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  • CD45
  • The kit incorporates a non-enzymatic single cell tissue homogenization process, using incellPREP, for unfixed tumor biopsy samples, labels cell suspensions with antibodies to CD45, CD8, CD3, PD-L1, stained with a Cell Cycle Dye, and then analyzes samples via flow cytometry. (pzafiropoulos.gr)
  • CTLs
  • However, such protocols are complicated by extensive ex vivo manipulations of tumor-reactive cells and have largely focused on CD8 + CTLs, with much less emphasis on the role and contribution of CD4 + T cells. (rupress.org)
  • Although CD4 + T cells are critical for orchestrating immunological processes, cancer immunotherapy has focused primarily on tumor-reactive CD8 + CTLs, largely because of their capacity to directly engage and kill transformed cells. (rupress.org)
  • Extensive testing of PBMC from vaccinees receiving all three RTS,S formulations failed to reveal CD8 + CTLs to CS protein peptides. (jimmunol.org)
  • CD25
  • CD95, Brilliant Violet 650TM anti-human CD25, and Brilliant Violet 785TM anti-human CD127 antibodies) we defined a 13-color tube which allows for the identification of major peripheral T cell subsets according to classical and more recent characterization criteria, with a minimum of sample preparation effort. (ramcon.dk)
  • alveolar
  • The two major species of medical and public health importance are Echinococcus granulosus and Echinococcus multilocularis , which cause cystic echinococcosis (CE) 3 and alveolar echinococcosis (AE), respectively. (jimmunol.org)
  • tumor
  • Sysmex Inostics highly sensitive OncoBEAM™ tests allow for molecular genetic analysis of cell-free tumor DNA from blood, eliminating the need for invasive tissue biopsies. (pzafiropoulos.gr)
  • vitro
  • CE: Products intended for in vitro diagnostic use and conforming to European Directive (98/79/EC). (beckman.com)
  • targets
  • An important class of HIV-1 broadly neutralizing antibodies, termed the VRC01 class, targets the conserved CD4-binding site (CD4bs) of the envelope glycoprotein (Env). (iavi.org)
  • However
  • However, a substantial portion of eOD-GT8-elicited antibodies target non-CD4bs epitopes, potentially limiting its efficacy. (iavi.org)
  • However, diabetes progression was only slightly affected in a subset of insulin antibody-positive patients treated with oral insulin in the Diabetes Prevention Trial-Type 1 ( 19 - 24 ). (diabetesjournals.org)
  • activation
  • The resulting close proximity between the TCR complex and CD4 (extracellular and intracellular) allows the tyrosine kinase Lck bound to the cytoplasmic tail of CD4 to tyrosine-phosphorylate the Immunoreceptor tyrosine activation motifs (ITAM) on the cytoplasmic domains of CD3 to amplify the signal generated by the TCR. (wikipedia.org)
  • human
  • Comparative studies are now allowing many of these properties to be more fully understood in the context of human immunology. (biomedsearch.com)
  • previously
  • Previously, we have shown that vaccination with B16-GM-CSF (Gvax) or B16-Flt3-ligand (Fvax) promotes the rejection of preimplanted B16-BL6 melanomas when combined with antibody blockade of CTLA-4 ( 6 , 7 ). (pnas.org)
  • measure
  • The BÜHLMANN Quantum Blue® Infliximab is the first rapid test to measure infliximab trough level in patient's serum to allow immediate decision making for potential drug dose adjustments. (pzafiropoulos.gr)