• The anti-GAS alphamer was shown to recruit anti-Gal antibodies to the streptococcal surface in an α-Gal-specific manner, elicit uptake and killing of the bacteria by human phagocytes, and slow growth of invasive GAS in human whole blood. (springer.com)
  • These studies provide a first in vitro proof of concept that alphamers have the potential to redirect pre-existing antibodies to bacteria in a specific manner and trigger an immediate antibacterial immune response. (springer.com)
  • La Jolla, CA. November 14, 2002-Professor Richard A. Lerner, M.D., Associate Professor Paul Wentworth, Jr., Ph.D., and a team of investigators at The Scripps Research Institute (TSRI) is reporting that antibodies can destroy bacteria, playing a hitherto unknown role in immune protection. (mold-survivor.com)
  • Now, Lerner, Wentworth and their colleagues have demonstrated that antibodies also have the ability to kill bacteria. (mold-survivor.com)
  • In the Science paper, the TSRI team reports the effective killing of E. coli bacteria through hydrogen peroxide production by antibodies specific for that bacteria. (mold-survivor.com)
  • The Scripps Research Institute (TSRI) President Richard A. Lerner, Associate Professor Paul Wentworth, Jr., Ph.D., and a team of investigators at TSRI is reporting that antibodies can destroy bacteria, playing a hitherto unknown role in immune protection. (medicalozone.info)
  • If an Invitrogenantibody doesn't perform as described on our website or datasheet, we'll replace the product at no cost to you, or provide you with a credit for a future purchase. (thermofisher.com)
  • We have observed that egg yolk antibodies (IgY) harvested from White leghorn chickens that target P. aeruginosa opsonize the pathogen and enhance the PMN-mediated respiratory burst and subsequent bacterial killing in vitro. (ku.dk)
  • Each antibody is crafted with care according to rigorous protocols for immunogen design and preparation, presentation to host animal, and high-affinity purification against the antigen. (abgent.com)
  • There is no 'universal' expression system, that can guarantee high yields of recombinant product, as every antibody-based molecule will pose its own problems in terms of expression. (nih.gov)
  • They have not yet demonstrated conclusively that what they found is ozone, but they are highly confident that ozone is what the antibodies are producing because no other known molecule has the same chemical signature. (mold-survivor.com)
  • All antibodies have the ability to produce hydrogen peroxide, the report adds, but they need to first have available a molecule known as 'singlet' oxygen-another highly reactive oxygen species-to use as a substrate. (mold-survivor.com)
  • Antibodies to B. burgdorferi were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoblot analysis. (prohealth.com)
  • Regular ELISA for HPV6/11/16/18/31/33/45 antibodies was utilized [10,24- with adjustments [17-for HPV16 antibody avidity evaluation. (acmbcb.org)
  • Hence knowledge of the precise binding site (epitope) of antibodies on the target protein is one of the most important features for understanding its performance and determining its reliability in immunoassays. (diva-portal.org)
  • As a result the choice of system will depend on many factors, including the molecular species being expressed, the precise sequence of the individual antibody and the preferences of the individual investigator. (nih.gov)
  • 1. A continuous cell line which produces human anti-exotixin antibodies, comprising: a stable fused cell hybrid of a human peripheral blood lymphocyte immunized by a toxin, or an imunogenic fragment thereof, or a toxoid prepared from an exotoxin, or an immunogenic fragment thereof, and a mouse myeloma cell, in which the antibodies are capable of neutralizing exotoxin. (freepatentsonline.com)
  • 3. A continuous cell line which produces human anit-tetanus toxin antibodies, comprising: a stable fused cell hybrid of a tetanus toxin-immunized or toxoid-immunized human peripheral blood lymphocyte and a mouse myeloma cell, in which the anitbodies are capable of neutralizing tetanus toxin. (freepatentsonline.com)
  • The unique property of specific high-affinity binding to more or less any target of interest has made antibodies tremendously useful in numerous applications. (diva-portal.org)
  • The aims of this thesis are: to provide insight into the structural and biomechanical differences of fimbriae expressed by enterotoxigenic and uropathogenic Escherichia coli, and to investigate how fimbrial mechanics are affected in the presence of anti-fimbrial antibodies. (diva-portal.org)
  • We provide tools for path-breaking research by developing antibodies that detect a comprehensive library of novel and established targets. (abgent.com)
  • For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease. (abgent.com)
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • During this right time, HPV is solved through T helper cell activation of cytotoxic T cells and B cells to create neutralizing IgG antibodies . (acmbcb.org)
  • In the throat, IgG was mostly bound to the bacterial surface via Fc, whereas in the blood IgG was mostly bound via fragment antigen-binding (Fab). (lu.se)
  • Certainly the most surprising result that Lerner, Wentworth, and their colleagues found was that antibodies appear to make ozone, which they detected through its chemical signature. (mold-survivor.com)
  • Alternatively, low-avidity antibodies have already been found (beyond your six months period) in chronic attacks, e.g., cytomegalovirus (CMV) and HPV16 [21- (acmbcb.org)
  • We used force measuring optical tweezers to characterize the force-extension responses of fimbriae in the absence and presence of antibodies. (diva-portal.org)
  • This ability of antibodies to generate toxic compounds may also link them to a number of inflammatory diseases, such as atherosclerosis, lupus, multiple sclerosis, and rheumatoid arthritis. (mold-survivor.com)
  • Proper validation with controls and optimization ensure the quality of the antibody, and establish confidence in your results. (abgent.com)
  • Immunoblots of the 3 controls with increased antibodies showed only isolated 41-kd reactivity. (prohealth.com)
  • Both seroprevalence and antibody optical density index exhibited 1-year cycles, indicating that disease outbreaks were seasonal and suggesting that long-lasting antibody protection was transient. (nih.gov)
  • Bispecific antibody-targeted minicells, packaged with the chemotherapeutic paclitaxel, were shown to be safe in patients with advanced solid tumors with modest clinical efficacy observed. (edu.au)