Loading...
  • lung
  • The syndrome is now defined as an autoimmune disorder consisting of the triad of glomerulonephritis, lung hemorrhage, and antiglomerular basement membrane antibody formation, and it includes a broad spectrum of clinical features, ranging from massive pulmonary hemorrhage with little overt evidence of renal disease to fulminant crescentic glomerulonephritis and little overt evidence of pulmonary hemorrhage (24). (springer.com)
  • anti-laminin antibody
  • Original Message----- From: histonet-bounces@lists.utsouthwestern.edu [mailto:histonet-bounces@lists.utsouthwestern.edu] On Behalf Of Coolen, Neeltje Sent: Thursday, April 07, 2005 3:37 AM To: histonet@lists.utsouthwestern.edu Subject: [Histonet] Laminin antibody Dear Histonetters, Are there any people who have experience with the following anti-laminin antibody: mouse monoclonal, clone 4C7 from DAKO (code no: M0638)? (histosearch.com)
  • kalinin
  • The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. (abcam.com)
  • LAMB2 Antibody
  • This LAMB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1579-1606 amino acids from the C-terminal region of human LAMB2. (lsbio.com)
  • 67kDa
  • Synthetic peptide within Human 67kDa Laminin Receptor aa 250 to the C-terminus (C terminal). (abcam.com)
  • heterotrimeric
  • Laminins are heterotrimeric molecules that consist of alpha, beta, and gamma subunits that assemble through a coiled-coil domain. (lsbio.com)
  • The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. (lsbio.com)
  • Signal Transduction
  • Laminins are essential for formation and function of the basement membrane and have additional functions in regulating cell migration and mechanical signal transduction. (lsbio.com)
  • chain
  • Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. (abcam.com)
  • This gene encodes the gamma chain isoform laminin, gamma 2. (abcam.com)
  • Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. (genetex.com)
  • Antibody 2F12 binds to the LMα5 chain, 3G10 binds to the LMβ1 chain and 3C12 binds to the LMγ1 chain. (edu.au)
  • Recognizes mouse laminin B2/g1 chain at ~210kD. (lsbio.com)
  • This mAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. (lsbio.com)
  • Reacts with EHS (Engelbreth-Holm-Swarm) mouse laminin, A chain. (lsbio.com)
  • coiled coil
  • The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure. (abcam.com)
  • extracellular
  • Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (abcam.com)
  • Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. (abcam.com)
  • 67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. (abcam.com)
  • cell adhesion
  • One of the antibodies (3G10) is a potent inhibitor of the activity of LM-511 in cell adhesion, spreading and proliferation assays. (edu.au)