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  • rituximab
  • Rituximab (RTX), a monoclonal antibody to CD20, leads to B lymphocyte depletion and has been used in some autoimmune disorders, including small case series of myasthenia gravis patients. (curehunter.com)
  • Consistent with studies in NOD mice, early clinical trials addressing whether depletion of B cells by the Rituximab CD20-specific antibody provides an effective means for type 1 diabetes reversal have produced promising results. (nih.gov)
  • The murine CD20-specific 18B12 antibody that like Rituximab, depletes the follicular (FO) but not marginal zone subset of B cells, efficiently inhibited diabetes development in NOD mice in a likely regulatory T-cell-dependent manner only when treatment was initiated before IAA detection. (nih.gov)
  • CD20
  • Anti-CD20 or control antibody treatment was initiated in 10-week-old NOD female mice typed to be IAA negative, with a subset also injected at 2-week intervals with a CD25-specific antibody to deplete Tregs. (nih.gov)
  • It is significant that the ability of anti-CD20 treatment to inhibit diabetes development in pre-IAA onset NOD mice was abrogated by coinfusions with a depleting CD25-specific antibody to a disease rate indistinguishable from controls (Fig. 6). (nih.gov)
  • molecules
  • Immunoglobulin G (IgG) antibodies are large heterodimeric molecules, approximately 150 kDa and are composed of two kinds of polypeptide chain, called the heavy (~50kDa) and the light chain (~25kDa). (wikipedia.org)
  • CD94 : NKG2 (heterodimers), a C-type lectin family receptor, is conserved in both rodents and primates and identifies nonclassical (also nonpolymorphic) MHC I molecules such as HLA-E. Expression of HLA-E at the cell surface is dependent on the presence of nonamer peptide epitope derived from the signal sequence of classical MHC class I molecules, which is generated by the sequential action of signal peptide peptidase and the proteasome. (wikipedia.org)
  • infection
  • Murine influenza infection of the lungs stimulated the expression of ANGPTL4 via a STAT3-mediated mechanism. (wikipedia.org)
  • Each HERV family is derived from a single infection of the germline by an exogenous retrovirus that once integrated expanded and evolved. (wikipedia.org)
  • however
  • Surprisingly, however, studies with monoclonal antibody (mAb) PRC5, which discriminates OvPrP-A136 from OvPrP-V136, revealed substantial conversion of OvPrP-A136. (nih.gov)
  • However, apoptosis was not observed following culture with other anti-CD47 antibodies. (wikipedia.org)
  • responses
  • Live, attenuated vaccines, such as smallpox and polio vaccines, are able to induce killer T-cell (TC or CTL) responses, helper T-cell (TH) responses and antibody immunity. (wikipedia.org)
  • They can generate TH and antibody responses, but not killer T cell responses. (wikipedia.org)
  • patients
  • The 'TRACTISS' Study (Anti-B-Cell Therapy In Patients With Primary Sj√∂gren's Syndrome), in UK, will include 100 patients having anti-Ro/La antibodies, reduced basal secretion but an increased salivary flow with stimulation, within 10years of diagnosis, symptomatic oral dryness, fatigue and at least one systemic feature. (biomedsearch.com)
  • In addition to surgery, chemotherapy and radiation, many neuroblastoma patients at MSKCC were treated with a murine (mouse-derived) monoclonal antibody called 3F8. (wikipedia.org)
  • Several
  • Several monoclonal antibody technologies had been developed recently, such as phage display, single B cell culture, single cell amplification from various B cell populations and single plasma cell interrogation technologies. (wikipedia.org)
  • cancer
  • The cancer may derive from the microscopic Merkel cell nervous organ in the skin and viscera which is responsible for touch and pressure sensation. (wikipedia.org)