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  • Lymphocytes
  • Cytolytic T lymphocytes (CTL) were identified during the late 1960's (1,2) and are thought to be important effector cells in immunity to viruses (3) and in allograft rejection (4), Despite considerable effort during the past decade, little has been learned about the biochemical basis for the killing event. (springer.com)
  • Non-random distribution of surface immunoglobulin on murine b lymphocytes. (jax.org)
  • lymphoid
  • In particular, leukemias with the t(11;19)(q23;p13.3) translocation express HRX-ENL fusion proteins and display features which suggest the malignant transformation of myeloid and/or lymphoid progenitor(s). (embopress.org)
  • Since HRX ‐associated leukemias often express markers of both lymphoid and myeloid lineages, it is possible that HRX translocations may occur at the level of a multipotent hematopoietic progenitor or hematopoietic stem cell (HSC), leading to the disruption of normal genetic programs for terminal differentiation. (embopress.org)
  • viral
  • Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. (asm.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • mink
  • Identification of a nonvirion protein of Aleutian disease virus: mink with Aleutian disease have antibody to both virion and nonvirion proteins. (asm.org)
  • antiviral
  • The three H-2 linked Rmv genes are immune response genes controlling the antiviral antibody response. (histrecmed.fr)
  • We introduced several mutations disrupting two putative but noncanonical glyco-gag proteins in the leader sequence region in XMRV and found that those mutations did not affect virus release nor susceptibility to the antiviral activity of hA3G (human APOBEC3G). (biomedcentral.com)
  • replication
  • These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. (springer.com)
  • The recognition of the importance of Rous's discovery after such a long delay was largely owing to the cell transformation assay in monolayer culture of chick embryo fibroblasts reported by Temin & Rubin [ 7 ] in 1958 which enabled quantitative experimental studies of virus replication and cell transformation. (royalsocietypublishing.org)
  • feline immun
  • Evolutionarily conserved epitopes on human immunodeficiency virus type 1 (HIV-1) and feline immunodeficiency virus reverse transcriptases detected by HIV-1-infected subjects. (ucsf.edu)
  • Induction
  • 2009. Proposed algorithm to investigate latent and occult viruses in vaccine cell substrates by chemical induction. (asmscience.org)
  • Induction d'une leucemie virale de gross chez des souris c57bl/6 adultes par injection de cellules akr (k36). (jax.org)
  • Strains
  • Biologic, serologic, and molecular characterization of several HIV-1 and HIV-2 strains has revealed their extensive heterogeneity and how viruses can evolve differently in the same individual in the immune system, bowel, and the brain. (ucsf.edu)
  • For example, while variola virus caused only a mild and localized disease in some individuals, many succumbed to severe disease with very high mortality rates especially for some strains of the virus (reviewed in Bray and Buller, 2004 ). (frontiersin.org)
  • Isolation
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • Levy
  • Research in the Levy laboratory is directed at understanding the interaction of viruses and the immune system in microbial pathogenesis. (ucsf.edu)
  • antigen
  • A highly buy generic cialis sensitive one-step immunocapture EIA for the detection of influenza A virus antigen directly in a clinical specimen was developed. (buymetformin.site)
  • Evidence for two classes of chromatin-associated Epstein-Barr virus-determined nuclear antigen. (asm.org)
  • lineage
  • According to the leukocyte lineage, the effects of DA are associated with such processes as respiratory burst, cytokine and antibody secretion, chemotaxis, apoptosis, and cytotoxicity. (hindawi.com)
  • genes
  • Functional mapping of Autographa california nuclear polyhedrosis virus genes required for late gene expression. (asm.org)
  • vaccinia virus
  • Mapping and identification of the vaccinia virus thymidine kinase gene. (asm.org)
  • Vaccinia virus-encoded ribonucleotide reductase: sequence conservation of the gene for the small subunit and its amplification in hydroxyurea-resistant mutants. (asm.org)
  • Given that human diseases caused by poxviruses can be as lethal as smallpox or as benign as Molluscum contagiosum, and that vaccinia virus, the prototypic member of the pox family, persists as a mainstay of vaccine design and has potential as an oncolytic virus for tumor therapy, further research in this area remains important. (frontiersin.org)
  • and vaccinia virus, a virus likely derived from an extinct equine virus. (frontiersin.org)
  • Vaccinia virus was used as the vaccine successfully to eradicate variola virus and remains under investigation as a general vaccine vector as well as an oncolytic virus. (frontiersin.org)
  • cell
  • The DMF10 62.3 mAb stained a number of immortalized murine and human cell lines and, where tested, blocked their proliferation and caused death to varying extents by apoptosis. (jimmunol.org)
  • An influenza a virus specific and HLA DRw8 restricted T cell clone cross reacting with a transcomplementation product of the HLA DR2 and DR4 haplotypes. (histrecmed.fr)
  • Studies on the terminal stages of antibody-complement-mediated killing of a tumor cell. (springer.com)
  • Description of a specific murine t cell marker different from the theta marker. (jax.org)
  • protein
  • Charge microheterogeneity of the major capsid protein of polyoma virus. (asm.org)
  • Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1. (asm.org)
  • rabbits
  • Chemically modified peptides based on the membrane-proximal external region of the HIV-1 envelope induce high-titer, epitope-specific nonneutralizing antibodies in rabbits. (ucsf.edu)
  • Genetic
  • Genetic diversity of enzootic isolates of vesicular stomatitis virus New Jersey. (asm.org)
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Coffin JM (1986) Genetic variation in AIDS viruses. (springer.com)
  • simian
  • The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts. (asm.org)
  • type
  • Orthopox viruses cause a wide range of diseases and even a single type of virus will have a range of clinical course in different individuals. (frontiersin.org)