AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
PseudomonasPseudomonas aeruginosaPseudomonas InfectionsPseudomonas putidaPseudomonas fluorescensAnti-Bacterial AgentsPseudomonas syringaeMicrobial Sensitivity TestsAntibiotic ProphylaxisBacterial ProteinsPseudomonas PhagesPseudomonas stutzeriDrug Resistance, MicrobialDrug Resistance, BacterialBacteriaGenes, BacterialAminoglycosidesMolecular Sequence DataDNA, BacterialGene Expression Regulation, BacterialEscherichia coliGentamicinsCystic FibrosisADP Ribose TransferasesTobramycinBiofilmsStreptomycesBacterial InfectionsGram-Negative Bacteriabeta-LactamsCulture MediaAntibiotics, AntineoplasticDrug Resistance, Multiple, BacterialPyocyaninePenicillinsCephalosporinsExotoxinsCarbenicillinPlasmidsMutationAlginatesCiprofloxacinBiodegradation, EnvironmentalVirulence FactorsAmino Acid SequenceAnti-Infective AgentsGram-Positive Bacteriabeta-LactamasesStaphylococcus aureusKanamycinPseudomonas mendocinaOxygenasesCeftazidimePhenazinesBase SequenceColony Count, MicrobialFermentationThienamycinsImipenemDrug UtilizationQuorum SensingSoil MicrobiologyAmpicillinPneumonia, BacterialSequence Analysis, DNATetracyclinePolymyxinsEnterobacteriaceaePhloroglucinolCloning, MolecularAmikacinPlant DiseasesCross InfectionBacterial ToxinsErythromycinLactamsDioxygenasesTolueneColistinChemistryStreptomycinMacrolidesChemical PhenomenaHexuronic AcidsPseudomonas Vaccines4-ButyrolactoneCarbapenemsConjugation, GeneticBacterial Outer Membrane ProteinsEye Infections, BacterialGlucuronic AcidPyocinsVirulenceBurkholderia cepaciaGram-Negative Bacterial InfectionsOperonPenicillin ResistanceChloramphenicolAztreonamCatechols
BacteriaInfectionsIsolatesInfectionStaphylococcusBiofilmSusceptibility of Pseudomonas aeruginosaPathogensCysticColistinIsolatePathogenBacteriumBiofilmsAntimicrobialAminoglycosidesPathogenicVirulenceCarbapenem-resistantBroad-spectrum anMulti-drug resiStrainMultidrug-resistantSpeciesGenomicOveruseVivoGenes are responsibleEffectiveness of antibioticsKoreensisBiosynthesisPneumoniaEfflux pumpChronicIntravenous antibioticsSensitivityKirby-BauerPlanktonic cellsTreatmentCytotoxicTranscriptionalVitroFluorescensClinicalMethodsAntibacterialPenicillin
Bacteria47
  • Oxazolidinone antibiotics are active against many Gram-positive bacteria, but are only weakly active against Gram-negative pathogens. (rsc.org)
  • In addition, the drug, which targets the outer membrane of bacteria, specifically focuses on Pseudomonas , which might have certain advantages over broad-spectrum antibiotics. (cff.org)
  • CDC's Antibiotic Resistance Threats in the United States, 2019 [PDF - 150 pages] (2019 AR Threats Report) includes the latest national death and infection estimates for 18 antimicrobial-resistant bacteria and fungi. (cdc.gov)
  • The 2013 AR Threats Report helped inform the first National Action Plan for Combating Antibiotic-Resistant Bacteria . (cdc.gov)
  • C. difficile , or C. diff , bacteria causes life-threatening diarrhea and colitis (an inflammation of the colon), mostly in people who have had both recent medical care and antibiotics. (cdc.gov)
  • The bacteria might produce compounds antagonistic to other soil microbes, such as phenazine-type antibiotics or hydrogen cyanide. (wikipedia.org)
  • The problem is that bacteria have become increasingly resistant to antibiotics, making the antibiotics that you readily get from your doctor less effective. (lifehack.org)
  • Antibiotic resistance occurs when targeted bacteria show resistance to an antibiotic, continuing to thrive and multiply, even in the presence of an antibiotic's therapeutic levels. (lifehack.org)
  • Selective pressure is an antibiotic influence on natural selection where susceptible bacteria, or those having low chance of survival, are killed or inhibited by the antibiotic while the resistant strains of bacteria are allowed to survive. (lifehack.org)
  • However, sometimes, the natural selection to promote resistance to antibiotics is influenced at a low level without human action - bacteria have the ability to produce and use antibiotics against other bacteria. (lifehack.org)
  • Whether it is about protecting people from different classes of bacteria or saving countless number of lives since the first antibiotic (penicillin) was clinically used in the 1940s, antibiotics have a significant attribution in the human health history. (lifehack.org)
  • Colistin is a last resort antibiotic most physicians use when all other antibiotics don't work against a bacteria. (lifehack.org)
  • A similar strain of the antibiotic resistant bacteria was found in a pig intestine by the U.S. Department of Agriculture (USDA). (lifehack.org)
  • The CDC reports a minimum 2 million cases of infection from other antibiotic resistant bacteria each year and 23,000 consequent deaths to say the least. (lifehack.org)
  • Secretion of antibiotics is one means by which bacteria interact with neighboring microbes and sometimes change community composition. (nih.gov)
  • We expand the known repertoire of antibiotics produced by Pseudomonas in the rhizosphere and demonstrate the role of the metabolites in interactions with other rhizosphere bacteria. (nih.gov)
  • Pseudomonas aeruginosa is the gram negative rod shaped bacteria is found in all natural and man made environments. (ukessays.com)
  • Pseudomonas aeruginosa is a member of gamma proteobacteria class of bacteria. (ukessays.com)
  • Patients who would have met the criteria for HCAP should not be empirically treated with antibiotics to cover MDR bacteria unless they have valid risk factors for acquiring MDR organisms. (medscape.com)
  • University of Michigan researchers, for example, in collaboration with colleagues at Harvard University, have discovered a key difference between the way immune cells attack bacteria and the way antibiotics do. (jonbarron.org)
  • Gentamicin sulfate is an aminoglycoside antibiotic active against a wide variety of pathogenic gram-negative and gram-positive bacteria. (medi-vet.com)
  • What Is Pseudomonas Aeruginosa Bacteria? (personalinjurylawcal.com)
  • Pseudomonas aeruginosa is a type of bacteria. (personalinjurylawcal.com)
  • The purpose of the study is to discuss the correlation between the resistance rate of gram negative bacteria to fluoroquinolones (FQ) and antibiotic consumption intensity of 145 China tertiary hospitals in 2014. (biomedcentral.com)
  • Each participating hospital required to report annual consumption of each antibiotic, and the resistance rate of gram negative bacteria to FQ. (biomedcentral.com)
  • A strong correlation was demonstrated between the antibiotic consumption and the rates of FQR gram-negative bacteria. (biomedcentral.com)
  • As unreasonable antibiotics usage remains crucial in the proceeding of resistant bacteria selection, our study could greatly promote the avoidance of unnecessary antibiotic usage. (biomedcentral.com)
  • In this study, the aim was to investigat the correlation between resistance rate of gram-negative bacteria and antibiotic usage. (biomedcentral.com)
  • The three microbes used in the experiment were the bacteria Pseudomonas aeruginosa and Staphylococcus aureus , and the fungus Candida albicans - a combination commonly present in the airways of people with cystic fibrosis. (cam.ac.uk)
  • The researchers found that significantly higher doses of each antibiotic were needed to kill bacteria when it was part of poly-microbial infection, compared to when no other pathogens were present. (cam.ac.uk)
  • [13] The biofilm bacteria can share nutrients and are sheltered from harmful factors in the environment, such as desiccation, antibiotics, and a host body's immune system. (wikipedia.org)
  • An antibiotic is a type of antimicrobial substance active against bacteria . (wikipedia.org)
  • However, the effectiveness and easy access to antibiotics have also led to their overuse [8] and some bacteria have evolved resistance to them. (wikipedia.org)
  • In current usage, the term "antibiotic" is applied to any medication that kills bacteria or inhibits their growth, regardless of whether that medication is produced by a microorganism or not. (wikipedia.org)
  • Building upon this understanding, a research team led by Professor Hongzhe SUN from the Department of Chemistry, The University of Hong Kong (HKU), introduced a 'Dual Trojan Horse' strategy, where a metal-based-drug and sideromycins, a class of antibiotic structurally resembling iron, work together in combating antibiotic-resistant bacteria. (hku.hk)
  • We are short of new antibiotics, and infection caused by resistant bacteria (i.e. superbugs) may lead to another pandemic. (hku.hk)
  • The overuse and misuse of existing antibiotics have accelerated the acquired drug resistance in bacteria, resulting in resistance to almost all antibiotics used in clinical settings across various bacteria strains. (hku.hk)
  • For example, the high resistance of P. aeruginosa against conventional antibiotics can be attributed in part to the limited permeability of the outer membrane (OM) and the expression of 'efflux pump', specialised proteins within bacteria that actively remove antibiotics, thus reducing their effectiveness. (hku.hk)
  • Gram-negative bacteria, including Pseudomonas aeruginosa , can cause a range of infections in humans. (hku.hk)
  • We found that subpopulations of biofilm bacteria undergo cell death and lysis as a feature of the Pseudomonas aeruginosa biofilm life cycle. (southampton.ac.uk)
  • Can Predatory Bacteria Succeed Where Antibiotics Fail? (newswise.com)
  • A team led by researchers at the University of Medicine and Dentistry of New Jersey-New Jersey Dental School suggests that some of these predator microbes might be put to work against disease-causing bacteria that have become resistant to antibiotics. (newswise.com)
  • Kadouri hopes that one day medical practitioners can use these predator bacteria to supplement antibiotic drugs in treating life-threatening infections. (newswise.com)
  • Healthcare providers treating VIM-GES-CRPA infections should consult with a specialist knowledgeable in the treatment of antibiotic-resistant bacteria to determine the best treatment option. (cdc.gov)
  • This is a medical illustration of multidrug-resistant, Pseudomonas aeruginosa bacteria, presented in the Centers for Disease Control and Prevention (CDC) publication entitled, Antibiotic Resistance Threats in the United States, 2019 (AR Threats Report). (cdc.gov)
  • Therefore, effective strategies must be implemented to combat antibiotic-resistant bacteria, along with stricter adherence to infection control programmes. (who.int)
  • For example, bacteria such as Staph aureus , E. coli , Klebsiella , and Pseudomonas are known to develop resistance to antibiotics relatively quickly. (cdc.gov)
Infections33
  • Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium responsible for severe infections in which resistance to most of the approved families of antibiotics is increasing. (rsc.org)
  • Today, the Cystic Fibrosis Foundation announced it has awarded up to $3.3 million to Polyphor AG to develop an inhaled version of murepavadin, an antibiotic that targets multi-drug resistant Pseudomonas aeruginosa infections in people with cystic fibrosis. (cff.org)
  • About 17% of individuals with CF who had Pseudomonas infections last year had multi-drug resistant strains. (cff.org)
  • Many individuals also suffer severe side effects from long-term antibiotic use and are at increased risk of developing antibiotic-resistant infections. (cff.org)
  • Currently, the CF Foundation is funding 13 new industry programs to develop treatments for CF-related infections and is advocating for Congress to create solutions that promote a robust, sustainable pipeline of antibiotics. (cff.org)
  • Strains possessing the exoU gene are predominant in eye infections and are more resistant to antibiotics. (monash.edu)
  • When Clostridioides difficile -a bacterium that is not typically resistant but can cause deadly diarrhea and is associated with antibiotic use-is added to these, the U.S. toll of all the threats in the report exceeds 3 million infections and 48,000 deaths. (cdc.gov)
  • Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterium commonly found in wound infections and airways of cystic fibrosis patients. (researchwithrowan.com)
  • P.aeruginosa is one of the most important pathogens in nosocomial infections and fails to respond to standard treatment, particularly in the case of patients subjected to prolong antibiotic treatment. (ljmu.ac.uk)
  • These P. aeruginosa cell clusters are in vitro models of the chronic P. aeruginosa infections in cystic fibrosis patients which display recalcitrance to antibiotic treatments , leading to exacerbated morbidity and mortality . (bvsalud.org)
  • Pseudomonas aeruginosa is the commonest agent causing opportunistic nosocomial infections, contributing to mortality and morbidity worldwide. (innovareacademics.in)
  • Along with its intrinsic and acquired resistance mechanisms, infections caused by Pseudomonas species further lead to treatment failure. (innovareacademics.in)
  • The present study highlights that Pseudomonas species remains a major cause of hospital-acquired infections. (innovareacademics.in)
  • Surveillance of antimicrobial resistance and strict infection control measures are essentially to be practiced in managing and control of infections caused by Pseudomonas. (innovareacademics.in)
  • Routine susceptibility testing of four antibiotic combinations for improvement of laboratory guide to therapy of cystic fibrosis infections caused by Pseudomonas aeruginosa. (helmholtz-hzi.de)
  • Pseudomonas aeruginosa is a frequent cause of respiratory infections in cystic fibrosis (CF) patients. (omu.edu.tr)
  • Pseudomonas aeruginosa is a biofilm-forming opportunistic pathogen which causes chronic infections in immunocompromised patients and leads to high mortality rate. (frontiersin.org)
  • Although TMP/SMX is a drug that is frequently used to treat skin and soft-tissue infections of the leg and foot, particularly if methicillin-resistant Staphylococcus aureus is identified, it is not an innocuous antibiotic. (japmaonline.org)
  • The WHO report also noted that, currently, there are few potential treatment options for those antibiotic-resistant infections-including drug-resistant tuberculosis which kills around 250,000 people each year. (jonbarron.org)
  • As of March 21, 2023, 16 states have reported Pseudomonas aeruginosa infections. (personalinjurylawcal.com)
  • The results highlight the need to consider the interaction between different species of microbe when treating infections with antibiotics - and to adjust dosage accordingly. (cam.ac.uk)
  • Chronic bacterial infections such as those in the human airways are very difficult to cure using antibiotics. (cam.ac.uk)
  • Despite treatment with strong doses of antibiotics, these infections often persist long-term. (cam.ac.uk)
  • Pseudomonas aeruginosa , a common environmental bacterium, can colonize different body parts, such as the lungs, leading to persistent, chronic infections that can last a lifetime - a common occurrence in people with cystic fibrosis. (eurekalert.org)
  • It is the most important type of antibacterial agent for fighting bacterial infections , and antibiotic medications are widely used in the treatment and prevention of such infections. (wikipedia.org)
  • Antibiotics are used to treat or prevent bacterial infections, [29] and sometimes protozoan infections . (wikipedia.org)
  • Strategies for combating microbial infections - antibiotics, antiviral agents and vaccines - will be discussed in detail. (sfu.ca)
  • Gram-negative bacterial infections, such as those caused by Pseudomonas aeruginosa , pose significant challenges in treatment due to their complicated structure. (hku.hk)
  • In severe cases, these infections can be particularly challenging to treat due to the bacteria's resistance to antibiotics, making them a significant health concern. (hku.hk)
  • Aminoglycosides are bactericidal antibiotics used primarily to treat gram-negative infections. (medscape.com)
  • Pseudomonas aeruginosa and other members of this group of gram-negative bacilli are opportunistic pathogens that frequently cause hospital-acquired infections, particularly in ventilator patients, burn patients, and patients with neutropenia or chronic debility. (msdmanuals.com)
  • Pseudomonas aeruginosa is an opportunistic pathogen often causing nosocomial infections that are resilient to treatment due to an extensive repertoire of intrinsic and acquired resistance mechanisms. (who.int)
  • What was believed to be a routine Escherichia coli urinary tract infection harbored a particular gene making it resistant to colistin , usually viewed as a last-resort antibiotic for the treatment of gram-negative infections. (medscape.com)
Isolates11
  • Overall, higher antibiotic resistance was observed in the isolates possessing exoU. (monash.edu)
  • and showed the least resistance tocolistin and polymyxin B. 46 isolates out of the 162 (28%) were found to be Multi-Drug Resistant (MDR) Pseudomonas aeruginosa . (innovareacademics.in)
  • Pseudomonas aeruginosa isolates and their antimicrobial susceptibility pattern among catheterized patients at Jimma University Teaching Hospital, Jimma, Ethiopia. (innovareacademics.in)
  • Evaluation of the E test for the assessment of synergy of antibiotic combinations against multiresistant Pseudomonas aeruginosa isolates from cystic fibrosis patients. (helmholtz-hzi.de)
  • The determination of synergistic effects of antimicrobial drug combinations can lead to improved therapeutic options in the antibiotic treatment of cystic fibrosis patients who are chronically infected with multiresistant Pseudomonas aeruginosa isolates. (helmholtz-hzi.de)
  • Comparison of the Micronaut Merlin automated broth microtiter system with the standard agar dilution method for antimicrobial susceptibility testing of mucoid and nonmucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients. (helmholtz-hzi.de)
  • The aim of the present study was to examine the antibiotic resistance patterns and presence of nan1 and int1 virulence genes (encoding neuraminidase and class 1 integrons, respectively) in clinical P. aeruginosa isolates and to analyze the measured values with regard to hospital wards, specimens, and antibiotic resistance of the strains. (brieflands.com)
  • Colistin was the most effective antibiotic against the isolates, and ticarcillin was the least effective antimicrobial agent. (brieflands.com)
  • In summary, we demonstrated that P. aeuginosa clinical isolates with novel epigenetic markers could form excessive biofilm, which might enhance its antibiotic resistance and in vivo colonization in COVID-19 patients. (frontiersin.org)
  • We looked at overall resistance and the number of isolates which were resistant to all antibiotics, comparing LES with non-LES and also trends over time. (bmj.com)
  • This study was aimed at determining the urinary bacterial isolates and their susceptibility to selected antibiotics among pregnant women attending antenatal clinics of selected Hospitals in Ilorin, Nigeria. (who.int)
Infection16
  • An inhaled version could make it easier for someone with a Pseudomonas infection to take the drug from home. (cff.org)
  • Pseudomonas aeruginosa has become an important cause of gram-negative infection, especially in patients with compromised host defense mechanisms. (medscape.com)
  • The virulence of these strains and their antibiotic susceptibility was measured in vivo using a Galleria mellonella larval infection model. (st-andrews.ac.uk)
  • The use of antibiotics was a milestone in the effort to prevent wound infection. (medscape.com)
  • Antibiotics for dirty wounds are part of the treatment because infection is established already. (medscape.com)
  • Qualities of prophylactic antibiotics include efficacy against predicted bacterial microorganisms most likely to cause infection (see Table 3 below), good tissue penetration to reach wound involved, cost effectiveness, and minimal disturbance to intrinsic body flora (eg, gut). (medscape.com)
  • Four separate categories of chronic Pseudomonas aeruginosa ( Pa ) infection in children with cystic fibrosis (CF) have been previously defined, based on airway cultures taken over the previous year. (ersjournals.com)
  • In cystic fibrosis (CF), Pseudomonas aeruginosa ( Pa ) is the most important lung pathogen causing progressive lung infection and shortened survival 1 . (ersjournals.com)
  • Background Strategies to prevent chronic lung infection with Pseudomonas aeruginosa (Psa) in cystic fibrosis (CF) include early eradication and the prevention of cross-infection by patient segregation. (bmj.com)
  • Background Transmissible Pseudomonas aeruginosa (Psa) strains in the cystic fibrosis (CF) community increase the risk of chronic infection which, in turn, confers a poor prognosis and is difficult to treat, often requiring the use of multiple toxic intravenous antibiotics. (bmj.com)
  • These products may have given you a Pseudomonas aeruginosa eye infection. (personalinjurylawcal.com)
  • What Are The Symptoms Of A Pseudomonas Aeruginosa Eye Infection? (personalinjurylawcal.com)
  • A study has found that much higher doses of antibiotics are needed to eliminate a bacterial infection of the airways when other microbes are present. (cam.ac.uk)
  • We were surprised to find that an antibiotic that we know should clear an infection of Pseudomonas effectively just didn't work in our lab model when other bugs were present," said Wendy Figueroa-Chavez in the University of Cambridge's Department of Biochemistry, joint first author of the paper. (cam.ac.uk)
  • The most important component of the treatment of kidney infection is the prompt administration of antibiotics . (emedicinehealth.com)
  • Melioidosis Melioidosis is an infection caused by the gram-negative bacterium Burkholderia (formerly Pseudomonas ) pseudomallei . (msdmanuals.com)
Staphylococcus3
Biofilm8
  • The influence of LxA 4 on antibiotic efficacy and the combined effects on biofilm formation were also investigated. (researchwithrowan.com)
  • Together these results suggest that LxA 4 has direct effects on P. aeruginosa biofilm formation and can increase antibiotic efficacy directly. (researchwithrowan.com)
  • A model for antibiotic accumulation in bacterial biofilm microcolonies utilizing heterogenous porosity and attachment site profiles replicated the periphery sequestration reported in prior experimental studies on Pseudomonas aeruginosa PAO1 biofilm cell clusters. (bvsalud.org)
  • This resistance has been partially attributed to periphery sequestration, where antibiotics fail to penetrate biofilm cell clusters. (bvsalud.org)
  • The aims of this study were to investigate the biofilm formation and the relation of this property with genotype and antibiotic susceptibilities of P.aeruginosa strains isolated from CF patients. (omu.edu.tr)
  • Microbes form a biofilm in response to a number of different factors, [9] which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics . (wikipedia.org)
  • Role of a new filamentous prophage Pf4 in Pseudomonas aeruginosa biofilm development. (southampton.ac.uk)
  • We showed that strains of Pseudomonas aeruginosa with increased mutation rates (caused by deletion of genes involved in DNA mismatch repair) produced more biofilm biomass in laboratory experiments. (southampton.ac.uk)
Susceptibility of Pseudomonas aeruginosa3
  • Objectives: The objectives of this study were to compare the antibiotic susceptibility of Pseudomonas aeruginosa strains with increased efflux pump expression in vitro and in vivo and to use these same strains to evaluate the efficacy of combinations of antibiotics with putative efflux pump inhibitors in vivo. (st-andrews.ac.uk)
  • Prevalence and antibiotic susceptibility of Pseudomonas aeruginosa isolated from chronic suppurative otitis media. (innovareacademics.in)
  • Five-year antimicrobial susceptibility of Pseudomonas aeruginosa from a local tertiary hospital in Bacolod City, Philippines. (innovareacademics.in)
Pathogens7
  • Because aerobic gram-negative bacilli (eg, Pseudomonas aeruginosa) are the major pathogens associated with HAP, the pathophysiology of nosocomial pneumonia relates to the destructive effect on lung tissue. (medscape.com)
  • As a result of over-prescribing and wide-spread use in the meat, poultry, and dairy industries-not to mention fish farming and the ability of pathogens to easily evolve around traditional man-made antipathogens-the standard arsenal of antibiotics is under severe stress. (jonbarron.org)
  • I've been saying for several decades that the fundamental difference between manmade antibiotics and nature-based defenses against pathogens is that manmade antibiotics are one-trick ponies around which pathogens can easily evolve. (jonbarron.org)
  • But when the other pathogens were present alongside Pseudomonas aeruginosa , the antibiotic didn't work. (cam.ac.uk)
  • All three species-specific antibiotics were less effective against their target when three pathogens were present together," said Martin Welch, Professor of Microbial Physiology and Metabolism in the University of Cambridge's Department of Biochemistry and senior author of the paper. (cam.ac.uk)
  • Other important hospital-acquired pathogens formerly classified as Pseudomonas include Burkholderia cepacia and Stenotrophomonas maltophilia . (msdmanuals.com)
  • The isolation of bacterial pathogens resistant to the commonly prescribed antibiotics from pregnant women symptomatic and asymptomatic for UTI calls for early screening of all pregnant women for UTI during antenatal care service delivery. (who.int)
Cystic7
Colistin2
Isolate3
  • Prevalence and antibiotic sensitivity pattern of Pseudomonas aeruginosa isolate from respiratory samples, pus samples and body fluids in a tertiary care hospital, Kashmir. (innovareacademics.in)
  • Therefore, an antibiotic-sensitive isolate PA30 and a multi-resistant isolate PA49 originating from waste waters were compared via whole genome and transcriptome Illumina sequencing after exposure to municipal waste water and tap water. (kit.edu)
  • Pseudomonas aeruginosa was the predominant isolate. (who.int)
Pathogen4
  • P. aeruginosa readily forms biofilms which can reduce the efficacy of antibiotics used to eradicate the pathogen. (researchwithrowan.com)
  • Khomeini Hospital was reviewed to identify patients who had nosocomial bacteraemia between 1 May 1999 and 31 May 2001 and identify the pathogen responsible and its resisitance to antibiotics. (who.int)
  • At present antibiotics are usually only laboratory tested against the main pathogen they are designed to target, to determine the lowest effective dose. (cam.ac.uk)
  • Antibiotic choice varies with the pathogen and must be guided by susceptibility testing because resistance is common. (msdmanuals.com)
Bacterium2
  • Pseudomonas fluorescens is a common Gram-negative, rod-shaped bacterium. (wikipedia.org)
  • The guidelines for each bacterium include antibiotics of confirmed effectiveness, which show acceptable results in antibiotic susceptibility tests. (brieflands.com)
Biofilms4
Antimicrobial5
  • This analysis does not include mutations that may result in antibiotic resistance or resistance determinants added to newer versions of the ResFinder database or other antimicrobial resistance gene databases. (cdc.gov)
  • This study was done to determine the prevalence and antimicrobial susceptibility pattern of different species of Pseudomonas isolated from various clinical samples by phenotypic methods. (innovareacademics.in)
  • Prevalence and antimicrobial susceptibility pattern of Pseudomonas aeruginosa isolated from pus samples in a tertiary care Hospital, Bathinda. (innovareacademics.in)
  • We have uncovered a dual Trojan Horse strategy to restore antibiotics activity, such as cefiderocol, and hope to provide a novel arsenal for combating antimicrobial resistance,' commented Professor Sun. (hku.hk)
  • The overuse and misuse of antibiotics are the major drivers of antimicrobial resistance. (cdc.gov)
Aminoglycosides3
Pathogenic2
  • This study highlights the association between virulence traits and antibiotic resistance in pathogenic P. aeruginosa. (monash.edu)
  • Mohammadzadeh A, Mardaneh J, Ahmadi R, Adabi J. Evaluation of the Virulence Features and Antibiotic Resistance Patterns of Pathogenic Pseudomonas aeruginosa Strains Isolated from Hospitalized Patients in Gonabad, Iran. (brieflands.com)
Virulence2
  • Pseudomonas aeruginosa produces multiple virulence factors that have been implicated in pathogenesis and quorum sensing. (uwi.edu)
  • Virulence genotype analysis revealed that strain CR1 lacked hemolytic phospholipase C and D, three genes for LPS biosynthesis and had reduced antibiotic resistance genes when compared with clinical strains. (frontiersin.org)
Carbapenem-resistant1
Broad-spectrum an2
  • [ 3 ] Retrospective studies actually have suggested a worse outcome when broad-spectrum antibiotics were used in these cases. (medscape.com)
  • Fluoroquinolones (FQs) were introduced as broad-spectrum antibiotics. (biomedcentral.com)
Multi-drug resi1
  • In recent years, increasing resistance rates to antibiotics such as carbapenems and extended-spectrum cephalosporins have been reported, as well as multi-drug resistant and possible extremely drug-resistant rates of approximately 21% and 15%, respectively. (who.int)
Strain2
  • The inhibitory effect of combinations of putative efflux pump inhibitors (trimethoprim and sertraline) with antibiotics on the strain overexpressing MexAB-OprM was also measured in vitro and compared with their efficacy in vivo in terms of larval survival and bacterial burden. (st-andrews.ac.uk)
  • Bismuth and cefiderocol showed synergistic effect both in vitro and in vivo (lung infectious model) against PAO1, a strain of Pseudomonas aeruginosa, as a metallo-sideromycin complex transported actively into bacterial cells. (hku.hk)
Multidrug-resistant1
Species7
  • This finding is in accordance with previous analyses of 107 Pseudomonas species, using four core 'housekeeping' genes, that consider P. fluorescens as a relaxed species complex. (wikipedia.org)
  • Koreenceine-type pathways are widely distributed among Pseudomonas species, and koreenceine C was detected in another Pseudomonas species from a distantly related cluster. (nih.gov)
  • This study involved the examination of clinical samples for various species of Pseudomonas by using different standard biochemical tests. (innovareacademics.in)
  • Analysis of the antibiogram pattern was done to study the multi-drug resistance among Pseudomonas species. (innovareacademics.in)
  • Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas. (ox.ac.uk)
  • Antibiotic resistance often evolves by mutations at conserved sites in essential genes, resulting in parallel molecular evolution between divergent bacterial strains and species. (ox.ac.uk)
  • The new model system will enable the effectiveness of potential new antibiotics to be tested against a mixture of microbe species together. (cam.ac.uk)
Genomic2
Overuse1
  • Nonetheless, today's higher level of antibiotic resistance is solely due to antibiotic abuse or overuse. (lifehack.org)
Vivo1
  • Expression levels of the efflux pumps clearly influenced antibiotic efficacy in vivo. (st-andrews.ac.uk)
Genes are responsible1
Effectiveness of antibiotics1
  • Much of the effectiveness of antibiotics is threatened in the modern food animal industry by the use of low doses of antimicrobials for faster growth of livestock and poultry animals , and to compensate for unhygienic environments they are raised in. (lifehack.org)
Koreensis2
  • In our analysis of a taxonomically diverse consortium from the soybean rhizosphere, we found that Pseudomonas koreensis selectively inhibits growth of Flavobacterium johnsoniae and other members of the Bacteroidetes grown in soybean root exudate. (nih.gov)
  • In this study, we characterized competition between Pseudomonas koreensis and Flavobacterium johnsoniae , two common rhizosphere inhabitants. (nih.gov)
Biosynthesis1
  • The mupirocin trans-AT polyketide synthase pathway, provides a model system for manipulation of antibiotic biosynthesis. (birmingham.ac.uk)
Pneumonia1
Efflux pump1
  • Conclusions: This study has demonstrated the utility of using G. mellonella to screen for novel therapeutic options for MDR P. aeruginosa and has shown that antibiotic/efflux pump inhibitor combinations should be further investigated for clinical application. (st-andrews.ac.uk)
Chronic1
  • We compared the outcome of primary nonoperative antibiotic treatment versus digital amputation in patients with diabetes-related chronic digital osteomyelitis. (japmaonline.org)
Intravenous antibiotics1
  • Patients were divided into two groups according to initial treatment: 1) nonoperative treatment with intravenous antibiotics and 2) amputation of the involved toe or ray. (japmaonline.org)
Sensitivity1
  • Depending on the source of specimen, treatment with antibiotics, as indicated for the purpose of determining sensitivity, may be required before inoculation of tissue cultures. (medscape.com)
Kirby-Bauer1
  • Antibiotic susceptibility testing to selected antibiotics was done using Kirby-Bauer disk diffusion technique. (who.int)
Planktonic cells1
  • From these results, chemostat studies were designed to examine prolonged exposure of the antibiotic to planktonic cells. (ljmu.ac.uk)
Treatment5
  • Some Enterobacterales are resistant to nearly all antibiotics, leaving more toxic or less effective treatment options. (cdc.gov)
  • Conducting experiments using robust systems renders this project extremely novel in the field of microbiology and this will contribute to the development of viable treatment options and ultimately the reduction of the emergence of antibiotic resistance. (ljmu.ac.uk)
  • Selection Criteria for Home Intravenous Antibiotic Treatment. (archbronconeumol.org)
  • Antibiotic Treatment in Exacerbations. (archbronconeumol.org)
  • Sarah Gregory] If a microbe becomes resistant to a certain treatment, can't we just use a different treatment or antibiotic or something? (cdc.gov)
Cytotoxic2
  • Virulent strains of Pseudomonas aeruginosa are often associated with an acquired cytotoxic protein, exoenzyme U (ExoU) that rapidly destroys the cell membranes of host cells by its phospholipase activity. (monash.edu)
  • For anti-tumor antibiotics, see Chemotherapy § Cytotoxic antibiotics . (wikipedia.org)
Transcriptional2
  • The fitness of sensitive and resistant Pseudomonas aeruginosa in different aquatic environments depends on genetic capacities and transcriptional regulation. (kit.edu)
  • To investigate the functional basis of epistasis, and because rpoB plays a central role in transcription, we measured the effects of common rpoB mutations on transcriptional efficiency across three strains of Pseudomonas Transcriptional efficiency correlates strongly to fitness across strains, and epistasis arises because individual rpoB mutations have differential effects on transcriptional efficiency in different genetic backgrounds. (ox.ac.uk)
Vitro2
  • This study set out to develop an in vitro model to examine the effect of continual exposure of P.aeruginosa PA01 to the antibiotics studied. (ljmu.ac.uk)
  • The results of the in vitro analysis showed that, from among the three antibiotics used, amikacin was the antibiotic where resistance was most readily developed. (ljmu.ac.uk)
Fluorescens2
Clinical3
  • In conclusion, the current authors confirmed an agreement between Pseudomonas aeruginosa status according to the new definition and clinical status, as well as with the level of Pseudomonas aeruginosa antibodies. (ersjournals.com)
  • According to the WHO report, as of May 2017, a total of 51 antibiotics (including combinations) were in the clinical pipeline. (jonbarron.org)
  • For these reasons, there is now an urgent need for both new antibiotic discovery and other modifications or strategies to enhance or prolong the antibacterial activity of existing clinical antibiotics. (hku.hk)
Methods1
  • RAPD-PCR (Random amplification of polymorphic DNA polymerase chain reaction) and disc diffusion methods were used for genotyping and antibiotic susceptibility testing, respectively. (omu.edu.tr)
Antibacterial1
  • Antibacterials" include antiseptic drugs, antibacterial soaps , and chemical disinfectants , whereas antibiotics are an important class of antibacterials used more specifically in medicine [6] and sometimes in livestock feed . (wikipedia.org)
Penicillin1
  • Sometimes, the term antibiotic -literally "opposing life", from the Greek roots ἀντι anti , "against" and βίος bios , "life"-is broadly used to refer to any substance used against microbes , but in the usual medical usage, antibiotics (such as penicillin ) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics ) are fully synthetic . (wikipedia.org)