PerfringensBotulinumTetaniBacteriaMonoclonal AntibodyToxinsClostridioidesPolyclonal AntibodyInfectionSalmonellaSporesInfectionsColitisElisaAntigensAntibioticsBezlotoxumabMicrobiota TransplantationReactivitySpeciesNeutralizeSerumBotulismNovyiSpecimenBindsTherapeuticInhibitsAntibioticVaccinesRibotypeChickenImmunizationSoilObligateInvitrogenNeutralizationDiseaseMicroorganismsProductsTcdB
Perfringens6
- Necrotic enteritis (NE) is a common disease of broiler chickens caused by the bacterium Clostridium perfringens, which produces toxins that damage gut tissues. (canadianpoultrymag.com)
- PLGA Nanoparticle-Based Dissolving Microneedle Vaccine of Clostridium perfringens ε Toxin. (bvsalud.org)
- Epsilon toxin (ETX) is an exotoxin produced by type B and D Clostridium perfringens that causes enterotoxemia or necrotic enteritis in animals such as goats , sheep , and cattle . (bvsalud.org)
- Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination. (cornell.edu)
- UNLABELLED: Clostridium perfringens epsilon toxin (ε-toxin) is responsible for a devastating multifocal central nervous system (CNS) white matter disease in ruminant animals. (cornell.edu)
- Epsilon toxin (ε-toxin)-carrying Clostridium perfringens strains are responsible for a devastating white matter disease in ruminant animals that shares similar features with human multiple sclerosis. (cornell.edu)
Botulinum7
- More recent 16S-rDNA studies however have suggested, that C. haemolyticus and types B and C of C. novyi may form a distinct genus, closely related to Clostridium botulinum type C and D, instead. (wikipedia.org)
- The toxins normally produced by the various types are shown in table 1 The alpha-toxin of Clostridium botulinum types C and D, is similar to the C novyi beta-toxin. (wikipedia.org)
- Cloning, expression and purification of Clostridium botulinum neurotoxin type E binding domain', Iranian Journal of Biotechnology , 2(3), pp. 183-188. (ijbiotech.com)
- Bar Goldberg] Botulism is a rare but potentially lethal disease caused by a toxin produced by the bacterium Clostridium botulinum , a gram-negative, spore-forming anaerobic bacteria. (cdc.gov)
- the subject of our study), also known as 'floppy baby syndrome', results from ingestion of Clostridium botulinum spores with subsequent colonization in the gut and releases botulism toxin, causing acute flaccid descending paralysis. (cdc.gov)
- And the second type is wound botulism, in which Clostridium botulinum spores get into wounds, especially after a traumatic injury, post-op, or IVDU. (cdc.gov)
- And the common belief is that infant intestinal flora is insufficient to suppress Clostridium botulinum colonization. (cdc.gov)
Tetani5
- 2 Kitasato Shibasaburo first isolated Clostridium tetani from humans in 1891 later demonstrated how the bacteria produced disease when subjected to animals and also demonstrated the neutralization of toxin by specific antibodies. (pediatriconcall.com)
- Tetanus results from contamination of wounds or lacerations with Clostridium tetani spores from the environment. (mayocliniclabs.com)
- Tetanus is caused by Clostridium tetani , an anaerobic, spore-forming bacterium. (ufl.edu)
- Clostridium tetani produces spores that can survive for years in the environment. (ufl.edu)
- The vaccine provides specific active immunization against infections caused by Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis, Haemophilus influenzae type B and the Hepatitis B virus in children from six weeks of age. (bvsalud.org)
Bacteria9
- Clostridium novyi (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class Clostridia. (wikipedia.org)
- a type of bacteria that can cause severe or life-threatening diarrhea) from coming back in people who are at high risk for C. difficile infection and who are already taking an antibiotic drug to treat Clostridium difficile . (medlineplus.gov)
- This study aimed to evaluate the effects of bacteria-specific IgY antibodies and glycerol on rates of free fatty acid (FFA) accumulation during in vitro incubation of mixed rumen microbes. (usda.gov)
- The positive ruminal bacteria Anaerovibrio lipolytica 5S, Butyrivibrio fibrisolvens strain H17C, Clostridium chauvoei, and Propionibacterium acnes were harvested and used for preparation of IgY antibodies. (usda.gov)
- The developed antibodies were tested against the lipolytic activity expressed by mixed populations of rumen bacteria obtained from a cannulated cow receiving a 50% grain, 50% dried distillers grains diet. (usda.gov)
- Bezlotoxumab works by binding to a specific toxin produced by the Clostridium difficile bacteria, to help neutralize the toxin's effects. (cigna.com)
- The company is currently developing a compound to fight against Clostridium difficile , a bacteria that disrupts normal, healthy colons and can be very challenging to treat, even in highly advanced medical care facilities. (umbc.edu)
- Overview of Clostridial Infections Clostridia are bacteria that commonly reside in the intestine of healthy adults and newborns. (msdmanuals.com)
- Cytotoxin production by other bacteria (ie, Shigella dysenteriae, Vibrio parahaemolyticus, Clostridium difficile, enterohemorrhagic E coli ) results in mucosal cell destruction that leads to bloody stools with inflammatory cells. (medscape.com)
Monoclonal Antibody1
- Bezlotoxumab is a monoclonal antibody. (cigna.com)
Toxins8
- Treatment with monoclonal antibodies against Clostridium difficile toxins. (jenner.ac.uk)
- Recently, two anti-C. difficile toxin antibodies, actoxumab andbezloxumab, that bind to and neutralize C. difficile toxins A and B, respectively, have achieved success for CDItreatment in a phase II clinical trial. (tamu.edu)
- We propose toengineer a non-antibody protein, designed ankyrin repeat protein (DARPin), that is able to bind to andneutralize toxins A and B from a broad range of C. difficile strains. (tamu.edu)
- Clostridioides difficile ( formerly Clostridium difficile) colitis results from a disturbance of the normal bacterial flora of the colon, colonization by C difficile , and the release of toxins that cause mucosal inflammation and damage. (medscape.com)
- Clostridium novyi is considered to be made up from three clades, labelled A, B and C, distinguished by the range of toxins they produce. (wikipedia.org)
- The A and B toxins of Clostridium difficile show homology with the alpha-toxin of C novyi as does the lethal toxin of clostridium sordellii. (wikipedia.org)
- Detection of Clostridium difficile toxins A and B by ELISA. (tamu.edu)
- The antitoxins are actually antibodies that neutralize the circulatory toxins and prevent them from binding to the neuromuscular junction in the presynaptic acetylcholine release area. (cdc.gov)
Clostridioides1
- This article highlights the main differences between the recommendations of the Swiss Society for Infectious Diseases on the management of "Clostridioides difficile infection" and the IDSA/SHEA reference guideline "Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)" and discusses some important challenges in -treatment of C. difficile . (smw.ch)
Polyclonal Antibody2
- Description: A polyclonal antibody against SARS. (microarraystation.com)
- The following product was used in this experiment: ZO-2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # 71-1400, RRID AB_2533976. (thermofisher.com)
Infection13
- Clostridium difficile infection (CDI) is the leading cause of infectious diarrhea in hospitalized patients, with anestimated annual cost to the United States of between $750 million and $3.2 billion. (tamu.edu)
- citation needed] Wound infection by C novyi and many other clostridium species cause gas gangrene Spontaneous infection is mostly associated with predisposing factors of hematologic or colorectal malignancies and with diabetes mellitus, although Gram-negative organisms, including Escherichia coli, may lead to a gas gangrene-like syndrome in diabetic patients. (wikipedia.org)
- Clostridium difficile infection (CDI) is a common hospital-acquired infection that is associated with a high clinical and economic burden. (ajmc.com)
- Douglas Slain, PharmD, BCPS, FASHP, a clinical assistant professor of infectious disease at West Virginia University, discussed Clostridium difficile infection (CDI), including current treatment options and the most appropriate situations for use of current therapies. (ajmc.com)
- Bezlotoxumab is used together with antibiotic medicine in adults with Clostridium difficile (C. difficile), an infection that can cause life-threatening diarrhea. (cigna.com)
- Clostridium difficile infection in Europe: a hospital-based survey. (smw.ch)
- Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual, point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID). (smw.ch)
- Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). (smw.ch)
- An experimental antibody developed by Merck & Co Inc was shown in pivotal studies to reduce by about 10 percentage points the risk that infection with Clostridium difficile will recur. (the-hospitalist.org)
- My research interests are in the field of Clinical Microbiology, including Clostridium difficile infection, human microbiome in health and diease and antimicrobial resistance. (exeter.ac.uk)
- I have investigated many aspects of Clostridium difficile infection biology, including sporulation and germination, host immune responses, antimicrobial resistance, epidemiology and surveillance of novel transposable elements encoding antimicrobial resistance in C. difficile and other gut microorganisms. (exeter.ac.uk)
- Spore germination is an important part of the pathogenesis of Clostridium difficile infection (CDI). (exeter.ac.uk)
- Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses. (exeter.ac.uk)
Salmonella4
- Dr. Prescott decided to start with one of these vaccines and modify it so it could confer resistance to Clostridia in addition to Salmonella. (canadianpoultrymag.com)
- These chickens produced antibodies to antigens from both Salmonella and Clostridia. (canadianpoultrymag.com)
- Unfortunately the new and improved turkey remains vulnerable to enteric diseases such as enterovirus, astrovirus, corona virus, reovirus, rotavirus and other unnamed viruses, not to mention the bacterial challenges ( E. coli , Salmonella and Clostridium) and protozoal issues (coccidia, Hexamita, Trichomonas, Cochlosoma and cryptosporidia). (thepoultrysite.com)
- Poults need to be free of Salmonella, Pseudomonas and Clostridium at hatch. (thepoultrysite.com)
Spores1
- Germination efficiency of clinical Clostridium difficile spores and correlation with ribotype, disease severity and therapy failure. (exeter.ac.uk)
Infections2
- Kohler P, Bregenzer-Witteck A, Rafeiner P, Schlegel M. Presumably hospital-transmitted Clostridium difficile infections based on epidemiological linkage. (smw.ch)
- Over half of the nontraditional products in development are for the treatment of Clostridium difficile (an organism associated with serious, sometimes life-threatening diarrhea) or Staphylococcus aureus (associated with skin and a variety of systemic infections). (pewtrusts.org)
Colitis1
- Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis. (smw.ch)
Elisa1
- Detection of antibodies to Coxiella burnetii, the causative agent of Q fever, by ELISA. (tamu.edu)
Antigens3
- We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
- We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
- We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
Antibiotics2
- Clostridium difficile is an opportunistic pathogen that establishes in the colon when the gut microbiota are disrupted by antibiotics or disease. (rcsb.org)
- Dr Slain then described the pathogen that these antibiotics are intended to kill- Clostridium difficile . (ajmc.com)
Bezlotoxumab1
- Bezlotoxumab is in a class of medications called monoclonal antibodies. (medlineplus.gov)
Microbiota Transplantation1
- Newer therapy options such as fidaxomicin, the administration of monoclonal antibodies or faecal microbiota transplantation demonstrate significant advantages over traditional therapies, particularly regarding the reduction of the recurrence rate. (smw.ch)
Reactivity2
- This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
- In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
Species2
- Find IKZF2 Antibodies for a variety of species such as anti-Human IKZF2, anti-Mouse IKZF2, anti-Rat IKZF2. (antibodies-online.com)
- Detection of 5 histotoxic clostridial species by the fluorescent antibody method. (tamu.edu)
Neutralize1
- These broadly neutralizing anti-toxin DARPins canpotentially be fused to Fc and used as antibody therapy for CDI, or be formulated for oral administration todirectly neutralize C. difficile toxin(s) in the gut. (tamu.edu)
Serum1
- In vitro neutralization experiments showed that the serum antibodies from the dMN and SC PLGA NPs groups both protect naive mice from 10 × LD50 GST-ETX attack after being diluted 20 times and could also protect MDCK cells from 20 × CT50 GST-ETX attack. (bvsalud.org)
Botulism1
- This study is also implicated in antibody production against botulism syndrome. (ijbiotech.com)
Novyi2
- Based on toxin production, Clostridium haemolyticum has been suggested to be considered a part of C. novyi, forming a separate type D in the genus. (wikipedia.org)
- Clostridium novyi has been implicated in mortality among injecting illegal drug users. (wikipedia.org)
Specimen1
- A type and antibody screen specimen obtained before the transfusions revealed that his red cells were type B positive, a screen for unexpected antibodies was negative, and direct antibody tests (DAT) for both anti-IgG and anti-C3b were also negative. (medscape.com)
Binds1
- This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Therapeutic2
- FZata, a company that develops therapeutic and preventive medicines using antibody technology, won the best life sciences company category. (umbc.edu)
- Single Domain Antibodies: Therapeutic Tools for the Future? (gen9bio.com)
Inhibits1
- A neutralizing antibody against ε-toxin inhibits oligodendrocyte death and demyelination. (cornell.edu)
Antibiotic1
- Vernaz N, Sax H, Pittet D, Bonnabry P, Schrenzel J, Harbarth S. Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile. (smw.ch)
Vaccines3
- More than half of the nontraditional products in development are vaccines or antibodies. (pewtrusts.org)
- These firms are primarily developing vaccines or antibodies. (pewtrusts.org)
- Broodmares require specific vaccines during gestation to prevent abortion and provide antibody-rich colostrum to the newborn foal. (ufl.edu)
Ribotype1
- Surveillance of a novel erythromycin resistance determinant first isolated from Clostridium difficile ribotype 027, in human gut microorganisms. (exeter.ac.uk)
Chicken2
- Chicken Clostridium difficile Binary Toxin Antibody - 0.1 mg - 1 vial is backordered and will ship as soon as it is back in stock. (karlan.com)
- The MSDS of Chicken for Clostridium is available from Karlan upon request. (karlan.com)
Immunization1
- After immunization of subcutaneous (SC) and dMN, antibody titers of the PLGA and Al adjuvant groups were similar in both two immune ways. (bvsalud.org)
Soil1
- Clostridia also reside in animals, soil, and decaying vegetation. (msdmanuals.com)
Obligate1
- Obligate anaerobes such as Bifidobacterium and Clostridium survive in the anoxic region. (nature.com)
Invitrogen1
- NEW YORK (GenomeWeb News) - Invitrogen said today that it will become the exclusive North American distributor of all of MitoSciences products, which includes monoclonal antibodies and immunoassays for researching mitochondrial proteins and diseases. (genomeweb.com)
Neutralization1
- The neutralization potency of antibody is strongly epitope-dependent. (tamu.edu)
Disease2
- Epidemiology of Clostridium difficile-associated disease at University Hospital Basel including molecular characterisation of the isolates 2006-2007. (smw.ch)
- Host anti-toxin immune responses play important roles in Clostridium difficile disease and outcome. (exeter.ac.uk)
Microorganisms1
- Compared to Italians, the Hadza enterocyte-associated microbiome was characterized by a greater amount of adhesive microorganisms with pathogenic potential, such as Proteobacteria, Erysipelotrichaceae , Enterococcus , Clostridium and Sarcina . (frontiersin.org)
Products1
- The pact will add more than 200 new products to Invitrogen's antibody and kit catalog, the Carlsbad, Calif.-based firm said. (genomeweb.com)
TcdB1
- Furthermore, we report three crystal structures of TcdB-antibody complexes that reveal how antibodies could specifically inhibit the activities of individual TcdB domains. (rcsb.org)