• Our results indicated that AST inhibits cell proliferation through phase-specific cell cycle arrest and caspase-dependent apoptosis. (spandidos-publications.com)
  • It also stops proliferation of cancer cells by arresting them at different phases of the cell cycle and/or by inducing their apoptosis (programmed cell death). (beatcancer.org)
  • Stimulate Apoptosis - Curcumin encourages programmed cancer cell death. (beatcancer.org)
  • 1 - 4 Multiple mechanisms may be involved in its potent antitumor effect, including induction of apoptosis, cell cycle arrest, telomerase inhibition, antiangiogenesis activity, and an antimetastasis effect. (dovepress.com)
  • Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
  • We summarized that four main organic sulfides in garlic, diallyl disulfide (DADS), diallyl trisulfide (DATS), S‑allylmercaptocysteine (SAMC) and allicin, may contribute to the regulation of tumor cell apoptosis, migration and the cell cycle. (spandidos-publications.com)
  • The active ingredients in garlic oil correspond mainly to a family of organosulfur molecules, which selectively increase redox stress in cancer cells, leading to apoptosis and death ( 23 ). (spandidos-publications.com)
  • Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)
  • The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
  • ZK 219477 inhibits microtubule depolymerization, causing cell cycle blockage in G2/M phase and induction to apoptosis. (knowcancer.com)
  • Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
  • The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
  • In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. (oncotarget.com)
  • Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. (techscience.com)
  • TRAIL, Tumor necrosis factor Related Apoptosis Inducing Ligand). (uni-muenchen.de)
  • As described in the literature, wildtype p53 leaded to an increase in intrinsic cell death, whereas different p53 mutations reduced apoptosis. (uni-muenchen.de)
  • As a next step we studied the influence of cell cycle arrest induced by p53 activation on TRAIL apoptosis sensitivity (Ehrhardt/Wachter et al. (uni-muenchen.de)
  • 2013). Cell cycle arrest was induced in tumor cell lines and patient samples in G0, G1 or G2 with cytostatic drugs, phase-specific inhibitors or RNA interference against cyclinB and E. Molecular or biochemical arrest at any point of the cell cycle augmented the rate of apoptosis by TRAIL. (uni-muenchen.de)
  • The extrinsic apoptosis by TRAIL was increased in senescent tumor cells. (uni-muenchen.de)
  • The impact of the p53 status of tumor cells on extrinsic apoptosis signaling should be considered, especially in the context of therapeutic approaches that aim to restore p53 function to enable cell death. (uni-muenchen.de)
  • Palcitoclax [APG-1252] is a novel and potent inhibitor of the Bcl-2 family of proteins and induces apoptosis in tumor cells. (pharmiweb.com)
  • Silencing RPL29 by RNA interference in cancer cells induces the cell cycle arrest at G0/G1 phase and promotes its apoptosis. (okayama-u.ac.jp)
  • Phase contrast microscopy evidenced some specific morphological modifications indicating apoptosis allied cytotoxicity of piperine like apoptotic bodies, condensed nucleus and membrane blabbing. (ijpsonline.com)
  • Acridine orange/ethidium bromine staining assay revealed that piperine induced apoptosis in MCF-7 cells which was further investigated by Western blotting. (ijpsonline.com)
  • This revealed increased expression of B-cell lymphoma 2 associated X and reduced expression of B-cell lymphoma 2, indicating apoptosis induction by piperine. (ijpsonline.com)
  • It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
  • Western Blotting was used to determine the level of expression of CDC2 protein as measure to quantify down regulation of CDC2 expression along with use of flow cytometry to investigate effect of shRNAs on cell cycles and detection of apoptosis. (biomedcentral.com)
  • Retroviral vectors expressing short hairpin RNAs (shRNAs) against CDC2 caused efficient deletion of CDC2, cellular G2/M arrest concluding in apoptosis and inhibition of proliferation in human glioma cells U251 and SHG-44 cell lines ex vivo. (biomedcentral.com)
  • Then, the relatively insensitive gastric cancer cell lines (MGC-803 and BGC-823) were treated with low concentrations of chidamide alone, bortezomib alone, or chidamide and bortezomib combination to detect the effects on cell proliferation, apoptosis, migration, and invasion. (dovepress.com)
  • Compared with low-dose chidamide or bortezomib alone, the low-dose drug combination significantly inhibited the proliferation, migration, and invasion of MGC-803 and BGC-823 cells and induced apoptosis of the cells. (dovepress.com)
  • Histone deacetylase (HDAC) plays a pivotal role in regulating the level of cellular DNA acetylation and participate in cell growth, differentiation, and apoptosis. (dovepress.com)
  • IL-24 can inhibit the proliferation of many cancer cells by inducing apoptosis without damaging normal cells. (creative-proteomics.com)
  • After IL-24 is combined with IL-20 and IL-22 receptor complex, it can activate JAK/ signal transducers and activators of transcription (STAT) signal pathway, and rapidly increase the phosphorylation transduction of tyrosine in JAK/STAT complex Signal, thereby regulating cell proliferation, migration and apoptosis. (creative-proteomics.com)
  • It can promote tumor cell apoptosis, inhibit tumor cell growth, inhibit tumor angiogenesis, inhibit tumor cell metastasis, etc., so that it has a wide range of selective anti-tumor effects and immune regulation. (creative-proteomics.com)
  • And it can promote tumor cell apoptosis by increasing the synthesis of reactive oxygen species (ROS) and mitochondrial dysfunction. (creative-proteomics.com)
  • In cervical cancer, colon cancer, nasopharyngeal cancer and osteosarcoma and other tumor cells, IL-24 has played a significant role in growth inhibition and apoptosis. (creative-proteomics.com)
  • Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
  • MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
  • Many potential anticancer mechanisms of these compounds were proposed, including the inhibition of cell proliferation, changes in enzyme activity and immune regulation ( 21 , 22 ). (spandidos-publications.com)
  • It causes malignant proliferation of hematopoietic stem cells in the bone marrow, resulting in the production of cancerous cells that lack normal physiological functions. (frontiersin.org)
  • In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
  • Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival. (aacrjournals.org)
  • PD-1 expression by cancer cells blocks the proliferation of T-cells. (shu.edu)
  • P15 INK4 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclind-CDK4,6, inhibiting it from hypophosphorylating Rb, thereby, rendering the cell cycle unresponsive to external proliferation signals. (shu.edu)
  • When JNK signalling pathway is blocked by inhibitor SP600125, hepatic stellate cells (HSCs) activation is inhibited, with less proliferation and reduced expression of α-smooth muscle actin (α-SMA) [ 15 ]. (biomedcentral.com)
  • Dr. Yasuhiro Miyake (Assistant Professor of Okayama University Hospital) with his colleagues have found the presence of anti-60S ribosomal protein L29 (RPL29) antibody in sera, and showed that the anti- recRPL29-peptides polyclonal antibody inhibited the proliferation of human pancreatic cancer Panc-1 cells via the down-regulation of Wnt/β-Catenin signaling pathway in a dose dependent manner. (okayama-u.ac.jp)
  • Anti-RPL29 antibody also showed the suppressive effects on the proliferation of other cancer cells such as lung adenocarcinoma, breast cancer, and hepatocellular carcinoma. (okayama-u.ac.jp)
  • Reishi suppresses the proliferation of ovarian cell cells. (greenmedinfo.com)
  • Suppression of proliferation and oxidative stress by extracts of Ganoderma lucidum in the ovarian cancer cell line OVCAR-3. (greenmedinfo.com)
  • Our results suggest that the combination of chidamide and bortezomib can significantly reduce the proliferation, invasion, and migration of MGC-803 and BGC-823 cells, providing a framework for the clinical evaluation of combined therapies for gastric cancers. (dovepress.com)
  • IL-24 can also induce the secretion of cytokines such as IL-6, TNF-α, IFN-γ, and stimulate T cell proliferation, thereby promoting the activation of the immune system. (creative-proteomics.com)
  • Hodgkin lymphoma is a localized or disseminated malignant proliferation of cells of the lymphoreticular system, primarily involving lymph node tissue, spleen, liver, and bone marrow. (msdmanuals.com)
  • Further, GA-mPEG 2000 micelles were effective in inhibiting tumor growth and prolonged survival in subcutaneous B16-F10 and C26 tumor models. (dovepress.com)
  • U373 inoculated subcutaneous in nude mice (2 mg/kg and 9 mg/kg) as well as paclitaxel (8 mg/kg), but on the contrary of paclitaxel, only ZK 219477 demonstrated antitumour activity against U373 implanted in nude mice (9 mg/kg): 8 complete response out 9 treated mice. (knowcancer.com)
  • For subcutaneous tumors, injection of CDC2-shRNA retroviruses significantly decreased tumor weight and volume compared with control. (biomedcentral.com)
  • The effects of the low-dose chidamide and bortezomib combination reduced the growth on gastric cancer in vivo were investigated by using a subcutaneous tumor mouse model. (dovepress.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • Melanoma is the most malignant and lethal skin tumor owing to its high metastatic ability and the incidence of melanoma has been increasing over the years. (medsci.org)
  • However, a phase II clinical trial in patients with bone-metastatic castration-resistant prostate cancer was halted because of lack of efficacy. (mirnainhibitors.com)
  • We investigated the ability of the ATR inhibitor, AZD6738, to prevent the gemcitabine-induced intra-S-phase checkpoint activation and evaluated the antitumor potential of this combination in vitro and in vivo In PDAC cell lines, AZD6738 inhibited gemcitabine-induced Chk1 activation, prevented cell-cycle arrest, and restrained RRM2 accumulation, leading to the strong induction of replication stress markers only with the combination. (nih.gov)
  • ZK 219477 demonstrated both in vitro and in vivo considerable anti-tumour activity against a wide range of malignancies, and it is now about to enter phase II studies in a number of selected indications. (knowcancer.com)
  • In pre-clinical model ZK 219477 has demonstrated anti-tumorigenic activity for gliomas tumours both in vitro and in vivo. (knowcancer.com)
  • The authors found that the peptide induces apoptotic effects on multiple cancer cells both in vitro and in vivo , inhibits tumor cell migration and invasion, and arrests cell cycle primarily in the G2M phase. (cytoskeleton.com)
  • BK011P) was an essential reagent in this study, complementing the in vivo results and in vitro cell culture data which demonstrated conclusively that the C36L1 peptide targets microtubules in exerting its anti-tumor effects. (cytoskeleton.com)
  • 2015. A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays anti-tumor activity against melanoma in vitro and in vivo . (cytoskeleton.com)
  • Retroviral vectors expressing short hairpin RNAs (shRNAs) targeted against CDC2 were designed and transducted into human glioma cell line ex vivo in order to downregulate the expression of CDC2. (biomedcentral.com)
  • Following ex vivo study, viral particles containing small interfering RNA for CDC2 were subsequently injected into xenogeneic graft tumor of nude mice and the weight of human glioma xenografts, survival and resulting phenotypic changes of target gene were investigated. (biomedcentral.com)
  • Downregulation of CDC2 could potentialy inhibit human gliomas cells growth ex vivo and in vivo. (biomedcentral.com)
  • To reveal the roles of CDC2/Cyclin B1 in human malignant gliomas, CDC2 in glioma cell line, it was down-regulated by retrovirus vectors expressing short hairpin RNAs (shRNAs) ex vivo and in vivo. (biomedcentral.com)
  • Tenacigenin B had anti-tumor effects on lymphoma via regulation of Aurora-A in vitro and in vivo . (medscimonit.com)
  • Among these derivatives, 8a exhibited more than 10-fold antiproliferation activity in several tumor cells than KX01 and significantly improved in vivo antitumor effects. (mirnainhibitors.com)
  • Laboratory studies have shown that Ganoderma lucidum enhances immune functions and also inhibits growth of various cancer cells both in vitro and in vivo. (greenmedinfo.com)
  • Finally, the inhibitory effect of the combined chidamide and bortezomib treatment on MGC-803 cells was verified in vivo through tumor formation experiments in nude mice. (dovepress.com)
  • In vivo, combination treatment resulted in slower tumor growth and increased survival of neuroblastoma PDX models. (lu.se)
  • KSP inhibition caused tumor regression in vivo and resulted in increased survival of multiple PDX models. (lu.se)
  • In vivo, rigosertib treatment resulted in decreased tumor growth and increased survival of PDX mice. (lu.se)
  • The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
  • Besides, 12% of patients have second- or third-degree skin reactions that are sensitive to light, and about 18% of patients develop cutaneous squamous-cell carcinoma and keratoacanthoma or occurred at the same time [ 6 ]. (medsci.org)
  • A Phase 1/2 trial is currently enrolling to evaluate the safety and efficacy of repeat cycles of Gedeptin therapy in patients with recurrent head and neck squamous cell carcinoma (HNSCC), with tumors accessible for injection and no curable treatment options. (gabio.org)
  • New devices have demonstrated significant results for the treatment of medical conditions, including mild-to-moderate acne vulgaris, wound healing, psoriasis, squamous cell carcinoma in situ (Bowen's disease), basal cell carcinoma, actinic keratosis, and cosmetic applications. (researchgate.net)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • Angiogenesis is essential in the process of carcinogenesis to facilitate tumor progression and metastasis. (spandidos-publications.com)
  • The vascular endothelial growth factor (VEGF) is a well characterized angiogenic factor known to stimulate angiogenesis within a tumor ( 1 ). (spandidos-publications.com)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • Curcumin can slow the growth of these tumors by inhibiting angiogenesis. (beatcancer.org)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • IL-24 has anti-angiogenic activity and reduces tumor micro vessel density by inhibiting angiogenesis. (creative-proteomics.com)
  • In September 2021, GeoVax expanded its immuno-oncology pipeline and added a new technology platform through the acquisition of exclusive rights to Gedeptin ® , a novel patented product for the treatment of solid tumors through a gene therapy strategy known as GDEPT (Gene-Directed Enzyme Prodrug Therapy). (gabio.org)
  • Given the promising evidence of safety and efficacy in the Phase I trial, further evaluation of efficacy in select solid tumors is warranted. (pharmiweb.com)
  • APG-115-US-002 is an open-label, multi-center, Phase Ib/II study in U.S. , which was designed to assess safety, toxicity, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of APG-115 in combination with pembrolizumab in patients with advanced solid tumors. (pharmiweb.com)
  • Remarkably, the combination also induced regression of a subgroup of KPC autochthonous tumors, which generally do not respond well to conventional chemotherapy. (nih.gov)
  • Inhibit Cancer Stem Cells - Curcumin makes cancer stem cells (normally resistant to chemotherapy and radiation) more sensitive to treatment and thereby less likely to allow cancer to regrow. (beatcancer.org)
  • Drugs used in chemotherapy halts this division and kills cancer cells. (yashodahospitals.com)
  • Currently, use of cannabinoids is limited to improve adverse effects of chemotherapy and their palliative administration during treatment is curiously concomitant with improved prognosis and regressed progression in patients with different tumor types. (frontiersin.org)
  • Chemotherapy drugs can kill cancerous cells through several mechanisms. (medicalnewstoday.com)
  • Chemotherapy drugs work by disrupting cell growth . (medicalnewstoday.com)
  • Chemotherapy drugs are unable to differentiate between healthy and cancerous cells, which can cause side effects during treatment. (medicalnewstoday.com)
  • Healthy cells typically rebound from the effects of chemotherapy, but cancer cells usually do not. (medicalnewstoday.com)
  • Doctors administer chemotherapy in cycles of treatment and recovery. (medicalnewstoday.com)
  • Tumor specimens were obtained with informed consent from a 37-year-old female patient who underwent initial surgical removal in January 1999 and subsequent recurrent resections of a right temporal tumor July 1999 and February 2001 at the 2nd Affiliated Hospital of Soochow University (Suzhou, China) and did not receive chemotherapy and radiation between these stages of progression. (biomedcentral.com)
  • This phase I trial studies the best dose and side effects of CD19/CD22 chimeric antigen receptor (CAR) T cells when given together with chemotherapy, and to see how well they work in treating children or young adults with CD19 positive B acute lymphoblastic leukemia that has come back or does not respond to treatment. (stanford.edu)
  • Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (stanford.edu)
  • Giving CD19/CD22-CAR T cells and chemotherapy may work better in treating children or young adults with B acute lymphoblastic leukemia. (stanford.edu)
  • Patients with aggressive tumors are treated intensely with multi-modal therapy including chemotherapy, surgery, radiotherapy and immunotherapy. (lu.se)
  • 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
  • JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)
  • Consequently, when cell cycle arrest was deactivated by adding caffeine, the antitumor activity of TRAIL was decreased. (uni-muenchen.de)
  • While it is well understood that doxorubicin activates p53 and induces cell-cycle arrest, we observed that cell-cycle arrest disabled inactivation of anti-apoptotic Bcl-2-family members by vincristine. (uni-muenchen.de)
  • Additional studies to assess antitumor activity confirmed that this peptide showed capability to increase the adhesion capacity of tumor cells, to decrease the migration capacity of cancer cells, and to arrest cell cycle on S phase. (uah.es)
  • Treatment of neuroblastoma PDX cells with ARRY-520 resulted in mitotic arrest and subsequent cell death. (lu.se)
  • Rigosertib reduced cell viability of neuroblastoma cells and caused cell cycle arrest in the G2/M phase. (lu.se)
  • Both laboratory and live animal studies demonstrate that the compound can dramatically reduce the occurrence and severity of malignant tumors. (beatcancer.org)
  • A variety of evidence suggests that spontaneous immune responses to autologous tumor-associated antigens affect the cure of malignant tumors, and that some antibodies in sera could influence cancer cells. (okayama-u.ac.jp)
  • Based on the results of these studies, anti-RPL29 antibody could be a first-in-class molecular-targeted drug for the treatment of malignant tumors. (okayama-u.ac.jp)
  • In addition, the concentration of the anti-RPL29 antibody in sera can be a new diagnostic biomarker for the treatment of malignant tumors. (okayama-u.ac.jp)
  • 1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
  • Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. (bdbiosciences.com)
  • The phosphorylation of pRB, and relief of transcriptional repression by pRB induces genes involved in the induction of S-phase entry. (shu.edu)
  • Hodgkin lymphoma results from the clonal transformation of cells of B-cell origin, giving rise to pathognomic binucleated Reed-Sternberg cells. (msdmanuals.com)
  • T he presence and activity of various proteins are required in the cell cycle progression. (ukessays.com)
  • Targeted therapy is a cancer treatment that targets specific genes and proteins responsible for cancerous cell growth and survival. (yashodahospitals.com)
  • Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
  • Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)
  • The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. (bdbiosciences.com)
  • Lectins, the carbohydrate-binding proteins, are capable of binding to receptors present on the target cell/tissue and interact with transformed glycans better than normal cells. (bvsalud.org)
  • Mechanistically, both peptides caused a significant reduction at G0/G1 phase, in correlation with an augmented expression of the cell cycle inhibitory proteins p53, p27, p21, necrosis, exacerbated generation of reactive oxygen species and diminished mitochondrial membrane potential, all hallmarks of cellular stress. (nature.com)
  • RPL29 is one of approximately 80 structural ribosomal proteins, and is highly expressed on the surface of a cancer cell. (okayama-u.ac.jp)
  • A CAR is a genetically-engineered receptor made so that immune cells (T cells) can attack cancer cells by recognizing and responding to the CD19/CD22 proteins. (stanford.edu)
  • Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer? (mdpi.com)
  • Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
  • Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
  • Prevent DNA Damage - Curcumin protects against DNA damage to genes regulating cell replication by toxins, radiation, and other environmental factors. (beatcancer.org)
  • Normalize Cell Growth - Curcumin restores normal growth controls, reverses uncontrolled reproduction of malignant cells, blocks access of cancer cells to growth factors, turns on genes that prevent cell growth and turns off genes that promote cancer growth. (beatcancer.org)
  • Subsequently, T cells receiving PD-1 signals displayed impaired Cdk2 activation and failed to phosphorylate two critical Cdk2 substrates, the retinoblastoma gene product (Rb) and the TGFβ-specific transcription factor Smad3 , leading to suppression of E2F target genes but enhanced Smad3 transactivation (Figure 3). (shu.edu)
  • Tissue microarrays were utilized to investigate the expression of genes in a large number of tumor samples and to identify overexpressed genes which could be potentially causing tumorigenesis. (biomedcentral.com)
  • The cell cycle is a complex process with myriad genes involved and elaborate and complex signaling mechanisms to allow for this critical cellular process. (biomedcentral.com)
  • The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
  • It is suggested that curcumin can selectively kill tumor cells through its multifaceted metabolic effects, that culminate in its anti-oxidant and anti-inflammatory activities ( Hewlings and Kalman, 2017 ). (frontiersin.org)
  • In GDEPT, a vector is used to selectively transduce tumor cells with a nonhuman gene, which expresses an enzyme that can convert a nontoxic prodrug into a very toxic antitumor compound. (gabio.org)
  • Conjugation of glucose with metabolic agents to selectively target cancer cells was inspired by the widespread use of radiolabeled glucose analog to visualize tumors and their metastases. (oncotarget.com)
  • In vitro, VG9-IL-24 induced an increased number of apoptotic cells and blocked colorectal cancer cells in the G 2 /M phase of the cell cycle. (techscience.com)
  • Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
  • In vitro studies using infra-/red light have not shown any useful impact on wound healing by activating cells located in deeper skin layers such as fibroblasts or stem cells [2] . (researchgate.net)
  • In order to test our hypothesis, we examined, for the first time in vitro , the anti-proliferative properties of the spider-venom peptide gomesin and its analogues as potential therapeutic lead candidates against DFTD. (nature.com)
  • The inhibitors demonstrated promising effects in vitro with reduced viability, increased differentiation and cell death of neuroblastoma cells. (lu.se)
  • We have also confirmed that non-steroidal anti-inflammatory drug activated gene (NAG-1) is a major molecular target of AST during its antitumorigenic action, which has a strong correlation with the PI3K-Akt signaling pathway during its action ( 9 ). (spandidos-publications.com)
  • Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
  • The researchers also studied the cell-signaling pathway in the mitochondria of these mice. (lifeextension.com)
  • Chemopreventive activities elicited by Ganoderma lucidum were demonstrated by the induction of antioxidant SOD and catalase as well as the phase IIdetoxification enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) and glutathione S-transferase P1 (GSTP1) via the Nrf2 mediated signaling pathway known to provide chemoprotection against carcinogenicity. (greenmedinfo.com)
  • It can kill sensitive prostate cancer cells through the extra cellular signal-regulated kinase1/2 (ERK1/2) signaling pathway. (creative-proteomics.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • The researchers observed that because available anti-cancer drugs exhibit limited efficacy, are associated with severe side effects , and are also expensive, identification of pharmacological agents without these disadvantages is necessary. (beatcancer.org)
  • Its anti-cancer effects are predominantly mediated through its negative regulation of tumor growth factors, inflammatory cytokines, and other oncogenic molecules. (beatcancer.org)
  • Conjugation of hydrophilic polymers with small molecule drugs to produce polymer-drug conjugate systems has been demonstrated to be a viable formulation strategy for utilizing hydrophobic drugs in a water-soluble manner, which may offer advantages over the corresponding parent drugs, including fewer side effects, improved solubility, passive tumor targeting, an improved pharmacokinetic profile, and lower plasma concentrations. (dovepress.com)
  • Most antibiotic antitumor drugs are cell-cycle nonspecific except Bleomycin which shows significant effects in G2 and M phases. (yashodahospitals.com)
  • Moreover, common targeted therapeutic drug formulations have weak stability in malignant tumor leukemia, and their application effects are limited. (frontiersin.org)
  • Drug delivery systems seem to be a new method for improving drug targeting and release into cells, bringing new opportunities for improving drug efficiency and avoiding potential side effects. (frontiersin.org)
  • According to the JIB extract's anti-melanoma capacity, to assess the synergistic effects of cisplatin and JIB extract. (medsci.org)
  • Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
  • It was earlier thought that cannabinoids exert their physiologic and behavioral effects via nonspecific interaction with cell membranes. (aacrjournals.org)
  • An increasing number of studies have emphasized the antitumor effects of TPL on non-small cell lung cancer (NSCLC). (techscience.com)
  • We constructed a targeted vaccinia virus of Guang9 strain harboring IL-24 (VG9-IL-24) to evaluate its antitumor effects. (techscience.com)
  • Different drugs target different phases of growth and have different effects against some cancers . (medicalnewstoday.com)
  • Today, resveratrol is attracting attention for its unique ability to mimic the gene expression effects of caloric restriction, the only intervention that has been shown in peer-reviewed studies to prolong maximum life span and/or produce anti-aging effects in a variety of organisms, including mice, rats, dogs, and monkeys. (lifeextension.com)
  • 4 That made resveratrol the first compound to show anti-aging effects in widely divergent species. (lifeextension.com)
  • examined the mechanism of action underlying the anti-tumor effects of the complementarity-determining region (CDR) C36L1 synthetic peptide derived from the V L CDR1 of the C36 Fab fragment of the anti-vaccinia immunoglobulin. (cytoskeleton.com)
  • 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was executed for determination of effects of piperine on breast cancer cell viability. (ijpsonline.com)
  • In conclusion, the current investigation regarding anticancer effects of piperine against breast cancer revealed remarkable suppression of cancer cells. (ijpsonline.com)
  • ABSTRACT: Klisyri (KX01) is a dual tubulin/Src protein inhibitor that has shown potential therapeutic effects in several tumor models. (mirnainhibitors.com)
  • In this study, we investigated whether Ganoderma lucidum elicits its anti-tumor effects by suppressing cell growth and inducing antioxidative/detoxification activity in human ovarian OVCAR-3 cells. (greenmedinfo.com)
  • LSA has speedy and profound effects on critical aspects of cell biology including inhibition of cell adhesion activation of PKC and activation of the mitogen-activated protein kinases (MAPK) ERK1/2 and p38 [8 12 13 Figure 1 shRNA screen for genetic determinants of lasonolide A (LSA) sensitivity. (biomedigs.org)
  • When the genetic information containing the "blueprint" for these substances is disrupted, cell homeostasis is disrupted, resulting in a wide-range of immediate and/or delayed toxicological effects. (cdc.gov)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • Reduce Production of Adhesion Molecules - Curcumin keeps malignant tissue from sticking to vessel walls and reduces cancer cells' ability to form distant metastases. (beatcancer.org)
  • 1) The regulation of these protein levels is vital for the understanding of the cell cycle control and its dysregulation. (ukessays.com)
  • Thus, ECA39 may be involved in the regulation of the cell cycle, possibly at the G1 to S phase transition. (bdbiosciences.com)
  • Schuldiner O, Eden A, Ben-Yosef T, Yanuka O, Simchen G, Benvenisty N. ECA39, a conserved gene regulated by c-Myc in mice, is involved in G1/S cell cycle regulation in yeast. (bdbiosciences.com)
  • Abnormalities in cell cycle regulation are reported to be strongly associated with tumorigenesis and progression of tumors. (biomedcentral.com)
  • The results showed that Ganoderma lucidum inhibits cell growth and disruption of cell cycle progression via down regulation of cyclin D1. (greenmedinfo.com)
  • Cell migration and invasion was monitored by transwell chambers assay. (ijpsonline.com)
  • Cell migration as well as cell invasive ability of MCF-7 cells was reduced to minimum by the application of piperine in dose dependent-manner. (ijpsonline.com)
  • Of interest for GBM indication, ZK 219477 is not metabolized by liver cytochrome P450, which is induced by phenytoin and other anti-convulsion drug, commonly used in post-surgery GBM patients. (knowcancer.com)
  • Aim of the study: The purpose of this single arm phase II study is to evaluate safety and efficacy of ZK 219477 in the treatment of pre-treated, recurrent GBM patients. (knowcancer.com)
  • As of April 1, 2020, in the Phase Ib study, 19 patients were treated with APG-115 in 4 alternate-day (QOD) dose cohorts (50 mg, 100 mg, 150 mg, and 200 mg) in combination with pembrolizumab. (pharmiweb.com)
  • Increasingly numerous results have demonstrated overexpression of CDC2/Cyclin B1 in various tumors however there is still no report of CDC2/Cyclin B1 expression in clinical samples from patients with gliomas. (biomedcentral.com)
  • In selected patients with limited-stage, nonbulky HL with early response confirmed by functional imaging, ABVD for six cycles without RT has proved effective and safe. (medscape.com)
  • Most patients also develop a slowly progressive defect in cell-mediated immunity (T-cell function) that, in advanced disease, contributes to common bacterial and unusual fungal, viral, and protozoal infections. (msdmanuals.com)
  • Pdx-Cre (KPC) mouse cancer cell line, significantly extending survival. (nih.gov)
  • Abstract Glioma is the most common primary malignant brain tumor with a poor survival rate. (techscience.com)
  • however, the strength of the recommendation to treat should be based on the patient's willingness to accept therapy as well as the prognosis for AIDS-free survival as determined by the HIV RNA copy per mL of plasma and the CD4+ T cell count. (cdc.gov)
  • The presence of p53 in tumor cell lines and xenograft tumor cells resulted in augmented, unaffected or decreased cell death. (uni-muenchen.de)
  • For this work, I have used patient-derived xenograft mouse models and neuroblastoma cells grown as 3D tumor organoids. (lu.se)
  • Ovarian cancer is the most common cause of cancer death from gynecologic tumors in the United States. (medscape.com)
  • The determination of testosterone in women is helpful in the diagnosis of androgenic syndrome (AGS), polycystic ovaries (Stein-Leventhal syndrome) and when an ovarian tumor, adrenal tumor, adrenal hyperplasia or ovarian insufficiency is suspected. (cdc.gov)
  • Recently, Australian research fellow Gautam Sethi and his colleagues at Curtin University have found strong anti-cancer potential of curcumin, based on a scientific review of past clinical trials ( Molecules, Vol. 20, No. 2, Feb 2015). (beatcancer.org)
  • The clinical application of gambogic acid, a natural component with promising antitumor activity, is limited due to its extremely poor aqueous solubility, short half-life in blood, and severe systemic toxicity. (dovepress.com)
  • Calcitriol has been used in a number of clinical trials and it is important to note that sufficient dose and exposure to calcitriol is critical to achieve anti-tumor effect. (jcancer.org)
  • Furthermore, we observed some encouraging signs of clinical activity, which warrants further evaluation in specific patient populations, including microsatellite-stable colorectal cancer [CRC] and non-small-cell lung cancer [NSCLC]. (pharmiweb.com)
  • In parallel to my clinical training, I constructed an AML specific CAR and demonstrated its ability to redirect T cell function mediating eradication of AML cells. (stanford.edu)
  • Ataxia telangiectasia and Rad3-related protein (ATR), the apical kinase of the intra-S-phase DNA damage response, plays a central role in safeguarding cells from replication stress and can therefore limit the efficacy of antimetabolite drug therapies. (nih.gov)
  • Arming vaccinia virus with immunostimulatory cytokines can enhance the tumor cell-specific replication and antitumor efficacy. (techscience.com)
  • Presumably, oxaliplatin forms inter- and intrathecal bonds with DNA, thus inhibiting its replication and transcription phases. (ru-pills.com)
  • In contrast the cytotoxicity of LSA is dependent on drug exposure time [12 13 During normal cell cycle chromosomes condense in a highly ordered manner at the onset of mitosis and PCC is defined by its occurrence outside of mitosis before completion of DNA replication. (biomedigs.org)
  • The Phase Ib dose-escalation study has been completed, and the Phase II is ongoing. (pharmiweb.com)
  • The antimetabolite gemcitabine remains part of the standard of care but shows very limited antitumor efficacy. (nih.gov)
  • To this end, supported by research demonstrating superior antitumor function of naïve derived effector T cells compared to central memory derived effector T cells, I am investigating whether preferential modification of naïve T cells to express CARs will generate a T cell subpopulation with increased efficacy. (stanford.edu)
  • extract (JIB extract) for melanoma cells. (medsci.org)
  • Our results indicated the anti-melanoma activity of JIB extract. (medsci.org)
  • PD-1 inhibition (Figure 1) has quickly become a front-line therapy for non-small cell lung cancer and melanoma . (shu.edu)
  • A combined effect is attributed to its antineoplastic activity inhibiting the cell's uncontrolled cell division. (yashodahospitals.com)
  • Recent studies demonstrated that piperine potentiates curcumin's inhibitory effect on tumor progression via enhancing its delivery and therapeutic activity. (frontiersin.org)
  • Triptolide (TPL), a diterpenoid triepoxide from the Chinese herb Tripterygium wilfordii Hook F, has exhibited attractive cytotoxic activity on several cancer cells. (techscience.com)
  • Newcastle disease virus (NDV), a negative-stranded RNA virus that exhibits oncolytic activity, has been investigated for its capacity to elicit antitumor activity in many types of cancers, including glioma. (techscience.com)
  • p27 is a cyclin dependent kinase inhibitor that blocks the activity of Cyclin E-CDK2, which phosphorylates pRb, thereby ushering the cell from G1 into S phase through the Restriction point (Figure 2). (shu.edu)
  • Therefore, it's necessary to express Cs sPLA2 in water-soluble form and determine whether the enzymatic activity of Cs sPLA2 or cell signalling pathways is involved in liver fibrosis caused by clonorchiasis. (biomedcentral.com)
  • This CDR exhibits both anti-tumor activity and functions as a microtubule destabilizing molecule. (cytoskeleton.com)
  • Here, the authors investigated whether its microtubule-destabilizing effect is responsible for its anti-tumor activity. (cytoskeleton.com)
  • Vinorelbine, a semi-synthetic vinca alkaloid, exerts its anti-tumour activity by binding to tubulin and inhibiting microtubule assembly, thereby preventing cell mitosis and causing cell death. (cancercareontario.ca)
  • Oxaliplatin has antitumor activity in various types of tumors, including colorectal cancer. (ru-pills.com)
  • Curcumin has been found to suppress initiation, progression, and metastasis of a variety of tumors. (beatcancer.org)
  • 1 These tumors are difficult to find because their early symptoms are not obvious, and most of these tumors would have already progressed to the late stage with lymphatic or distal metastasis by the time they are discovered. (dovepress.com)
  • It can also down-regulate the synthesis of phosphatidylinositol 3-kinase/protein kinase B, focal adhesion kinase, matrix metalloproteinase 2/9, and inhibit cancer cell invasion and metastasis. (creative-proteomics.com)
  • In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
  • We assessed their cytotoxic effect after sensitizing cancer cells with insulin. (oncotarget.com)
  • In this study, we report the cell-autonomous antiproliferative and cytotoxic activities exhibited by the spider peptide gomesin (AgGom) and gomesin-like homologue (HiGom) in DFTD cells. (nature.com)
  • The screening of a novel panel of AgGom-analogues revealed that, unlike changes in the hydrophobicity and electrostatic surface, the cytotoxic potential of the gomesin analogues in DFTD cells lies on specific arginine substitutions in the eight and nine positions and alanine replacement in three, five and 12 positions. (nature.com)
  • This observation prompted us to characterise the cell-autonomous cytotoxic and anti-proliferative profile of gomesin in DFTD cells and in comparison, to non-transformed (healthy) Tasmanian devil fibroblasts (FIBS). (nature.com)
  • The mechanism of antitumor effect of oxaliplatin is based on cytotoxic action and is not fully understood. (ru-pills.com)
  • Peptides in fraction F5 were identified by RP-HPLC- and HILIC-ESI-Q-ToF and cytotoxic effect was assessed in different cell lines. (uah.es)
  • In studies using animals or cells grown in labs, cinnamon has shown promise for its ability to slow cancer growth and even kill tumor cells. (webmd.com)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • Moreover, synergistic growth inhibition was identified in a panel of 5 mouse and 7 human PDAC cell lines using both Bliss Independence and Loewe models. (nih.gov)
  • Curcumin can help protect against cancer initiation, slow its growth when it occurs, and even sensitize cancer cells to treatment. (beatcancer.org)
  • These medications only work at specific stages in a cell's growth cycle. (medicalnewstoday.com)
  • They can work throughout a cell's growth cycle, but they are most effective during certain phases. (medicalnewstoday.com)
  • Flow cytometric analysis evidenced that piperine arrested the cell cycle at growth 2/mitosis phase, hence suppressed the breast cancer progression. (ijpsonline.com)
  • In breast cancer, IL-24 inhibits the growth of breast cancer cells through an anti-tumor-bystander effect. (creative-proteomics.com)
  • The tumor size and the number of proliferating cells were reduced in the tumor tissues obtained from the formononetin-treated group. (spandidos-publications.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • IL-22R1 is mainly expressed in normal liver and kidney tissues and various tumor cells. (creative-proteomics.com)
  • Interleukin-24 (IL-24) is an important immune mediator, as well as a broad-spectrum tumor suppressor. (techscience.com)
  • As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1α, 25-dihydroxycholecalciferol (calcitriol) also has broad spectrum anti-tumor activities as supported by numerous epidemiological and experimental studies. (jcancer.org)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • Enhance Immune Surveillance - Curcumin prevents cancer cells from evading normal immune system detection and improves the body's ability to detect and destroy malignant cells. (beatcancer.org)
  • Unlike normal cells, cancer cells lose the ability to stop division. (yashodahospitals.com)
  • Blocks or turn off signals that tell cancer cells to grow and divide. (yashodahospitals.com)
  • Destroy cancer cells. (yashodahospitals.com)
  • Targeted therapy uses targeted drugs to maintain a high concentration of the drug in the tumor area, improving the killing efficiency of cancer cells while avoiding damage to other normal cells. (frontiersin.org)
  • Most cancer cells have PD-L1 on their surface and escape being killed by turning off the T cell in this way. (shu.edu)
  • Cycling cells are required for vincristine to kill cancer cells efficiently. (uni-muenchen.de)
  • Conjugating sugar-stabilised NPs with lectins there for is expected to multiply the potential for the early diagnosis of cancer cells and the specific release of drugs into the tumor site. (bvsalud.org)
  • Investigation of the interaction between sugar-stabilised silver nanoparticles and MCL has been performed by fluorescence spectroscopy to explore the possibility of creating an effective biocompatible drug delivery system against cancer cells. (bvsalud.org)
  • Clonogenic assay was implemented for checking the effect of piperine on clonogenic potency of breast cancer cells. (ijpsonline.com)
  • Western blotting assay was implemented to check the levels of phosphatidylinositol 3-kinase and protein kinase B. Results revealed that piperine induced dose reliant cytotoxicity in MCF-7 human breast cancer cells. (ijpsonline.com)
  • In the USA, obesity has recent- obesity is associated with progres- aberrations of cancer cells, summa- ly surpassed tobacco use as the sion but not incidence [9]. (who.int)
  • We identified the association between garlic intake and reduced risk of gastric and colorectal cancers and hypothesized that the active ingredients in garlic may act on multiple pathways to reduce the risk of gastrointestinal tumors according to published papers. (spandidos-publications.com)
  • Adjuvant therapy for colorectal cancer is 85 mg/m 2 once every 2 weeks for 12 cycles (6 months). (ru-pills.com)
  • 2 Results and Discussion 2.1 A Kinome shRNA Screen Identified Candidate LSA Molecular Targets and Pathways To probe the genetic pathways that might mediate the cellular response to LSA we screened a pool of 2951 retroviral shRNA targeting most kinases and phosphatases (1140 RefSeq transcripts) at two different drug concentrations of 10 and 100 nM in the colorectal cancer cell line HCT-116. (biomedigs.org)
  • These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
  • VLPs mimic a natural infection, triggering the body to produce a robust and durable immune response with both antibodies and T cells. (gabio.org)
  • Anti-PD-1 antibodies (dark green) or anti-PD-L1 antibodies (light green) can prevent the tumor cell from binding PD-1 and thus allow T cells to remain active. (shu.edu)
  • Bleomycin interacts with cancerous cells and binds with the DNA, and inhibits cell synthesis by breaking DNA strands. (yashodahospitals.com)
  • 2 Thus, simple surgical treatment cannot aid in full eradication of these tumors. (dovepress.com)
  • Low-risk types (e.g., types 6 and 11) can cause benign or low-grade cervical cell changes, genital warts, and recurrent respiratory papillomatosis ( 4 ). (cdc.gov)
  • But, how does PD-1 blunt the anti-tumor immune response? (shu.edu)
  • Chest Pain , sometimes accompanied by changes in electrocardiograms, occurs mostly in those with a previous history of cardiovascular disease or the presence of a bulky tumour within the chest. (cancercareontario.ca)
  • Stromal tumors of the ovary include germ-cell tumors, sex-cord stromal tumors, and other more rare types. (medscape.com)
  • Chinese hamster ovary) cell suspension culture and purified by chromatography including specific viral inactivation and removal procedures. (who.int)
  • In eukaryotes, the entry into mitosis is regulated by the activation of CDC2/Cyclin B1 complex (M-phase promoting factor, MPF). (biomedcentral.com)
  • For example, while TIPE is primarily associated with tumor progression and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. (techscience.com)
  • Accumulation of p27 in the nucleus, therefore, blocks cell cycle progression of T-lymphocytes that are being induced to act against cancer antigens. (shu.edu)
  • The urgent need for novel treatments inspired me to pursue a research project in adoptive immunotherapy, genetically modifying Tcells to express artificial T cell receptors, termed chimeric antigen receptors (CARs), that target AML specific antigens. (stanford.edu)
  • In our work we discovered that the influence of p53 status on extrinsic cell death induction was much more multifaceted. (uni-muenchen.de)
  • Our findings suggest that GA-mPEG 2000 micelles may have promising applications in tumor therapy. (dovepress.com)
  • Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. (frontiersin.org)
  • These results support our previous findings that wild-type TP53 is a predictive biomarker of response to APG-115, and liposarcoma may be one of its potential target tumor types. (pharmiweb.com)
  • 2) Therefore, the proper control of protein levels is crucial for the cell cycle. (ukessays.com)
  • Cells have a protein on their surface called PD-1 (in orange above). (shu.edu)
  • In tumor cells, IL-24 can induce the transcription of GADD gene, which is related to protein misfolding and DNA damage, such as lung cancer. (creative-proteomics.com)
  • Analysis of KSP expression across multiple tumor types demonstrated that neuroblastoma is highly dependent on this protein. (lu.se)
  • 1% incidence, reported in post-marketing, phase 1 studies, isolated data or anecdotal reports. (cancercareontario.ca)
  • In addition, obesity is associated with progression (but not incidence) of tumour microenvironment through prostate cancer. (who.int)
  • Both compounds proved to have an antitumor effect which was significantly enhanced in combination with insulin. (oncotarget.com)
  • MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide) tests demonstrated that the GA-mPEG 2000 micelle formulation had obvious cytotoxicity to tumor cells and human umbilical vein endothelial cells. (dovepress.com)
  • Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. (oncotarget.com)