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  • binds
  • Researchers at University of California San Diego School of Medicine discovered that they can block inflammation in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. (ucsd.edu)
  • An anti-circumsporozoite monoclonal antibody, N2H6D5, whose corresponding heavy- and light-chain gene variable regions were engineered as a single-chain antibody construct, binds to P. gallinaceum sporozoites and prevents infection of Ae. (ajtmh.org)
  • Conclusions- Collectively, our findings demonstrate that EL2Ab binds to and exhibits P2Y 1 R-dependent function-blocking activity in the context of platelets. (ahajournals.org)
  • Their research into the spike glycoprotein, the part of the virus that binds and allows entry into human cells, provided the knowledge needed to identify several human antibodies against the SARS virus. (infectioncontroltoday.com)
  • Dimitrovs team next determined the structure of m396 and its complex with the SARS RBD and showed that the antibody binds to the region on the RBD that allows the virus to attach to host cells. (infectioncontroltoday.com)
  • bind
  • Witztum, Que and team engineered mice with two special attributes: 1) they have a gene mutation that makes them a good model for atherosclerosis and 2) they generate a piece of an antibody called E06 that's just enough to bind OxPL and prevent their ability to cause inflammation in immune cells, but not enough to cause inflammation on its own. (ucsd.edu)
  • Dimitrov and his colleagues identified two human antibodies that bind to a region on the SARS virus spike glycoprotein that is called the receptor binding domain (RBD). (infectioncontroltoday.com)
  • Surprisingly, antibody-derivatized beads that have been incubated with mt+ gametes acquire the ability to bind mt- gametes. (rupress.org)
  • inhibitory
  • In a recently developed human breast cancer model, treatment of tumor cells in a 3-dimensional culture with inhibitory β1-integrin antibody or its Fab fragments led to a striking morphological and functional reversion to a normal phenotype. (rupress.org)
  • potent
  • In a placebo-controlled, randomized study, the monoclonal antibody PRO 140 had a prolonged, potent, and dose-dependent antiviral effect, Jeffrey Jacobson, M.D., of Drexel University in Philadelphia, reported at the Interscience Conference on Anti-microbial Agents and Chemotherapy here. (medpagetoday.com)
  • This new type of broadly neutralizing HIV antibodies (bnAbs) is most potent and can be used as a template for vaccine design. (medindia.net)
  • We demonstrated that anti-enolase antibody is a potent inducer of mitochondrial injury and the caspase-3-dependent apoptotic pathway. (arvojournals.org)
  • epitopes
  • For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. (abgent.com)
  • novel
  • We provide tools for path-breaking research by developing antibodies that detect a comprehensive library of novel and established targets. (abgent.com)
  • These novel antibodies were characterized in vitro and in vivo studies using various ovarian cancer cell lines. (aacrjournals.org)
  • Approach and Results- Our goal is to determine whether a novel antibody targeting the ligand-binding domain, ie, second extracellular loop (EL2) of the P2Y 1 R (EL2Ab) could inhibit platelet function and protect against thrombogenesis. (ahajournals.org)
  • vaccine
  • Scientists at the International AIDS Vaccine Initiative (IAVI) and The Scripps Research Institute (TSRI) show that some human beings living with HIV generate powerful, HIV-blocking antibodies. (medindia.net)
  • Scientists at the International AIDS Vaccine Initiative (IAVI) and The Scripps Research Institute (TSRI) have new data to show that some human beings living with HIV generate powerful, HIV-blocking antibodies. (medindia.net)
  • Uncovering the process by which neutralizing antibodies develop is critical to HIV vaccine design," said Elise Landais, Senior Research Scientist with IAVI and lead author of the study. (medindia.net)
  • The new findings of powerful neutralizing antibodies against various HIV strains could offer a possible template for vaccine design that would protect healthy people from HIV infection. (medindia.net)
  • Despite multiple datasets for the Plasmodium sexual-stage transcriptome and proteome, there have been no rational screens to identify candidate antigens for transmission-blocking vaccine (TBV) development. (mcponline.org)
  • intravenously
  • a 14-day course of anti-CD3 monoclonal antibody (mAb) intravenously (IV) comprised of daily doses of 51 µg/m2, 103 µg/m2, 207 µg/m2, 413 µg/m2, and 10 days of 826 µg/m2 [Cycle and, when eligible per protocol, receipt of a second 14-day course after a 12-month interval (at month 13)[Cycle (clinicaltrials.gov)
  • antigens
  • In a vaccination model, antibodies directed to sexual-stage antigens, when ingested in the mosquito blood meal, can inhibit parasite growth in the midgut and consequently arrest transmission. (mcponline.org)
  • molecule
  • Explain to interested patients that several small-molecule drugs are now either approved or in the pipeline to block HIV from entering its target cells. (medpagetoday.com)
  • Dr. Gulick, who has been a leading figure in studying small-molecule CCR5 inhibitors, said the long lifetime of the antibody is also a plus. (medpagetoday.com)
  • In the studies reported here, we describe a monoclonal antibody directed against an mt+ flagellar surface molecule. (rupress.org)
  • tumor
  • All of the antibodies against the N- glycosylation sites closest to the cell membrane of MUC16 block Galectin-3-mediated polymerization to cell surface signaling molecules and inhibit the tumor-promoting effects of MUC16. (aacrjournals.org)
  • By blocking the PD-L1/PD-1 immune checkpoint, atezolizumab reduces immunosuppressive signals found within the tumor microenvironment and, consequently, increases T-cell-mediated immunity against the tumor. (aacrjournals.org)
  • Tumor cells treated with the same antibody and injected into nude mice had significantly reduced number and size of tumors in nude mice. (rupress.org)
  • On the other hand, nonmalignant cells when treated with either α6 or β4 function altering antibodies continued to grow, and had disorganized colony morphologies resembling the untreated tumor colonies. (rupress.org)
  • laboratory
  • This study is important because the viral strain that caused the outbreak in people in 2002 probably no longer exists in nature, explains Kanta Subbarao , MD , of the NIAID, whose laboratory verified the efficacy of the anti-SARS antibodies in animal models. (infectioncontroltoday.com)
  • Newswise -- An antibody plucked from a 'library' of human antibodies has powerfully blocked infection by the SARS virus in laboratory tests, scientists at Dana-Farber Cancer Institute report. (infectioncontroltoday.com)
  • Researchers from Dana-Farber, Brigham and Women's Hospital, the Centers for Disease Control and Prevention (CDC), and Children's Hospital Boston discovered that the antibody neutralized SARS infection in a laboratory setting by blocking the virus from entering cultured cells. (infectioncontroltoday.com)
  • strains
  • The antibodies also neutralized samples of the virus taken from wild civets (a cat-like mammal in which strains of the virus were found during the outbreaks), though with somewhat lower potency. (infectioncontroltoday.com)
  • mice
  • Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardening of the arteries and liver disease, and prolonged their lives. (ucsd.edu)
  • Here's what happened: Compared to control mice, the mice with E06 antibodies had 28 to 57 percent less atherosclerosis, even after one year and despite having high levels of cholesterol. (ucsd.edu)
  • The E06 antibody also prolonged the life of the mice. (ucsd.edu)
  • After 15 months, all of the E06 antibody-producing mice were alive, compared to 54 percent of the control mice. (ucsd.edu)
  • immune cells
  • A small fraction of people living with HIV can naturally produce exceptionally powerful and broad antibodies that could prevent HIV from infecting their immune cells , but not until several years post-infection - long after that protection can help them. (medindia.net)
  • cellular
  • For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease. (abgent.com)
  • significantly
  • The aorta of a mouse model of atherosclerosis on a high-fat diet for 12 months (top) has significantly more plaques (bright red) than the aorta of the same type of mouse that also produces the anti-inflammatory E06 antibody (bottom). (ucsd.edu)
  • Treatment of retinal cells with the anti-enolase antibody Enol-1 significantly blocked the activity of the enolase enzyme (p=0.0012). (arvojournals.org)
  • results
  • Proper validation with controls and optimization ensure the quality of the antibody, and establish confidence in your results. (abgent.com)
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • Any scientist working with antibodies has experienced the frustration of ambiguous results due reactive antibodies characterized by lack of specificity or low affinity. (mybiosource.com)
  • human
  • Witztum and team are now testing E06 antibody in mouse models of human diseases linked to inflammation, such as osteoporosis (bone loss) and nonalcoholic steatohepatitis (NASH, a type of liver disease). (ucsd.edu)
  • The collection contains about 27 billion monoclonal antibodies generated by a mixture of blood cells from 57 human donors. (infectioncontroltoday.com)