• Antibodies against proliferating cell nuclear antigen (PCNA) or monoclonal antibody termed Ki-67 can be used for grading of different neoplasms, e.g. astrocytoma. (wikipedia.org)
  • It is an extended bi-specific monoclonal antibody which contains both tumor antigen binding domain CD123 and cytotoxic T-cell binding domain (CD3 binding domain). (pharmaceutical-technology.com)
  • Xencor is a clinical stage biopharmaceutical company that focused on discovering and developing engineered monoclonal antibody and cytokine therapeutics to treat patients with cancer and autoimmune diseases. (pharmaceutical-technology.com)
  • Prolonged administration of HER-2/neu-specific monoclonal antibody therapy is now widely used for the treatment of HER-2/neu-overexpressing tumors in advanced-stage breast cancer patients. (elsevierpure.com)
  • Monoclonal antibody therapy has the potential to promote reduced tumor expression of HER-2/neu by receptor down-modulation and/or the generation of antigen-negative variants. (elsevierpure.com)
  • In this study, the effects of chronic neu-specific monoclonal antibody therapy on tumor growth and neu protein expression were examined in a murine model of neu-overexpressing breast cancer. (elsevierpure.com)
  • An understanding of the effects of monoclonal antibodies on target antigen expression is critical for the future design and testing of novel HER-2/neu-targeted therapies administered in combination with or after HER-2/neu-specific monoclonal antibody therapy. (elsevierpure.com)
  • Immunohistochemistry-Paraffin: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Human Tonsil stained with HLA-DRB Monoclonal Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • This monoclonal antibody reacts with the beta-chain of HLA-DRB1 antigen, a member of MHC class II molecules. (novusbio.com)
  • The monoclonal antibody was obtained by immunizing mice with human milk fat globulin and fusing the spleen cells with mouse myeloma cells. (histoprime.com)
  • A new monoclonal antibody to epithelial membrane antigen (EMA) - E29. (histoprime.com)
  • A comparison of its immunocytochemical reactivity with polyclonal anti-EMA antibodies and with another monoclonal antibody HMFG-2. (histoprime.com)
  • Recognition of malignant melanoma by monoclonal antibody HMB-45. (enzolifesciences.com)
  • Reference: Immunocytochemical identification of proliferative hepatocytes using monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin). (neb.com)
  • The authors investigated whether immunocytochemical staining with a monoclonal antibody to proliferating cell nuclear antigen (PCNA/cyclin) could be used to identify proliferative hepatocytes in frozen sections fixed in a mixture of periodate, lysine, and 2% paraformaldehyde. (neb.com)
  • Classical " CARs consist of an extracellular binding domain mostly derived from a monoclonal antibody fragment (single-chain variable fragment-scFv), which is linked to intracellular binding domains of the T-cell receptor complex. (nature.com)
  • Mib-1 monoclonal antibody recognizes the proliferation-related antigen Ki-67. (lu.se)
  • After intravenous injection, a radioimmunoconjugate compound (monoclonal antibody and isotope) attaches itself to the antigens expressed on the surface of neoplastic cells, causing them to emit gamma rays. (cnr.it)
  • PATIENTS AND METHODS: CA IX expression was evaluated by immunohistochemistry with a murine monoclonal antibody, M75, in a series of 103 women treated surgically for invasive breast cancer. (ox.ac.uk)
  • The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
  • Serum was analysed by immunoassay specific for prostate cancer and other fac- using a monoclonal antibody kit (Kavoshyar tors such as benign prostatic hyperplasia, Iran, Islamic Republic of Iran). (who.int)
  • NK cells respond to tumor and virus-infected cells directly through several activation receptors, including natural cytotoxicity receptors, or indirectly through the activating Fc receptor CD16 for antibody-coated cells. (nih.gov)
  • Xencor 's Vudalimab is a bispecific antibody that simultaneously targets immune checkpoint receptors PD-1 and CTLA-4 and is designed to promote tumor-selective T-cell activation. (pharmaceutical-technology.com)
  • Among these diverse features, it should be acknowledged that auto-antibodies toward glutamate receptors, GABA receptors, and K + channel-related proteins are preferentially found in autoimmune limbic encephalitis but not in IMCAs [ 10 ] (Table 1 ). (springer.com)
  • One way to achieve this is to genetically modify immune cells, mainly T cells and recently also natural killer (NK) cells, to express chimeric antigen receptors (CARs). (nature.com)
  • Chimeric antigen receptors (CAR)-engineered T cells have demonstrated remarkable efficacy in patients with B-cell malignancies. (unimedizin-mainz.de)
  • Treatment of neu-overexpressing tumors with neu-specific antibody, in vitro or in vivo, resulted in significant tumor growth inhibition. (elsevierpure.com)
  • With all assays, considerable heterogeneity of antigen expression between tumors from different Patients was observed. (elsevierpure.com)
  • In both fresh tumors and in cell lines, as well as in cell lines established from different metastatic sites in an individual Patient, we observed intratumor heterogeneity finding antigen Positive and negative cells and variation in antigenic density, by immunohistochemistry and indirect immunofluorescence assays. (elsevierpure.com)
  • Moreover, the antibody is particularly reactive in tumors of glandular origin (e.g. sweat glands). (histoprime.com)
  • Does not cross-react with normal melanocytes, intradermal nevus cells or other neoplasms including sarcomas, carcinomas and glial tumors. (enzolifesciences.com)
  • These armed second-generation CAR T cells empowered to secrete human anti-PD-L1 antibodies in the ccRCC milieu to combat T cell exhaustion is an innovation in this field that should provide renewed potential for CAR T cell immunotherapy of solid tumors where limited efficacy is currently seen. (oncotarget.com)
  • These are antigens that are found in both neoplastic cells and normal cells of the nerve tissue and are recognized as foreign, thereby causing the production of autoantibodies (anti-neural antibodies) that attack both tumors and parts of the nervous system. (athenslab.gr)
  • In addition, many antibodies are usually associated with specific tumors. (athenslab.gr)
  • The choice of antibodies is based on the common childhood tumors in Ibadan and limited by financial constraints and availability of antibodies. (bvsalud.org)
  • In ANCA-mediated vasculitis, intracellular proteins from neutrophils become expressed on the cell surface, leading to formation of antibodies (ANCA). (medscape.com)
  • however, rabbit antibodies raised against the recombinant proteins encoded by the gene of mouse bullous pemphigoid antigen 2 (BP180) are capable of inducing blisters in newborn mice in a complement-dependent manner. (medscape.com)
  • The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. (springer.com)
  • Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
  • These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
  • We were also able to define immunogenic membrane proteins from lung (squamous and adenoCa) as well as prostate neoplasms. (jcancer.org)
  • We show that 20-85% of these sera contain significant titers of antibodies against at least one of five frequently mutated and/or overexpressed tumor-associated proteins. (biomedcentral.com)
  • Tests employing bacterial-produced proteins can produce high backgrounds because it is difficult to completely eliminate or block serum antibodies reactive with trace amounts of bacterial contaminants present in most antigen preparations, even in pharmaceutical grade preparations [ 3 ]. (biomedcentral.com)
  • In addition to these autoantibodies, patients with thymoma-associated MG produce autoantibodies to various neuromuscular antigens, including antibodies to the skeletal muscle calcium release channel (ryanodine receptor of sarcoplasmic reticulum) and antibodies to cytoplasmic filamentous proteins (particularly titin) or neurofilaments. (medscape.com)
  • Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)
  • Using immunohistochemistry, radiobinding, and indirect immunofluorescence assays, seven distinct cell surface antigens, detected by monoclonal antibodies, were analyzed for the degree of homogeneity or heterogeneity of antigen expression on A Panel of human small cell lung cancers. (elsevierpure.com)
  • Variations in Alpha-1-Antichymotrypsin antibody staining intensity in immunohistochemistry on tissue sections are present across different anatomical locations. (enquirebio.com)
  • This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
  • Corresponding antigens seem to be expressed on placenta, since the lymphocytotoxic antibodies could be absorbed out with trophoblastic homogenates and one serum reacted with JAR cells (cultured choriocarcinoma line). (ox.ac.uk)
  • production of interferon or interferon-like susbstances in eb3 cultures after inoculation with human serum containing australia antigen]. (liverpool.ac.uk)
  • cancer is combined digital rectal exam and Blood samples were taken and 1 mL of determination of serum prostate specific centrifuged serum was used for the PSA antigen (PSA) level. (who.int)
  • Moreover, target antigen loss and the immunosuppressive microenvironment of hematological neoplasms facilitate resistance towards BiTEs/BiAbs. (bvsalud.org)
  • Studies with panels of allogeneic normal B cells and of HLA homozygous B-cell lines showed that the target antigen(s) recognized by these antibodies is clearly distinct from HLA-D antigens. (ox.ac.uk)
  • Vibecotamab(XmAb-14045) is under development for the treatment of hematologic malignancies such as relapsed/refractory acute myeloid leukemia, B-cell acute lymphoblastic leukemia, blastic plasmacytoid dendritic cell neoplasm, myelodysplastic syndrome and chronic myeloid leukemia. (pharmaceutical-technology.com)
  • Blastic Plasmacytoid Dendritic Cell Neoplasm: State of the Art and Prospects. (ncbcs.org)
  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an especially uncommon tumour, which often impacts aged males and presents within the pores and skin with frequent involvement of the bone-marrow, peripheral blood and lymph nodes. (ncbcs.org)
  • Immunotherapy with monoclonal antibodies, such as ipilimumab and nivolumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. (ucsd.edu)
  • Clinically, EBV-associated malignancies such as Hodgkin's lymphoma offer a unique model to explore antigen-defined immunotherapy approaches because EBV-derived tumor antigens are specific for tumor cells only. (dukecancerinstitute.org)
  • Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
  • We successfully applied this strategy to the human TAAs p53, gp100 and MDM2-specific TCRs as promising antigens-driven immunotherapy for both melanoma and hematologic malignancies. (unimedizin-mainz.de)
  • Cancer immunotherapy has demonstrated remarkable efficacy by checkpoint modulation in a large variety of neoplasms. (unimedizin-mainz.de)
  • When neu antibody was used to treat neu-overexpressing tumor cells both in vitro and in vivo in tumor-bearing mice, neu receptor expression was not diminished after cessation of therapy. (elsevierpure.com)
  • In addition, when cell lines or Patient samples expressing antigen Positive and antigen negative tumor cells were cloned, heterogeneity of antigenic expression was still Present in the clonal lines. (elsevierpure.com)
  • This suggests that either the expression of the antigen was not heritable and/or the ability to regenerate antigenic heterogeneity is an intrinsic Property of the tumor cells. (elsevierpure.com)
  • In hepatocellular carcinoma, many PCNA/cyclin-positive tumor cells were seen throughout the neoplasms. (neb.com)
  • Thus, our study reveals FcRγ-deficient NK cells as a novel subset of human NK cells that have remarkably potent responses toward antibody-coated targets. (nih.gov)
  • Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. (wikipedia.org)
  • PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the cell cycle. (wikipedia.org)
  • However, an important limitation of antibodies is that cells need to be fixed leading to potential artifacts. (wikipedia.org)
  • The heterogeneity of antigen expression on lung cancer cells has significant implications for the use of these and other monoclonal antibodies in the study and therapy of lung cancer. (elsevierpure.com)
  • Antigen-antibody complexes induce ia+ suppressor inducer cells that in" by S V. Rao, J A. Frelinger et al. (jax.org)
  • Antigen-antibody complexes induce ia+ suppressor inducer cells that initiate suppression of macrophages. (jax.org)
  • Flow Cytometry: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Flow Cytometric Analysis of Human Raji cells using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. (novusbio.com)
  • Second, these antibodies impair the induction of synaptic plasticity, rebound potentiation, and LTD, on Purkinje cells, resulting in loss of restoration and compensation of the distorted "internal models. (springer.com)
  • The E049 antibody reacts with a variety of human epithelial cells. (histoprime.com)
  • Recognizes a human melanoma-specific antigen present in melanocytic cells and junctional nevi. (enzolifesciences.com)
  • By directing T cells towards specific tumor antigens, BiTEs and BiAbs facilitate the T-cell-mediated lysis of neoplastic cells. (bvsalud.org)
  • cells of two ebna (epstein-barr virus nuclear antigen)-negative human lymphoma cell lines, bjab and ramos, were infected with two strains of epstein-barr virus (ebv). (liverpool.ac.uk)
  • Novel monoclonal and polyclonal antibodies that specifically recognize only the amino- or carboxyl-terminal ends of the human fractalkine molecule have revealed that epithelial cells are the predominant cell type expressing transmembrane forms of fractalkine in human skin, the tonsil, and the large intestine. (ox.ac.uk)
  • The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
  • Nivolumab is a type of antibody that is specific for human programmed cell death 1 (PD-1), a protein that is responsible for destruction of immune cells. (ucsd.edu)
  • CAR-expression on T or NK cells allows them to specifically target cancer cells via recognition of tumor associated antigens. (nature.com)
  • The addition of separate adapter molecules (AMs) specific for tumor antigens and CAR-immune cells targeting these AMs allows a more precise and temporally limited therapy. (nature.com)
  • This method is based on fusing protein antigens to an enzyme reporter, Renilla luciferase (Ruc), and expressing these fusions in mammalian cells, where mammalian-specific post-translational modifications can be added. (biomedcentral.com)
  • However, since such antigens do not carry post-translational modifications or may fold incorrectly, some immunoassays employ antigens produced in either yeast or insect cells. (biomedcentral.com)
  • Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. (loinc.org)
  • However, high-avidity T cells specific for tumor-associated antigens (TAAs) are usually absent in patients because of self-tolerance. (unimedizin-mainz.de)
  • Paraneoplastic neurological syndromes do not occur as a result of the direct effect of the tumor on nerve tissue cells, but most are thought to be caused by the body's immune response to various onconeural antigens . (athenslab.gr)
  • Two monoclonal antibodies identifying a subset of human peripheral mononuclear cells with natural killer cell activity. (ox.ac.uk)
  • Two monoclonal antibodies (H25 and H366) raised against the cultured T lymphoid cell line HSB-2 were shown to define a subset of peripheral mononuclear cells with natural killer and killer cell activity. (ox.ac.uk)
  • Both antibodies react with about 10% of E rosette-forming cells and a proportion of nonrosetting lymphocytes and monocytes. (ox.ac.uk)
  • Thymoma is a neoplasm of thymic epithelial cells. (medscape.com)
  • The lymphocytes' selection process and developmental progression are influenced by direct contact between the TCR-CD3 complex on the thymocyte and the major histocompatibility complex (MHC)-antigen complex on thymic epithelial cells, dendritic cells, and B lymphocytes. (medscape.com)
  • 1988). Coexpression of epithelial membrane antigen (EMA), Ki-1, and Interleukin-2 receptor by anaplastic large cell lymphomas. (histoprime.com)
  • Chimeric antigen receptor (CAR)-T cell therapies are on the verge of becoming powerful immunotherapeutic tools for combating hematological diseases confronted with pressing medical needs. (nature.com)
  • Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. (enquirebio.com)
  • Histopathology of peripheral nerve and sympathetic ganglion from a patient with autonomic failure, oat-cell carcinoma of the lung, and positive anti-HU antibody titer. (medscape.com)
  • Combined administration with anti-PD-1 antibody, NY-ESO-1 S-FLU virus augmented the tumour protection by reducing the tumour metastasis. (ox.ac.uk)
  • The antigen can also be detected in squamous cell carcinomas, even if the epithelium of origin (e.g. epidermis) itself is not reactive. (histoprime.com)
  • I - fibrous dysplasia, II - reactive lesions arising in the tooth-bearing area, and III - fibro-osseous neoplasms. (bvsalud.org)
  • the cerebrospinal fluid (csf) epstein-barr virus (ebv) fluorescent antibody (fa) titer was 1:64. (liverpool.ac.uk)
  • Paraneoplastic Neurological Syndromes (PNSs) are rare syndromes caused by or associated with an underlying neoplasm. (athenslab.gr)
  • Detection of antibodies against onconeural antigens indicates the diagnosis of paraneoplastic syndrome and helps to focus research on the underlying tumor in specific organs. (athenslab.gr)
  • The following table summarizes the anti-neural antibodies, the associated paraneoplastic neurological syndromes, and the most common underlying neoplasms. (athenslab.gr)
  • Tissues from cancer patients, for instance, have their own distinct pattern of Alpha-1-Antichymotrypsin expression as measured by anti-Alpha-1-Antichymotrypsin antibody immunohistochemical staining. (enquirebio.com)
  • Immunohistochemical (IHC) examination with antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 were detected in the basal layer of the epidermis and connective tissue. (ankara.edu.tr)
  • Western Blot: HLA DRB1 Antibody (LN-3 + HLA-DRB/1067) [NBP2-45316] - Western Blot Analysis of Human Spleen tissue lysate using HLA DRB1 Antibody (LN-3 + HLA-DRB/1067). (novusbio.com)
  • Ability of neoplasms to infiltrate and actively destroy surrounding tissue. (lookformedical.com)
  • this antibody can be used for staining of paraffin-embedded tissue sections fixed in neutral buffered formalin and is compatible with most commonly used histological fixatives. (enzolifesciences.com)
  • Although advances in tissue typing and cross-match testing have helped to deter severe transplant rejection, rejection may result from direct cellular attack (cellular rejection) or be mediated by antibodies (humoral rejection). (medscape.com)
  • The two antibodies show similar tissue distributions. (ox.ac.uk)
  • In one double-labelling immunofluorescence experiment, these antibodies could be stained by rhodamine-conjugated Fab'2 anti-mu fragments and thus appeared to belong to the IgM class. (ox.ac.uk)
  • Additionally, autoantibodies, such as antineutrophil cytoplasmic antibody (ANCA), may be associated with disease manifestations. (medscape.com)
  • Loss of antigen by either mechanism could potentially impact subsequent therapeutic strategies targeting HER-2/neu. (elsevierpure.com)
  • Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)
  • Relationships of platelet glycoprotein specific antibody with therapeutic efficacy of short-term high-dose dexamethasone and bleeding score in the newly diagnosed adult patients with primary immune thrombocytopenia. (cdc.gov)
  • Its Plamotamab is a tumor-targeted antibody that contains both a CD20 binding domain and a cytotoxic T-cell binding domain (CD3). (pharmaceutical-technology.com)
  • These antibodies exhibited a maximal cytotoxic activity at +4 degrees C. They reacted mainly with B lymphocytes as assessed by microlymphocytotoxicity assays using B- or T-cell enriched subpopulations and T- or B-cell lines as targets. (ox.ac.uk)
  • Ipilimumab is an antibody that acts against a molecule called cytotoxic T-lymphocyte antigen 4 (CTLA-4). (ucsd.edu)
  • Binding of a tumor antigen via the scFv activates the T cell in a major histocompatibility-independent manner which leads to a cytotoxic response [ 3 ]. (nature.com)
  • Imaging of the nuclear distribution of PCNA (via antibody labeling) can be used to distinguish between early, mid and late S phase of the cell cycle. (wikipedia.org)
  • Hatipoglu F, Ozdemir O, Kıran MM (2009): Detection of argyrophil nucleolar organizer regions (AgNORs) and proliferating cell nuclear antigen (PCNA) in epithelial skin tumours from domestic animals. (ankara.edu.tr)
  • Epithelial membrane antigen belongs to a group of homomolecular glycoproteins isolated from the membrane of human milk fat globules. (histoprime.com)
  • Virus-based tumour vaccines offer many advantages compared to other antigen-delivering systems. (ox.ac.uk)
  • We propose that the antigen delivery through S-FLU is highly efficient in inducing antigen-specific CD8+ T cell response and protection against tumour development in combination with PD-1 blockade. (ox.ac.uk)
  • 200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. (novusbio.com)
  • Antigen seize enzyme-linked immunosorbent assay (ELISA) for quantitation of the p24 gag protein of human immunodeficiency virus type-1 (HIV-1) is presently the commonest technique used to reveal virus replication each in vivo and in vitro. (ncbcs.org)
  • After mixing crude extracts, sera and protein A/G beads together and incubating, during which the Ruc-antigen fusion become immobilized on the A/G beads, antigen-specific antibody is quantitated by washing the beads and adding coelenterazine substrate and measuring light production. (biomedcentral.com)
  • This assay should be generally useful for analyzing sera for antibodies recognizing any protein or its post-translational modifications. (biomedcentral.com)
  • Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
  • More recently, the prostate-specific membrane antigen (PSMA) has been established as a theranostic target for prostate cancer. (snmjournals.org)
  • We engineered a non-replicating pseudotyped influenza virus (S-FLU) to deliver the well-known cancer testis antigen, NY-ESO-1 (NY-ESO-1 S-FLU). (ox.ac.uk)
  • The sample second after lung cancer as the most preva- size was calculated with level of 0.05 and lent neoplasm in men. (who.int)
  • GAD65 is involved in the synthesis, packaging, and release of GABA, whereas the other three play important roles in the induction of long-term depression (LTD). Thus, the auto-antibodies toward these synaptic molecules likely impair fundamental synaptic machineries involved in unique functions of the cerebellum, potentially leading to the development of cerebellar ataxias (CAs). (springer.com)
  • Auto-antibodies induced neurological diseases show various clinical phenotypes (see details in Table 1 ). (springer.com)
  • We developed a novel and simple immunoprecipitation technology for identifying clinical sera containing antigen-specific antibodies and for generating quantitative antibody response profiles. (biomedcentral.com)
  • p24 antigen capture assay for quantification of human immunodeficiency virus using readily available inexpensive reagents. (ncbcs.org)
  • Assays detecting human antigen-specific antibodies are medically useful. (biomedcentral.com)
  • Such chronic injury is usually mediated by anti-human leukocyte antigen antibodies. (medscape.com)
  • Whole blood was stained with FITC Mouse Anti-Human CD14 antibody (555397/557153/561712) and either BD Horizon™ BV650 Mouse IgG1, κ Isotype Control (Cat. (bdbiosciences.com)
  • dashed line histogram) or BD Horizon™ BV650 Mouse Anti-Human CD163 antibody (Cat. (bdbiosciences.com)
  • Active infection including Coronavirus disease 2019 (Polymerase chain reaction confirmed and or clinically suspected), tuberculosis, hepatitis B (known positive Hepatitis B virus (HBV) surface antigen result), hepatitis C, or Human immunodeficiency virus (HIV) (positive HIV 1 by 2 antibodies). (who.int)
  • Besides modification based on a second-generation CAR, more advanced CAR-immune cell therapeutics are being tested, which utilize precise insertion of genes to circumvent graft-versus-host disease (GvHD) or employ a dual targeting approach and adapter CARs in order to avoid therapy resistance caused by antigen loss. (nature.com)
  • These antibodies bind to the circulating antigen and create immune complexes, which then deposit within vessels, activating complement and inducing inflammatory mediators. (medscape.com)
  • Despite their immune diversity, the majority of IMCAs is commonly associated with auto-antibodies against cerebellar autoantigens. (springer.com)
  • Furthermore, the so-called adapter CARs have been developed by splitting antigen recognition and CAR-immune cell activation. (nature.com)
  • The local antibody delivery led to marked immune checkpoint blockade. (oncotarget.com)
  • Efforts to identify antibody responses to tumor antigens are motivated primarily by their diagnostic potential. (biomedcentral.com)
  • Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. (loinc.org)
  • Bispecific T-cell engagers (BiTEs) and bispecific antibodies (BiAbs) have revolutionized the treatment landscape of hematological malignancies. (bvsalud.org)
  • Lymphocytotoxic antibodies reacting with husband's lymphocytes were demonstrated in 24 sera from women with trophoblastic neoplasia studied before any chemotherapy. (ox.ac.uk)
  • sera from children were tested for antibodies to viral capsid antigens of epstein-barr virus. (liverpool.ac.uk)
  • However, the usefulness of existing simple immunoassay formats is limited by technical considerations such as sera antibodies to contaminants in insufficiently pure antigen, a problem likely exacerbated when antigen panels are screened to obtain clinically useful data. (biomedcentral.com)
  • The results of competition experiments, preincubating positive sera with unmodified E. coli -produced antigens, varied dramatically. (biomedcentral.com)
  • Hence the outcome of reduced intensity HSCT with lymphodepleting antibodies in older patients with intermediate/high-risk hematological malignancies appears comparable to that obtained with fully ablative transplantation in younger patients, even when these older recipients lack HLA-identical sibling donors. (nih.gov)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
  • An enhancing role of such antibodies in the growth of trophoblastic malignancies may be suggested. (ox.ac.uk)
  • A second group of seven patients received CD45 monoclonal antibodies in addition. (nih.gov)
  • Antibodies against a presynaptic structure, the voltage-gated potassium channels of peripheral nerves, have been detected in patients with neuromyotonia with or without thymoma. (medscape.com)
  • Neuromyotonia and antibodies to the voltage-gated potassium channels have also been found in patients with MG. Twenty percent of patients with MG and neuromyotonia have been demonstrated to have thymoma. (medscape.com)