Antibodies against human. Medical search. Frequent questions

Type-specific antibodies of any Ig class are detected by competing with and blocking the binding of fluorescently tagged neutralizing monoclonal antibody from VLP-coated microspheres. (cdc.gov)
Anti-IRF4 Antibody, clone 3E4 is a highly specific rat monoclonal antibody, that targets IRF4 and has been tested in western blotting, immunohistochemistry and Flow Cytometry. (fishersci.com)
A murine monoclonal antibody to an epitope on C8 protein. (quidel.com)
This monoclonal Antibody was raised against purified human C8. (quidel.com)
Quidel's C8 monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, and Immunohistochemistry. (quidel.com)
CD141 + and HLA-DR + human peripheral blood monocytes were isolated by staining with (A) Mouse Anti-Human HLA-DR Fluorescein-Conjugated Monoclonal Antibody (Catalog # FAB4869F ) and Mouse Anti-Human Thrombomodulin/BDCA-3 (CD141) APC-Conjugated Monoclonal Antibody (Catalog # FAB3947A ). (rndsystems.com)
Isolated cells were then stained with (B) Rabbit Anti-Human XCR1 Monoclonal Antibody (Catalog # MAB8571, filled histogram) or isotype control antibody (Catalog # AB-105-C , open histogram), followed by Phycoerythrin-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # F0110 ). (rndsystems.com)
Cbx2 was detected in immersion fixed iPS2 human induced pluripotent stem cells, differentiated with 0.2 µM retinoic acid for 4 days (panels A and C) or undifferentiated (panels B and D), using Mouse Anti-Human Cbx2 Monoclonal Antibody (Catalog # MAB8098) at 10 µg/mL for 3 hours at room temperature. (rndsystems.com)
Bevacizumab is a humanized IgG1 monoclonal antibody that targets VEGF, a signaling protein that promotes the growth of new blood vessels. (invivogen.com)
The principle of this method is based on the BChE monoclonal antibody (MAb) capable of acting as both capture antibody and detection antibody. (cdc.gov)
Nivolumab is a human monoclonal antibody. (janusinfo.se)

Antibodies are proteins which are naturally formed by the body in response to a foreign substance, known as an antigen. (wikipedia.org)
These types of antibodies are typically called monoclonal antibodies because they are created to target one specific antigen. (wikipedia.org)
The SIgN Antibody Platform designs, develops and engineers human antibodies, including bispecific monoclonal antibodies that can bind two different types of antigen at one time. (a-star.edu.sg)
This extensive immune cross-reactivity between SARS-CoV-2 antibodies and different antigen groups may play a role in the multi-system disease process of COVID-19, influence the severity of the disease, precipitate the onset of autoimmunity in susceptible subgroups, and potentially exacerbate autoimmunity in subjects that have pre-existing autoimmune diseases. (frontiersin.org)
Immunological tests of crude and purified antigens against anti-nRNP sera from a total of 4 patients provided additional evidence that antibodies from different individuals are directed against the same nRNP antigen. (eurekamag.com)
In humans, MHC proteins are encoded by the Human Leukocyte Antigen (HLA), a group of more than 200 genes located closely together on the short arm of chromosome 6. (antibodies-online.com)
Classical class I and class II Human Leukocyte Antigen (HLA) are leading candidates for infectious disease susceptibility. (antibodies-online.com)
for example the MHC Class II antibody based on clone IVA12 recognizes the shared epitopes of human leucocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. (antibodies-online.com)
Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2. (antibodies-online.com)
Anti-glomerular basement membrane (anti-GBM) antibody disease is a rare autoimmune disorder in which circulating antibodies are directed against an antigen normally present in the GBM and alveolar basement membrane, specifically the alpha-3 chain of type IV collagen. (medscape.com)
In addition, anti-GBM disease has a strong positive association with the human leukocyte antigen (HLA)-DR15 haplotype, particularly the DRB1*1501 allele, which is found in more that 80% of patients with anti-GBM disease. (medscape.com)
All others are unexpected and can be divided into alloantibodies (an antibody to an antigen that an individual lacks) and autoantibodies (an antibody to an antigen a person has). (medscape.com)
The tubes are then spun for 15 seconds at room temperature to facilitate antigen-antibody interaction. (medscape.com)
LISS is usually added to reduce clustering by Na + and Cl - ions and speed antigen-antibody attraction. (medscape.com)
The presence of agglutination with the addition of AHG indicates antibody binding to a specific red cell antigen. (medscape.com)

respiratorysyndromecoronavirus(MERS-CoV).Tosearch forevidenceofautochthonousMERS-CoVinfectioninhu- mans, we tested archived serum from livestock handlers The Study in Kenya for MERS-CoV antibodies. (cdc.gov)
Even more startling, at least ten percent of the general population has been observed to carry some form of animal-derived antibodies, most often from mice, due to the preponderance of medical agents made from the serum of animals. (wikipedia.org)
No antibody was detected against non-immunoglobulin serum proteins. (jacksonimmuno.com)
After obtaining data indicating the presence of a neutrophil attractant protein-1 (NAP-1)-IgG complex in normal human serum, we developed sandwich ELISAs that could quantify NAP-1 and NAP-1-IgG in mixtures of the two moieties. (nih.gov)
The antibody exhibits inherent minimal cross-reaction to mouse serum proteins and has been tested by ELISA and/or solid-phase adsorbed to ensure minimal cross-reaction with bovine, horse and mouse serum proteins. (jacksonimmuno.com)
We have used serum from patients with amebic liver abscess to investigate the role of antibody in the prevention of invasive amebiasis using the severe combined immunodeficient (SCID) mouse model of Entamoeba histolytica infection. (ajtmh.org)
The SCID mice were passively immunized with serum or purified antibody from patients with amebic liver abscess 24 hr prior to the direct intrahepatic challenge with 10 6 virulent E. histolytica trophozoites. (ajtmh.org)
The Anti Human Dr5 Antibody From Biolegend Antibodies reagent is RUO (Research Use Only) to test human serum or cell culture lab samples. (iowaodes.com)
Description: A sandwich ELISA for quantitative measurement of Human Cathepsin Antibodies in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (iowaodes.com)
The staining pattern of AQP4-expressing cells treated with each serum of these eight NMO patients corresponded to that with a commercially available anti-AQP4 antibody. (go.jp)
As a consequence, the identification of anti-GBM antibodies in the patient's serum or tissues is of paramount importance in the diagnosis of Goodpasture disease. (medscape.com)
Naturally occurring anti-A and anti-B are the only RBC antibodies in normal human serum or plasma. (medscape.com)
The antibody screening test performed in a clinical laboratory and/or blood bank is designed to detect the presence of unexpected antibodies, especially alloantibodies in the serum to antigens of the non-ABO blood group system: Duffy, Kell, Kidd, MNS, P, and certain Rh types that are considered clinically significant. (medscape.com)
It is also used in antenatal screening to detect the presence of antibodies in a pregnant woman's serum that could result in hemolytic disease of the fetus and newborn . (medscape.com)

The antibody was purified by affinity chromatography, and conjugated with FITC under optimal conditions. (biolegend.com)
FITC (Fluorescein isothiocyanate) is the form of fluorescein used for conjugation to all of our antibodies and purified proteins, with the exception of streptavidin. (jacksonimmuno.com)

Randox Biosciences is a world-leading primary manufacturer of high quality monoclonal and polyclonal antibodies, antibody fragments and human recombinant proteins. (randox.com)
Randox Biosciences offers an extensive portfolio of over 900 products for a multitude of R&D applications including more than 500 monoclonal and polyclonal antibodies and over 140 human recombinant proteins as well as antibody fragments, buffers & diluents and plasma. (randox.com)
Our custom development service, which encompasses antibodies and human recombinant proteins has achieved tremendous success within the biopharmaceutical and diagnostic industries. (randox.com)
Here, we show that human Abs can induce increased Fn-binding affinity in M proteins, likely by enhancing the weak A-B domain binding. (lu.se)
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
We found that SARS-CoV-2 antibodies had reactions with 28 out of 55 tissue antigens, representing a diversity of tissue groups that included barrier proteins, gastrointestinal, thyroid and neural tissues, and more. (frontiersin.org)
We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
In this mechanism, antibodies formed against SARS-CoV-2 would also bind to human tissue proteins leading to autoimmune reactivity. (frontiersin.org)
None of the 4 sera contained antibodies to DNA, histones, RNA, DNA histone complexes, or nonhistone chromosomal proteins. (eurekamag.com)
Antibodies and autoantibodies are proteins made by the immune system . (medlineplus.gov)
ECSA Scientific Day 2023 (23 November 2023): Antibodies against high-risk human papillomavirus proteins as markers for noncervical HPV-related cancers in a black South African population, according to HIV status. (who.int)
Human papillomavirus (HPV) proteins may elicit antibody responses in the process towards HPV-related malignancy. (who.int)
Antibodies against E6, E7 and L1 proteins of HPV16 and HPV18 were measured in sera of 535 cases of noncervical HPV-related cancers (anal (n=104), vulval (n=211), vaginal (n=49), penile (n=37) and oropharyngeal (n=134)) and 6,651 non-infection-related cancer controls, from the Johannesburg Cancer Study that recruited Black South African with newly diagnosed cancer between 1995 and 2016. (who.int)

The ELISA for NAP-1-IgG was based on omission of the anti-NAP-1 detection antibody (required for the free NAP-1 ELISA) and on interaction of phosphatase-conjugated anti-human IgG with the human NAP-1-IgG complex. (nih.gov)
Rabbit Anti-Human IgG antibody (HRP) Cat. (genetex.com)

Human anti-mouse antibody or human anti-murine antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice. (wikipedia.org)
The HIT2 antibody reacts with CD38, an ~45 kDa type II transmembrane glycoprotein expressed by many cell types, especially leukocytes. (stemcell.com)
The MoP9 antibody reacts with CD14, a 53 - 55 kDa glycosylphosphatidylinositol (GPI)-anchored transmembrane glycoprotein expressed at high levels on the surface of peripheral blood monocytes and macrophages, and at lower levels on granulocytes. (stemcell.com)
Based on immunoelectrophoresis and/or ELISA, the antibody reacts with whole molecule human IgG. (jacksonimmuno.com)
It also reacts with the light chains of other human immunoglobulins. (jacksonimmuno.com)

NKp30 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. (prospecbio.com)
Ablexis' AlivaMab® Mouse platform is used by the majority of the world's leading pharmaceutical companies as the platform of choice for the rapid and efficient generation of diverse panels of antibodies with inherent qualities needed for antibody drugs, including affinity, potency, specificity and developability. (pharmiweb.com)
However, the substrates of the immunofluorescence assay were not human but mouse brain tissues, which could influence the sensitivity and specificity of the antibody. (go.jp)

In addition, antibodies function via unique mechanisms, such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), which are unachievable with small molecule drugs. (a-star.edu.sg)
Bevacizumab displays no antibody-dependent cell-mediated cytotoxicity (ADCC) [4]. (invivogen.com)

Thus, our results can establish the potential risk for autoimmunity and multi-system disorders with COVID-19 that may come from cross-reactivity between our own human tissues and this dreaded virus, and thus ensure that the badly-needed vaccines and treatments being developed for it are truly safe to use against this disease. (frontiersin.org)
This product shows no reactivity at a dilution of 1:100 when tested against purified Sm, nRNP, La/SS-B, Scl-70, Jo-1, Mitochondrial, or Ribosomal P antigens in an ELISA system designed to detect IgG antibody. (calbiotech.com)
Based on multiplex screening assays performed on the Beacon® platform, these SARS-CoV-2 S1 antibodies may be binned into subsets based on their binding to the receptor binding domain (S1 B ) of SARS-CoV2, blocking of S1 B binding to the ACE2 receptor, and cross-reactivity with the S1 spike protein of the SARS-CoV virus. (pharmiweb.com)

Key components of our custom service are our range of monoclonal antibodies as well as our recombinant antibody fragments (sdAbs, scFvs, fAbs). (randox.com)

This method uses the Luminex platform to simultaneously assay antibodies to HPV 6, 11, 16 and 18. (cdc.gov)
Opalka D, Lachman CE, MacMullen SA, Jansen KU, Smith JF, Chirmule N, Esser MT. Simultaneous quantitation of antibodies to neutralizing epitopes on virus-like particles for human papillomavirus types 6, 11, 16, and 18 by a multiplexed luminex assay. (cdc.gov)
Cytokine arrays are an antibody-pair-based assay, analogous to ELISA, but using a membrane as a substrate rather than a plate. (abcam.com)
In the present study, we have established human cell lines that stably express human AQP4 and used these cells to detect and titrate anti-AQP4 antibody present in the sera of patients with NMO by immunofluorescence assay. (go.jp)
However, using the new anti-AQP4 antibody assay, we showed that eight patients with NMO including the six NMO-IgG-positives were positive for anti-AQP4 antibody. (go.jp)
Thus, the newly developed anti-AQP4 antibody assay appears to have a higher sensitivity for NMO than the original NMO-IgG assay and is expected to be useful for the diagnosis of NMO. (go.jp)
Antibody response was evaluated using a glutathione S-transferase-based multiplex serology assay. (who.int)
Simultaneous detection of dual biomarkers from humans exposed to organophosphorus pesticides by combination of immunochromatographic test strip and ellman assay. (cdc.gov)

CCP antibodies, also called anti-CCP antibodies, are a type of antibody called autoantibodies. (medlineplus.gov)

The protein-sized polymer nanoparticles, with a binding affinity and selectivity comparable to those of natural antibodies, were prepared by combining a functional monomer optimization strategy with molecular-imprinting nanoparticle synthesis. (bibliotecapleyades.net)
Antibodies elicit remarkable therapeutic efficacy due to their unmatched high affinity, high selectivity and low toxicity characteristics. (a-star.edu.sg)
NKp30 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. (prospecbio.com)
Ig[immunoglobulin]G antibodies from 2 mixed connective tissue disease patients were used to construct affinity columns to isolate the antigenic complexes from rat liver nuclei. (eurekamag.com)
Affinity purified polyclonal antibody to human IgM heavy chains (mu) made in goat and biotinylated. (seracare.com)
AlivaMab Discovery Services immunized AlivaMab Mouse by expressing native trimeric SARS-CoV-2 spike protein in vivo using its propriety AMMPD-DNA technology, a process validated for rapidly eliciting strong IgG titers, and molecularly diverse, high affinity (very low picomolar) antibodies. (pharmiweb.com)
The BChE MAb which was immobilized on the test line was able to recognize both organophosphorus BChE adducts (OP-BChE) and BChE and provided equal binding affinity, permitting detection of the total enzyme amount in post-exposure human plasma samples. (cdc.gov)

By this approach we have generated a large panel of neutralizing antibodies against dengue virus. (a-star.edu.sg)

The antibody may cross-react with immunoglobulins from other species. (jacksonimmuno.com)

[ 1 , 2 ] PEG, a water-soluble linear polymer, appears to accelerate antibody-RBC binding by steric exclusion of water molecules in the diluents and to promote antibody detection. (medscape.com)

Here we report two monoclonal antibodies (mAbs) cloned from memory B cells of patients recently recovered from COVID-19, and both mAbs specifically bind to the spike (S) protein of SARS-CoV-2, block the binding of receptor binding domain (RBD) of SARS-CoV-2 to human angiotensin converting enzyme 2 (hACE2), and effectively neutralize S protein-pseudotyped virus infection. (medrxiv.org)

This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human CD138 Positive Selection Kit II (Catalog #1877) and EasySep™ Human Whole Blood and Bone Marrow CD138 Positive Selection Kit II (Catalog #17887). (stemcell.com)
This antibody has been removed from our catalog. (invivogen.com)

Human immunodeficiency virus type 1 (HIV-1) was identified as the cause of AIDS in 1983. (health.mil)
Title : Testing for Antibodies to Human Immunodeficiency Virus Type 2 in the United States Published Date : July 17, 1992 Source : MMWR. (cdc.gov)
The Food and Drug Administration (FDA) has recommended that all donated blood be screened for antibodies to human immunodeficiency virus type 2 (HIV-2) beginning no later than June 1, 1992. (cdc.gov)

The ELISA for free NAP-1 used a monoclonal capture antibody that did not bind NAP-1-IgG. (nih.gov)
Combining the portability and rapidity of test strip and the compatibility of BChE MAb as both capture antibody and detection antibody, the developed method provides a baseline-free, low-cost and rapid tool for in-field monitoring of OP exposures. (cdc.gov)

HAMA bridging interference produces artificially higher results because HAMA's bind to immobilized mouse antibodies in place of substrate, secondary labeled antibodies will then bind to HAMA and produce a positive signal falsely indicative of substrate presence. (wikipedia.org)
Since the substrate will no longer be able to bind to the immobilized mouse antibodies because of HAMA interference, labeled secondary antibodies will not give a signal for substrate presence. (wikipedia.org)
In a study published last year, the team found that some human antibodies can bind to this site on SARS-CoV-2 in a way that apparently disrupts viral fusion and blocks infection. (indiatimes.com)
Such antibodies (Abs) circumvent antigenic escape and efficiently bind to various M types. (lu.se)
Coadministration of efgartigimod with medications that bind to the human neonatal Fc receptor may lower systemic exposures and effectiveness of such medications. (medscape.com)
Closely monitor for reduced effectiveness of medications that bind to the human neonatal Fc receptor. (medscape.com)

Antibody treatment is a type of therapy that is used to treat certain types of cancer and immune disorders. (wikipedia.org)
Antibodies can also be grown outside of the patient's body and injected into them to help aid the immune system to fight disease. (wikipedia.org)
The unintended, adverse effects of injecting plastic antibodies into animals or humans in order to improve on, optimize or replace natural immune processes, are likely beyond our present ability to comprehend, but nonetheless immense. (bibliotecapleyades.net)
Group A streptococcus (GAS) is a highly adapted, human-specific pathogen that is known to manipulate the immune system through various mechanisms. (lu.se)
His laboratory studies the human immune response to infection for a wide variety of major human pathogens, including emerging infections. (hstalks.com)
He is the Director of the Human Immunome Project, an ambitious effort to identify the sequence of all transcripts for human adaptive immune receptors. (hstalks.com)

We also use combinatorial phage display technology to discover antibodies against human disease antigens, including cytokines and tumor markers on cancer stem cells. (a-star.edu.sg)
ab133998 is for simultaneous detection of 80 Human Cytokines. (abcam.com)

Tests to detect antibody to human immunodeficiency virus (HIV), the virus that causes acquired immunodeficiency syndrome (AIDS), were first licensed by the Food and Drug Administration (FDA) in 1985, primarily as screening tests for blood and plasma donation. (cdc.gov)
In order to detect Human Activin A by indirect ELISA a dilution of at least 1:1,000 of the Activin A antibody is required. (prospecbio.com)
Activin A antibody, in conjunction with compatible secondary reagents (anti rabbit AP conjugated), allows the detection of 0.2-1 ng /well of Human Activin A. In order to detect human Activin A by WB analysis this IgG can be used in a dilution of 1:1,000. (prospecbio.com)
The purpose of the immediate spin is to detect "cold" antibodies, usually of the IgM class. (medscape.com)
The last 2 phases (37°C and AHG phases) are necessary to detect clinically significant IgG antibodies. (medscape.com)

Human Antibody Laboratories manufactures the anti human dr5 antibody from biolegend antibodies reagents distributed by Genprice. (iowaodes.com)
Broad and potently neutralizing antibodies are also important research reagents for identification of protective epitopes that can be engineered into active vaccines through structure-based reverse vaccinology . (bvsalud.org)

Small volumes of Anti-carbamylated Protein Antibody elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (caslab.com)
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. (iowaodes.com)

The feasibility of using human autoimmune antibodies to isolate and characterize specific nuclear ribonucleoprotein (nRNP) complexes was investigated. (eurekamag.com)
Calbiotech specializes in immunoassay development and manufacturing, with a comprehensive range of ELISA and CLIA assays for human and animal research, including specific assays for hormone, autoimmune disorders, cancer, infectious diseases and much more. (calbiotech.com)
Pulmonary and/or renal manifestations can be encountered in various conditions, such as antineutrophilic cytoplasmic antibody (ANCA)-positive vasculitis and other autoimmune disorders. (medscape.com)

NK cells respond to tumor and virus-infected cells directly through several activation receptors, including natural cytotoxicity receptors, or indirectly through the activating Fc receptor CD16 for antibody-coated cells. (nih.gov)

Detection of XCR1 in CD141 + and HLA-DR + Human Blood Monocytes by Flow Cytometry. (rndsystems.com)
ab134002 is for simultaneous detection of 41 Human Growth Factors. (abcam.com)
Flow cytometric analysis of antibody binding to pooled cells was found to be a reliable and sensitive method for the detection of HLA class I and class II specific antibodies. (open.ac.uk)
After immediate spin, the tubes are incubated at 37°C. To promote the detection of warm reactive antibodies, especially of the IgG class, additional enhancement techniques such as low ionic strength saline (LISS) and polyethylene glycol (PEG) are often used. (medscape.com)

Anti-GBM antibodies are almost exclusively of the immunoglobulin G (IgG) isotype. (medscape.com)
These antibodies can be either immunoglobulin (Ig) M or IgG. (medscape.com)
AHG is an animal antibody that binds to the F c portion of human immunoglobulin. (medscape.com)

Antibodies protect you from disease by fighting foreign substances like viruses and bacteria. (medlineplus.gov)

Detects human XCR1 in direct ELISAs. (rndsystems.com)
Detects human Cbx2 in ELISA. (rndsystems.com)
PRA-STAT also detects both class I and class II specific antibodies. (open.ac.uk)
The AHG detects bound RBC antibodies that do not produce direct agglutination (sensitizing antibody). (medscape.com)

In this article, Goodpasture disease and anti-GBM disease are used synonymously and refer to the presence of anti-GBM antibodies in tissues (eg, kidney, lungs, or both), independent of clinical manifestations. (medscape.com)
CCP antibodies target healthy tissues in the joints. (medlineplus.gov)

Since that time, millions of HIV antibody tests have been performed in laboratories of blood and plasma collection centers, in counseling and testing centers, and in clinical facilities as well as for purposes such as screening active duty military personnel and applicants for military service. (cdc.gov)
This report provides an update through June 2021 of the results of routine screening for antibodies to the human immunodeficiency virus (HIV) among members of the active and reserve components of the U.S. Armed Forces and through Dec. 2020 among civilian applicants for military service. (health.mil)
The routine screening for antibodies to HIV for over 30 years has enabled the U.S. military to provide adequate and timely medical care to infected service members, counseling to prevent unwitting transmission, and protection of the battlefield blood supply. (health.mil)
As part of the U.S. military's total-force HIV screening program, civilian applicants for military service are screened for antibodies to HIV during pre-accession medical examinations. (health.mil)
Screening for HLA specific antibodies is an important part of laboratory testing for transplantation. (open.ac.uk)
The aim of this study was the development of a flow cytometric screening technique which would be as sensitive as the flow cytometric crossmatch and the investigation of the newly developed ELISA screening method PRA-STAT. These methods were used to investigate antibody production in patients with failed transplants. (open.ac.uk)
Screening of patients with failed transplants by these sensitive methods showed that the majority of patients produce both HLA class I and class II donor specific antibodies following failure of a primary transplant. (open.ac.uk)
Flow cytometric and PRA-STAT screening detected antibody production earlier than cytotoxic screening in some patients. (open.ac.uk)
Using the Berkeley Lights platform with our process of ultra high-throughput function-first screening, we efficiently recovered different categories of antibodies with diverse activities, each of which we believe could contribute to the fight against this terrible disease. (pharmiweb.com)
The antibody screening test, as part of pretransfusion compatibility testing (see Special Considerations ), along with the type and crossmatch, prevents transfusion reactions such as hemolysis from occurring. (medscape.com)
Antibody screening is routinely used in conjunction with typing and crossmatch before the administration of blood products, especially RBCs, to avoid transfusion reactions and to prevent notably decreased survival of transfused RBCs. (medscape.com)
Antibody screening may be performed in advance of a crossmatch to permit early recognition and identification of clinically significant antibodies and thereby permit selection of the appropriate crossmatch procedure and RBC units. (medscape.com)

Thus, our study reveals FcRγ-deficient NK cells as a novel subset of human NK cells that have remarkably potent responses toward antibody-coated targets. (nih.gov)
The principal targets for anti-GBM antibodies are two adjacent, conformational disulfide-bond-dependent regions in the NC1 domain of the alpha-3 chain of type IV collagen. (medscape.com)

The Human Monoclonal Antibodies Platform at SIgN was established to discover, engineer, and develop human therapeutic antibodies for unmet medical needs. (a-star.edu.sg)
Antibodies represent a relatively new class of therapeutic that has shown great success in treating devastating diseases in the field of cancer, inflammation and infection. (a-star.edu.sg)
We actively pursue industrial collaboration to further develop our therapeutic antibody candidates. (a-star.edu.sg)
Not for any clinical, therapeutic, or diagnostic use in humans or animals. (genetex.com)
We have observed excellent combinatorial and somatic diversity in this panel of antibodies selected for activities consistent with possible therapeutic mechanisms of action. (pharmiweb.com)
We believe the key to anti-SARS-CoV-2 therapeutic development is to rapidly screen and recover functionally diverse antibodies from an in vivo model", said Eric Hobbs, Ph.D., Chief Executive Officer of Berkeley Lights. (pharmiweb.com)
Using the assays described above to screen for binding and function, the Beacon system efficiently recovered the naturally evolved fully human VH and VL sequences, and therein connects antibody function to variable region sequence for the development of therapeutic treatments. (pharmiweb.com)
Ablexis, LLC created and commercializes the AlivaMab Mouse technology, a unique, patented next generation transgenic mouse platform for human therapeutic antibody discovery. (pharmiweb.com)
AlivaMab Discovery Services was founded by a team with proven success in the development and use of transgenic animals in the discovery of human therapeutic antibodies. (pharmiweb.com)
The ADS team applies its decades of combined experience in therapeutic antibody discovery and development to each client project to provide human therapeutic antibody discovery services customized for target type, antibody design goals, and needs of the client. (pharmiweb.com)

The anti-GBM antibodies can target the EA and EB epitope separately. (medscape.com)
[ 5 ] The more abundant D-hexamers have dimer-reinforced crosslinks between NC1 domains that help to retain the cryptic nature of the Goodpasture epitopes, whereas the less abundant M-hexamers, composed of only monomeric subunits, allow epitope unmasking and antibody binding under inflammatory states. (medscape.com)

Capture antibodies are supplied arrayed/spotted on a membrane with each pair of spots representing a different analyte. (abcam.com)
Sample is added (0.2-1ml of 1 sample to each membrane), and then paired biotinylated detector antibodies and streptavidin HRP. (abcam.com)
A table listing all of our human membrane antibody cytokine arrays and other arrays and the analytes they measure is available here . (abcam.com)
We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)

False-negative test results are observed among persons who have recently become infected with HIV and who have not yet developed detectable antibody (6). (cdc.gov)
Patients with detectable post graft failure antibodies had a lower chance of receiving a second transplant and had significantly worse regraft survival than patients with no antibody. (open.ac.uk)

I am looking for goat, rabbit, or sheep anti-human Rb antibodies. (bio.net)

only the immobilized mouse antibodies and the HAMA remain in the immunoassay when the labeled secondary antibodies are administered. (wikipedia.org)
A novel sandwich immunoassay based immunochromatographic test strip (ICTS) has been developed for simultaneously measuring both butyrylcholinesterase (BChE) activity and the total amount of BChE (including inhibited and active enzyme) from 70 microLpost-exposure human plasma sample. (cdc.gov)

In vivo imaging of the polymer nanoparticles (or 'plastic antibodies') established that the NPs accelerate clearance of the peptide from blood and accumulate in the liver. (bibliotecapleyades.net)

Therefore, nivolumab is exempt from preparation of an Environmental Risk Assessment as per the "Guideline on the Environmental Risk Assessment of Medicinal Products for Human Use" (EMEA/CHMP/SWP/4447/00). (janusinfo.se)

The discovery of IgG Fc region modifications that extend antibody half-life in humans to three months or more suggests that antibodies could become the principal tool with which we manage future viral epidemics . (bvsalud.org)

NAP-1-IgG was detected in 18 of 26 sera from normal humans. (nih.gov)

Coupled with their biocompatibility and nontoxic characteristics, plastic antibodies offer the potential for neutralizing a wide range of biomacromolecules in vivo. (bibliotecapleyades.net)
IgM antibodies are generally considered to be less significant than IgG, because they are reactive at room temperature but not body temperature and, therefore, rarely cause hemolysis in vivo. (medscape.com)

Anti-human NKp30 mAb, is derived from hybridization of mouse P3-X63-Ag8.653 myeloma cells with spleen cells from BALB/c immunized with recombinant human NKp30 amino acids 19-138 purified from E. coli. (prospecbio.com)

A different allele, HLA-B*15:03, showed the greatest capacity to present highly conserved SARS-CoV-2 peptides that are shared among common human coronaviruses, suggesting it could enable cross-protective T-cell based immunity. (antibodies-online.com)

Antibody responses targeting the M protein have been shown to favor the conserved C region. (lu.se)

One problem was that patients reacted to the mouse antibodies as if they were a foreign substance, and created a new set of antibodies to the mouse antibodies. (wikipedia.org)
Doctors have termed this the "HAMA response," referring to the development of Human Anti-Mouse Antibodies (HAMA). (wikipedia.org)
The HAMA response is essentially an allergic reaction to the mouse antibodies that can range from a mild form, like a rash, to a more extreme and life-threatening response, such as kidney failure. (wikipedia.org)
HAMA can also decrease the effectiveness of the treatment, or create a future reaction if the patient is given a subsequent treatment containing mouse antibodies. (wikipedia.org)
It has been observed that anywhere from one-third to more than half of patients receiving mouse-derived antibodies will develop some form of HAMA response. (wikipedia.org)
HAMAs will capture immobilized mouse antibodies. (wikipedia.org)
Over the extracellular regions used for immunization, human XCR1 shares 62%, 54% and 64% aa identity with canine, mouse and porcine XCR1, respectively. (rndsystems.com)
Within amino acids 131-217, human Cbx2 shares 94% and 92% aa sequence identity with mouse and rat Cbx2, respectively. (rndsystems.com)

Scientists have found antibodies in the blood of certain Covid-19 donors that can block infection from a broad set of coronaviruses, specifically in people who have recovered from the SARS-CoV-2 virus and were then vaccinated. (indiatimes.com)
Human papillomavirus (HPV) infection is the most common sexually transmitted infection in the United States. (cdc.gov)
The observed diversity includes activities consistent with different mechanisms of action hypothesized for highly efficacious antibody therapy and prophylaxis of infection by SARS-CoV-2. (pharmiweb.com)
Psittacosis --- also known as parrot fever and ornithosis --- is spread by a bacterial infection of birds that can cause severe pneumonia and other serious health problems among humans. (cdc.gov)
In humans, the resulting infection is referred to as psittacosis (also known as parrot fever and ornithosis). (cdc.gov)
Because human infection can result from brief, passing exposure to infected birds or their contaminated droppings, persons with no identified leisure-time or occupational risk can become infected. (cdc.gov)
IgG antibody typically appears within prepard in 0.85% NaCl containing 0.05 weeks of infection and, in the absence of mol/L MET. (who.int)

Using state-of-the-art antibody technologies we have developed streamlined, high-throughput single B-cell PCR cloning technology to isolate natural disease-fighting antibodies directly from virus-infected patient blood samples. (a-star.edu.sg)

Anatomy21

Organisms20

Diseases6

Chemicals and Drugs113

Analytical, Diagnostic and Therapeutic Techniques and Equipment56

Phenomena and Processes45

Disciplines and Occupations2

Information Science3

Health Care5

Monoclonal antibody11

Antigen15

Serum14

FITC2

Proteins13

Anti-Human IgG2

Reacts5

Specificity3

Cell-mediated cytotoxicity2

Reactivity3

Recombinant antibody1

Assay8

Autoantibodies1

Affinity7

Panel of neutralizi1

Species1

Diluents1

Neutralize1

Catalog2

Immunodeficiency virus type3

Capture antibody2

Bind6

Immune6

Cytokines2

Detect5

Reagents2

Elisa kit2

Autoimmune3

Receptor1

Detection4

Immunoglobulin3

Substances1

Detects4

Tissues2

Screening12

Targets2

Therapeutic10

Epitope2

Membrane4

Detectable2

Rabbit1

Immunoassay2

Nanoparticles1

Products1

Epidemics1

Sera1

Vivo2

Coli1

Peptides1

Responses1

Mouse8

Infection7

Isolate1