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  • clinical
  • 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. (kobo.com)
  • myeloma cells
  • The key idea was to use a line of myeloma cells that had lost their ability to secrete antibodies, come up with a technique to fuse these cells with healthy antibody producing B-cells and be able to select for the successfully fused cells. (mdanderson.org)
  • human
  • Schlom J., Wunderlich D., Teramoto Y.A.: Generation of human monoclonal antibodies reactive with human mammary carcinoma cells. (springer.com)
  • Taylor-Papadimitriou J., Peterson J.A., Arklie J., Burchell J., Ceriani R.L., Bodmer W.F.: Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. (springer.com)
  • Mènard S., Tagliabue E., Canevari S., Fossati G., Colnaghi M.I.: Generation of monoclonal antibodies reacting with normal and cancer cells of human breast. (springer.com)
  • Serum from a Lewis rat immunized with this partially purified estradiol-receptor complex contained antiestrophilin antibodies that reacted not only with nuclear and extranuclear estradiol-receptor complexes from MCF-7 cells but also with estrophilin from rat, calf, and monkey uterus, hen oviduct, and human breast cancers. (pnas.org)
  • These monoclonal antibodies should prove useful in the study of estrogen receptors of human reproductive tissues, in particular for the radioimmunochemical assay and immunocytochemical localization of receptors in breast cancers. (pnas.org)
  • Neuberger MS, Williams GT, Mitchell EB, Jouhal SS, Flanagan JG, Rabbitts TH (1985) A hapten-specific chimaeric IgE antibody with human physiological effector function. (springer.com)
  • Lonberg N, Huszar D (1995) Human antibodies from transgenic mice. (springer.com)
  • More particularly, the invention relates to monoclonal antibodies to an extracellular epitope of human Pgp and to their preparation and diagnostic and clinical uses. (google.com)
  • WASHINGTON, DC - July 24, 2013 - Researchers from the National Institute of Allergy and Infectious Diseases (NIAID) provide the first proof of concept data showing that a monoclonal antibody can neutralize human norovirus. (asm.org)
  • Cite
  • Publications should cite the Core grant in the acknowledgment section, if publications use antibodies or data generated by the Core facility. (mdanderson.org)
  • mouse
  • A small example is, if the mice were injected with a certain virus, the mouse will have B-Lymphocytes that produce those specific virual antibodies. (prospecbio.com)
  • CDRs
  • 6. A monoclonal antibody of claim 1 comprising a variable domain having CDRs, CDR1, CDR2 and CDR3, which have amino acid sequences which are the same as the amino acid sequences of the corresponding CDRs of the heavy chain variable domain of SEQUENCE ID NO. 2. (google.com)
  • produce
  • The main focus of the facility is to produce high-affinity antibodies in a high-throughput and effective manner, while concentrating on quality of product and service, as well as saving time and money for potential users. (mdanderson.org)
  • Hybrid cells produce only 1 exact antibody that is more pure than polyclonal antibodies produced by conventional techniques. (prospecbio.com)
  • treatment
  • Synthetic Biologics, Inc., a developer of synthetic biologics and innovative medicines for unmet medical needs, and Intrexon Corporation (Intrexon), a synthetic biology company that utilizes its proprietary technologies to provide control over cellular function, entered into a second worldwide exclusive channel collaboration through which Synthetic Biologics intends to develop and commercialize a series of monoclonal antibody (mAb) therapies for the treatment of certain infectious diseases not adequately addressed by existing therapies. (synbioproject.org)