Anti tumor dendritic immunotherapy adoptive. Medical search. Frequent questions

These data suggest that Tc1-based adoptive transfer therapy may represent an effective modality for CNS tumors, particularly when combined with strategies that promote a type 1 polarized tumor microenvironment. (nih.gov)
While GB tumors are frequently infiltrated by natural killer (NK) cells, these are actively suppressed by the GB cells and the GB tumor microenvironment. (frontiersin.org)
Here, we discuss effects of the GB tumor microenvironment on NK-cell functionality, summarize early treatment attempts with ex vivo activated NK cells, and describe relevant CAR target antigens validated with CAR-T cells. (frontiersin.org)
Nevertheless, the composition of the immunologic tumor microenvironment undergoes changes upon radiotherapy, chemotherapy, or even after anti-angiogenic therapy ( 6 ). (frontiersin.org)
Although RT is an important modality for cancer treatment, the consequential changes caused by RT in the tumor microenvironment (TME) have not yet been fully elucidated. (nature.com)
Furthermore, inflammatory mediators released by irradiated dying cells can attract and regulate immune cells in the tumor microenvironment (TME), further killing cancer cells. (nature.com)
In collaboration with Hi-TIDe's Tumor microenvironment & biomarkers group and T cell discovery group , we capture tumor-infiltrating lymphocytes in human tumors in action, at the steady state or following adoptive T-cell therapy and other therapeutic perturbations, and interrogate them exhaustively to unveil the underlying T cell intrinsic signaling regulatory networks. (unil.ch)
Local administration or OV mediated-expression of ligands for Toll-like receptors can rescue the function of tumor-infiltrating CD8 + T cells inhibited by the immunosuppressive tumor microenvironment and thus enhances the antitumor effect. (biomedcentral.com)
However, increasing data has indicated that the clinical potential of most immunotherapies is usually hampered by immunosuppressive status of the tumor microenvironment (TME) [ 7 ]. (thno.org)
A2BR deletion also intrinsically favored accumulation of myeloid and CD11bdim antigen-presenting cells (APC) in the tumor microenvironment. (figshare.com)
Another approach relies upon the use of chimeric antigen receptors (CARs) that directly target cancer cells or immunosuppressive cellular elements in the tumor microenvironment. (upenn.edu)
SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment. (amedeo.com)
Although there is ample evidence that the chemotherapeutic drugs trigger an immune response, the efficient tumor rejection or regression is not guaranteed probably due to the massive immunosuppression within the tumor microenvironment. (thno.org)
This work represents a novel approach for cancer immunotherapy by integrating nanotechnology and platinum-based therapeutics which not only efficiently exerts the chemotherapeutic cytotoxic effect on tumor cell but also restores immune response of immunological cells within the tumor microenvironment. (thno.org)
First, the stimulatory or death signals are released from apoptotic tumor cells into the tumor microenvironment. (thno.org)
During the early phase of tumor development, immune cells could spontaneously infiltrate into the tumor microenvironment to evoke an immune response and fight against the growth of the tumor. (thno.org)
In experiments on mice, the researchers found that the microenvironment of pancreatic tumors contains very few dendritic cells. (bookinghealth.com)
In contrast, the microenvironment of lung cancer, which responds well to immunotherapy, contains 80 times more dendritic cells. (bookinghealth.com)
Discuss therapeutic approaches to cancer immunotherapy including: vaccination strategies including combinations of vaccines and molecularly targeted therapies, adoptive T cell transfer, dendritic cells, innate/adaptive immune interplay, countering negative regulation and immune cell trafficking to tumor microenvironment. (sitcancer.org)
Breakthroughs in anti-tumor immunity have led to unprecedented advances in immunotherapy, yet it is now clear that the tumor microenvironment (TME) restrains immunity. (elifesciences.org)
As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)

T helper 1 (TH1) cells, when injected with overexpressed tumor antigens, have been shown to enhance migration of antigen-presenting cells (APCs) into the draining lymph node in mice, further enhancing immune response through activation of CTLs. (wikipedia.org)
Tumor antigens are typically cancer/testis antigens. (wikipedia.org)
Research carried out at the Department of Tumour Cell Biology in Copenhagen has shown that CTL clones targeting specific melanoma tumor associated antigens (gp100 and MART-1) can successfully proliferate if melanoma cell lines are carefully preselected. (wikipedia.org)
NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
DCs are the most potent antigen-presenting cells, with the capacity to take up, process, and present tumor antigens to T cells and stimulate an immune response, thus providing a rational platform for vaccine development. (ox.ac.uk)
Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
For example, antibodies specific to tumor antigens, adoptively transferred immune cells, therapeutic vaccines, and recombinant cytokines effectively boost the host immune system to recognize tumor cells as pathogens and eliminate them [ 1 - 3 ]. (thno.org)
Then these signals are engulfed as antigens and presented by antigen-presenting cells within the tumor-derived lymph nodes. (thno.org)
These therapies boost the immune system's ability to detect and destroy cancer cells by exposing it to tumor-specific antigens or genetically modified immune cells programmed to recognize cancer. (theusaknowledge.net)
This approach involves isolating patient's dendritic cells, loading them with tumor antigens and reinfusing to induce a wider immune reaction. (theusaknowledge.net)
Cancer vaccines introduce tumor antigens to the immune system. (theusaknowledge.net)
Adoptive cell transfer involves engineering patient's own T-cells to create receptors on their surface that recognize specific tumor antigens. (theusaknowledge.net)
Dendritic cells (DCs) are immune cells that recognize antigens (targets for attack) and show them to T-cells. (bookinghealth.com)
Apparently, this is due to the lack of stimulation of antitumor immunity during the mass decay of cancer cells and the release of antigens into the systemic bloodstream, as it happens with other tumors. (bookinghealth.com)
For DSc activation doctors use antigens of a patient's own tumor or lysate of allogeneic (donor) dendritic cells, which contains antigens common to different tumors. (bookinghealth.com)
Monocytes (a type of leukocytes) for dendritic cell production are harvested from the patient's blood by leukapheresis and are treated with tumor antigens. (bookinghealth.com)
However, except for virus-induced cancers, tumor antigens are mostly self or near-self protein epitopes that are often poorly immunogenic and submitted to central and peripheral tolerance. (biomedcentral.com)
Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. (nwbio.com)
They help immune cells to recognize antigens found on tumor cells that are absent from, or found in low numbers on, normal cells. (immunogenetics.com)

Cytotoxic T lymphocytes (CTL) are activated to target the cells that present proteins characteristic of tumor cells Some tumor cells, however, do not present an antigen due to lack of a major histocompatibility complex (MHC) and therefore cannot be recognized by the CTLs. (wikipedia.org)
The lymphocytes are frozen and the monocytes are differentiated into dendritic cells. (wikipedia.org)
After 6 days, the lymphocytes are mixed with dendritic cells and incubated for eight days. (wikipedia.org)
After that, dendritic cells are added to the lymphocytes to induce further lymphocyte proliferation. (wikipedia.org)
In contrast to other cancers such as adenocarcinomas of the lung or melanoma, primary brain tumors like GB and low grade gliomas (LGG) are known as rather immunologically "cold" tumors, typically with low numbers of tumor-infiltrating lymphocytes (TILs) ( 4 ), and the mere amount of TILs is not associated with patient survival ( 5 ). (frontiersin.org)
4 According to the number of tumor-infiltrating lymphocytes, tumors can be divided into three phenotypes: immune-inflamed, immune-excluded, and immune-desert types. (nature.com)
Breast tumor infiltrating lymphocytes (TIL) are enriched in tumor-specific cytotoxic T lymphocytes (CTL), and may represent a superior source of CTL compare to peripheral blood lymphocytes (PBL), for adoptive T cell immunotherapy of breast cancer. (utmb.edu)
Tumor-infiltrating lymphocytes (TIL) were assessed by hematoxylin/eosin stain and quantitative fluorescence. (aacrjournals.org)
HCC is an attractive target for immunotherapy as evidenced by an active recruitment of tumor-infiltrating lymphocytes that are capable of lysing autologous tumor cells in ex vivo studies. (ox.ac.uk)
and (ii) tumour-infiltrating lymphocyte (TIL) therapy, in which cells are extracted from lymphocytes recovered from the patient with cancer and incubated with high concentrations of IL-2 before being injected back into the patient. (hindawi.com)
a Specimen with tumor-infiltrating lymphocytes. (springeropen.com)
Most of them generally follow the same pathway to make immune-activated cytotoxic T lymphocytes (CTLs) abundantly infiltrate into tumor tissues and destroy tumor cells [ 6 ]. (thno.org)
CD4 Phenotypes Are Associated with Reduced Expansion of Tumor-Infiltrating Lymphocytes in Melanoma Patients Treated with Adoptive Cell Therapy. (amedeo.com)
This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)

Using C57BL/6 mice bearing intracranial (i.c.) ovalbumin-transfected melanoma (M05), we evaluated the efficacy and tumor homing of i.v. transferred type 1 or 2 CTLs (Tc1 or Tc2, respectively) prepared from ovalbumin-specific T-cell receptor-transgenic OT-1 mice. (nih.gov)
I.t. injections of DC-IFN-alpha remarkably enhanced the tumor homing, therapeutic efficacy, and in situ IFN-gamma production of i.v. delivered Tc1, resulting in the long-term survival and persistence of systemic ovalbumin-specific immunity. (nih.gov)
To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
An approach that targets multiple essential processes of tumorigenesis can overcome tumor-associated plasticity, clonal evolution and adaptive resistance, all of which limit the durable efficacy of current treatments. (mayo.edu)
Over the last Etretinate few years, immunotherapy has Etretinate demonstrated impressive efficacy for many tumors. (mindunwindart.com)
2015) have been studied in HCC for many decades, with some but uncertain antitumor efficacy. (mindunwindart.com)
We characterize novel synthetic T cell states at the epigenetic, transcriptional, proteomic, and metabolomic level to infer new genetic perturbations with the potential to improve T cell antitumor efficacy. (unil.ch)
UNLABELLED: This is a phase II clinical trial investigating the safety and efficacy of intravenous vaccination with mature autologous dendritic cells (DCs) pulsed ex vivo with a liver tumor cell line lysate (HepG2) in patients with advanced hepatocellular carcinoma (HCC). (ox.ac.uk)
CONCLUSION: Autologous DC vaccination in patients with HCC is safe and well tolerated with evidence of antitumor efficacy assessed radiologically and serologically, with generation of antigen-specific immune responses in some cases. (ox.ac.uk)
Combination with other immunotherapy regimens improve overall therapeutic efficacy. (biomedcentral.com)
For example, the relative inefficiency of delivering OVs to tumor nodules, selective viral replication inside tumor nodules and spread to distant micrometastases limits its overall efficacy. (biomedcentral.com)
Overall, these data indicate that combining p50-IMC with a tumor-specific Ab or CAR has the potential to increase the anti-tumor efficacy already observed with p50-IMC alone. (bmj.com)
A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells. (amedeo.com)
A series of in vitro and in vivo analyses, including physical and chemical characterizations, targeting property, biosafety, and antitumor efficacy of Wpep-DGL/Pt were systematically carried out. (thno.org)
Wpep-DGL/Pt showed potent antitumor efficacy in MDA-MB-231 cells tumor-bearing nude mice with a deficient immune system, demonstrating targeted delivery of chemotherapeutics and the resultant cytotoxicity. (thno.org)
Furthermore, in immunocompetent mice bearing 4T1 cells tumors, Wpep-DGL/Pt activated immune cells and induced cell death proving their dual function of chemotherapeutic and immunomodulatory efficacy. (thno.org)
Genetic or molecular profiling of individual tumors would provide critical information to predict efficacy and/or risk of toxicity of drugs. (cancerbiomed.org)
This improved efficacy was associated with higher tumor T-cell infiltration and overexpression of PD-1/PD-L1. (unav.edu)
B16-OVA tumors benefited from a synergistic effect, reaching 75% of tumor rejection, but higher levels of exhausted T-cells in LLC-OVA tumors co-expressing PD-1, LAG3 and TIM3 precluded similar levels of efficacy. (unav.edu)
Ex vivo interleukin-12-priming during CD8(+) T cell activation dramatically improves adoptive T cell transfer antitumor efficacy in a lymphodepleted host. (musc.edu)
Researchers must ensure reproducibility, efficacy and potency of cancer immunotherapy treatments before these reach the clinic. (technologynetworks.com)
While different methods exist to evaluate the efficacy of immunotherapy products, more efficient and robust in vitro assays are still required to ensure their safety and consistency. (technologynetworks.com)
The need for a novel cancer immunotherapy assay The most significant challenge faced by cancer immunotherapy researchers is the inability to predict treatment efficacy and response. (technologynetworks.com)
Altogether, our study in mice demonstrates that αGC/CD1d-antitumor fusion protein greatly increases the efficacy of a therapeutic CpG-based cancer vaccine, first as an adjuvant during T cell priming and second, as a therapeutic agent to redirect immune responses to the tumor site. (biomedcentral.com)
Transfer of these hyperexpanded T cells after lymphodepletion showed significant antitumor efficacy, and tumor-specific effector T cells were primed from these expanded T cells in tumor-bearing hosts. (nii.ac.jp)

Nevertheless, ex vivo activation with cytokines can restore cytolytic activity of NK cells against GB, indicating that NK cells have potential for adoptive immunotherapy of GB if potent cytotoxicity can be maintained in vivo . (frontiersin.org)
Nonspecific immunotherapies, including cytokines (such as IFN, IL-2, TGF- inhibitors, and so forth) and cytokines-induced killer cells (CIK) (Lee et al. (mindunwindart.com)
Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors. (nshealth.ca)
Immunotherapy includes the use of antigen- and nonantigen-specific substances, such as cytokines, as well as adoptive cellular immunotherapy (ACI) [ 3 ]. (hindawi.com)
Of note, the TME is rich in immunosuppressive cells (e.g., tumor-associated macrophages (TAMs), regulatory T cells (Tregs), immature dendritic cells (iDCs) and myeloid-derived suppressor cells (MDSCs)), that can suppress antitumor immunity as a result of secretion of various cytokines and chemokines, which enables tumor escape from immune surveillance [ 8 ]. (thno.org)
Moreover, TAMs usually display M2-like phenotypes that exert tumor-promoting role in TME, and promote production of related immunosuppressive factors that trigger immunotherapy resistance, including cytokines, chemokines, growth factors and soluble signaling mediators [ 12 ]. (thno.org)
High doses of cytokines like IL-2 can be administered to boost anti-cancer immune activity. (theusaknowledge.net)
Cytokines like IL-2 stimulate activity and growth of T-cells, NK cells and macrophages - key players in anti-tumor immune response. (theusaknowledge.net)
The pancreatic tumor does not respond to cytokines, immune checkpoint inhibitors, and adoptive cell therapy. (bookinghealth.com)
Cancer immunotherapies can be divided into four major categories: - Cytokines/immunomodulation agents - Monoclonal antibodies - Cell‑based therapies - Oncolytic viruses Though monoclonal antibodies currently represent the largest class of commercialized cancer immunotherapies, cell‑based therapies are rapidly making headway. (technologynetworks.com)

Research on adoptive transfer in melanoma patients laid the groundwork for companies focusing on adoptive transfer research in other types of cancer. (wikipedia.org)
Using this model, eradication of a human melanoma tumor by in vitro generating CTL clone was accomplished. (wikipedia.org)
In a study run at the University de la Sante, the adoptive transfer of cloned T cells in "in vitro immunization" caused increased frequencies of cancer fighting T cells in 18 out of 35 melanoma patients. (wikipedia.org)
To determine the mechanisms of how innate immune activation via lymphodepletion potentiated antitumor T cell immunity, we utilized the pmel-1 melanoma mouse model. (biomedcentral.com)
PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma. (amedeo.com)
IL-1alpha Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma. (amedeo.com)
Outcomes for patients with melanoma have improved over the past decade with the clinical development and approval of immunotherapies targeting immune checkpoint receptors such as programmed death-1 (PD-1), programmed death ligand 1 (PD-L1) or cytotoxic T lymphocyte antigen-4 (CTLA-4). (biomedcentral.com)
The resulting antitumor therapy is tested against established tumor grafts of B16 melanoma cells expressing human HER2 and ovalbumin. (biomedcentral.com)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)

This method of activation may be used for the preparation of anti-tumor vaccines or for ex vivo activation of the cytotoxic T-cells which can then be followed by the expansion of T-cells through normal, mature dendritic cells. (wikipedia.org)
These include personalized anti-cancer vaccines (dendritic cell based) and chimeric antigen receptor (CAR)-T cell therapies for gastrointestinal and hepatobiliary cancers. (mayo.edu)
On leading of particular immunotherapies, cancers vaccines, T cell receptor (TCR) and chimeric antigen receptor (CAR) geneengineered T cells (TCRTs and CARTs) have already been actively examined for HCC. (mindunwindart.com)
We briefly summarize the existing HCC cancers vaccines and focus on researching the ongoing research of TCRTs and CARTs in HCC immunotherapy. (mindunwindart.com)
2.?Cancers vaccines Despite the fact that autologous dendritic cells (DCs) pulsed with antigen-undefined tumor cell lysate are also explored to take care of HCC (Palmer et al. (mindunwindart.com)
KEY MESSAGES: This newest therapy, immunotherapy combined with virotherapy (oncolytic viruses and cancer vaccines), is displaying encouraging signs for combating GBM. (bvsalud.org)
These anti-viral vaccines are highly effective in curbing virus infections and onset of cancer. (biomedcentral.com)
First, OVs are tumor-selective, thus in situ cancer vaccines, providing higher cancer specificity and better safety margin. (biomedcentral.com)
modelled the effects of immunotherapy, specifically dendritic cell vaccines and T cell adoptive therapy, on tumour growth with and without chemotherapy [ 13 ]. (hindawi.com)
Precise prediction of neoantigens should accelerate the development of personalized immunotherapy including cancer vaccines and T-cell receptor-engineered T-cell therapy for a broader range of cancer patients. (cancerbiomed.org)
Immunotherapy is one of the novel treatment modalities that include the checkpoint blockade therapy, personalized cancer vaccines, and adoptive T-cell therapies. (cancerbiomed.org)
Let's talk about the administration of dendritic cells in pancreatic cancer, what problems they solve and the results of using dendritic cell vaccines in preclinical and clinical trials. (bookinghealth.com)
Maturation and trafficking of monocyte-derived dendritic cells in monkeys: implications for dendritic cell-based vaccines. (nwbio.com)

We also tested our hypothesis that intratumoral (i.t.) delivery of dendritic cells that had been transduced with IFN-alpha cDNA (DC-IFN-alpha) would enhance the tumor-homing and antitumor effectiveness of adoptively transferred Tc1 via induction of an IFN-gamma-inducible protein 10 (IP-10). (nih.gov)
Here we report that while exogenous administration of LPS was able to enhance adoptively transferred CD8 + T cells' tumor destruction, LPS treatment alone did not replace individual components of the tripartite ACT regimen, or obviate TBI. (biomedcentral.com)
Although T-cell A2BR plays an insignificant role for A2BR-mediated immunosuppression and tumor promotion, A2BR deficiency in tumor-bearing mice caused increased infiltration of myeloid and CD103+ dendritic cells, which was associated with more effective cross-priming of adoptively transferred tumor antigen-specific CD8+ T cells. (figshare.com)
Dendritic Cells in Irradiated Mice Trigger the Functional Plasticity and Antitumor Activity of Adoptively Transferred Tc17 Cells via IL12 Signaling. (musc.edu)

Dr. Kankeu Fonkoua's major research focus is understanding ways to integrate and exploit the synergy among therapeutic modalities to reprogram or boost the host's anti-tumor immune response. (mayo.edu)
An unusual and modern treatment has been created, especially for stage 4 GBM, using the latest therapeutic techniques, including immunotherapy and virotherapy. (bvsalud.org)
Coadministration with a HDAC inhibitor inhibits innate immunity transiently to promote infection and spread of OVs, and significantly enhances anti-tumor immunity and improves the therapeutic index. (biomedcentral.com)
Novel therapeutic strategies have been investigated, and immunotherapy has been recently approved for the treatment of various types of cancer [ 4 ]. (hindawi.com)
Thus, TAMs can be considered as a promising therapeutic target for improved immunotherapy, and TAMs-focused molecular targeting agents have made ideal progress in clinical practice. (thno.org)
It is hoped that, with rapid development of nanomedicine in cancer immunotherapy, TAMs-focused therapeutic strategies may be anticipated to become an emerging immunotherapeutic modality for future clinical cancer treatment. (thno.org)
Immunotherapy is currently considered as a promising next-generation therapeutic strategy for various cancers thanks to its ability to modulate cell-specific immune responses toward tumors [ 1 ], which has gradually remodeled the landscape of clinical anticancer modality [ 2 ]. (thno.org)
Autocrine and therapeutic IL-10 increases anti-apoptotic signals and IFN?in those antigen experienced CD8+ T cells. (baxkyardgardener.com)
Different clinics use different approaches and it is still not known at what time, dose, course and intervals dendritic cell therapy for pancreatic cancer should be administered to achieve the best therapeutic results. (bookinghealth.com)
Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
We remain confident in the potential therapeutic benefit of our AIM platform-based product candidates and their ability to significantly impact the emerging, rapidly moving field of antigen specific immunotherapies and novel combinations and look forward to providing updates in the future. (neximmune.com)

In this blog, we explore the different types of immunotherapies, their mechanisms of action, current uses in cancer treatment, limitations, and the exciting future possibilities of this transformative therapy. (theusaknowledge.net)
There are various types of immunotherapies used to treat cancer today, and still more being developed and used in clinical trials. (immunogenetics.com)

Immunotherapy mainly includes immune checkpoint inhibitors (ICIs), such as inhibitors of PD-1 (programmed cell death 1)/programmed cell death ligand 1 (PD-L1). (nature.com)
In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
Oncological therapy includes individual analysis of the properties of a tumour and targeted therapy using small-molecule inhibitors. (bvsalud.org)
New model systems are being developed to test and optimize various immunotherapy strategies, including bispecific antibodies, checkpoint inhibitors, epigenetic modifiers and adoptive T cell transfer both in vitro and in vivo. (upenn.edu)
Alternative inhibitory receptors have been identified that may be targeted for anti-tumor immune therapy, such as lymphocyte-activation gene-3 (LAG-3), as have several potential target oncogenes for molecularly targeted therapy, such as tyrosine kinase inhibitors. (biomedcentral.com)
Cancer immunotherapies, including immune checkpoint inhibitors, would be one of the potential approaches to apply the results of genomic sequencing most effectively. (cancerbiomed.org)
Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. (unav.edu)

As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery. (nature.com)
The emergence of immunotherapy has recently disrupted the paradigm of traditional cancer treatment (including the three traditional treatments RT, chemotherapy, and surgery), and immunotherapy functions by activating the body's immune system to fight cancer. (nature.com)
These results may have important implications for the treatment of chemotherapy resistant breast cancer with active or adoptive immunotherapy. (utmb.edu)
Sphingolipid-targeting drugs have been tested alone or in combination with chemotherapy, exhibiting antitumor activity alone and in synergism with chemotherapy in vitro and in vivo . (frontiersin.org)
Various mathematical models have been studied for cancer treatments with virotherapy, radiotherapy, chemotherapy, and immunotherapy [ 6 - 11 ]. (hindawi.com)
The model demonstrated that chemotherapy increases tumorigenicity, whereas CSC-targeted immunotherapy tumorigenicity. (hindawi.com)
Pratap proposed a model that describes the nonlinear dynamics between tumour cells, immune cells, and three forms of therapy: chemotherapy, immunotherapy, and radiotherapy [ 14 ]. (hindawi.com)
Three months later, when a recurrence-suspected lesion was detected in segment 5 (S5) of his liver, we started adoptive immunotherapies with cytokine-activated killer (CAK) cell infusions, combined with chemotherapy. (springeropen.com)
We report here a rare case of a patient who has currently survived almost 10 years with recurrent GBC with peritoneal dissemination and liver metastases, which has been well controlled by a multidisciplinary approach including chemotherapy, immunotherapy, and surgery. (springeropen.com)
Unlike chemotherapy or radiation which directly attack tumors, immunotherapy helps train the immune cells to recognize markers on cancer cells and boosts their killing capability. (theusaknowledge.net)

IL-2 and IFN-γ), immune checkpoint blockade (ICB) therapy (e.g., anti-PD-1/PD-L1 antibodies), and adoptive T-cell transfer (e.g., chimeric antigen receptor (CAR) T-cell therapy) [ 3 - 5 ]. (thno.org)
We now evaluate whether we can enhance wild-type (WT) or p50-IMC tumor localization and/or the phagocytosis of PSMA+ prostate cancer cells by expressing a prostate-specific membrane antigen (PSMA)-specific chimeric antigen receptor (CAR) on IMC, or by combining IMC with PSMA antibody (Ab), which binds to the surface of myeloid cells via their Fc receptors. (bmj.com)

Blood samples containing the required precursors for CD4+ helper T-cell, CD8+ cytotoxic T-cell, and natural killer (NK) cell are extracted from the patient and activated before being re-administered to the patient to induce anti-tumor activity. (wikipedia.org)
By isolating immature and immunosuppressive cells from a patient's blood, transforming them into potent immune-stimulatory cells in the laboratory, and then injecting them back directly into the patient's bloodstream or tumor, these novel therapies have the potential to induce long-term tumor-specific durable responses. (mayo.edu)
OVs armed with GM-CSF (such as T-VEC and Pexa-Vec) or other immunostimulatory genes, induce potent anti-tumor immunity in both animal models and human patients. (biomedcentral.com)
1 2 p50-IMC develop into tumor macrophages and dendritic cells and induce increased total and activated tumor T cells. (bmj.com)
Cancer immunotherapies, which target neoantigens, could lead to a precise treatment for cancer patients, despite the challenge in accurately predicting neoantigens that can induce cytotoxic T cells in individual patients. (cancerbiomed.org)
Because tumors have been demonstrated to induce immunosuppressive networks and regulate the function of T cells, obtaining a sufficient number of fully functional naive T cells that are able to differentiate into tumor-specific effector T cells remains difficult. (nii.ac.jp)
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs. (nwbio.com)

This serves as a guidepost for rationally designing new combination checkpoint therapies, downstream T cell receptor (TCR) isolation, cancer antigen identification and molecular characterization of naturally occurring tumor-reactive T cells in human cancer. (upenn.edu)
Unfortunately, many patients still progress and acquire resistance to immunotherapy and molecularly targeted therapies. (biomedcentral.com)

The development of effective immunotherapeutic strategies for central nervous system (CNS) tumors requires a firm understanding of factors regulating the trafficking of tumor antigen-specific CTLs into CNS tumor lesions. (nih.gov)
CTLs and NK cells are both effector cells so helper T-cells (Th) are also prepared in order to create memory cells for long term resistance toward tumor cells. (wikipedia.org)
At the same department, the SCID mouse model was demonstrated as "an excellent model system" for studying interaction between tumors and CTLs. (wikipedia.org)
The combined CD1d/iNKT antitumor therapy and CpG/peptide-based immunization leads to optimized expansion of NK and OVA-specific CD8 T cells (CTLs), likely resulting from the maturation of highly pro-inflammatory DCs as seen by a synergistic increase in serum IL-12. (biomedcentral.com)
The enhanced innate and adaptive immune responses result in higher tumor inhibition that correlates with increased numbers of OVA-specific CTLs at the tumor site. (biomedcentral.com)
Antibody-mediated depletion experiments further demonstrate that in this context, CTLs rather than NK cells are essential for the enhanced tumor inhibition. (biomedcentral.com)

Among most immunosuppressive cells, TAMs, as crucial drivers of immunosuppressive TME, account for the largest proportion of immune cells in the TME (approximately 50% of tumor mass) [ 9 , 10 ], which possess highly heterogeneity and play a complex regulatory role in tumor immunity and immunotherapy due to helping tumor evade immune surveillance [ 11 ]. (thno.org)
To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive dendritic cell (DC) population induced during vaccination, with the goal of identifying druggable inhibitory mechanisms. (unav.edu)

Finally, TBI was no longer needed to regress tumors in mice who were depleted of host CD4 + T cells, given a tripartite ACT regimen and then treated with low dose LPS. (biomedcentral.com)
Mice with a mutation in the adenomatous polyposis coli gene (APC468) develop intestinal tumors, driven by focal inflammation to their microbial gut flora. (baxkyardgardener.com)
In the small intestine of the same mice, overshooting severe inflammation prevented development of tumors at an early age, however progressive loss of IFN+ T cells and cellular cytotoxicity led to cancer development [37]. (baxkyardgardener.com)
Adoptive transfer of CD25hi T cells into MifaMurtide APC468 mice with colonic tumors lead to an IL-10Cdependent reduction of tumor burden [38]. (baxkyardgardener.com)
For tumor localization experiments, WT-IMC or p50-IMC were combined with PSMA Ab or IgG, or transduced with PSMA.CAR or EV, then CFSE-labeled and injected into mice bearing subcutaneous MyC-CaP/PSMA tumors. (bmj.com)
Optimizing Flow Cytometric Analysis of Immune Cells in Samples Requiring Cryopreservation from Tumor-Bearing Mice. (amedeo.com)
Consistent with in vitro observations, in mice with PD-L1-deficient MC38 colorectal tumors where only host cells were the source of PD-L1, antibody blockade of both PD-1/PD-L1 and PD-L1/B7-1 interactions reduced tumor growth, while blocking only PD-L1/B7-1 interactions slightly accelerated tumor growth due to an increased availability of PD-L1. (acir.org)
In animals bearing PD-L1-deficient MC38 tumors, mice with total PD-L1 knockout (KO) controlled tumor growth better than wild-type (WT) mice, as observed previously. (acir.org)
PD-L1 ΔDC mice controlled tumors as effectively as PD-L1 KO mice, while PD-L1 ΔMF mice were not effective, reducing tumor growth only slightly compared to WT controls. (acir.org)
Similar results were observed in mice bearing PD-L1-sufficient tumors. (acir.org)
Treating tumor-bearing PD-L1 ΔDC mice with anti-PD-L1 antibodies that blocked either only the PD-L1/B7-1 interactions or both the PD-L1/B7-1 interactions and PD-L1/PD-1 interactions did not further enhance tumor control. (acir.org)
Analysis of T cell responses at day 10 post inoculation revealed increased frequency and number of CD8 + T cells within PD-L1-deficient MC38 tumors of PD-L1 KO and PD-L1 ΔDC mice compared to WT controls. (acir.org)
misc{oai:niigata-u.repo.nii.ac.jp:00005999, author = {Tanaka, Tomohiro}, month = {Mar}, note = {The adoptive transfer of effector T cells combined with lymphodepletion has demonstrated promising antitumor effects in mice and humans, although the availability of tumor-specific T cells is limited. (nii.ac.jp)

We then outline preclinical approaches that employ CAR-NK cells for GB immunotherapy, and give an overview on the ongoing clinical development of ErbB2 (HER2)-specific CAR-NK cells currently applied in a phase I clinical trial in glioblastoma patients. (frontiersin.org)
Dr. Kankeu Fonkoua collaborates with scientists and clinicians from various disciplines to conduct clinical trials and translational studies evaluating novel rational combinations to enhance anti-tumor immune response and improve clinical outcomes. (mayo.edu)
Clinical cancer immunotherapies are usually impeded by tumor immunosuppression driven by tumor associated macrophages (TAMs). (thno.org)
Lastly, some severe challenges related to functional nanomedicines for TAMs-focused cancer immunotherapy are proposed, and some feasible perspectives on clinical translation of TAMs-associated anticancer immunonanomedicines are provided. (thno.org)
In clinical practice, cancer immunotherapies have been well developed in recent years, mainly including cytokine therapy (e.g. (thno.org)
Other current efforts include the exploration of immunomodulation to potentiate endogenous antitumor T cell responses, use of bispecific antibodies, pharmacological sensitization of tumor cells to immune attack, tumor vasculature targeting, preclinical validations, clinical translation and trial support. (upenn.edu)
In this review, we will discuss the current status and future direction of implementing cancer precision medicine in the clinical setting, specially focusing on the personalized immunotherapies. (cancerbiomed.org)
The mutational landscape of metastatic cancers of more than 10,000 patients with clinical sequencing showed that up to 80% of tumors sequenced by the NGS-based targeted gene panel tests had at least one genetic alteration 2 . (cancerbiomed.org)
For instance, a peptide/CpG-based cancer vaccine has been evaluated in several clinical trials and was shown in pre-clinical studies to favor the expansion of effector T versus Tregs cells, resulting in a potent antitumor activity, as compared to other TLR ligands. (biomedcentral.com)
In our clinical trials with our adoptive cell therapy, we have demonstrated the ability to expand AML tumor-specific T cells with combined memory and effector functions and have observed clinical responses. (neximmune.com)

Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)
Further analyses revealed that combination therapy consisting of vaccination with dendritic cells that were co-cultured with irradiated whole tumor cells and the transfer of ex vivoÐexpanded T cells significantly enhanced antitumor immunity. (nii.ac.jp)
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (nwbio.com)
Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Babatz J, Röllig C, Löbel B, Folprecht G, Haack M, Günther H, Köhne CH, Ehninger G, Schmitz M, Bornhäuser M. Induction of cellular immune responses against carcinoembryonic antigen in patients with metastatic tumors after vaccination with altered peptide ligand-loaded dendritic cells. (nwbio.com)
Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)

Adoptive transfer of immature myeloid cells lacking p50 (p50-IMC) slows the growth of syngeneic murine prostate cancer, pancreatic ductal carcinoma, or neuroblastoma when given after a dose of myelo-depleting 5-fluorouracil. (bmj.com)
Adoptive transfer of immature myeloid cells lacking NF-κB p50 (p50-IMC) impedes the growth of MHC-matched high-risk neuroblastoma. (bmj.com)
Analysis of the tumor-infiltrating myeloid populations at days 3, 7, and 14 post tumor inoculation revealed that the majority of myeloid cells were macrophages, which far outnumbered cross-presenting dendritic cells (DCs). (acir.org)
Most myeloid cells within tumors and tumor-draining lymph nodes expressed PD-L1 without co-expressing B7-1 (but still expressing B7-2, which does not interact in cis with PD-L1), thus leaving plenty of PD-L1 free to interact with PD-1 on T cells. (acir.org)
Most intratumoral PD-L1 + myeloid cells were macrophages (~75%), while cross-presenting DCs accounted for less than 2% of this population by day 14 post tumor inoculation. (acir.org)
These include the T cell immunoglobulin and mucin-domain containing-3 (TIM-3), lymphocyte-activation gene-3 (LAG-3), TIGIT, and B-and T-lymphocyte-associated protein (BTLA) receptors associated with T cell exhaustion and V-domain immunoglobulin suppressor of T cell activation (VISTA), a receptor found on tumor-infiltrating myeloid cells. (biomedcentral.com)

for example, there are inconsistent views 24 on the intratumoral γδ T-cell signature as the most favorable prognostic biomarker 25 of cancers and discussions on the pro- and antitumor activities of γδ T cells. (nature.com)
Departing from prior knowledge and the above observations, we design novel synthetic T cell states, aspiring to overcome tumor immune resistance and T cell deregulation in order to defeat difficult cancers. (unil.ch)
Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. (frontiersin.org)
In recent years, immunotherapies have led to remarkable strides in treating certain cancers. (mdpi.com)
Multidisciplinary approach including immunotherapy for such cancers has received much attention in recent years. (springeropen.com)
One focus of the Powell lab is on the generation/isolation high avidity, tumor-reactive T cells from heterogenous tumor infiltrating lymphocyte populations in traditionally "non-immunogenic" cancers utilizing novel T cell capture techniques, and to deeply examine the characteristics and function of these immune cells. (upenn.edu)
After decades of research, immunotherapy has now emerged as a revolutionary approach against certain types of cancers. (theusaknowledge.net)

Lymphodepletion enhances adoptive T cell transfer (ACT) therapy by activating the innate immune system via microbes released from the radiation-injured gut. (biomedcentral.com)
Finally, the innate immunity or adaptive immunity is stimulated leading to regulation and inhibition of tumor growth. (thno.org)
Cancer immunotherapy consists of multiple approaches that harness and enhance the innate powers of the immune system to fight the disease. (technologynetworks.com)

It uses a patient's own immune system to target tumor cells in prostate cancer, glioblastomas, and potentially pancreatic cancer. (wikipedia.org)
This involves extracting a patient's T-cells, genetically modifying them to enhance their cancer-fighting ability, growing more of them in the lab, and transfusing them back into the patient to attack the tumor. (theusaknowledge.net)
Tumor-Infiltrating Lymphocyte (TIL) therapy harvests T cells found in or near the patient's tumor. (immunogenetics.com)
In this approach, the patient's T cells are equipped with a man-made T cell receptor that targets a specific antigen found on the patient's tumor cells. (immunogenetics.com)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)

In this study we evaluated the potential of tumor antigen-pulsed fully mature dendritic cell (DC) stimulation in restoring tumor-specific cytotoxicity in anergic TIL populations from advanced breast cancer patients. (utmb.edu)
We also switched the adoptive immunotherapy for tumor-associated antigen-pulsed dendritic cell-activated killer (DAK) cell immunotherapy. (springeropen.com)

These data provide a strong rationale to combine A2BR inhibition with T-cell-based immunotherapy for the treatment of tumor growth and metastasis. (figshare.com)

Taken together, these data show that tumor lysate-pulsed mature DC can consistently restore tumor-specific lytic activity in non-cytotoxic breast cancer TIL. (utmb.edu)
Simultaneously, tumor-infiltrating CD8+ T cells and their cytotoxic mediators and IFN- are highly prevalent [41]. (baxkyardgardener.com)

Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)
Adoptive cellular immunotherapy. (mayo.edu)
Also known as cellular immunotherapy, adoptive cell therapy uses T cells to fight cancer. (immunogenetics.com)

Wei X, Wang J, Liang M, Song M. Development of functional nanomedicines for tumor associated macrophages-focused cancer immunotherapy. (thno.org)
Together, these results indicated that despite their lower frequency, DCs played a bigger, and crucial role as a source of PD-L1 in PD-L1/PD-1 regulation of the antitumor response compared with the more abundant macrophages. (acir.org)

Bleumer I, Tiemessen DM, Oosterwijk-Wakka JC, Völler MC, De Weijer K, Mulders PF, Oosterwijk E. Preliminary analysis of patients with progressive renal cell carcinoma vaccinated with CA9-peptide-pulsed mature dendritic cells. (nwbio.com)

Herein, we used TLR4 agonist LPS as a tool to address how and when to use TLR agonists to effectively improve cancer immunotherapy. (biomedcentral.com)
Exploiting IL-17-producing CD4+ and CD8+ T cells to improve cancer immunotherapy in the clinic. (musc.edu)

M05 and mediated antitumor responses more effectively than Tc2, and their effect was IP-10 dependent. (nih.gov)
In addition we have compared tumor-specific T cell responses induced by tumor antigen-loaded DC stimulation of TIL to responses induced from PBL. (utmb.edu)
Together, these experiments showed that PD-L1 expression on antigen-presenting cells (APCs) played a role in antitumor T cell responses via PD-1 interactions. (acir.org)
Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
Circulating and intratumoral NK and H-2Kb/OVA-specific CD8 responses are monitored, as well as the state of activation of dendritic cells (DC) with regard to activation markers and IL-12 secretion. (biomedcentral.com)
We believe that the ability to bypass the host dendritic cell and directly engage T cells in the body provides the potential for greater specific T cell responses. (neximmune.com)

Feng and Navaratna demonstrated that the initial ratio between regulatory T cells and effector T cells impacts the tumour recurrence time and that the effectiveness of IL-2 use may reverse the immunotherapy outcome [ 15 ]. (hindawi.com)
We and others have also demonstrated that the transfer of polyclonal naïve T cells induces tumor-specific effector T cells and enhances antitumor immunity after lymphodepletion. (nii.ac.jp)
To establish culture methods to obtain a large number of polyclonal T cells that are capable of differentiating into tumor-specific effector T cells, naïve T cells were activated with anti-CD3 mAbs in vitro. (nii.ac.jp)

This atlas is a concise but comprehensive guide to the diverse patterns of response to immunotherapy as observed on Positron Emission Tomography/Computed Tomography (PET/CT) and other conventional imaging modalities, including CT and Magnetic Resonance Imaging (MRI). (nshealth.ca)

Although an undeniable metastasis was found in his para-aortic lymph node, this patient visits our clinic regularly for immunotherapy. (springeropen.com)

A key area of Dr. Kankeu Fonkoua's research endeavors is to identify mechanisms of resistance to immunotherapy. (mayo.edu)
To bypass resistance, combination treatment with immunotherapies and single or multiple TKIs have been shown to improve prognosis compared to monotherapy. (biomedcentral.com)
In ICB-refractory MM models, increasing CD8(+) T cell cytotoxicity or depleting T-reg cells reversed immunotherapy resistance and yielded prolonged MM control. (unav.edu)

Dendritic cell immunotherapy for patients with metastatic renal cell carcinoma: University of Tokyo experience. (nwbio.com)

In order to have efficient eradication of cancer cells, the immune system cells should be able to both populate in the secondary lymphoid organs for a long-lasting effect and target a shared variety of tumor cells as opposed to one, specific cancer cell. (wikipedia.org)
Chemically inducing this antigen in T-cells by DNA demethylation allows the immune system to recognize a wide range of tumors. (wikipedia.org)
Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. (nshealth.ca)
Cancer immunotherapy approaches designed to surmount tumor suppression take into consideration the pivotal molecular processes involved in the activation of immune system. (thno.org)
Checkpoint inhibitor drugs block these proteins and take the brakes off the immune system, enabling it to recognize and eliminate tumor cells. (theusaknowledge.net)
Dendritic cells are key antigen-presenting cells of the immune system. (theusaknowledge.net)
It was thought that targeting dendritic cells would make the human immune system 'come alive' and attack the tumor. (bookinghealth.com)
4 How can the immune system be harnessed to target tumors? (technologynetworks.com)
Immunotherapy is a type of treatment that stimulates or restores the body's own immune system to fight infection and disease. (immunogenetics.com)

With a better understanding of molecular details in tumor immunology and tumor biology, tailored cancer immunotherapy is considered as a promising strategy for cancer treatment. (thno.org)
Cancer Immunology, Immunotherapy. (illinois.edu)
Furthermore, our collaborations have generated preclinical data that highlights the potential to drive response in solid tumor indications, as well as non-malignant immunology diseases such as MS and SLE," said Kristi Jones, NexImmune's CEO. (neximmune.com)

The benefit of dual checkpoint blockade with anti CTLA-4 and anti PD-1 inhibitor over monotherapy with a CTLA-4 inhibitor has been shown, with durable disease control and improved overall survival (OS). (biomedcentral.com)
Two of the primary immunotherapies are immune checkpoint blockade (ICB) and adoptive cell transfer (ACT). (elifesciences.org)

Our cells exhibit potential superior potency and durability in preclinical models, combining a low dose of AIM multi-tumor expanded T cells with low doses of T-cell engaging bispecific agents, and showing synergistic tumor killing. (neximmune.com)
Preclinical data to date has been consistent across modalities in the ability to selectively activate and expand important tumor specific T cells with cancer cell killing capacity. (neximmune.com)
Initiated multiple preclinical studies to evaluate NEXI-100 as a monotherapy and in combination with other cancer immunotherapies to support the Company's oncology program. (neximmune.com)

Glioblastoma (GB) is the most frequent malignant primary brain tumor in adults, without any curative treatment options available at present. (frontiersin.org)
BACKGROUND: Glioblastoma multiforme (GBM) is a WHO grade 4 glioma and the most common malignant primary brain tumour. (bvsalud.org)

Suppression of IL-17, TNFa and IL-1 inhibit neutrophil and macrophage activation in tumor associated irritation and inflammatory illnesses. (baxkyardgardener.com)
Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity. (amedeo.com)
Recent research suggests that the cause is a deficiency of dendritic cell activation. (bookinghealth.com)
The aim of the present study is to combine the activation and tumor targeting of activated iNKT, NK and T cells. (biomedcentral.com)
Activation and tumor targeting of iNKT cells via recombinant α-galactosylceramide (αGC)-loaded CD1d-anti-HER2 fusion protein (CD1d-antitumor) is combined or not with OVA peptide/CpG vaccine. (biomedcentral.com)

Here, we showed that A2BR expression by hematopoietic cells was primarily responsible for promoting tumor growth. (figshare.com)

Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity. (amedeo.com)
Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8(+) T cells. (musc.edu)

The timing of LPS administration and the requirement of individual components of the tripartite therapy were evaluated based on tumor growth and the phenotype of recovered splenocytes by flow cytometry. (biomedcentral.com)
Moreover, we found that sequentially administering LPS during or one day prior to ACT therapy compromised tumor regression. (biomedcentral.com)
Pharmacologic blockade of A2BR improved the antitumor effect of adoptive T-cell therapy. (figshare.com)
Alternative inhibitory receptors have been identified that may also be targeted for anti-tumor immune therapy. (biomedcentral.com)

Thus, monocyte depletion by gemcitabine administration reduced the generation of these DC and increased vaccine-induced immunity, which rejected about 20% of LLC-OVA and B16-OVA tumors, which are non-responders to anti-PD-1. (unav.edu)

Anatomy25

Organisms12

Diseases66

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Phenomena and Processes39

Disciplines and Occupations1

Information Science4

Health Care9

Microenvironment21

Antigens20

Lymphocytes14

Efficacy26

Cytokines10

Melanoma9

Vaccines13

Adoptively transferred4

Therapeutic11

Types of Immunotherapies2

Inhibitors7

Chemotherapy10

Chimeric antigen receptor2

Induce7

Therapies2

CTLs6

Immunosuppressive2

Mice13

Clinical10

Vaccination6

Myeloid cells6

Cancers7

Innate3

Patient's5

Antigen-pulsed2

Inhibition1

Cytotoxic2

Cellular3

Macrophages2

Mature dendritic cells1

Improve cancer immunotherapy2

Responses6

Effector3

Response to immunotherapy1

Lymph1

Resistance3

Renal Cell Carc1

Immune system9

Immunology3

Checkpoint blockade2

Preclinical3

Malignant primary brain2

Activation5

Promoting tumor growth1

Enhances2

Therapy4

Depletion1