (DCs) are part of the body's innate immune system and are present in areas that come in close contact with pathogens such as the skin, respiratory tract, and gastrointestinal tract. (eurekalert.org)

Multicolor flow cytometric analysis of mouse splenic dendritic cells. (bdbiosciences.com)
Flow cytometric analysis was performed using a BD LSRFortessa™ Cell Analyzer System. (bdbiosciences.com)
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis . (biolegend.com)

T cells develop from stem cells in the bone marrow that have travelled to an organ in the chest called the thymus. (msdmanuals.com)
Leukocytes are produced in stem cells in bone marrow. (lu.se)
Anna has explored the regenerative dynamics of hematopoietic stem cells, also known as blood stem cells. (lu.se)

Overall, the present study describes a novel and potent pathway of pDC activation that is linked to the macrophage-mediated clearance of infected cells. (nature.com)

Despite abrogation of all indicators of asthma pathology, TNF-alpha neutralization had no effect on serum IgE levels or IgG-specific TDI antibodies, suggesting the lack of importance of a humoral response in the manifestation of TDI-induced asthma. (cdc.gov)
The cellular response is mainly a lymphocyte-mediated reaction, whereas the humoral response includes production of antibodies against the antigen by the plasma cells. (medscape.com)
In vivo studies have verified the role of cytokines such as interleukin-10 (IL-10), interleukin-17 (IL-17) and INF-γ during the development of PD, as well as the influence of humoral antibodies in cases of PD. (bvsalud.org)

Dendritic cells (DCs) are bone-marrow-derived immune cells found in blood, lymphoid organs, and various tissue of the body. (origene.com)
B and T cells, type 2 dendritic cells, and natural killer (NK) cells share a common ancestor: common lymphoid progenitor (CLP). (medscape.com)
Secondary B lymphopoiesis is an antigen-dependent process and occurs in the germinal center of peripheral lymphoid organs with specific antibody production. (medscape.com)

The uptake of labeled MPs in the presence of protein S and Gas6 in human aortic endothelial cells (HAEC) and human umbilical vein endothelial cells (HUVEC) was monitored by flow cytometry, western blotting and confocal/electron microscopy. (lu.se)

Functionalization of nanocarriers with antibodies and their ability of targeting dendritic cells in vitro and in vivo. (mpg.de)
Reporting on our use of the clinically applied anti-TNF-α antibody infliximab, we further demonstrate in vitro that IDO induction is TNF-α dependent. (jci.org)
The lead antibody Sym021 blocked PD-L1 and PD-L2 ligand binding, resulting in elevated T-cell cytokine production in vitro. (bvsalud.org)

Hence, wild type chickens were immunized with an immune checkpoint inhibitor programmed cell death 1 (PD1) antigen, and a repertoire of 144 antibodies was generated. (bvsalud.org)

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions. (biolegend.com)
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions. (biolegend.com)
Centroblasts progress to centrocytes with high-affinity antibody production, then differentiate further to long-term memory cells and plasmablasts. (medscape.com)
Its Pivekimab sunirine (PVEK), is an ADC comprised of a high-affinity antibody designed to target CD123 with site-specific conjugation. (stockhouse.com)

However, high orthologue protein sequence homology between human and rodent species disfavors generation of antibodies against functionally conserved binding epitopes. (bvsalud.org)

Anatomy36

Organisms11

Diseases9

Chemicals and Drugs117

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes49

Disciplines and Occupations1

Information Science3

Health Care3

Monoclonal antibodies3

Plasmacytoid8

Antigens20

Proteins11

Immunity11

Lymphocytes12

Vaccine16

Cytotoxicity5

Monocytes7

Antigen-prese5

Known as dendritic cells2

Human Antibodies42

ImmunoTherapy5

Receptor13

Macrophages and dendritic cells1

Binds4

Vaccines4

Immunology1

Therapeutic8

Mouse monoclonal antibody1

Immune response8

Subsets1

Phagocytosis4

Lymph Nodes4

Antitumor2

Responses8

Enhanced antibody production1

Myeloid6

Follicular1

Reactivity3

Immunoglobulin6

Drug conjugates1

Neutralizing Antibodies3

Interferon1

Autologous2

Fluorescence1

Tumor Microenvironment1

Chicken antibodies2

Infection10

Therapy2

CD401

Complexes4

CD11c1

Pathways3

Maturation2

Molecules4

Proinflammatory cytokines1

Innate2

Flow cytometric analysis3

Stem cells3

Potent1

Humoral3

Lymphoid3

Endothelial cells1

Vitro3

Checkpoint1

Affinity5

Epitopes1