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  • ELISA
  • Demonstration of antibodies against the agent either with the classic Huddleson, Wright, and/or Bengal Rose reactions, either with ELISA or the 2-mercaptoethanol assay for IgM antibodies associated with chronic disease Histologic evidence of granulomatous hepatitis on hepatic biopsy Radiologic alterations in infected vertebrae: the Pedro Pons sign (preferential erosion of the anterosuperior corner of lumbar vertebrae) and marked osteophytosis are suspicious of brucellic spondylitis. (wikipedia.org)
  • chronic
  • After applying these data to the human condition, Domingue reasoned that in some patients who suffer from chronic bacterial infections, the disease process could be related to the fact that bacteria are able to differentiate into the resistant electron dense bodies that he observed in tissue cultures. (wikipedia.org)
  • gastric
  • By 2003 several PDP products for the treatment of human diseases were under development by nearly 200 biotech companies, including recombinant gastric lipase for the treatment of cystic fibrosis, and antibodies for the prevention of dental caries and the treatment of non-Hodgkin's lymphoma. (wikipedia.org)
  • immune
  • Passive immunity can occur naturally, when maternal antibodies are transferred to the fetus through the placenta, and it can also be induced artificially, when high levels of antibodies specific to a pathogen or toxin (obtained from humans, horses, or other animals) are transferred to non-immune persons through blood products that contain antibodies, such as in immunoglobulin therapy or antiserum therapy. (wikipedia.org)
  • disease
  • Passive immunization can be provided when people cannot synthesize antibodies, and when they have been exposed to a disease that they do not have immunity against. (wikipedia.org)
  • either
  • It binds to an antibody at either κ or λ light chains using hydrogen bonds and salt bridges, from backbone atoms and conserved side chains, and some conserved van der Waals interactions with other nonconserved interactions. (wikipedia.org)
  • type
  • Maternal passive immunity is a type of naturally acquired passive immunity, and refers to antibody-mediated immunity conveyed to a fetus or infant by its mother. (wikipedia.org)
  • cause
  • Dust, dried-up plants, tall vegetation, and oversized or incorrectly placed ear tags may cause mechanical damage to the eye and facilitate bacterial colonization. (wikipedia.org)
  • response
  • Because animal tests of their first vaccine - a purified polysaccharide - were inconclusive, Anderson and his colleagues tested the vaccines on themselves, finding a useful antibody response. (wikipedia.org)
  • Blood
  • Diagnosis is based upon a combination of symptoms, history of tick exposure, and possibly testing for specific antibodies in the blood. (wikipedia.org)
  • In vitro hemolysis can be caused by improper technique during collection of blood specimens, by the effects of mechanical processing of blood, or by bacterial action in cultured blood specimens. (wikipedia.org)
  • Bacteria
  • However, analysis of samples from a patient with invasive S. pyogenes infection revealed dramatic differences in the presence and orientation of IgG antibodies at the surface of bacteria from different sites. (lu.se)
  • As a consequence, the bacteria are protected against phagocytic killing, whereas in blood plasma where the concentration of IgG is high, the antibodies preferentially bind via Fab, facilitating opsonization and bacterial killing. (lu.se)
  • The anti-GAS alphamer was shown to recruit anti-Gal antibodies to the streptococcal surface in an α-Gal-specific manner, elicit uptake and killing of the bacteria by human phagocytes, and slow growth of invasive GAS in human whole blood. (springer.com)
  • These studies provide a first in vitro proof of concept that alphamers have the potential to redirect pre-existing antibodies to bacteria in a specific manner and trigger an immediate antibacterial immune response. (springer.com)
  • To overcome this problem, identifying new therapeutic targets in bacteria is essential, which necessitates scrutinizing the bacterial infection mechanism. (diva-portal.org)
  • La Jolla, CA. November 14, 2002-Professor Richard A. Lerner, M.D., Associate Professor Paul Wentworth, Jr., Ph.D., and a team of investigators at The Scripps Research Institute (TSRI) is reporting that antibodies can destroy bacteria, playing a hitherto unknown role in immune protection. (mold-survivor.com)
  • Now, Lerner, Wentworth and their colleagues have demonstrated that antibodies also have the ability to kill bacteria. (mold-survivor.com)
  • This suggests that rather than simply recognizing foreign antigens and then activating other parts of the immune system to the site of infection, the antibodies may further enhance the immune response by directly killing some of the bacteria themselves. (mold-survivor.com)
  • In the Science paper, the TSRI team reports the effective killing of E. coli bacteria through hydrogen peroxide production by antibodies specific for that bacteria. (mold-survivor.com)
  • Bacterial display (or bacteria display or bacterial surface display) is a protein engineering technique used for in vitro protein evolution. (wikipedia.org)
  • He enjoys international recognition as an authority on the basic biology and medical significance of atypical bacterial organisms and is considered a pioneer and an expert on the role of these unusual bacteria in the persistence and expression of kidney and urological infectious diseases. (wikipedia.org)
  • They noted that the forms, which they called electron dense bodies were so small that they could pass through bacterial filters that normally withheld ordinary bacteria with cell walls. (wikipedia.org)
  • After applying these data to the human condition, Domingue reasoned that in some patients who suffer from chronic bacterial infections, the disease process could be related to the fact that bacteria are able to differentiate into the resistant electron dense bodies that he observed in tissue cultures. (wikipedia.org)
  • The papers detail how L-form bacteria inside an experimental human embryonic kidney tissue culture system are able to persist in cells and explains how they are able to revert into the cell wall-containing parent bacterial form. (wikipedia.org)
  • Passive immunity is also provided through colostrum and breast milk, which contain IgA antibodies that are transferred to the gut of the infant, providing local protection against disease causing bacteria and viruses until the newborn can synthesize its own antibodies. (wikipedia.org)
  • pathogen
  • Passive immunity can occur naturally, when maternal antibodies are transferred to the fetus through the placenta, and it can also be induced artificially, when high levels of antibodies specific to a pathogen or toxin (obtained from humans, horses, or other animals) are transferred to non-immune persons through blood products that contain antibodies, such as in immunoglobulin therapy or antiserum therapy. (wikipedia.org)
  • Lerner
  • Certainly the most surprising result that Lerner, Wentworth, and their colleagues found was that antibodies appear to make ozone, which they detected through its chemical signature. (mold-survivor.com)
  • humans
  • As a result of exposure of humans to α-Gal in the environment, a large proportion of circulating antibodies are specific for the trisaccharide. (springer.com)
  • In humans, maternal antibodies (MatAb) are passed through the placenta to the fetus by an FcRn receptor on placental cells. (wikipedia.org)
  • Only a few other species besides humans transfer maternal antibodies before birth, including primates and lagomorphs (which includes rabbits and hares). (wikipedia.org)
  • recognize
  • For established targets we seek to add antibodies that recognize new epitopes, including post-translational modifications such as phosphorylation and methylation. (abgent.com)
  • specific
  • The unique property of specific high-affinity binding to more or less any target of interest has made antibodies tremendously useful in numerous applications. (diva-portal.org)
  • hydrogen
  • The ozone may be part of a previously unrecognized killing mechanism that would enhance the defensive role of antibodies by allowing them to subject pathogens to hydrogen peroxide and participate directly in their killing. (mold-survivor.com)
  • Antibodies do this by producing the chemical oxidant hydrogen peroxide-best known as the foamy formulation used for first-aid. (mold-survivor.com)
  • Hydrogen peroxide is lethal to bacterial cells because it pokes holes in their cell walls, bursting the cells and killing them. (mold-survivor.com)
  • It binds to an antibody at either κ or λ light chains using hydrogen bonds and salt bridges, from backbone atoms and conserved side chains, and some conserved van der Waals interactions with other nonconserved interactions. (wikipedia.org)
  • targets
  • We provide tools for path-breaking research by developing antibodies that detect a comprehensive library of novel and established targets. (abgent.com)
  • For new targets we consult with leading experts to accelerate development of antibodies that will propel state-of-the-art research in cellular health and disease. (abgent.com)
  • Cell
  • Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abgent.com)
  • Type
  • Bacteriophage display is the most common type of display system used although bacterial display is becoming increasingly popular as technical challenges are overcome. (wikipedia.org)
  • Maternal passive immunity is a type of naturally acquired passive immunity, and refers to antibody-mediated immunity conveyed to a fetus or infant by its mother. (wikipedia.org)
  • Further
  • Further investigation showed that efficient bacterial IgGFc-binding occurs only in IgG-poor environments, such as saliva. (lu.se)
  • We suggest further elucidation of how antibodies disrupt fimbrial mechanics, providing insights for the development of antibody-based therapeutics. (diva-portal.org)
  • presence
  • The aims of this thesis are: to provide insight into the structural and biomechanical differences of fimbriae expressed by enterotoxigenic and uropathogenic Escherichia coli, and to investigate how fimbrial mechanics are affected in the presence of anti-fimbrial antibodies. (diva-portal.org)
  • We used force measuring optical tweezers to characterize the force-extension responses of fimbriae in the absence and presence of antibodies. (diva-portal.org)
  • ability
  • But, the ability of bacterial pathogens to adapt to these life-saving medicines was underestimated. (diva-portal.org)
  • This ability of antibodies to generate toxic compounds may also link them to a number of inflammatory diseases, such as atherosclerosis, lupus, multiple sclerosis, and rheumatoid arthritis. (mold-survivor.com)
  • results
  • Proper validation with controls and optimization ensure the quality of the antibody, and establish confidence in your results. (abgent.com)