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  • viruses
  • The anti-α-Gal antibody-complement reaction is probably the main reason why humans and higher primates are not infected by enveloped viruses of other animals. (virology.ws)
  • When the same viruses are propagated in human cells, which lack α-Gal, fresh human serum has no effect on viral infectivity. (virology.ws)
  • Natural antibodies prevent the spread of viruses to vital organs, and improve immunogenicity by enhancing the trapping of antigen in secondary lymphoid organs such as lymph nodes. (virology.ws)
  • A controlled serologic survey of antibody titres to 17 viruses was undertaken in multiple sclerosis patients in the Orkney and Shetland Islands. (bmj.com)
  • Besides the common receptor/coreceptor-dependent mechanism of cellular attachment, some viruses rely on antiviral antibodies for their efficient entry into target cells. (nih.gov)
  • Recent studies have suggested that additional mechanisms underlie ADE: involvement of complement component C1q and its receptor (Ebola virus), antibody-mediated modulation of the interaction between viral protein and its coreceptor (human immunodeficiency virus) and suppression of cellular antiviral genes by the replication of viruses entering cells via ADE (Ross River virus). (nih.gov)
  • The use of antibodies in viral research is essential in the continuing efforts to develop vaccines and drug therapies for viruses. (antibodies-online.com)
  • Ebola
  • Bruno Gaillet, University Laval (Quebec, Canada) and coauthors from National Research Council Canada (Montreal), Public Health Agency of Canada and University of Manitoba (Winnipeg), University of Pennsylvania (Philadelphia), and McGill University (Montreal) coauthored the article entitled "Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections. (medicalxpress.com)
  • Vectored antibody delivery has the potential to revolutionize how we respond to emerging pathogens like Ebola virus disease," says Editor-in-Chief Terence R. Flotte, MD, Celia and Isaac Haidak Professor of Medical Education and Dean, Provost, and Executive Deputy Chancellor, University of Massachusetts Medical School, Worcester, MA. (medicalxpress.com)
  • Marc-André Robert et al, Gene Transfer of ZMapp Antibodies Mediated by Recombinant Adeno-Associated Virus Protects Against Ebola Infections, Human Gene Therapy (2017). (medicalxpress.com)
  • epitopes
  • The Fab portion of the antibodies made against epitopes of the virus attachment site blocks the virus from adsorbing to the receptor site on the host cell membrane. (ccbcmd.edu)
  • For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. (abgent.com)
  • rebound
  • HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. (nih.gov)
  • Interruption of combination antiretroviral therapy in HIV-1-infected individuals leads to rapid viral rebound. (nih.gov)
  • July 25, 2017 (PARIS) -- A new study has shown that infusion of a broadly neutralizing antibody (bNAb) in virally suppressed, early treated volunteers was associated with a modestly delayed rebound of HIV after interruption of antiretroviral therapy (ART). (eurekalert.org)
  • Seventeen of the 18 volunteers experienced viral rebound and reinitiated ART. (eurekalert.org)
  • Although the delayed time to viral load rebound with VRC01 seen here is likely not clinically significant, it taught us two important lessons," said Dr. Jintanat Ananworanich, Associate Director for Therapeutics Research at MHRP. (eurekalert.org)
  • strains
  • When strains of mice that cannot produce any antibodies are infected with vesicular stomatitis virus, titers in the kidney and brain are 10-100 times higher than in normal mice. (virology.ws)
  • Thirteen volunteers with undetectable viral loads were randomized into an intervention group that received VRC01, a broadly neutralizing antibody that inhibits multiple strains of HIV by adhering to the CD4 binding site on the virus. (eurekalert.org)
  • Consistent
  • Consistent with this observation, antibody-coated adenovirions in the cell cytoplasm contained both TRIM21 and ubiquitin. (virology.ws)
  • No consistent pattern of elevated antibody titre levels or the presence of antibody was noted in patients compared with two control groups. (bmj.com)
  • Keywords: antibody, avidity, genital infections, HPV, prevalence Background Consistent attacks with high-risk individual papillomavirus (hrHPV) type 16 trigger half of cervical cancers (CxCa) morbidity/mortality [1, (acmbcb.org)
  • loads
  • f , Plasma viral loads and CD4 counts in all study participants. (nih.gov)
  • The left y -axis shows plasma viral loads in RNA copies per ml (black curves), and right y -axis shows absolute CD4 counts in cells per μl (red curves). (nih.gov)
  • establish
  • Proper validation with controls and optimization ensure the quality of the antibody, and establish confidence in your results. (abgent.com)
  • mice
  • Furthermore, virus titers in lymph nodes are 10-100 times lower than in antibody-producing mice. (virology.ws)
  • Perhaps raising lab mice in a (semi-)sterile environment also has an impact on their natural antibody repertoire? (virology.ws)
  • complement
  • Anti-α-Gal antibodies are an example of how the adaptive immune system cooperates with the innate complement cascade to provide immediate action before specific anti-viral antibodies are developed. (virology.ws)
  • Finally, as you mentioned, natural antibodies are generally complement-dependent and also very low titer, at least in the VSV example. (virology.ws)
  • time
  • Great post, from my perspective as I have been interested in the antibody response to VSV for quite some time. (virology.ws)
  • During this right time, HPV is solved through T helper cell activation of cytotoxic T cells and B cells to create neutralizing IgG antibodies . (acmbcb.org)
  • Certify that your antibodies work, while saving time and money. (abgent.com)
  • Abgent offers single-use antibody panel for cost- and time-efficient screening assays. (abgent.com)
  • clinical
  • CONCLUSIONS The presence of aCLs in viral infections is principally cofactor independent, suggesting that cofactor dependence of the aCLs should be assessed to distinguish subjects most likely to suffer from clinical symptoms observed in the presence of these antibodies. (bmj.com)
  • presence
  • The presence of this activity in many mammalian species suggested that there could be ways that antibodies operate within cells. (virology.ws)
  • researchers
  • The researchers evaluated the therapeutic effectiveness of three ZMapp antibodies (c2G4, c4G7, and c13C6) and different doses and various routes of administration (intravenous, intramuscular and intranasal). (medicalxpress.com)
  • treatment
  • It is intended for the treatment of viral Upper Respiratory Tract Infections (URTIs) such as common cold, influenza or influenza-like illnesses. (clinicaltrials.gov)
  • RESULTS
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • host
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)