Antibacterial molecules. Medical search. Frequent questions

Nature-inspired synthesis of antibacterial glucovanillin derivatives. (nih.gov)
His main research interests are the structure-based design, synthesis and evaluation of small-molecule enzyme inhibitors and receptor ligands. (degruyter.com)
Like most enzymes of peptidoglycan biosynthesis, MurD constitutes an attractive target for the design and synthesis of new antibacterial agents. (degruyter.com)
Our medicinal chemistry program involves the development, synthesis, and biological evaluation of antibacterial agents derived from naturally occurring molecules. (unca.edu)

Health benefits that are associated with the use of garlic are attributed to its anticancer, anti-inflammatory, antifungal, antiviral, and antibacterial activity. (frontiersin.org)
In 1981, Dr. Peter Molan of the University of Waikato in New Zealand began researching the antibacterial, antiviral, anti-inflammatory and antioxidant properties and health benefits of manuka honey. (naturalnews.com)
Cordycepin exhibits various bio-activities, including anticancer, antibacterial, antiviral and immune regulation activities, and is a significant focus of research. (spandidos-publications.com)
Cordycepin ( Fig. 1A ) with the molecular formula C 10 H 13 N 5 O 3 has been demonstrated to have various bio-activities, including anticancer ( 4 - 7 ), antibacterial ( 8 ), antiviral ( 9 , 10 ) and immune regulation activities ( 11 ) and has became a topic of interest to various research groups. (spandidos-publications.com)

Cancer, inflammation, and the evolution of antibiotic-resistant pathologies, together with other human diseases, are continuously stimulating the search for new bioactive molecules from natural sources. (frontiersin.org)
Studies are continuing on sub-Saharan Erythrina for identifying new biological activities or bioactive molecules. (scialert.net)
Plant extracts with these bioactive molecules are widely used in the food, pharmaceutical and cosmetics industries[ 1 ]. (ijpsonline.com)
Imbed Biosciences Inc (Imbed) operates as a medical device company that develops technologies for imbedding bioactive molecules in wound dressings and surgical implants. (globaldata.com)
The company's polymeric microfilm product platform develops bioactive molecules on tissue surfaces to manage wound infections, biofilms, and local pain and support wound healings. (globaldata.com)

Treatment of infections with antibacterials, antifungals, and antivirals. (lu.se)

In this study, 21 diatoms, 7 dinoflagellates, and 4 flagellate species were grown in three different culturing conditions and the corresponding extracts were tested for possible antioxidant, anti-inflammatory, anticancer, anti-diabetes, antibacterial, and anti-biofilm activities. (frontiersin.org)

Pharmacology studies on P . oleracea have also showed its significant antibacterial effects on the enteropathogenic bacteria, which might reveal the treatment of P . oleracea in cases of bacillary dysentery to some extent. (mdpi.com)
The organosulfur compounds of garlic exhibit a range of antibacterial properties such as bactericidal, antibiofilm, antitoxin, and anti-quorum sensing activity against a wide range of bacteria including multi-drug resistant (MDR) strains. (frontiersin.org)
The antibacterial activity against various pathogenic and drug-resistant bacteria was tested using crude garlic extracts, garlic powder (GP), garlic extracts using various solvents, GO, and phytochemicals isolated from garlic. (frontiersin.org)
Trials on mice showed that the molecule, which they called teixobactin, rapidly cleared infections of drug-resistant strains of Mycobacterium tuberculosis and Staphylococcus aureus bacteria, according to the study. (latimes.com)
Researchers said they would work to broaden the spectrum of bacteria the molecule can fight, and tinker with its chemistry to ensure it can be administered in reasonable doses. (latimes.com)
Initial efforts had the goal of making the bacteria susceptible to existing fluoroquinolones, and potentially to other classes of antibacterial drugs. (defenseindustrydaily.com)
Antibacterial efficacy studies after exposing Pseudomonas aeruginosa to a 10 mM dose of the synthesized compound show a 55-75% reduction in bacteria after 24 hours. (rsc.org)
This work is the first instance of a small molecule dual-function material that can both detect and kill bacteria. (rsc.org)
The knowledge about essential cell functions in bacteria and the experimental systems that we develop can be used to find new targets for antibiotics and to screen for molecules that can work as antibiotics. (lu.se)

Aim: The present article aims to study and compare the antioxidant activity of aqueous solutions of leaves and flowers of Sambucus nigra L obtained at different exposure times and assess the antibacterial activity of these solutions against Escherichia coli ATCC 8739, Salmonella NCTC 6017, Listeria monocytogenes NCTC 11994, and Staphylococcus aureus ATCC 25093. (researchgate.net)
The G. lancifolia fruit juice exhibited high antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Micrococcus luteus, Streptococcus mutans, Bacillus mycoides and Bacillus subtilis. (ijpsonline.com)
To evaluate antibacterial behavior, we used two bacterial strains Gram-negative Escherichia coli ( E. coli ) and Gram-positive Staphylococcus aureus ( S. aureus ). (nature.com)

The molecules found in the pollen of manuka honey are potent antibacterial substances. (naturalnews.com)
Nitric oxide is a known potent antibacterial agent, but due to its gaseous and highly reactive nature, it is difficult to incorporate into a stable antibacterial compound. (rsc.org)

Molecules;27(15)2022 Aug 08. (bvsalud.org)

This study was conducted to identify the major constituents of the ethanolic Origanum vulgare extract and examine the cytotoxic, antioxidant, and antibacterial properties of the extract but more importantly the contribution of its specific major constituent(s) or their combination to the overall extract biological activity. (hindawi.com)
In conclusion, the oregano extract has cytotoxic, antioxidant, and antibacterial activities mostly attributed to carvacrol and thymol. (hindawi.com)

Antibacterial Anacardic Acid Derivatives. (nih.gov)
We will also evaluate our derivatives in house using an antibacterial assay. (unca.edu)

With this +2 valence, they can bond in place of each other, provided there is space in a constructed enzyme molecule for them to fit. (ra-infection-connection.com)

To mitigate this mitochondria-related functional impairment, a variety of agents (including endogenous and food derived antioxidants, natural plants extracts, mitochondria-targeted molecules) combined with conventional therapies could be employed. (medscape.com)

Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L. (mdpi.com)
The principal phytochemicals that exhibit antibacterial activity are oil-soluble organosulfur compounds that include allicin, ajoenes, and allyl sulfides. (frontiersin.org)
The review provides a focused and comprehensive portrait of the status of garlic and its compounds as antibacterial agents. (frontiersin.org)
She is especially interested in the search for antimicrobial compounds and has been working on peptidoglycan as an antibacterial target for 8 years. (degruyter.com)

The diameters (in millimeters) of the growth inhibition zones of four pathogens were measured, and a comparative assessment of their antibacterial activity was made. (researchgate.net)
Antibacterial Activity of Aureonuclemycin Produced by Streptomyces aureus Strain SPRI-371. (bvsalud.org)
Although studies have shown that cordycepin is a broad-spectrum antibiotic ( 18 ), studies focusing on the mechanism of the antibacterial activity and the possible targets are lacking. (spandidos-publications.com)
Our target molecules include ficellomycin, pestalone, depsidones, and p-terphenyls, which have all shown promising preliminary activity as antibiotics. (unca.edu)
In the lab we systematically derivatize each targets core structure to improve both their antibacterial activity and their physical properties in order to make them a viable drug molecule. (unca.edu)
Antibacterial activity of the prepared sample was assessed by determining the number of colony-forming units per milliliter (CFU/ml) using a standard viable cell count assay. (nature.com)
An earlier study, published in a 2011 edition of the Journal of Food Protection , showed that vanillin, ethyl vanillin and vanillic acid have antibacterial activity that combats the Cronobacter species. (livestrong.com)

In tumor necrosis factor (TNF)-alpha-stimulated human aortic endothelial cells, beta-sitosterol was found to significantly inhibit vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression. (drugs.com)
Their approach focuses on small molecules that inhibit the emergence of bacterial resistance to antibiotics. (defenseindustrydaily.com)
A practical approach utilized in this study involves the preparation of an antibacterial thin film on the surfaces, which can effectively inhibit and reduce biofilm formation and bacterial adherence. (nature.com)
These molecules inhibit HSV polymerase with 30-50 times the potency of human alpha-DNA polymerase. (medscape.com)

We then isolate the small molecule antibiotics produced during co-culture using organic chemistry extraction and purification techniques. (unca.edu)

Bits of the transcriptome once believed to function as RNA molecules are in fact translated into small proteins. (the-scientist.com)
Cognitive deficits in diabetes could result from toxic oxidative stress in the brain: damage to lipids, proteins, and DNA caused by free-floating ions and oxygen-containing molecules. (issuu.com)
Processes like these have evolved from common ancestors of both eukaryotes and prokaryotes, and it becomes increasingly clear that the bacterial versions of these basic cell functions use similar ancestral molecules, for example cytoskeletal proteins, as those used in animal and plant cells. (lu.se)
ROS are highly active molecules that may oxidize proteins, lipids and nucleic acids with a consequent damage of cells and tissues. (medscape.com)

It conducts research for the development of antibacterial, antibiofilm and analgesic wound dressings. (globaldata.com)

The results of computational molecular docking analysis indicated that the interaction energy between cordycepin and NAD+‑dependent DNA ligase (LigA) was lower than that between cordycepin and other common antibacterial targets. (spandidos-publications.com)
Therefore, molecular docking was also used in the present study to simulate the binding of cordycepin with different antibacterial targets, such as β-ketoacyl-(acyl-carrier-protein) synthase III (FabH), DNA gyrase B and thymidylate kinase, in order to identify the most likely antimicrobial mechanism of cordycepin. (spandidos-publications.com)

EACH & every time a free radical strips electrons from other stable molecules damage will be done - setting up a whole cascade of knock on reactions (most of them being negative)! (mmshealthy4life.com)
The chlorhexidine is a stable antibacterial molecule and a potent inhibitor of MMPs. (bvsalud.org)

Antibacterial effects have been reported for oregano against Clostridium perfringens , Pseudomonas aeruginosa , and Staphylococcus aureus [ 8 - 10 ]. (hindawi.com)

The antibacterial and antioxidant properties of oregano have been attributed mainly to carvacrol and thymol, which are the major components of its essential oil [ 7 ]. (hindawi.com)

Screening of the antibacterial effects of a variety of essential oils on microorganisms responsible for respiratory infections. (doterra.com)

These factors play a significant role in the antibacterial properties of the surface. (nature.com)
The health benefits of vanilla include antibacterial properties, meaning it may help prevent infection. (livestrong.com)
DMAE-CB is, as MDPB, a monomer with antibacterial properties. (bvsalud.org)

BPaL was approved in accordance with the Limited Population Pathway for Antibacterial and Antifungal Drugs (LPAD) for development of drugs targeting infections that lack effective therapies. (cdc.gov)

Plants produce molecules to interact with their environment and protect themselves against external threats. (phys.org)
Wolfe, A. L. "Effects of Shade on Antibacterial Production in Aloe Vera Plants: A Model Course Based Undergraduate Research Experience for First- and Second-Year Chemistry and Biochemistry Students" World Journal of Chemical Education 2019 , 7 (4), 248. (unca.edu)

Every animal group and system is being scrutinized revealing levels of biological organization from developmental/functional molecules to organs to systems to organisms. (hindawi.com)

Se llevó a cabo un estudio experimental in vitro en una muestra de 18 premolares humanos, los cuales fueron tratados con una de las tres pastas dentales evaluadas y una fluorada. (bvsalud.org)

The target molecule of Acnacidol™ BG, 10-HDA, is a synthetic bio-mimetic version of a hydroxyl acid naturally present in Royal Jelly. (ashland.com)
It's also naturally antibacterial, so it's great for anyone prone to breakouts or congestion. (nymag.com)

Marine microalgae are considered a potentially new and valuable source of biologically active molecules for applications in the food industry as well as in the pharmaceutical, nutraceutical, and cosmetic sectors. (frontiersin.org)
Overview of the Immune System The immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. (msdmanuals.com)

For example, a free radical is a problem as it is inherently an unstable molecule - ONLY being neutralised when finding the extra electrons to balance it. (mmshealthy4life.com)
Thus when they bond to other molecule parts they bond to atoms providing two electrons. (ra-infection-connection.com)

Mucinases are enzymes capable of degrading mucins (the complex high molecular weight molecules that are the major non-aqueous components of mucous gels). (bmj.com)
Partial or complete degradation of mucin molecules by microbial enzymes is often a fundamental step in disruption of defensive mucosal barriers, as these constitute direct interfaces between internal and external environments. (bmj.com)
For more than 30 years, his main research interests have been the functional and structural study of the enzymes of peptidoglycan biosynthesis, the determination of the structure of peptidoglycan from certain bacterial species, and the search for peptidoglycan biosynthesis inhibitors that could act as antibacterial agents. (degruyter.com)

As it stands, the chlorine dioxide molecule has proven itself amazingly versatile across a wide range of applications - proving deadly to most pathogens known to exist. (mmshealthy4life.com)

Bacterial adaptation makes antibacterial resistance inevitable. (cdc.gov)

Since then, extensive research has been performed on the antibacterial effects of garlic. (frontiersin.org)

Mucous gels exhibit non-specific antibacterial capabilities as they contain molecules such as lactoferrin, lysozyme, and immunoglobulins. (bmj.com)

Lipid A is a glycophospholipidic structure that anchors the LPS molecule to the cellular membrane. (scirp.org)

LPSs are molecules that possess the ability to elicit an innate immune response via Toll-like receptor 4 (TLR-4) activation. (scirp.org)
The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

Research carried out with the participation of the University of Navarra has shown how a determinate molecule helps an important pathogen, Brucella abortus, escape destruction within the cells charged with eliminating infectious agents (macrophages). (sciencedaily.com)
The findings of the recent study suggest the use of EOs as natural antibacterial agents for food preservation. (scielo.br)
For more than 15 years he has been involved in discovery of inhibitors of bacterial cell-wall biosynthesis as potential antibacterial agents. (degruyter.com)

Antibacterial experiments showed that ANM was less active or inactive against Xanthomonas oryzae pv. (bvsalud.org)
Tests in mice showed that the newfound molecule is "exquisitely active against some very hard-to-deal-with bugs," said Northeastern University microbiologist Kim Lewis, the senior author of a study published Wednesday in the journal Nature. (latimes.com)
Each drop of essential oil contains on average 150 active molecules. (loreal.com)

The Ti-Cu films displayed superior antibacterial ability, with a 99.9% reduction (equivalent to a 5-log reduction) in bacterial viability after 2 h compared to Ti alone against both bacterial strains. (nature.com)

The study that appeared in the journal Molecular Nutrition and Food Research identified and quantified methylglyoxal (MGO) as the dominant antibacterial constituent of manuka honey from New Zealand. (naturalnews.com)
Also, the molecular target with which cordycepin interacts to cause an antibacterial effect remains unknown. (spandidos-publications.com)

Radioactive SnF is used as a marker for bone infection radioisotope imagery, proving the affinity of this molecule to the site of the infection. (ra-infection-connection.com)

The research done in the Cravens lab is inspired by a desire to understand life at a fundamental level, primarily through biophysical studies of DNA and sequence-specific DNA targeting molecules. (gonzaga.edu)

Ultimately, our goal is to try to find a treatment that could limit the symptoms of the disease and improve the quality of life of patients and their families" To do this, the research team performed high-throughput screening of thousands of approved drugs with the idea of identifying a molecule capable of reactivating hydrolysis. (unige.ch)

Cells make those molecules according to the genetic blueprints. (engineeringchallenges.org)

The journal Molecules published research in November 2014 showing that when vanilla essential oil was applied to medical devices, it inhibited the growth of specific bacterial cells. (livestrong.com)

Anatomy12

Organisms35

Diseases4

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Phenomena and Processes56

Disciplines and Occupations4

Technology, Industry, Agriculture6

Information Science3

Health Care1

Synthesis4

Antiviral4

Bioactive5

Antifungals1

Anticancer1

Bacteria9

Escherichia3

Potent antibacterial2

20221

Cytotoxic2

Derivatives2

Enzyme1

Extracts1

Compounds4

Activity7

Inhibit4

Antibiotics1

Proteins4

Antibiofilm1

Targets2

Stable2

Pseudomonas1

Antioxidant properties1

Microorganisms1

Properties3

Infections1

Plants2

Biological1

Vitro1

Naturally2

Potentially2

Electrons2

Enzymes3

Pathogens1

Resistance1

Effects1

Exhibit1

Cellular1

Receptor2

Agents3

Active3

Strains1

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