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  • hapten design
  • In addition to demonstrating that the active site of antibody 28B4 does indeed reflect the mechanistic information programmed in the aminophosphonic acid hapten, these high-resolution structures provide a basis for enhancing turnover rates through mutagenesis and improved hapten design. (rcsb.org)
  • mechanism
  • To our knowledge, these structures are the highest resolution catalytic antibody structures to date and provide insight into the molecular mechanism of this antibody-catalyzed monooxygenation reaction. (rcsb.org)
  • We profoundly changed the catalytic activity and mechanism of 4-oxalocrotonate tautomerase by means of a rationally designed and synthetically produced amino acid substitution. (scripps.edu)
  • Hussain S., Pinitglang S., Bailey T.S.F., Reid J.D., Noble M.A., Resmini M., Thomas E.W., Greaves R.B., Verma C.S. and Brocklehurst K. (2003) Variation in the pH-dependent pre-steady state and steady state kinetic characteristics of cysteine proteinase catalytic mechanism: evidence for electrostatic modulation of catalytic site function by the neighbouring carboxylate anion. (qmul.ac.uk)
  • structures
  • The x-ray crystal structures of the sulfide oxidase antibody 28B4 and of antibody 28B4 complexed with hapten have been solved at 2.2-angstrom and 1.9-angstrom resolution, respectively. (rcsb.org)
  • Our specific aims i n this proposal are (1) to characterize the catalytic mechanisms and structures of three previously generated catalytic antibodies - a chorismate mutase, nucleoside acylase and cis-- trans enone isomerase. (grantome.com)
  • biological
  • Catalytic antibodies offer unique capabilities in a range of scenarios, including stereoselective organic synthesis, therapeutic potential in the treatment of disease, the elimination of toxins, the attenuation of agents used in chemical and biological warfare, and cessation of abused and/or addictive drugs. (schoolbag.info)