Antibody against vaccine pneumococcal serotypes. Medical search. Frequent questions

In its MAPS vaccine against Streptococcus pneumoniae , the company says, protein antigens enable the potential for an additional antibody response to protect against disease due to a broader range of pneumococcal serotypes, as well as a T-cell response to reduce nasopharyngeal colonization, the first step in pneumococcal infection. (genengnews.com)
The trimer stimulates the immune system to form antibodies against the bacterium Streptococcus pneumoniae of serotype 8, short ST8, as researchers of the Max Planck Institute for Colloids and Interfaces in Potsdam demonstrated by in vivo tests. (mpg.de)
Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n=8 per group) during pregnancy was examined for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. (mdc-berlin.de)
When admixed with PCV13 and administered i.m. on the first day of life to rhesus macaques, 3M-052 dramatically enhanced generation of Th1 CRM-197-specific neonatal CD4 + cells, activation of newborn and infant Streptococcus pneumoniae polysaccharide-specific (PnPS-specific) B cells as well as serotype-specific antibody titers, and opsonophagocytic killing. (jci.org)
In preclinical studies, Tweten's vaccine appeared to protect against nearly all Streptococcus pneumoniae variants. (ou.edu)
Currently approved vaccines are carbohydrate-based, meaning they prompt the immune system to recognize part of the sugar coating found on Streptococcus pneumoniae , thereby protecting against infection. (ou.edu)
Tweten's vaccine, in contrast, uses a genetically modified, inactive version of a Streptococcus pneumoniae toxin called pneumolysin, against which the immune system makes antibodies. (ou.edu)
Unlike the current vaccines, which prompt the immune system to respond to specific variants, we believe our vaccine will protect against the majority of Streptococcus pneumoniae serotypes. (ou.edu)
Prevnar 13® is a vaccine that protects against Streptococcus pneumoniae bacteria, which causes pneumonia, meningitis, and bacteremia. (rhghspace.com)
Prevnar 13®, also known as Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein), is a vaccine used to protect against diseases caused by the Streptococcus pneumoniae bacteria. (rhghspace.com)
Due to its effectiveness, the wide spread of pneumococcal disease, and the severity of infections caused by Streptococcus pneumoniae, Prevnar 13® is considered an important vaccine for public health. (rhghspace.com)
Streptococcus pneumoniae serotype 1 (Sp1) constitutes an important cause of seasonal endemic meningitis in all age groups in the African meningitis belt. (ehesp.fr)
We aimed to identify a dose of Streptococcus pneumoniae serotype 6B sufficient to establish nasopharyngeal carriage in 40% of those nasally inoculated and evaluate nasal mucosal immunity before and after experimental inoculation. (lstmed.ac.uk)
Healthy student volunteers were recruited and inoculated with saline, 20,000 CFU/naris or 80,000 CFU/naris of Streptococcus pneumoniae serotype 6B Post inoculation carriage was determined by nasal sampling for bacterial culture and lytA PCR. (lstmed.ac.uk)
90 serotypes of Streptococcus pneumoniae (pneumococci). (merckmanuals.com)
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae. (mpg.de)
Improving vaccines against Streptococcus pneumoniae using synthetic glycans. (mpg.de)
A Streptococcus pneumoniae Type 2 Oligosaccharide Glycoconjugate Elicits Opsonic Antibodies and Is Protective in an Animal Model of Invasive Pneumococcal Disease. (mpg.de)
Synthetic vaccines against Streptococcus pneumoniae serotype 2. (mpg.de)
Carriage prevalence and serotype distribution of Streptococcus pneumoniae prior to 10-valent pneumococcal vaccine introduction: A population-based cross-sectional study in South Western Uganda, 2014. (kemri-wellcome.org)
Standard method for detecting upper respiratory carriage of Streptococcus pneumoniae: updated recommendations from the World Health Organization Pneumococcal Carriage Working Group. (kemri-wellcome.org)
The authors describe a case of invasive pneumonia caused by Streptococcus pneumoniae serotype 9V in a previously healthy 35-year-old female. (biomedcentral.com)
Streptococcus pneumoniae was detected as the causative microorganism by a blood and sputum culture and positive urine antigen testing, and identified as serotype 9V. (biomedcentral.com)
This category includes pneumonia, bronchitis, bacteremia, and meningitis caused by any one of the 83 serotypes of Streptococcus pneumoniae . (nationalacademies.org)
Conjugation of the capsular polysaccharides of Streptococcus pneumoniae to protein carriers has introduced a generation of pneumococcal vaccines which may be efficacious in preventing pneumococcal otitis media during infancy. (docksci.com)
Pneumococcal infections are caused by the bacterium Streptococcus pneumoniae and can lead to various illnesses, such as pneumonia, meningitis, and bloodstream infections. (qwarkhealth.com)

It has existed since the invention of vaccination and pre-dates the coining of the terms "vaccine" and "vaccination" by nearly eighty years. (wikipedia.org)
Although myths, conspiracy theories, misinformation and disinformation spread by the anti-vaccination movement and fringe doctors leads to vaccine hesitancy and public debates around the medical, ethical, and legal issues related to vaccines, there is no serious hesitancy or debate within mainstream medical and scientific circles about the benefits of vaccination. (wikipedia.org)
Opposition to mandatory vaccination may be based on anti-vaccine sentiment, concern that it violates civil liberties or reduces public trust in vaccination, or suspicion of profiteering by the pharmaceutical industry. (wikipedia.org)
Two to three million deaths are prevented each year worldwide by vaccination, and an additional 1.5 million deaths could be prevented each year if all recommended vaccines were used. (wikipedia.org)
There is anti-vaccine literature that argues that reductions in infectious disease result from improved sanitation and hygiene (rather than vaccination) or that these diseases were already in decline before the introduction of specific vaccines. (wikipedia.org)
This report contains updated information regarding a) antimicrobial resistance among pneumococci, b) vaccine effectiveness and cost-effectiveness, c) indications for vaccination, d) guidelines for revaccination, e) strategies for improving delivery of vaccine, and f) development of pneumococcal conjugate vaccine. (cdc.gov)
INTRODUCTION: Pneumococcal infection causes significant morbidity in patients with underlying lung disease, and vaccination has been associated with reduced disease rates. (manchester.ac.uk)
METHODS: In a prospective observational study, consecutive patients with CPA, allergic aspergillosis and bronchiectasis attending a national referral centre received pneumococcal 23-valent polysaccharide vaccine (PPV-23) and had pre- and post-vaccination antibody concentrations quantified as part of routine clinical care. (manchester.ac.uk)
1.3μg/mL or a ≥ fourfold rise in concentration for ≥70% of serotypes, pre to post-vaccination. (manchester.ac.uk)
In vaccine-naïve patients (n=127), the lowest pre-vaccination levels were seen with serotypes 1 and 4 and the highest with serotype 19A. (manchester.ac.uk)
Post-vaccination serotype-specific concentrations waned gradually, however they were still elevated compared to pre-vaccination after 2-5 years. (manchester.ac.uk)
Response to vaccination has not been studied in chronic lung conditions characterised by ongoing infection or inflammation like chronic pulmonary aspergillosis (CPA).METHODS: In a prospective observational study, consecutive patients with CPA, allergic aspergillosis and bronchiectasis attending a national referral centre received pneumococcal 23-valent polysaccharide vaccine (PPV-23) and had pre- and post-vaccination antibody concentrations quantified as part of routine clinical care. (manchester.ac.uk)
METHODS: We performed a prospective cohort study to estimate the prevalence of IgG antibodies to SARS-CoV-2 before and after ChAdOx1 nCoV-19 vaccination. (cdc.gov)
RESULTS: Before vaccination, 1/617 participants (0.16%) had antibodies to SARS-CoV-2. (cdc.gov)
Nahm was able to develop an assay to look at antibody response to vaccination that requires only one-fourth of the serum used in previous tests. (sciencedaily.com)
Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. (mdc-berlin.de)
In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants. (mdc-berlin.de)
The Q-Plex™ Human Pneumococcal IgG (14-Plex) plate detects antibodies recognizing 14 common serotypes individuals are vaccinated against while the second kit, the Q-Plex™ Human Pneumococcal IgG (9-Plex), detects antibodies recognizing 9 additional serotypes commonly used as vaccination targets. (quansysbio.com)
There are multiple vaccination options for protection against S. pneumoniae, with the major difference being the number and composition of specific serotypes present in the vaccine. (quansysbio.com)
RESULTS: We found participant age to be associated with serotype-specific and functional antibody titers after pneumococcal vaccination, with a mean 6.2% (95% confidence interval, 2.9%-9.5%) reduction in postvaccination functional antibody titers per year. (ox.ac.uk)
CMV status was not associated with serotype-specific immunoglobulin G concentrations or functional antibody titers after pneumococcal vaccination. (ox.ac.uk)
The vision of "Sabko vaccine, muft vaccine" by the Prime Minister guiding The Covid-19 vaccination programme has ensured that the eligible population gets access to the Covid-19 vaccines across the country. (chemrobotics.in)
Because we have changed the structure of pneumolysin very little, the body's immune memory will respond after vaccination and start making antibodies," Tweten said. (ou.edu)
This Phase I study is an exciting milestone for Matrivax, and a major step forward in the development of a vaccine that has potential to be a technological breakthrough in vaccination options against pneumococcal disease," said Enda Moran, chief executive officer of Matrivax. (ou.edu)
The vaccine is approved by the US Food and Drug Administration (FDA) and is recommended by the Centers for Disease Control and Prevention (CDC) for routine vaccination in infants and young children. (rhghspace.com)
Persistent carriage of pneumococcal vaccine serotypes has occurred after introduction of PCV13 vaccination in Africa but the mechanisms are unclear. (lstmed.ac.uk)
For more information, see Pneumococcal Advisory Committee on Immunization Practices Vaccine Recommendations and Centers for Disease Control and Prevention (CDC): Pneumococcal Vaccination . (merckmanuals.com)
For detailed information on administering the pneumococcal vaccine to children see CDC: Pneumococcal Vaccination: Summary of Who and When to Vaccinate and CDC: Child and Adolescent Immunization Schedule by Age ). (merckmanuals.com)
Coverage and timeliness of vaccination and the validity of routine estimates: Insights from a vaccine registry in Kenya. (kemri-wellcome.org)
Antibodies in lymphocyte supernatants can distinguish between neutralising antibodies induced by RSV vaccination and pre-existing antibodies induced by natural infection. (kemri-wellcome.org)
Sustained reduction in vaccine-type invasive pneumococcal disease despite waning effects of a catch-up campaign in Kilifi, Kenya: A mathematical model based on pre-vaccination data. (kemri-wellcome.org)
Patients with recurrent respiratory tract infections and an impaired response to pneumococcal polysaccharide vaccination are diagnosed with a specific antibody deficiency. (biomedcentral.com)
It is unknown whether these patients are unable to produce an adequate anti-polysaccharide antibody response to pneumococcal vaccination after recovery. (biomedcentral.com)
After pneumococcal polysaccharide vaccination 3 months after recovery, she responded adequately to most other pneumococcal serotypes, but still had no response to the infecting serotype 9V. (biomedcentral.com)
However, after 9 years (and prior to pneumococcal-conjugate vaccination) normal antibody levels against 9V were found. (biomedcentral.com)
These antibody levels further increased after pneumococcal-conjugate vaccination. (biomedcentral.com)
Vaccination with a 23-valent pneumococcal polysaccharide vaccine (23vPPV) induces antibody production against the external polysaccharide capsule of the pneumococcus [ 3 ]. (biomedcentral.com)
An impaired response to pneumococcal polysaccharide vaccination can be a risk factor for recurrent respiratory tract infections [ 4 ]. (biomedcentral.com)
This raises the question whether these patients are able to mount a serotype-specific antibody response after vaccination with 23vPPV. (biomedcentral.com)
After recovery, an assessment of the humoral immune status was made, including analysis of the antibody response to pneumococcal polysaccharide vaccination. (biomedcentral.com)
The Phase 3 randomized, double-blind trial (NCT03760146) included 902 adults aged 18 or older with no history of pneumococcal vaccination. (pfizer.com.sg)
1 For the primary immunogenicity objectives in adults ages 60 years or older, the ratio of serotype-specific OPA geometric mean titers (GMTs) responses one month after vaccination were noninferior for all the serotypes in common with licensed Prevnar 13 and six of the seven additional serotypes when compared to a PPSV23. (pfizer.com.sg)
The present data contribute to pneumococcal vaccination public health policies for vulnerable patients, mainly those with comorbidity and the elderly. (bvsalud.org)
Defining surrogate serologic tests with respect to predicting protective vaccine efficacy: Poliovirus vaccination. (who.int)
The 'gold standard' method to assess humoral antibody responses fol owing vaccination is the neutralization assay. (who.int)

The benefits considered critical outcomes in GRADE included prevention of death, invasive pneumococcal disease (IPD), pneumococcal pneumonia, hospitalizations due to pneumococcal disease, and vaccine-induced immunogenicity was considered an important outcome. (cdc.gov)
The benefits considered critical outcomes in GRADE included prevention of invasive pneumococcal disease (IPD), pneumococcal community-acquired pneumonia, and hospitalizations due to pneumococcal disease. (cdc.gov)
Evidence used to evaluate efficacy of PCV13 against IPD and pneumococcal pneumonia was from the randomized placebo-controlled trial (RCT) conducted among approximately 85,000 adults aged ≥65 years in Netherlands (CAPiTA). (cdc.gov)
We are enthusiastic about Affinivax' vaccine program targeting pneumococcal pneumonia because it is urgent that we reach all children with the vaccines they need. (genengnews.com)
Each year in the United States, pneumococcal disease accounts for an estimated 3,000 cases of meningitis, 50,000 cases of bacteremia, 500,000 cases of pneumonia, and 7 million cases of otitis media (1-4). (cdc.gov)
Nahm uses the lab to help achieve a new goal -- affordable pneumonia vaccines for the world. (sciencedaily.com)
Pneumonia vaccine creation is challenging because pneumococci have a welter of different capsule types. (sciencedaily.com)
OKLAHOMA CITY - A new vaccine candidate to provide broad protection against pneumonia, developed by a researcher at the University of Oklahoma College of Medicine, is being given to humans for the first time in a Phase I clinical trial. (ou.edu)
It is exciting because, theoretically, this vaccine should protect against most of the 90 or so different variants (serotypes) of streptococcal pneumonia that we know about. (ou.edu)
The promise of Tweten's vaccine is that it takes a different approach than the handful of pneumonia vaccines now on the market. (ou.edu)
In addition, Tweten's vaccine should cost less to manufacture than other pneumonia vaccines, which would make it more affordable for developing countries. (ou.edu)
This pneumonia vaccine candidate represents a milestone for Dr. Tweten's laboratory, for the OU College of Medicine, and for the OU Health Sciences. (ou.edu)
The vaccine has mild side effects and is highly effective in preventing IPD, pneumonia, and other invasive pneumococcal diseases. (rhghspace.com)
It is highly effective in preventing IPD, pneumonia, and other invasive pneumococcal diseases. (rhghspace.com)
First pneumococcal conjugate vaccine that fights against 20 serotypes leading to most of the invasive pneumococcal diseases and pneumonia[2],[3] &md. (biopharmaapac.com)
In adult patients with pneumococcal pneumonia an impaired antibody response to the infecting pneumococcal serotype can sometimes be found. (biomedcentral.com)
This case report describes a patient with pneumococcal pneumonia in whom the infecting serotype was identified. (biomedcentral.com)
Pneumococcal pneumonia is the most common form of community-acquired pneumonia in the elderly, accounting for up to 60 percent of cases 14 , 34 , 35 , 36 , 37 , 52 and for up to 20 percent of nosocomial pneumonias. (nationalacademies.org)
10 , 52 Pneumococcal bacteremia, which is more easily proven than pneumococcal pneumonia, occurs in up to one-quarter of cases of pneumococcal pneumonia. (nationalacademies.org)
26 , 32 Although pneumococcal pneumonia does not result in permanent lung damage, complications from bacteremia and meningitis are common and can damage other organ systems. (nationalacademies.org)
This vaccine helps to prevent diseases such as pneumonia, meningitis, and sepsis caused by various strains of the pneumococcal bacteria. (qwarkhealth.com)

immunogenicity evidence was assessed using two phase III RCTs of PCV13 compared to PPSV23, which measured antibody responses by opsonophagocytic assay (OPA) and four RCTs of PCV7 compared to PPSV23, which measured antibody responses by enzyme-linked immunosorbent assay (ELISA). (cdc.gov)
With the PREVIX randomised controlled trials, we aimed to evaluate the immunogenicity of novel pneumococcal conjugate vaccine (PCV) schedules. (bvsalud.org)
Co-primary outcomes were immunogenicity against protein D and serotypes 3, 6A, and 19A. (bvsalud.org)
Immunogenicity measures were geometric mean concentrations (GMC) and proportion of children with IgG concentrations of 0·35 µg/mL or higher (threshold for invasive pneumococcal disease), and GMCs and proportion of children with antibody levels of 100 EU/mL or higher against protein D. Standardised assessments of otitis media, hearing impairment, nasopharyngeal carriage, and developmental outcomes are reported. (bvsalud.org)
Immunogenicity and Tolerability to Human Papillomavirus-like Particle Vaccine in Girls and Young Women with Inflammatory Bowel Disease. (vakciny.net)
We did a postlicensure assessment of serotype-specific vaccine effectiveness and immunogenicity in England, Wales, and Northern Ireland to derive the correlates of protection for individual serotypes. (edu.au)
Adjuvantation is a key approach to enhancing vaccine immunogenicity, but responses of human newborn leukocytes to most candidate adjuvants, including most TLR agonists, are functionally distinct. (jci.org)
Design: This is a sub-study within a retrospective analysis of a prospective cohort study on the safety and immunogenicity of 7-valent pneumococcal polysaccharide-protein conjugate vaccine (PncCV) and the immunogenicity of a H. influenzae type b conjugate vaccine (HibCV). (vut.ac.za)
A sensitive, isotype-specific anti-PCP assay is required to explore further the immunogenicity of the new PCP-OMPC conjugate vaccines and to study the immunopathogenesis of pneumococcal otitis media in the chinchilla model. (docksci.com)
NEW YORK--(BUSINESS WIRE)-- Pfizer Inc. (NYSE:PFE) today announced the full analysis from one of its Phase 3 studies (NCT03760146), which evaluated the safety and immunogenicity of its 20-valent pneumococcal conjugate vaccine (20vPnC) candidate in adults 18 years of age or older not previously vaccinated against pneumococcal disease. (pfizer.com.sg)

Recent studies show that parenterally administered capsular polysaccharide (PS) based vaccines can induce mucosal immune responses. (bmj.com)
At the heart of the VaxArray Pneumococcal Assay Kit are simple microarrays, each of which contains 24 serotype-specific monoclonal antibodies for high priority pneumococcal capsular polysaccharide serotypes present in a variety of both on-market and in-development pneumococcal vaccines. (indevr.com)
Pneumococcus capsular polysaccharide has been characterised and more than 90 different serotypes have been identified. (ruc.dk)
Serotype-specific antibodies against the capsular polysaccharide are produced during infection.At present, many countries follow the WHO pneumococcal ELISA IgG measurement protocol, in which polysaccharides from ATCC are used as antigens. (ruc.dk)
Conclusion: Pneumococcal conjugate vaccines induce pneumococcal capsular polysaccharide specific antibodies in both serum and saliva. (vut.ac.za)
Enzyme immunoassay for detection of immunoglobulin G (IgG), IgM, and IgA antibodies against type 6B pneumococcal capsular polysaccharide and cell wall C polysaccharide in chinchilla serum. (docksci.com)
The chinchilla model has been used extensively for studying the pathogenesis of pneumococcal otitis media and for testing the efficacy of early pneumococcal capsular polysaccharide (PCP) vaccines, but immunologic studies in the chinchilla have been limited by the lack of antibodies against specific immunoglobulin isotypes. (docksci.com)

For a summary of changes to the 2023 adult immunization schedule, including new recommendations for the use of PCV15 and PCV20 in people who previously received pneumococcal vaccines, see the Advisory Committee on Immunization Practices Recommended Adult Immunization Schedule, United States, 2023: Changes to the 2023 Adult Immunization Schedule . (merckmanuals.com)
Vaccine , (2023). (kemri-wellcome.org)

MAPS vaccines, according to Affinivax, combine protective polysaccharides and proteins to induce a broad protective immune response. (genengnews.com)
Animals that received a particular sugar combination profuced antibodies that were effective against the genuine capsule polysaccharides isolated from ST8 bacteria. (mpg.de)
There are more than 80 specific pneumococcal capsular polysaccharides. (vaccinealliance.org)
In recent years, serotype specific polysaccharides from different producers have been tested in pneumococcal antibody assay's. (ruc.dk)
One breakthrough was his finding that the then-accepted second-generation ELISA assay lacked specificity to quantitate human antibodies against pneumococcal polysaccharides. (sciencedaily.com)
Objectives: The main aim of this study was to assess the saliva and serum antibody concentration response to pneumococcal capsular polysaccharides in children vaccinated and unvaccinated. (vut.ac.za)
Measurements: Saliva IgG and IgA concentrations against pneumococcal capsular polysaccharides serotype 4, 6B, 7F, 9V, 14, 18C, 19F and 23F were quantified a by multiplex bead-based assay using the Luminex technology. (vut.ac.za)
Those patients with an impaired response to pneumococcal polysaccharides are diagnosed with a specific antibody deficiency [ 5 ]. (biomedcentral.com)
The purified capsular polysaccharides (PCPs) from the most common pneumococcal serotypes that cause disease have been formulated into polyvalent vaccines, and children immunized with the vaccines develop specific antibodies against some of the serotypes (3, 7, 10, 11, 22-24, 33). (docksci.com)
It is suspected that the high frequency of disease caused by these serotypes is, therefore, related to the poor immunogenicities of these capsular polysaccharides. (docksci.com)
Conjugation of the capsular polysaccharides of S. pneumoniae to protein carriers has introduced a second generation of pneumococcal vaccines (30). (docksci.com)

GRADE was used to evaluate 13-valent Pneumococcal Conjugate Vaccine (PCV13) and 23-valent pneumococcal polysaccharide vaccine (PPSV23) for routine use among immunocompromised adults. (cdc.gov)
The intervention evaluated was a single dose of PCV13 compared to a dose of 23-valent polysaccharide vaccine (PPSV23). (cdc.gov)
Laboratory testing shows a deficient response to polysaccharide vaccines (eg, pneumococcal vaccine ) and a normal response to protein antigens (eg, tetanus toxoid, diphtheria toxoid) and/or conjugate vaccines (eg, Haemophilus influenzae type b, PCV7, PCV13). (msdmanuals.com)
Non-PCV13 serotypes and non-typeable H influenzae continue to cause substantial disease and disability in Australian First Nation's children. (bvsalud.org)
Background: Efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13) was inferred before licensure from an aggregate correlate of protection established for the seven-valent vaccine (PCV7). (edu.au)
We measured serotype-specific IgG concentration in infants after they were given two priming doses of PCV7 (n=126) or PCV13 (n=237) and opsonophagocytic antibody titre from a subset of these infants (n=100). (edu.au)
Findings: For the 706 cases of invasive pneumococcal disease included in the study, PCV13 vaccine effectiveness after two doses before age 12 months or one dose from 12 months was 75% (95% CI 58-84). (edu.au)
Vaccine effectiveness was 90% (34-98) for the PCV7 serotypes and 73% (55-84) for the six additional serotypes included in PCV13. (edu.au)
Protection was shown for four of the six additional PCV13 serotypes (vaccine effectiveness for serotype 3 was not significant and no cases of serotype 5 infection occurred during the observation period). (edu.au)
The vaccine effectiveness for PCV13 and PCV7 was lower than predicted by the aggregate correlate of protection of 0·35 μg/mL used during licensing. (edu.au)
Interpretation: PCV13 provides significant protection for most of the vaccine serotypes. (edu.au)
13-valent pneumococcal conjugate vaccine (PCV13) is a licenced product, procured by the Gambia Government EPI, delivered in two schedules, one with doses scheduled at ages 6, 10 and 14 weeks (3+0 schedule) and the other with doses scheduled at ages 6 weeks and 9 months (1+1 schedule). (who.int)
In one arm of this substudy, PCV13 will be given at 9 months of age and YF vaccine at 10 months of age. (who.int)
Herein, we demonstrate that 3M-052 is a locally acting lipidated imidazoquinoline TLR7/8 agonist adjuvant in mice, which, when properly formulated, can induce robust Th1 cytokine production by human newborn leukocytes in vitro, both alone and in synergy with the alum-adjuvanted pneumococcal conjugate vaccine 13 (PCV13). (jci.org)
Unlike the older PPSV23, PCV13 can stimulate antibody responses in infants. (merckmanuals.com)

9-17 ] Evidence was not available for the critical outcome of hospitalization due to pneumococcal disease. (cdc.gov)
Recurrent MERS-CoV infection spiratory syndrome coronavirus (MERS-CoV) is crucial for disease prevention and vaccine development. (cdc.gov)
However, longitu- studied the antibody responses in 48 human MERS-CoV dinal studies in seropositive camels detected recurrent infection survivors who had variable disease severity in infections and intermittent shedding of RNA ( 3 ). (cdc.gov)
Vaccine hesitancy often results in disease outbreaks and deaths from vaccine-preventable diseases. (wikipedia.org)
A Centers for Disease Control and Prevention website aimed at countering common misconceptions about vaccines argued, "Are we expected to believe that better sanitation caused the incidence of each disease to drop, just at the time a vaccine for that disease was introduced? (wikipedia.org)
Other critics argue that the immunity granted by vaccines is only temporary and requires boosters, whereas those who survive the disease become permanently immune. (wikipedia.org)
Incomplete vaccine coverage increases the risk of disease for the entire population, including those who have been vaccinated, because it reduces herd immunity. (wikipedia.org)
The focus of this report is the prevention of invasive pneumococcal disease (i.e., bacteremia, meningitis, or infection of other normally sterile sites) through the use of pneumococcal polysaccharide vaccine. (cdc.gov)
This vaccine protects against invasive bacteremic disease, although existing data suggest that it is less effective in protecting against other types of pneumococcal infections. (cdc.gov)
Rates of invasive pneumococcal disease are exceptionally high among Alaskan Natives and American Indians. (cdc.gov)
Although vaccines for adults and children aged two and over have been available for years, these have not been suitable for the babies and toddlers who are most vulnerable to the disease because they do not stimulate an appropriate immune response. (vaccinealliance.org)
The pneumococcal conjugate vaccine licensed by the US Food and Drug Administration stimulates the production of protective antibodies against the seven serotypes that most frequently cause invasive disease in the United States. (vaccinealliance.org)
However, this '7-valent' vaccine does not stimulate antibodies against two serotypes, 1 and 5, which together are thought to be responsible for 12%-25% of invasive pneumococcal disease in many developing countries. (vaccinealliance.org)
The introduction of Haemophilus influenzae type b conjugate vaccines during the 1990s was followed by dramatic decreases both in the incidence of Haemophilus influenzae type b related invasive disease and in nasopharyngeal carriage of the organism. (bmj.com)
It has long been recognised that serum antibodies to capsular PS of some bacteria including H influenzae type b, S pneumoniae , and N meningitidis are protective against invasive disease. (bmj.com)
Methods: We assessed vaccine effectiveness against invasive pneumococcal disease using the indirect cohort method. (edu.au)
Effective vaccines produce antibodies that can bind to the capsule and help phagocytes engulf and destroy the bacteria, thus preventing disease and saving lives. (sciencedaily.com)
Antibodies play an essential role in the protection against pneumococcal disease. (quansysbio.com)
65 years since 2003 to prevent pneumococcal disease. (ox.ac.uk)
Combined with invasive pneumococcal disease estimates, it will estimate the impact of polysaccharide conjugate vaccines. (warwick.ac.uk)
The antibodies essentially coat the toxin and prevent it from causing disease. (ou.edu)
While there are effective vaccines currently available, they are very expensive to the end user, and they don't protect against all the bacterial serotypes that can cause disease. (ou.edu)
Our low-cost manufacturing platform and the prospect of a single-component, broad-coverage vaccine can translate directly into a much-needed low-cost vaccine for pneumococcal disease. (ou.edu)
The vaccine helps the body build immunity against 13 pneumococcal serotypes responsible for invasive pneumococcal disease. (rhghspace.com)
These serotypes are often associated with invasive pneumococcal disease (IPD) in children, which can lead to serious illness or death. (rhghspace.com)
The vaccine can also be given to older children and adults who have never been vaccinated for pneumococcal disease, or who need a booster dose. (rhghspace.com)
New data from Phase 3 European clinical trials reinforce that Wyeth's (NYSE: WYE) investigational pneumococcal vaccine, Prevenar 13* (Pneumococcal Polysaccharide Conjugate Vaccine, 13-valent [Adsorbed]), has the potential to provide coverage against the 13 most prevalent serotypes associated with pneumococcal disease (PD), the leading cause of vaccine-preventable death in children younger than five worldwide. (science20.com)
Our investigational vaccine, Prevenar 13, builds on the scientific foundation of Prevenar and is designed to provide more comprehensive protection against pneumococcal disease, says Emilio A. Emini, Ph.D., Executive Vice President, Vaccines Research and Development, Wyeth Pharmaceuticals. (science20.com)
These new data indicate that Prevenar 13 has the potential to provide direct coverage of the 13 most common disease-causing serotypes, including 3, 6A and 19A, which have been increasing in prevalence in many regions around the world. (science20.com)
Within the serotypes, serogroup 6 pneumococci are a frequent cause of serious disease and common colonizers of the nasopharynx in children. (ox.ac.uk)
We found that 43% of all genomes were of serotype 6E, and they were recovered worldwide from healthy children and patients of all ages with pneumococcal disease. (ox.ac.uk)
Sinopharm COVID-19 (BBIBP-CorV, COVILO, NVSI-06-07) is an inactivated vaccine made of virus particles grown in culture and lack disease-producing capability. (precisionvaccinations.com)
Vaccines are directed against many of the serotypes that cause disease. (merckmanuals.com)
Certain medical conditions (eg, chronic disorders, immunocompromising conditions, cerebrospinal fluid leaks, cochlear implants) increase the risk of pneumococcal disease. (merckmanuals.com)
There is already a dramatic decline in the rate of invasive pneumococcal disease in those under the age of 5. (bcmj.org)
On the basis of this evidence, BC's Communicable Disease Policy Committee has advised that BC follow Quebec, Australia, and the United Kingdom and provide a three-dose schedule of conjugated pneumococcal vaccine beginning January 2007. (bcmj.org)
Efficacy of the vaccine was 97.4% for invasive disease caused by a vaccine serotype, for fully vaccinated (four doses) children. (bcmj.org)
Vaccine shortages offered an opportunity for the Centers for Disease Control to conduct a case control study comparing the effectiveness of a three-dose series with a four-dose series. (bcmj.org)
Invasive pneumococcal disease (IPD) is reportable by physicians and laboratories in BC. (bcmj.org)
There will be ongoing efforts to ensure that we are as efficient as possible in providing protection from vaccine-preventable disease. (bcmj.org)
WHO preferred product characteristics for monoclonal antibodies for passive immunization against respiratory syncytial virus (RSV) disease in infants - Key considerations for global use. (kemri-wellcome.org)
This patient did not produce serotype-specific antibodies against the infecting serotype during disease. (biomedcentral.com)
Invasive and non-invasive pneumococcal disease has a high mortality risk, especially in the elderly patient with comorbidities [ 2 ]. (biomedcentral.com)
Pneumococcal disease has long been recognized as an important risk factor for the elderly. (nationalacademies.org)
New combination vaccines should induce similar or superior levels of neutralizing antibody in serum for individual protection against paralytic disease and mucosal immunity that effectively decreases viral replication in the intestine and pharynx for population protection against transmission of poliovirus. (who.int)

The new generation of whole-cell vaccines is based on an unencapsulated serotype that allows the expression of many bacterial antigens at a lower cost than a recombinant vaccine. (mdpi.com)
Selective antibody deficiency with normal immunoglobulins (Ig) is characterized by deficient specific antibody response to polysaccharide antigens but not to protein antigens, despite normal or near normal serum levels of immunoglobulins, including IgG subclasses. (msdmanuals.com)
This article reviews recent studies on mucosal immune responses induced by polysaccharide based vaccines and some protein vaccine antigens against several pathogenic nasopharyngeal bacteria, and discusses the mechanisms and functions of these immune responses that may help our understanding of mucosal immune responses to both immunisation and infection. (bmj.com)
In this project, purified serotype specific pneumococcal antigens from SSI Diagnostica and from ATCC were compared. (ruc.dk)
Overview of Immunization Immunity can be achieved Actively by using antigens (eg, vaccines, toxoids) Passively by using antibodies (eg, immune globulins, antitoxins) A toxoid is a bacterial toxin that has been modified. (merckmanuals.com)
3. Guillain-Barré Syndrome (GBS): In rare cases, GBS, a rare neurological disorder, has been reported following administration of vaccines containing similar antigens. (qwarkhealth.com)

New groundbreaking research is on the threshold of aiding researchers in producing vaccines at prices that will propel their widespread use and help protect the estimated 1.6 million children, most of them under the age of 5, who die yearly from S. pneumoniae infections. (sciencedaily.com)
One of Nahm's crucial discoveries was a method to rapidly and inexpensively test whether a vaccine candidate effectively elicits antibodies that can kill the S. pneumoniae bacteria. (sciencedaily.com)
October 2014: Screening & data extraction phases of a systematic review of S.pneumoniae serotype carriage globally, in parallel with my colleague, Riya Moodley. (warwick.ac.uk)
By doing so, the vaccine provides protection against the S. pneumoniae bacterium and associated infections. (rhghspace.com)
Samples collected from pneumococcal vaccine-naive Burkinabé and UK subjects were matched for age (1 to 39 years) and anti-Sp1 IgG level, analyzed for OPA to 3 S. pneumoniae serotypes (1, 5, and 19A), and compared to postvaccine samples. (ehesp.fr)

As a more modest example, infections caused by Haemophilus influenzae (Hib), a major cause of bacterial meningitis and other serious diseases in children, have decreased by over 99% in the US since the introduction of a vaccine in 1988. (wikipedia.org)
Severe pneumococcal infections result from dissemination of bacteria to the bloodstream and the central nervous system. (cdc.gov)
Several new mucosal vaccines against respiratory infections are under development. (bmj.com)
Prevnar 13® is designed to help the body build immunity against the 13 pneumococcal serotypes responsible for most of the infections caused by the bacterium. (rhghspace.com)
Overall, Prevnar 13® has been shown to be safe and effective in preventing pneumococcal infections, especially in young children. (rhghspace.com)
Prevnar 13, also known as pneumococcal 13-valent conjugate vaccine, is a vaccine that is specifically developed to protect against pneumococcal bacterial infections. (qwarkhealth.com)
Prevnar 13 targets 13 strains of the pneumococcal bacteria, which are known to be the most common and virulent strains that cause these infections. (qwarkhealth.com)
It is recommended for infants, children, and adults who are at increased risk of pneumococcal infections, such as those with weakened immune systems, chronic medical conditions, or who are older adults. (qwarkhealth.com)
It's important to receive the full recommended series of Prevnar 13 for optimal protection against pneumococcal bacterial infections. (qwarkhealth.com)

A subset of patients with SADNI initially have an appropriate response to polysaccharide antigen but lose antibody titers within 6 to 8 months (called SADNI memory phenotype). (msdmanuals.com)
Ideally, titers are done by the same laboratory both before and after vaccine administration. (msdmanuals.com)
Pearson evaluation between your phenotypic adjustments and OPKA titers shows that CD11c may be a good differentiation marker for HL-60 cells for make use of in pneumococcal OPKA. (biobender.com)
Antibody titers increased in serum from five chinchillas immunized with a type 6B outer membrane protein complex vaccine. (docksci.com)
Increases of anti-6B IgG and IgM antibody titers were more strildng than increases of anti-6B IgA or anti-C polysaccharide IgG, IgM, or IgA titers were. (docksci.com)

Serotype-specific pneumococcal IgG antibodies were quantified for 12 serotypes using a multiplex microsphere assay. (manchester.ac.uk)
Neither assay can distinguish natural from vaccine-induced antibodies. (cdc.gov)
Human IgG antibody Laboratories manufactures the pneumococcal opsonization igm competition assay reagents distributed by Genprice. (chipgrade.com)
The Pneumococcal Opsonization Igm Competition Assay reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (chipgrade.com)
He and his team rigorously validated the assay, found a way to make the pneumococcal colonies in the assay turn red for automated counting, and developed a software package to quickly analyze assay data. (sciencedaily.com)
Assessment of functional antibody levels (serotype specific opsonphagocytic assay) one month after the infant series and after the booster dose showed that a high percentage of infants receiving Prevenar 13 had functional antibodies for all serotypes. (science20.com)
Differentiated HL-60 can be an effector cell trusted for the opsonophagocytic-killing assay (OPKA) to measure efficacy of pneumococcal vaccines. (biobender.com)
by movement cytometry using 7-aminoactinomycin D. Function was examined by a regular OPKA against serotype 19F and chemiluminescence-based respiratory burst assay. (biobender.com)
Currently many pneumococcal conjugate vaccines far better compared to the 23-valent polysaccharide (PS) vaccine are under advancement (6 7 8 In analyzing pneumococcal vaccines an enzyme-linked immunosorbent assay (ELISA) is often used because the way of measuring vaccine efficiency by quantitating antibodies to serotype particular PS in sera (9). (biobender.com)
Nevertheless the ELISA assays for antibodies to pneumococcal PS weren't always particular and cross-reactivity of antibody binding to many serotypes was frequently noticed (10 11 Opsonophagocytic eliminating assay (OPKA) can be an in vitro surrogate assay to check protective efficacy from the pneumococcal vaccines and it is often used to check the ELISA outcomes (12). (biobender.com)

longevity of MERS antibody responses. (cdc.gov)
MERS-CoV Antibody Responses, Saudi Arabia diagnosis, MERS-CoV antibody responses were S1ELISA Kit (Euroimmun, https://www.euroim- measured 2-6 years postinfection. (cdc.gov)
The poorest responses were observed with serotypes 1, 3 and 4. (manchester.ac.uk)
Evidence has begun to accumulate that these new polysaccharide based conjugate vaccines can also reduce nasopharyngeal carriage and can induce immune responses at the local mucosal level, which may be responsible for these effects. (bmj.com)
To be effective against colonisation, vaccines must induce local immune responses, which promote elimination of the pathogen, break the chain of transmission, and induce herd immunity. (bmj.com)
The impaired antibody responses did not correlate with either history of infection or serum immunoglobulin isotype levels. (turkishjournalpediatrics.org)
The effect of chronic cytomegalovirus infection on pneumococcal vaccine responses. (ox.ac.uk)
METHODS: We evaluated the effect of age and CMV status on pneumococcal vaccine responses in 348 individuals aged 50-70 years. (ox.ac.uk)
CONCLUSIONS: These data imply that CMV infection is not directly responsible for the decline in pneumococcal vaccine responses seen with age but suggest that CMV-seropositive individuals differ in their natural exposure to pneumococci or have altered mucosal immune responses after colonization with this organism. (ox.ac.uk)
Prevenar 13 did not affect responses to the concomitantly administered vaccine and showed a safety profile comparable to Prevenar. (science20.com)
Experimentally induced type 6B pneumococcal carriage was associated with pro-inflammatory nasal mucosal responses prior to inoculation and altered mucosal recruitment of immune cells post bacterial challenge. (lstmed.ac.uk)
The association between age and the development of respiratory syncytial virus neutralising antibody responses following natural infection in infants. (kemri-wellcome.org)
However, the antibody responses in children younger than 2 years of age have been poor, especially against the most common serotypes, such as 6A and 6B. (docksci.com)
In the study, researchers found that all 20 vaccine serotypes induced robust responses across three age cohorts (≥60 years, 50-59 years, 18-49 years). (pfizer.com.sg)
Interference among the three attenuated poliovirus serotypes was minimized with a 'balanced- formulation' vaccine, and serologic responses after IPV were optimized by adjusting the antigenic content of each inactivated poliovirus serotype. (who.int)

Description: A competitive ELISA for quantitative measurement of Rat Platelet antibodies IgG in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (genscanner.com)
Evaluating the effectiveness of a potential generic vaccine against all these different serotypes is difficult, especially since researchers can get only small amounts of serum from vaccinated young children for use in testing. (sciencedaily.com)
Limits for these assays were set using the 007sp Human Anti-Pneumococcal capsule Reference Serum. (quansysbio.com)
In humans, serum antibodies typically act against the polysaccharide capsule in a serotype specific manner. (quansysbio.com)
Results: Post three primary vaccine doses, both serum IgG and saliva IgG and IgA antibody concentrations to vaccine serotypes were protective in children who received the vaccine. (vut.ac.za)
The antibody concentration in children whom did not receive the vaccine was much lower in comparison to the vaccine group in both serum and saliva to vaccine serotypes (P = 0.0001). (vut.ac.za)
There was no association with serum anti-capsular antibody. (lstmed.ac.uk)
By using affinity-purified rabbit immunoglobulin G (IgG) anti-chinchilla IgG, IgM, and IgA, we developed a sensitive enzyme immunoassay that is highly specific for IgG, IgM, and IgA antibodies against type 6B PCP (anti-6B) and against C polysaccharide in chinchilla serum. (docksci.com)
We describe here a sensitive enzyme immunoassay (EIA) that is highly specific for measuring immunoglobulin G (IgG), IgM, and IgA antibodies against type 6B PCP (anti-6B) in chinchilla serum. (docksci.com)

However, a new conjugate vaccine that is highly effective in infants has recently been approved for marketing by the Food and Drug Administration (FDA) in the United States, and several more are in late stages of development. (vaccinealliance.org)
Scientists and public health officials must for wait efficacy data to emerge from these trials before making recommendations about the use of the new pneumococcal vaccines among infants in developing countries. (vaccinealliance.org)
We derived correlates of protection by relating percentage protection to a threshold antibody concentration achieved by an equivalent percentage of infants. (edu.au)
Each of the 3 regimens was shown to elicit immune response levels against all 13 serotypes that were either comparable to or greater than the IgG antibody concentrations achieved in infants after a 3-dose infant series and to have acceptable tolerability and safety profiles. (science20.com)
The first successful conjugate vaccine was the 7-valent pneumococcal conjugate which resulted in a decrease in vaccine serotype IPD in infants and children below the age of two years. (vut.ac.za)
Setting and participation: Infants aged between ≥ 4 and ≤ 10 weeks were enrolled, who only received BCG and Polio vaccine following birth. (vut.ac.za)
Universal immunization of BC infants with four doses of conjugate pneumococcal vaccine was introduced in September 2003. (bcmj.org)
The immune response to conjugate vaccine is proving sufficiently robust-post-marketing studies now provide evidence that three doses will prove as immunogenic as four in healthy infants. (bcmj.org)
Since the conjugated polyribosyl ribitol phosphate-OMPC vaccine elicits a protective antibody response in infants as young as 2 months of age (31), it is reasonable to expect that the PCP-OMPC conjugates will have equally good immunogenicities. (docksci.com)
2 A similar percentage of infants receiving either vaccine experienced local reactions (pain at the injection site, redness, and swelling), fever, and other systemic events (decreased appetite, drowsiness, and irritability). (pfizer.com.sg)

It also seems to confer greater protection against invasive pneumococcal disorders than PPSV23. (merckmanuals.com)

Therefore, we analyzed a diverse data set of ∼1,000 serogroup 6 genomes, assessed the prevalence and distribution of serotype 6E, analyzed the genetic diversity among serogroup 6 pneumococci, and investigated whether pneumococcal conjugate vaccine-induced serotype 6A and 6B antibodies mediate the killing of serotype 6E pneumococci. (ox.ac.uk)
Pneumococcal conjugate vaccine induced IgG and nasopharyngeal carriage of pneumococci: Hyporesponsiveness and immune correlates of protection for carriage. (kemri-wellcome.org)

Instead of just one, pneumococci have 97 different capsule serotypes, seven of them discovered by Nahm. (sciencedaily.com)
Genomics Reveals the Worldwide Distribution of Multidrug-Resistant Serotype 6E Pneumococci. (ox.ac.uk)
Four genetic lineages, three of which were multidrug resistant, described ∼90% of the serotype 6E pneumococci. (ox.ac.uk)
Serological assays demonstrated that vaccine-induced serotype 6B antibodies were able to elicit killing of serotype 6E pneumococci. (ox.ac.uk)

the incidence of vaccine-preventable diseases tended to fluctuate over time until the introduction of specific vaccines, at which point the incidence dropped to near zero. (wikipedia.org)
Although Pneumococcal Conjugate Vaccines (PCVs) are available and have significantly reduced the rate of invasive pneumococcal diseases, there is still a need for new vaccines with unlimited serotype coverage, long-lasting protection, and lower cost to be developed. (mdpi.com)
These vaccines have been extensively studied, are currently in human trial phase 1/2, and seem to be the best treatment choice for pneumococcal diseases, especially for developing countries. (mdpi.com)
The costs of pneumococcal diseases are great because the elderly require hospitalization and the illnesses often cause complications. (nationalacademies.org)
Although antibiotics are considered to be effective in the treatment of pneumococcal diseases, deaths and complications often occur despite the prompt use of effective antibiotics. (nationalacademies.org)
Further reductions in morbidity and mortality from pneumococcal diseases require that preventive measures be used. (nationalacademies.org)
Background: Chronic conditions increase the risk of invasive pneumococcal diseases (IPD). (bvsalud.org)
Any detectable titer of neutralizing antibody against poliovirus is considered protective against clinical paralytic diseases. (who.int)

Due to the limited body of evidence on vaccine efficacy and safety among persons with most immunocompromising conditions, both vaccines were evaluated using data for HIV-infected adults. (cdc.gov)
CONCLUSIONS: The significant declines in the proportion of young women found to have genital warts and the absence of genital warts in vaccinated women in 2011 suggests that the human papillomavirus vaccine has a high efficacy outside of the trial setting. (vakciny.net)
Therefore, while vaccines appear to offer protection against serotype 6E, genetic variants may reduce vaccine efficacy in the longer term because of the emergence of serotypes that can evade vaccine-induced immunity. (ox.ac.uk)
The serotype 6B experimental human pneumococcal carriage model is feasible in Malawi and can now be used to determine the immunological correlates of protection against carriage and vaccine efficacy in this population. (lstmed.ac.uk)
Recommendations to assure the quality, safety and efficacy of live attenuated poliomyelitis vaccine (oral). (who.int)

The new company plans to use those funds to develop its Multiple Antigen Presenting System (MAPS) technology platform and also to develop novel vaccines its says will protect children and adults in both the developed and developing worlds. (genengnews.com)
Unconjugated PS vaccines have been available for many years and have received some use in adults. (bmj.com)
The authors believe that this case is the first description of a temporary deficient response to the infecting pneumococcal serotype in adults, while other reports with similar observations all involved children. (biomedcentral.com)
For adults and older children who have not received the vaccine previously, a single dose may be recommended. (qwarkhealth.com)

Mice that had been given a different combination also formed non-protective antibodies. (mpg.de)
Response to each serotype is characterized by the degree of rise in titer and whether the titer is considered protective, defined as an antibody level ≥ 1.3 mcg/mL (1.3 mg/L). (msdmanuals.com)
patients 6 to 65 years should have protective antibodies to ≥ 70% of serotypes. (msdmanuals.com)

INTERPRETATION: Low antibody concentrations 6 months post-booster might indicate increased risk of pneumococcal infection. (bvsalud.org)

We found defective IgG antibody production to all studied serotypes (3, 6B, 7F, 14, 19F, and 23F) in 22 of 31 A-T patients (71%) who were immunized with a polyvalent pneumococcal vaccine. (turkishjournalpediatrics.org)

However, there are differences between the vaccines' ability to induce mucosal immune response and there are also serotype specific differences in the antibody concentrations and in the proportion of positive samples after a series of vaccinations. (vut.ac.za)
The pneumococcal conjugate vaccine in this study was able to induce mucosal immune memory: the anti-pneumococcal IgA concentrations also increased with age in the saliva of unvaccinated children. (vut.ac.za)
Furthermore, the Burkinabé samples were assessed for IgG avidity and serotype-specific IgM concentrations. (ehesp.fr)

Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. (mdc-berlin.de)
However, these vaccines protect against 23 variants of the bacteria at most, which leaves open the possibility of infection from 60-plus other variants. (ou.edu)

Igg Antibody Laboratories manufactures the pneumococcal antibodies igg count reagents distributed by Genprice. (genscanner.com)

The extent of this effect has been influenced by the fact that Haemophilus influenzae type b conjugate vaccines reduce nasopharyngeal carriage and induce herd immunity. (bmj.com)

Sotrovimab Xevudy (VIR-7831, GSK4182136, S309) is a pan-sarbecovirus anti-SARS-CoV-2 monoclonal antibody treatment. (precisionvaccinations.com)
Synagis Palivizumab is a respiratory syncytial virus F protein inhibitor monoclonal antibody. (precisionvaccinations.com)

We conducted antibody testing among HCWs in February 2021 (baseline), before the second dose (June-July 2021), and 1 and 3 months after the second dose. (cdc.gov)
CONCLUSIONS: In this population, regardless of dosing interval, ChAdOx1 nCoV-19 induced antibodies within 3 months of the second dose. (cdc.gov)
This potent immunization strategy, potentially effective with one birth dose, could represent a new paradigm in early life vaccine development. (jci.org)
The vaccine is administered as a series of four doses, with the first dose given at 2 months and the final dose given at 12 months. (rhghspace.com)
The administrative coverage of the 3rd dose of oral polio vaccine (OPV3) varied across the years from 55% in 1991 to a maximum of 95% in 2007 before a progressive decrease to 86% in 2017. (immunologyresearchjournal.com)
Sputnik M vaccine (Gam-COVID-vac M) for children has the same components as Sputnik V but is 1/5 of the dose. (precisionvaccinations.com)
Studies that examined use of two doses of conjugate pneumococcal vaccine in early infancy followed by a further dose closer to age 1 year (a total of three doses) indicated excellent induction of memory response as ascertained by high levels of antibodies. (bcmj.org)
Effectiveness (intention to treat analysis) included all children who received at least one dose of the vaccine. (bcmj.org)
The National Advisory Committee on Immunization statement on conjugate pneumococcal immunization permits a reduced dose schedule. (bcmj.org)
Pneumococcal conjugate vaccine dose-ranging studies in humans: A systematic review. (kemri-wellcome.org)
4. Contraindications: Prevnar 13 should not be given to individuals who have a severe allergic reaction to any component of the vaccine or had a life-threatening reaction to a previous dose of Prevnar 13 or any other pneumococcal vaccine. (qwarkhealth.com)

The Q-Plex™ Human Pneumococcal IgG (9-Plex) is a chemiluminescent multiplex ELISA run on a 96-well plate. (quansysbio.com)

Conjugate vaccine technology, where a polysaccharide antigen is coupled chemically to a protein carrier, either by direct linkage or by indirect coupling via diamino spacer molecules, can render the PS specific immune response T cell dependent. (bmj.com)
With the help of T cell derived factors, the antigen specific B cells produce a much enhanced antibody response. (bmj.com)
We used novel serotype-specific urinary antigen detection (SSUAD) assays to determine whether pneumococcal cases were missed by traditional testing. (cdc.gov)

In order to keep the synthesis effort for the vaccine managable, the researchers identified the smallest possible sugar for immunization. (mpg.de)
This report updates the last recommendations by the Advisory Committee on Immunization Practices (ACIP) concerning pneumococcal polysaccharide vaccine (MMWR 1989;38:64-8,73-6). (cdc.gov)
Beginning in March 2021, we assessed different dosing schedules and adverse events following immunization (AEFIs) for ChAdOx1 nCoV-19 vaccine among healthcare workers (HCWs). (cdc.gov)
Union Health Minister expands Pneumococcal Conjugate Vaccine Under Universal Immunization Program. (chemrobotics.in)
Union Minister for Health and Family Welfare, Dr Mansukh Mandaviya launched the nationwide expansion of Pneumococcal Conjugate Vaccine (PCV) under the Universal Immunization Programme (UIP) as a part of Azadi ka Amrit Mahotsav. (chemrobotics.in)

Despite a higher meningitis incidence, the Burkinabé population has an Sp1-specific antibody seroprevalence similar to that reported in the United Kingdom (UK). (ehesp.fr)
In conclusion, despite a substantially higher pneumococcal meningitis incidence, no decreased functional immunity to Sp1 could be evidenced in the Burkinabé population compared to that in the population from the UK. (ehesp.fr)

Prevnar 13® is administered in a series of four doses and works by using a protein to stimulate the immune system to produce antibodies that fight the bacterium. (rhghspace.com)
Prevnar 13® works by using a protein from the diphtheria toxoid to stimulate the immune system to produce antibodies that fight against the 13 pneumococcal serotypes. (rhghspace.com)
The vaccine works by stimulating the immune system to produce antibodies against the pneumococcal bacteria. (qwarkhealth.com)

The Gambia PVT is the centerpiece of global efforts to determine the effectiveness of pneumococcal conjugate vaccines in developing countries. (vaccinealliance.org)
These findings may offer flexibility to policymakers when balancing programmatic considerations with vaccine effectiveness. (cdc.gov)
We used multivariable logistic regression to estimate vaccine effectiveness and reverse cumulative distribution curves to estimate correlates of protection. (edu.au)
My laboratory research project in summer 2014 assessed the effectiveness of combining indoor residual spraying with bednets in Sudan, through the measurement of specific malarial antibody titres. (warwick.ac.uk)
Case-control vaccine effectiveness studies: Preparation, design, and enrollment of cases and controls. (kemri-wellcome.org)
Case-control vaccine effectiveness studies: Data collection, analysis and reporting results. (kemri-wellcome.org)

There are 2 types of pneumococcal vaccines: conjugate and polysaccharide. (merckmanuals.com)

Addition of the synthetic sugar molecule to the current pneumococcal vaccine Prevnar 13, expanded the protection in vaccinated animals from 13 to 14 serotypes including the dangerous ST8 pathogen. (mpg.de)
This pneumococcal serotype test quantitatively measures antibody levels corresponding to the serotypes found in pure polysaccharide vaccines such as the Pneumovax®23 vaccine as well as protein conjugated vaccines such as Prevnar 7, Prevnar 13, Prevnar 20, and Vaxneuvance. (quansysbio.com)
It's important to note that Prevnar 13 is not a substitute for routine immunizations, and it does not protect against all strains of pneumococcal bacteria. (qwarkhealth.com)
There are several warnings associated with the use of Prevnar 13 (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]) that users should be aware of: 1. (qwarkhealth.com)
Allergy: Individuals who have had a severe allergic reaction to any component of Prevnar 13, including diphtheria toxoid, should not receive this vaccine. (qwarkhealth.com)
As always, it is important to consult with a healthcare professional to fully understand the warnings and contraindications of any medication or vaccine, including Prevnar 13. (qwarkhealth.com)
Allergies: Inform your healthcare provider if you have a known allergy to any ingredients in Prevnar 13 or any previous vaccines. (qwarkhealth.com)

Based on the success of Haemophilus influenzae type b conjugate vaccines, chemical conjugation has been applied to the development of pneumococcal and meningococcal polysaccharide conjugate vaccines. (bmj.com)
Other vaccines that combine DTP and/or Haemophilus influenzae type b and/or hepatitis B with IPV appear feasible but require further investigation. (who.int)

The company is currently testing the safety, tolerability and immune response of the vaccine at clinical sites in the United States. (ou.edu)
Both of the Prevenar 13 schedules induced a robust immune response for all 13 serotypes. (science20.com)
The Sputnik V vaccine (Gam-COVID-Vac) uses a weakened virus to deliver small parts of a pathogen and stimulate an immune response. (precisionvaccinations.com)

This study, managed by Olivier Le Polain at LSHTM and with involvement from other CMMID members, will record serotype prevalence by geographic region. (warwick.ac.uk)

Although use of the aggregate correlate of protection of 0·35 μg/mL has enabled the licensing of effective new PCVs, serotype-specific correlates of protection vary widely. (edu.au)

however, the specific antibody response is not well defined. (turkishjournalpediatrics.org)

Opsonophagocytic antibody titres of 1 in 8 or higher did not predict protection. (edu.au)

Its aim is to determine if child survival can be significantly improved by administration of 3 doses of 9-valent pneumococcal conjugate vaccine. (vaccinealliance.org)
The percentage of AFP cases with more than 3 doses of oral polio vaccines increased from 56% in 2014 to 88% in 2017. (immunologyresearchjournal.com)
[6] Preliminary results indicated that three doses of vaccine provided protection equivalent to four doses. (bcmj.org)

P=.036 for serotype 6B), independent of the concentration of secretory IgA antibodies. (mdc-berlin.de)

For many years scientists have used the characteristic sugar molecules on the surface of bacteria as a component of vaccines. (mpg.de)
Coupled with carrier proteins, these molecules are effective vaccines that are much simpler to prepare in the laboratory than the isolation of conventional vaccines from bacteria. (mpg.de)
Pneumococcal vaccines protect by stimulating antibodies against the specific polysaccharide (complex sugar) capsules that cover the bacteria. (vaccinealliance.org)

Population-based studies have shown that the elderly sustain the highest pneumococcal bacteremia rates of any population group-50 per 100,000 persons over the age of 65, 36 , 37 which is more than three times greater than the rates for younger persons. (nationalacademies.org)
Death rates from pneumococcal bacteremia range from 20 to 80 percent, increasing with age and complications. (nationalacademies.org)

Moreover, literature already exists that demonstrates the safety of vaccines using other experimental methods. (wikipedia.org)

Anatomy15

Organisms25

Diseases21

Chemicals and Drugs127

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes26

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science4

Named Groups1

Health Care8

Streptococcus26

Vaccination45

Pneumonia21

Immunogenicity10

Capsular polysaccharide7

20232

Polysaccharides11

PCV1315

Disease45

Antigens6

Pneumoniae5

Infections9

Titers5

Assay10

Responses15

Serum9

Infants10

PPSV231

Conjugate vaccine-induced2

Pneumococci4

Diseases8

Efficacy5

Adults4

Protective3

Risk of pneumococcal1

Polyvalent pneumococcal vaccine1

Concentrations3

Infection2

Manufactures the pneumococcal1

Nasopharyngeal1

Monoclonal2

Dose11

ELISA1

Antigen3

Immunization5

Meningitis2

Produce antibodies3

Effectiveness6

Types of pneumococcal1

Prevnar7

Haemophilus2

Immune response3

Prevalence1

PCVs1

Specific antibody1

Opsonophagocytic antibody1

Doses3

Concentration1

Bacteria3

Bacteremia2

Methods1