AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Carcinoembryonic AntigenAntibodiesAntigens, NeoplasmAntigensAntibodies, MonoclonalAntibody SpecificityColonic NeoplasmsAntigens, Tumor-Associated, CarbohydrateCA-19-9 AntigenAntibodies, ViralAntigens, BacterialAntigens, SurfaceCell Adhesion MoleculesAntibodies, BacterialEpitopesColorectal NeoplasmsAntibody FormationAdenocarcinomaKeratin-19Antibodies, NeoplasmAntigens, CDTumor Markers, BiologicalCross ReactionsAntibodies, Anti-IdiotypicImmunoenzyme TechniquesRectal NeoplasmsMucin-1Antigens, ViralRadioimmunoassayFluorescent Antibody TechniqueAntibody AffinityTissue Polypeptide AntigenGlycoproteinsAntibodies, NeutralizingCystadenocarcinomaMolecular Sequence DataBinding Sites, AntibodyImmunoglobulin FragmentsPerchloratesAntibodies, BispecificKeratinsalpha-FetoproteinsMice, Inbred BALB CGastrointestinal NeoplasmsAmino Acid SequenceImmunoglobulin GSensitivity and SpecificityLiver NeoplasmsGPI-Linked ProteinsKeratin-20Antigen-Antibody ReactionsCyst FluidIodine RadioisotopesEnzyme-Linked Immunosorbent AssayPregnancy-Specific beta 1-GlycoproteinsCell LineAntigens, ProtozoanTumor Cells, CulturedRadioimmunodetectionImmunohistochemistryCancer VaccinesCarcinomaLung NeoplasmsAntigens, DifferentiationNeoplasm MetastasisAntigen-Antibody ComplexRadioimmunotherapyImmunoglobulin Fab FragmentsCystadenomaImmune SeraNeoplasm TransplantationHLA-A2 AntigenCA-125 AntigenImmunodiffusionAntibodies, ProtozoanNeoplasm StagingMice, NudeImmunologic TechniquesT-LymphocytesBase SequenceHLA AntigensPrognosisMembrane GlycoproteinsImmunoassayAvipoxvirusPeritoneal LavageAntigens, CD15Stomach NeoplasmsNeoplasmsAntigens, Polyomavirus TransformingAntigens, FungalHIV AntibodiesNeoplasm Recurrence, LocalTransplantation, HeterologousReceptors, AntigenAntigens, HelminthAntibodies, HeterophileImmunoglobulin MMolecular WeightAntigens, CD58
Monoclonal AntibodiesGlycoproteinMembers of the carcinoembryonic antigen familyProteinsCross-reactinSurface antigenCD66BiomarkersCEACAM5Injected radiolabeledColorectal cancerDifferentiationCytokeratinAnti-CEA antiNonspecificPolyclonalGlycoproteinsAntinuclear AntibodyBispecific antibodiesCellColonicProteinCalcitoninBindsAffinityConjugateSpecificityImmunoglobulinTumor CellsBone marrowThyroglobulinCancerTherapeuticTumorsAssayApproachesAzideTissuesComplementMarkerHumanSensitivityPreclinicalAmountsConsistsNear-infrared
Monoclonal Antibodies10
  • The therapeutic landscape has witnessed a transformative shift with the dominating presence of monoclonal antibodies (mAbs). (reportlinker.com)
  • The biopharmaceutical industry is entering an era dominated by sophisticated therapeutics, and Bi-Specific Monoclonal Antibodies (MAbS) represent a cutting edge development in this sphere. (reportlinker.com)
  • Because even monoclonal antibodies to CEA tend to have some degree of cross-reactivity, occasionally giving false positive results, it is commonly employed in combination with other immunohistochemistry tests, such as those for BerEp4, WT1, and calretinin. (wikipedia.org)
  • Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. (abcam.com)
  • Monoclonal antibodies (mAbs) directed against tumor-associated antigens have excellent characteristics to target tumor cells selectively ( 1 - 3 ). (snmjournals.org)
  • We established an intracranial GBM model using C57BL/6 mice and GL261 cells, and treated the mice with single or combined monoclonal antibodies (mAbs) against Tim-3/CEACAM1. (medscimonit.com)
  • The antibody development team at BTI has built strong capabilities to generate and characterise monoclonal antibodies (mAbs) against novel glycosylated targets on cancer cells. (a-star.edu.sg)
  • Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies. (ucc.ie)
  • To determine whether PSGs are expressed in tumors, we characterized 16 novel monoclonal antibodies to human PSG1 and used 2 that do not cross-react with CEACAMs to study PSG expression in tumors and in the gastrointestinal (GI) tract using tissue arrays and immunohistochemistry. (ucc.ie)
  • This was followed by the immobilization of the following primary monoclonal antibodies: alpha-fetoprotein (AFP) antibody, which is used in liver cancer detection, prostate-specific antigen (PSA) antibody which is used in prostate cancer detection, and carcinoembryonic antigen (CEA) antibody which is used in ovarian cancer detection. (auburn.edu)
Glycoprotein6
  • Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a glycoprotein that has limited expression in normal adult tissues, but is overexpressed in carcinomas of the gastrointestinal tract, the genitourinary and respiratory systems, and breast cancer. (nih.gov)
  • Such antibodies to CEA are commonly used in immunohistochemistry to identify cells expressing the glycoprotein in tissue samples. (wikipedia.org)
  • One arm of the antibody binds to carcinoembryonic antigen (CEA), a glycoprotein that is expressed on the cell surface of a wide variety of tumor types. (genengnews.com)
  • CD66b is a member of the carcinoembryonic antigen (CEA)-like glycoprotein family present on granulocytes and referred to as non-specific crossreacting antigens (NCA). (bdbiosciences.com)
  • This antibody has a high affinity for CEA and shows no detectable reactivity to nonspecific cross-reacting antigen (NCA), biliary glycoprotein (BGP) and human polymorphonuclear leucocytes. (samatashkhis.com)
  • Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that is related to the Lewis blood group protein. (medscape.com)
Members of the carcinoembryonic antigen family1
  • CD66 identifies a neutrophil-specific epitope within the hematopoietic system that is expressed by members of the carcinoembryonic antigen family of adhesion molecules. (ox.ac.uk)
Proteins5
  • These lab-made proteins, designed to simultaneously target two or more antigens, promise to revolutionize treatment methods for a range of medical conditions, particularly in oncology and. (reportlinker.com)
  • The team reported on experiments using two biomarkers, carcinoembryonic antigens and Interleukin-1 beta proteins (and matching antibodies for both), purchased by the lab. (phys.org)
  • The epitope that EBC-129 binds to is a specific glycosylation 1 site that is conserved on both carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 5 and 6, which are proteins over-expressed in cancer cells. (a-star.edu.sg)
  • This antibody recognizes proteins of 80-200kDa, identified as different members of CEA family. (neobiotechnologies.com)
  • In neutrophils these proteins are activation antigens in that their surface expression is increased following stimulation. (umn.edu)
Cross-reactin1
  • This MAb does not react with nonspecific cross-reacting antigen (NCA) and with human polymorphonuclear leucocytes. (neobiotechnologies.com)
Surface antigen2
  • 5. That a Hepatitis B surface antigen test not be performed if the person requesting the test indicates that the test is for a prenatal assessment. (ontario.ca)
  • hepatitis B surface antigen negative and antibody positive. (spandidos-publications.com)
CD667
  • Kuijpers TW, van der Schoot CE, Hoogerwerf M, Roos D. Cross-linking of the carcinoembryonic antigen-like glycoproteins CD66 and CD67 induces neutrophil aggregation. (bdbiosciences.com)
  • Preliminary results from the IVth Leucocyte Culture Conference have classified the monoclonal antibody (MoAb), YTH 71.3.2, as CD66. (ox.ac.uk)
  • To examine their potential role in neutrophil signaling, the effects on neutrophil adhesion to human umbilical vein endothelial cells of a panel of well characterized CD66 mAbs was tested, CD66a, CD66b, CD66c, and CD66d antibodies each increased neutrophil adhesion to human umbilical vein endothelial cell monolayers. (umn.edu)
  • This increase in neutrophil adhesion caused by CD66 antibodies was blocked by a CD18 antibody and associated with up-regalation of CD11/CD18 on the neutrophil surface. (umn.edu)
  • This increase in neutrophil adhesion required physiological extracellular calcium concentrations at or near the time of CD66 antibody binding to the neutrophil. (umn.edu)
  • The incubation of CD66 antibodies with neutrophils in the absence of calcium for 10 min before repletion of calcium resulted in no increase in neutrophil adhesion. (umn.edu)
  • The data suggest that CD66, CD66b, CD66c, and CD66d antibody binding to the neutrophil surface triggers a transient activation signal that requires extracellular calcium and regulates the adhesive activity of CD11/CD18. (umn.edu)
Biomarkers2
  • When a fluid sample is put into the disposable device, microfluidic channels direct it to the sponges, which are infused with antibodies that detect and capture specific biomarkers. (phys.org)
  • After soaking the beads in the antibody solutions, the researchers tested their ability to recognize and capture their matching biomarkers. (phys.org)
CEACAM54
  • As such, CEACAM5 is an attractive target for antibody-based therapies designed to selectively deliver cytotoxic drugs to certain epithelial tumors. (nih.gov)
  • Here, we describe preclinical data for a novel antibody-drug conjugate (ADC), SAR408701, which consists of an anti-CEACAM5 antibody (SAR408377) coupled to a maytansinoid agent DM4 via a cleavable linker. (nih.gov)
  • Immobilized Human CEACAM6 at 2 μg/mL can bind Anti- CEACAM5/CEACAM6 recombinant antibody (CSB-RA005165MA2HU), the EC 50 is 0.9430-1.377 ng/mL. (cusabio.cn)
  • Immobilized Human CEACAM6 at 2 μg/mL can bind Human CEACAM8 (CSB-MP005168HU), the EC50 is 144.7-223.8 ng/mL.②Measured by its binding ability in a functional ELISA.Immobilized Human CEACAM6 at 2 μg/mL can bind Anti- CEACAM5/CEACAM6 recombinant antibody (CSB-RA005165MA2HU), the EC50 is 0.9430-1.377 ng/mL. (cusabio.cn)
Injected radiolabeled1
  • Intravenously injected radiolabeled anti-carcinoembryonic antigen monoclonal antibody into patients with colorectal cancer accumulated specifically in primary tumors, liver metastases, disseminated tumors and metastatic lymph nodes. (cancerprev.org)
Colorectal cancer1
  • Gerlinger and colleagues reported on their studies in the Journal for Immunotherapy of Cancer , in a paper titled, " CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids . (genengnews.com)
Differentiation3
  • This molecule was previously clustered as CD67 in the Fourth Human Leucocyte Differentiation Antigen (HLDA) Workshop and renamed CD66b in the Fifth HLDA Workshop. (bdbiosciences.com)
  • Leucocyte typing IV : white cell differentiation antigens. (bdbiosciences.com)
  • Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. (bdbiosciences.com)
Cytokeratin2
  • Immunohistochemistry (IHC) staining was conducted by using the avidin-biotin complex technique for detecting the antibodies to hypoxia inducible factor-1 (HIF-1) alpha, cytokeratin 20 (CK20), and cell proliferation factor Ki67. (hindawi.com)
  • Before any tissue dissociation procedure, the biopsies were characterised immunohistochemically with anti-CEA (carcinoembryonic antigen) and anti-cytokeratin antibodies as a positive control. (wordnik.com)
Anti-CEA anti1
Nonspecific1
  • Kuroki M, Matsuo Y, Kinugasa T, Matsuoka Y. Augmented expression and release of nonspecific cross-reacting antigens (NCAs), members of the CEA family, by human neutrophils during cell activation. (bdbiosciences.com)
Polyclonal4
  • A research team from Czech Republic immunohistochemically examined the expression of cyclooxygenase-2 (COX-2) in pancreatic ductal adenocarcinoma using monoclonal and polyclonal antibodies to validate the potential usefulness of this marker in predictive oncology. (wordnik.com)
  • For example, there were no T cell subsets and antibodies were all polyclonal. (cityofhope.org)
  • anti-human CEA rabbit polyclonal antibody purified from serum and prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% sodium azide. (samatashkhis.com)
  • anti-human Caspase 3 rabbit polyclonal antibody purified from rabbit anti-serum by Protein A chromatography. (samatashkhis.com)
Glycoproteins2
Antinuclear Antibody1
  • Several factors, including rising cases of autoimmune diseases, lifestyle changes, and healthcare advancements, spark a growing demand for Antinuclear Antibody (ANA) Screenings. (reportlinker.com)
Bispecific antibodies2
  • Engineered antibodies such as single-chain Fv antibodies (sFvs) or bispecific antibodies have been used for targeting and therapy of CEA expressing tumors both in vitro and in vivo with promising results Regions of high CEA levels in the body can be detected with the monoclonal antibody arcitumomab. (wikipedia.org)
  • Additional innovative therapeutic approaches include bispecific antibodies and immunocytokines. (cityofhope.org)
Cell13
  • In order to distinguish between KA and SCC, further histologic studies can be used, including proliferating-cell nuclear antigen immunostaining. (medscape.com)
  • [ 7 ] In KAs, cells that stain positive with proliferating-cell nuclear antigen immunostaining are distributed only in the outer edges of the tumor, corresponding to the proliferating squamous epithelial cells. (medscape.com)
  • In contrast, cells within an SCC that stain positive with proliferating-cell nuclear antigen immunostaining are more diffusely distributed. (medscape.com)
  • The G10F5 monoclonal antibody specifically binds to CD66b, also known as Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM8). (bdbiosciences.com)
  • Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been recently identified as a heterophilic ligand for Tim-3. (medscimonit.com)
  • The ensuing continual antigen amounts travel a procedure known as Testosterone levels cell tiredness, whereby reacting Testosterone levels cells go through hierarchical reduction of their effector features, including their capability to proliferate, their cytotoxic potential, and their capability to generate cytokines (1). (exposed-skin-care.net)
  • After the antibody binds to the epitope on the cell surface, the ADC will be internalised (taken into the cell) and the toxic payload is released within the cancer cell to kill it. (a-star.edu.sg)
  • Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). (neobiotechnologies.com)
  • Human GIST cell lines GIST-T1 and GIST-882M were incubated with IR700-conjugated anti-c-KIT antibody, IR700-12A8, and observed by confocal laser microscopy. (thno.org)
  • The antibody is useful for studying the phenomenon of cell death by apoptosis as a pathogenic mechanism of numerous pathologies: nerve damage, neurodegenerative diseases, cardiovascular diseases, autoimmune diseases, AIDS and malignancies. (samatashkhis.com)
  • Clear cell acanthoma usually stains positively for epithelial membrane antigen and negatively for carcinoembryonic antigen. (medscape.com)
  • With antikeratin antibodies, the clear cell acanthomas stain for AE1 and AE3, but did not stain for CAM5.2. (medscape.com)
  • BACKGROUND: Teclistamab, a B-cell maturation antigen × CD3 bispecific antibody, is approved in patients with relapsed/refractory multiple myeloma (RRMM) who have previously received an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 antibody. (bvsalud.org)
Colonic1
  • The antibodies identify 50- to 55-Kd, 80- to 100-Kd, and 130- to 200-Kd components present in a semi-purified carcinoembryonic antigen (CEA) preparation from colonic adenocarcinomas and a 90- to 130-Kd molecule from HL-60 cells. (ox.ac.uk)
Protein2
Calcitonin1
Binds1
  • The other antibody arm binds to T cells that kill the cancer cells. (genengnews.com)
Affinity2
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • In terms of differences between the model antibodies, CEA antibody showed the highest affinity to its immunogen (CEA) whereas the antibodies PSA and AFP showed cross-reactivities with other antigens from the QCM-D and FA results. (auburn.edu)
Conjugate2
  • EBC-129 is the first made-in-Singapore antibody-drug conjugate (ADC) that is entering clinical development. (a-star.edu.sg)
  • Singapore's drug discovery efforts reached a new milestone as EBC-129, the first made-in- Singapore antibody-drug conjugate, was cleared by the US FDA to progress into first-in-human studies. (a-star.edu.sg)
Specificity1
  • In this approach a nonradiolabeled bispecific monoclonal antibody (bs-mAb) with antitumor-associated antigen (TAA) and antihapten specificity is injected in the first phase. (snmjournals.org)
Immunoglobulin1
  • Milestones in technological advancements in immunoglobulin production processes, such as development of new plasma purification methods and more effective antibodies, have offered robust backings to. (reportlinker.com)
Tumor Cells2
  • In clinical studies we have evaluated a unique monoclonal antibody-based drug delivery system, a bifunctional antibody designed to deliver imaging or therapeutic agents, such as radioisotopes, drugs, or biologics, to tumor cells, while minimizing the dose to normal tissue. (aacrjournals.org)
  • When a tumor arises, the body may produce antibodies to fight it by binding to and destroying tumor cells. (medscape.com)
Bone marrow1
  • The combination of the long circulating half-life of the radiolabeled mAb and the radiosensitivity of the bone marrow limits the radioactive doses of labeled antibodies that can be administered safely ( 6 , 7 ). (snmjournals.org)
Thyroglobulin1
  • blood tests to check levels of thyroglobulin (Tg), thyroglobulin antibodies (TgAb), thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3). (cancer.ca)
Cancer4
  • EBC-129 was the result of a multi-institutional collaboration in Singapore which began when A*STAR's Bioprocessing Technology Institute (BTI) and the National Cancer Centre Singapore (NCCS) identified the antibody that EBC-129 is based on as well as its target epitope. (a-star.edu.sg)
  • The main objective of this research was to develop a multi-step reaction scheme to immobilize model cancer antibodies on the surfaces of CNC in a liquid dispersion and compare the results to a previously established method for immobilizing antibodies on solid CNC films. (auburn.edu)
  • An additional objective was to understand whether the modified CNC could be used as probe for the cancer detection of the corresponding antigens. (auburn.edu)
  • Cancer antigen 19-9 (CA 19-9) is used to help differentiate between cancer of the pancreas and other conditions, as well as to monitor treatment response and recurrence. (medscape.com)
Therapeutic3
  • Biopharmaceuticals, particularly therapeutic antibodies, are revolutionizing modern medical treatments due to their targeted approach and ability to harness the body's own immune responses. (reportlinker.com)
  • The increasing prevalence of neurodegenerative diseases and the mounting demand for effective therapeutic options propel interest in the neuroscience antibodies and assays segment. (reportlinker.com)
  • When monoclonal antibody technology became generally available in 1978, John Shively, Ph.D., in Todd's lab, produced a Mab to CEA that after genetic engineering and radiolabeling went into City of Hope patients as both an imaging and therapeutic agent. (cityofhope.org)
Tumors2
  • Tumors were pretargeted with the bispecific monoclonal antibody (bs-mAb) G250xDTIn-1 and, 72 h later, mice were injected intravenously with one of both radiolabeled peptides. (snmjournals.org)
  • The present study reports the characterization of a humanized anti-carcinoembryonic antigen monoclonal antibody conjugated to a PEGylated near-infrared dye, that targets and brightly labels human CRC tumors in metastatic orthotopic mouse models. (bvsalud.org)
Assay1
  • This sialylated Lewis A blood group antigen is identified by a radioimmunometric assay. (medscape.com)
Approaches1
  • Advances in genomics, coupled with the technological amplitude of antibody-based approaches, are strengthening the foundation of this niche market. (reportlinker.com)
Azide1
  • Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. (neobiotechnologies.com)
Tissues1
  • Unfortunately, in some cases these antibodies cross-react with normal tissues and destroy them, which may result in a paraneoplastic disorder. (medscape.com)
Complement2
  • This antibody recognizes the C4d fraction of complement. (samatashkhis.com)
  • Consecutively, C4d is a stable split product remnant of classical complement activation and an established marker of antibody-mediated acute renal allograft rejection. (samatashkhis.com)
Marker1
  • Todd, a chemist by training, was well known for his work on CEA (carcinoembryonic antigen), the best known tumor marker of its time, and his structural approach to immune problems. (cityofhope.org)
Human2
Sensitivity1
  • Earlier clinical studies reported a high sensitivity of pretargeted immunoscintigraphy using murine or chimeric anticarcinoembryonic antigen (CEA) bispecific antibody (BsMAb) and peptides labeled with 111 In or 131 I in medullary thyroid carcinoma (MTC). (snmjournals.org)
Preclinical1
Amounts1
  • QCM-D also enabled quantification of the amounts of antibody and antigen-binding. (auburn.edu)
Consists1
Near-infrared2
  • We aimed to detect GISTs by molecular fluorescence imaging using a near-infrared (NIR) photosensitizer (IR700)-conjugated anti-c-KIT antibody and to treat GISTs by photoimmunotherapy with NIR irradiation as a non-invasive theranostic procedure. (thno.org)
  • METHODS: The hT84.66-M5A (M5A) monoclonal antibody was conjugated with a polyethylene glycol (PEG) chain that incorporated a near infrared (NIR) IR800 dye to establish M5A-IR800 Sidewinder (M5A-IR800-SW). (bvsalud.org)