SynthesisBacteriaMembrane proteinsMetabolismAntimicrobialNatural antibacterial agentsAntibioticsVitro antibacterialAntifungalAntioxidantDrugsTargetsActivity was evaluatedAureusTherapiesAdsorptionEscherichiaPathogensBacteriumCharacteristicsProteomicsPathwaysVancomycinPropertiesNanoparticlesAgentsMicrobiologyCompoundsHumanProteaseIncorporationFormation2016InfectionBacterial speciesEffectsStructuralFunctional2017SpotsPeptidoglycanRenalTargetStudyCandidatesMolecularScientistsOuterStructures
Synthesis8
- So, the aim of this study is the synthesis, characterization, and antibacterial evaluation of vancomycin-containing soy protein nanoparticles (vancomycin-SPNs) as a new antimicrobial agent. (hindawi.com)
- Gentamicin is bactericidal and acts by inhibiting normal protein synthesis in susceptible microorganisms. (medi-vet.com)
- The antibacterial activity of tedizolid is mediated by binding to the 50S subunit of the bacterial ribosome resulting in inhibition of protein synthesis. (centerwatch.com)
- Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. (nih.gov)
- The contributors describe the mechanisms by which the agents disrupt cell wall assembly and maintenance, membrane synthesis and integrity, DNA and RNA metabolism, protein synthesis, and the folate cycle. (cshlpress.com)
- Clobetasol propionate is a class I superpotent topical steroid that suppresses mitosis and increases the synthesis of proteins that decrease inflammation and cause vasoconstriction. (medscape.com)
- by binding to the 50S subunit of the ribosome, they inhibit bacterial protein synthesis. (msdmanuals.com)
- It is a fantastic recognition of the work that people in our lab have been doing for many years: first on protein synthesis, antibiotics targeting it and antibiotic resistance mechanisms that counter the antibiotics - and more recently, on bacterial viruses, bacteriophages. (lu.se)
Bacteria16
- This acts as a decoy by mimicking high-mannose sugar chains on the surface of the urinary tract , to which bacteria would normally attach using a sugar-binding protein called FimH at the tip of their hair-like appendages. (phys.org)
- We wanted to determine which sugar chain of GP2 corresponded to the high-mannose chain of UMOD and understand how the proteins manage to keep these sugars 'special' so that they act as a bait for bacteria" explains Luca Jovine. (phys.org)
- The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, and anti-quorum sensing activity against a wide range of bacteria including multi-drug resistant (MDR) strains. (frontiersin.org)
- The antibacterial activity against various pathogenic and drug-resistant bacteria was tested using crude garlic extracts, garlic powder (GP), garlic extracts using various solvents, GO, and phytochemicals isolated from garlic. (frontiersin.org)
- Morphology observation of the bacteria by AFM revealed that the antibacterial bilayer film had a significant damaging effect on the cell structures of S. aureus and E. coli due to the dual antibacterial effect of curcumin and chitosan . (bvsalud.org)
- The identified broad-spectrum candidates, namely, integral membrane protein/virulence factor (MviN), preprotein translocase subunits SecB and SecG, carbon storage regulator (CsrA), and nitrogen regulatory protein P-II 1 (GlnB), contributed by the peptidoglycan pathway, bacterial secretion systems and two-component systems, were also found to be present in a wide range of other disease-causing bacteria. (blogspot.com)
- The Antibacterial activity was evaluated by the Kirby Bauer method with E. coli as the pathogen bacteria and L. casei as the probiotic bacteria. (ub.ac.id)
- Indeed, some of modern medicine's most reliable antibiotics disarm harmful bacteria by disrupting the proteins that build their protective armor. (harvard.edu)
- The newly profiled protein, RodA, belongs to a family collectively known as SEDS proteins, present in nearly all bacteria. (harvard.edu)
- SEDS" near-ubiquity renders these proteins ideal targets for the development of broad-spectrum antibiotics to disrupt their structure and function, effectively neutralizing a range of harmful bacteria. (harvard.edu)
- Additionally, because the protein is highly conserved across all bacterial species, the discovery of an inhibiting compound means that, at least in theory, a drug could work against many kinds of harmful bacteria. (harvard.edu)
- One approach to the development of innovative antibiotics aims at the degradation process of defective proteins in bacteria. (mpg.de)
- However, this leads to the uncontrolled degradation of essential proteins - with lethal consequences for the bacteria.This unique mechanism of action has considerable innovation potential in the fight against pathogenic bacteria. (mpg.de)
- In addition to its role in protein degradation ClpP is also a global regulator in the production of bacterial toxins - termed virulence factors - that are mainly responsible for the disease-causing effect of bacteria. (mpg.de)
- We also can look at bacteria and virus protein structures to identify how to target those proteins with drugs. (nasa.gov)
- Overview of Antibacterial Drugs Antibacterial drugs are derived from bacteria or molds or are synthesized de novo. (msdmanuals.com)
Membrane proteins3
- Cytoplasmic proteins SecG, CsrA and GlnB were considered as drug targets, while membrane proteins MviN and SecB were classified as vaccine targets. (blogspot.com)
- We've only done a fraction of the more important complex protein structures-I'm referring to membrane proteins and protein-protein complexes. (nasa.gov)
- Membrane proteins are the targets for about 55 percent of the drugs on the market today. (nasa.gov)
Metabolism2
Antimicrobial4
- This study aimed to investigate the antimicrobial activity of vancomycin-loaded soy protein nanoparticles (vancomycin-SPNs). (hindawi.com)
- A short period of desiccation-elevated peptidoglycan recognition protein-LC ( PGRP-LC ) expression in MTs, increased antimicrobial peptide ( AMP ) gene induction, and protected animals from bacterial infection. (biomedcentral.com)
- Naturally antibacterial and antimicrobial, with high numbers of antioxidants. (shopterrain.com)
- Antimicrobial protein candidates from the thermophilic Geobacillus sp. (lu.se)
Natural antibacterial agents2
- The findings of the recent study suggest the use of EOs as natural antibacterial agents for food preservation. (scielo.br)
- further studies are needed to confirm these extracts to be natural antibacterial agents for use in controlling dental caries. (bvsalud.org)
Antibiotics2
- Multiple antibacterial effects of organosulfur compounds provide an excellent framework to develop them into novel antibiotics. (frontiersin.org)
- While all common antibiotics work by inhibiting vital processes, in this new approach an antibacterial effect is achieved by activating a process. (mpg.de)
Vitro antibacterial2
- In vitro antibacterial effects, protein binding, and pharmacokinetic properties were similar between the generic vancomycin preparations and VAN-Lilly. (medscape.com)
- In vitro antibacterial and non-stick activity of extracts from leaves of Psidium guineense Sw. (bvsalud.org)
Antifungal3
- Health benefits that are associated with the use of garlic are attributed to its anticancer, anti-inflammatory, antifungal, antiviral, and antibacterial activity. (frontiersin.org)
- By virtue of it's three components - Gentamicin-Betamethasone-Clotrimazole - Otomox has antibacterial, anti-inflammatory, and antifungal activity. (medi-vet.com)
- Tunicamycin is an antibacterial and antifungal. (sigmaaldrich.com)
Antioxidant4
- In this study, 21 diatoms, 7 dinoflagellates, and 4 flagellate species were grown in three different culturing conditions and the corresponding extracts were tested for possible antioxidant, anti-inflammatory, anticancer, anti-diabetes, antibacterial, and anti-biofilm activities. (frontiersin.org)
- Aim: The present article aims to study and compare the antioxidant activity of aqueous solutions of leaves and flowers of Sambucus nigra L obtained at different exposure times and assess the antibacterial activity of these solutions against Escherichia coli ATCC 8739, Salmonella NCTC 6017, Listeria monocytogenes NCTC 11994, and Staphylococcus aureus ATCC 25093. (researchgate.net)
- In this study, antibacterial and antioxidant bilayer films were prepared by using curcumin (Cur) crosslinked soy rotein isolate (SPI) and chitosan (CS). (bvsalud.org)
- Based on its physical characteristic, antioxidant activity, and antibacterial properties, it can be concluded that WPI can protect the BPEO by stabilizing O/W emulsion and may have the potential to be used as an alternative natural antioxidant and antibacterial additive in many food applications. (ub.ac.id)
Drugs2
- Our latest findings reveal the molecular structure of RodA and identify targetable spots where new antibacterial drugs could bind and subvert its work," said study senior investigator Andrew Kruse , associate professor of biological chemistry and molecular pharmacology at Harvard Medical School. (harvard.edu)
- therefore, cross-resistance between tedizolid and other classes of antibacterial drugs is unlikely. (centerwatch.com)
Targets3
- The current study aims at prioritizing broad-spectrum antibacterial targets, present in multiple food and waterborne bacterial pathogens, through a comparative genomics strategy coupled with a protein interaction network analysis. (blogspot.com)
- The analyses revealed a set of promising broad-spectrum antibacterial targets, present in multiple food and waterborne pathogens, which are essential for bacterial survival, non-homologous to host and gut flora, and functionally important in the metabolic network. (blogspot.com)
- The identified broad-spectrum targets can aid in the design and development of antibacterial agents not only against food and waterborne pathogens but also against other pathogens. (blogspot.com)
Activity was evaluated1
- Antibacterial activity was evaluated by the radial diffusion assay (RDA) and absorbance methods. (hindawi.com)
Aureus2
- To evaluate antibacterial behavior, we used two bacterial strains Gram-negative Escherichia coli ( E. coli ) and Gram-positive Staphylococcus aureus ( S. aureus ). (nature.com)
- However, in a Staphylococcus aureus neutropenic mouse thigh infection model, the antibacterial activity of the generic vancomycin preparations marketed between 2002 and November 2004 (when Eli Lilly sold its brand name and production secrets to several manufacturers worldwide) proved to be significantly inferior to that of VAN-Lilly. (medscape.com)
Therapies1
- A particularly promising target for antibacterial therapies is the protease ClpP. (mpg.de)
Adsorption3
- These materials are designed to be non-fouling, meaning that protein adsorption and subsequent microbial adhesion are minimized. (mdpi.com)
- A new methodology combining QCM-D and proteomic profiling enables characterization of protein adsorption on 2D surfaces. (mpg.de)
- Antibacterial Nanostructured Surfaces Modulate Protein Adsorption, Inflammatory Responses, and Fibrous Capsule Formation. (mpg.de)
Escherichia1
- Summary: Colicins are a diverse family of large antibacterial protein toxins, secreted by and active against Escherichia coli and must cross their target cell's outer membrane barrier to kill. (nottingham.edu.cn)
Pathogens1
- The diameters (in millimeters) of the growth inhibition zones of four pathogens were measured, and a comparative assessment of their antibacterial activity was made. (researchgate.net)
Bacterium1
- Strain ZGt-1, an Antibacterial Peptide-Producing Bacterium from Hot Springs in Jordan. (lu.se)
Characteristics1
- To test whether this assumption is justified for vancomycin, researchers compared the pharmacokinetic characteristics and antibacterial activity of the original Eli Lilly vancomycin (VAN-Lilly) with those of the competitor generic preparations marketed in Colombia between November 2002 and November 2009. (medscape.com)
Proteomics2
- Samples were tested for cytokine production, markers of gut barrier integrity, metabolite profiles, and analysis of the fecal proteins (fecal proteomics). (medscape.com)
- After FMT, fecal proteomics detected 301 proteins composed of 154 of human origin - mostly related to gut barrier protection - and 147 of bacterial origin - mostly enzymes - at days 7, 30, and up to 90. (medscape.com)
Pathways2
- The proteins/enzymes involved in these pathways were prioritized following host non-homology analysis, essentiality analysis, gut flora non-homology analysis and protein interaction network analysis. (blogspot.com)
- To date, there are no direct means to measure specific proton-transfer pathways within proteins, and most research is based on following the end-product of the reaction. (technion.ac.il)
Vancomycin2
- For the preparation of SPNs, the desolvation method was applied in different concentrations of vancomycin and soy protein (15:5, 10:15, 6:20, 8:25, and 10:30 of vancomycin:soy protein). (hindawi.com)
- The best drug loading (% entrapment efficiency = 90.2%), the fastest release rate (% release = 88.2%), and the best antibacterial activity were observed in ratio 10:30 of vancomycin:SPNs. (hindawi.com)
Properties4
- Chitin also has antibacterial properties. (wikipedia.org)
- These compounds have been shown to have strong anti-inflammatory and antibacterial properties. (livescience.com)
- These factors play a significant role in the antibacterial properties of the surface. (nature.com)
- It's rich in antioxidants and is said to have antibacterial properties. (oscillo.com)
Nanoparticles1
- Endosomal sorting results in a selective separation of the protein corona from nanoparticles. (mpg.de)
Agents1
- The review provides a focused and comprehensive portrait of the status of garlic and its compounds as antibacterial agents. (frontiersin.org)
Microbiology1
- What makes us excited is that this protein has a fairly discrete pocket that looks like it could be easily and effectively targeted with a drug that binds to it and interferes with the protein's ability to do its job," said study co-senior author David Rudner , professor of microbiology and immunobiology at Harvard Medical School. (harvard.edu)
Compounds2
- The principal phytochemicals that exhibit antibacterial activity are oil-soluble organosulfur compounds that include allicin, ajoenes, and allyl sulfides. (frontiersin.org)
- Protein-based nanostructures are suitable compounds for drug delivery systems, especially antibiotic delivery systems [ 10 ]. (hindawi.com)
Human8
- And our structural work explains many human mutations associated with kidney diseases, as well as provides information on a protein region whose interaction with filtered light chains is implicated in cast nephropathy," says Professor Luca Jovine at the Department of Biosciences and Nutrition and corresponding author of the paper. (phys.org)
- With about 18,500 protein-coding genes, the platypus is quite normal in that regard (the human, chimp, cat, chicken, nematode, and sea anemone genomes have approximately the same number of genes). (creation.com)
- Whole crickets and cricket protein powder are also used in livestock and aquaculture feeds and human food. (pigprogress.net)
- Here, cells that were genetically modified to produce higher levels of a protein known as human beta defensin 4 are shown in green. (technologyreview.com)
- In today's A Lab Aloft, Dr. Larry DeLucas, a primary investigator for International Space Station studies on protein crystal growth in microgravity, explains the importance of such investigations and how they can lead to human health benefits. (nasa.gov)
- Consider that the human genome project is more than 20,000 protein-coding genes, and many of these genes or portions of those genes combine with others to create new proteins. (nasa.gov)
- The human body could have anywhere from a half million to as many as two million proteins-we're not sure. (nasa.gov)
- What we do know, is that these proteins control aspects of human health and understanding them is an important beginning step in developing and improving treatments for diseases and much more. (nasa.gov)
Protease2
- It recognizes proteins that are labelled for degradation, unfolds them while consuming energy and then directs them into the barrel-like degradation chamber of the protease. (mpg.de)
- Left: The central pore of the ClpP protease is closed and entry of folded proteins into the proteolytic chamber is not allowed. (mpg.de)
Formation4
- RNA codon misreading [formation of toxic, non functional proteins]. (mindmeister.com)
- The results provide evidence for considerable biotransformation and protein adduct formation when cytochrome P450 activity is induced in the cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin, a model Ah receptor ligand. (cdc.gov)
- Tunicamycin blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. (sigmaaldrich.com)
- A practical approach utilized in this study involves the preparation of an antibacterial thin film on the surfaces, which can effectively inhibit and reduce biofilm formation and bacterial adherence. (nature.com)
20161
- Then, in 2016, a team of Harvard Medical School scientists discovered that a previously unsuspected family of proteins that regulate cell division and cell shape had a secret skill: building bacterial walls. (harvard.edu)
Infection2
- A team led by Karolinska Institutet has combined Artificial Intelligence (AI) with structural biology to gain insights into two similar proteins that prevent bacterial infection in the urinary tract and the gastrointestinal system. (phys.org)
- Uromodulin (UMOD) is a protein whose filaments play an important role in preventing urinary tract infection , the most common form of non-epidemic bacterial infection that affects about 150 million people per year. (phys.org)
Bacterial species1
- The protein has antibacterial activity against a number of bacterial species. (sigmaaldrich.com)
Effects1
- Since then, extensive research has been performed on the antibacterial effects of garlic. (frontiersin.org)
Structural3
- Keratin is a structural protein located at the hard surfaces in many vertebrates. (wikipedia.org)
- Specifically, the protein's molecular profile reveals structural features reminiscent of other proteins whose architecture Kruse has disassembled. (harvard.edu)
- Scientists from the Max Planck Institute of Molecular Physiology in Dortmund and from the Technical University of Munich have now unveiled the first high-resolution 3D structure of the protein degrading complex ClpX-ClpP and thus created an important structural basis for future pharmacological applications. (mpg.de)
Functional1
- Predicted the functional importance of shortlisted proteins in metabolic network. (blogspot.com)
20171
- The Two-State Prehensile Tail of the Antibacterial Toxin Colicin N . Biophysical Journal 2017, 113 (8), 1673-1684. (ncl.ac.uk)
Spots3
- We collect hundreds of thousands, sometimes millions of diffraction spots for a protein. (nasa.gov)
- The more perfectly ordered the individual protein molecules are within the crystals, the more intense these spots. (nasa.gov)
- Using computers, we take those diffraction spots and mathematically determine the structure of where every atom is in the protein. (nasa.gov)
Peptidoglycan1
- DAP-type PGN is sensed by two receptors, both members of the peptidoglycan recognition protein (PGRPs) family of receptors. (biomedcentral.com)
Renal1
- The principal metabolite, monic acid, is eliminated by renal excretion, and demonstrates no antibacterial activity. (nih.gov)
Target2
- If you're trying to hit a certain daily protein target in order to build muscle or lose weight, you might wonder which fruits are high in protein. (livescience.com)
- ClpP and ClpX form a continuous pore instead, with ClpX unfolding target proteins and forwarding them to the proteolytic chamber of ClpP for degradation in a regulated manner. (mpg.de)
Study1
- In his new study, he will develop tools to explore the transfer of protons within proteins. (technion.ac.il)
Candidates1
- Among proteins, soy protein is one of the exciting candidates for the preparation of nanoparticle delivery systems due to its biodegradability, biocompatibility, low toxicity, low immunogenicity, and symmetrical shape [ 12 , 13 ]. (hindawi.com)
Molecular1
- Once we have a usable protein crystal-one that is large and perfect enough to examine-the primary technique we use to determine the protein molecular structures is x-ray crystallography. (nasa.gov)
Scientists2
- For decades, scientists knew of only one wall-making protein family. (harvard.edu)
- One particular feature caught the scientists' attention-a pocket-like cavity facing the outer surface of the protein. (harvard.edu)
Outer1
- OmpF) plus a low-copy-number, high-affinity, outer membrane protein receptor (e.g. (nottingham.edu.cn)
Structures4
- The naming convention for these keratins follows that for protein structures: alpha keratin is helical and beta keratin is sheet-like. (wikipedia.org)
- Today there are more than 50,000 proteins that have been crystallized and the structures of the three-dimensional proteins comprising these crystals have been determined. (nasa.gov)
- Unfortunately many important proteins that we would like to know the three-dimensional structures for have either resisted crystallization or have yielded crystals of such inferior quality that their structures cannot be determined. (nasa.gov)
- For example, in most protein structures we can't even see the hydrogen atoms. (nasa.gov)