Anti staphylococcal staphylococcal infections. Medical search. Frequent questions

Of note, recently an increasing number of community associated skin and soft tissue infections appear to be caused by methicillin-resistant Staphylococcus aureus (MRSA). (cdc.gov)
Tefibazumab (named Aurexis but not approved) is a humanized monoclonal antibody for the treatment of severe infections with Staphylococcus aureus. (wikipedia.org)
The ability to clot blood by producing coagulase distinguishes the virulent pathogen, Staphylococcus aureus , from the less virulent coagulase-negative staphylococcal species. (merckmanuals.com)
Staphylococcus aureus is the most common cause of surgical site infections both in New Zealand and globally. (hqsc.govt.nz)
Gram-positive organisms such as Staphylococcus aureus and Streptococcus species are the most commonly isolated organisms in patients with pyogenic vertebral infections. (wheelessonline.com)
Staphylococcus aureus bloodstream infections (bacteremia) in pediatric patients (1 to 17 years of age). (nih.gov)
Lysostaphin endopeptidase cleaves pentaglycine cross-bridges found in staphylococcal cell-wall peptidoglycans and proves very effective in combatting methicillin-resistant Staphylococcus aureus. (bvsalud.org)
We are currently enrolling patients in a Phase 1b/2 of exebacase being conducted in France in the setting of an arthroscopic debridement, antibiotics, irrigation, and retention (DAIR) procedure in patients with chronic prosthetic joint infections (PJI) of the knee due to Staphylococcus aureus or coagulase-negative staphylococci (CoNS). (kfor.com)
We now report our seminal findings on the major constituents including terpenes identified in native, historically significant herbal medicinal plant Elder (Sambucus nigra L.) flower and elder berry in particular and their concomitant strong antimicrobial effects exhibited on various nosocomial pathogens notably upon methicillin-resistant Staphylococcus aureus MRSA, recognised globally as a clinically significant pathogen, associated with skin and soft tissue infections. (researchgate.net)
Pyodermitis are primary skin infections mainly caused by pyogenic bacteria of the Staphylococcus and Streptococcus genera. (scielo.br)
Des isolats suspects de Staphylococcus ont d'abord été identifiés par l'analyse biochimique classique, puis les souches confirmées par amplification en chaîne par polymérase (29 isolats de S. aureus et 17 isolats de S. saprophyticus ) ont été analysées pour déterminer leur sensibilité aux différents antimicrobiens. (who.int)

For initial antimicrobial treatment of infected wounds, beta-lactam antibiotics with anti-staphylococcal activity (cephalexin, dicloxacillin, ampicillin/sulbactam etc.) and clindamycin are recommended options. (cdc.gov)
Infections caused by this organism will not respond to treatment with beta-lactam antibiotics and should be considered in patients who fail to respond to this therapy. (cdc.gov)
Unlike most coagulase-negative staphylococcal species, S. lugdunensis often remains sensitive to penicillinase-resistant beta-lactam antibiotics (ie, methicillin-sensitive). (merckmanuals.com)
Treatment is warm compresses and often oral antistaphylococcal antibiotics. (msdmanuals.com)
Since antibiotics are becoming increasingly ineffective in the treatment of biofilm-associated infections, the search for new compounds with anti-biofilm properties are urgently need.Methods: this study investigates the inhibitory effect of four phenolic compounds (named F1-F4 for simplicity) prior-to and post-biofilm formation by methicillin-sensitive S. aureus (MSSA) and MRSA strains related to the USA300 and USA100 clones. (conicet.gov.ar)
S. aureus is a pathogen that frequently causes severe morbidity and phage therapy is being discussed as an alternative to antibiotics for the treatment of S. aureus infections. (bvsalud.org)
Initial management is with oral anti-staphylococcal antibiotics. (aofoundation.org)

Vancomycin is reserved for staphylococcal strains that are resistant to penicillinase-resistant penicillins (ie, MRSA) and clindamycin, or for when the patient has potentially life-threatening infection or intoxication. (medscape.com)
Indicated for complicated skin and skin structure infections caused by susceptible gram-positive bacteria, including S aureus (both methicillin-resistant and methicillin-susceptible strains), S pyogenes, S agalactiae, S anginosus group, and E faecalis (vancomycin-susceptible isolates only). (medscape.com)
Anti-Vn antibodies could furthermore block the adhesion of the mentioned strain, but not of other strains tested. (lu.se)
No compound affected the formation of biofilm by AR77, a MSSA strain of bovine origin.Conclusions: post-exposure of S. aureus to F3 produced an anti-biofilm effect in most strains analysed. (conicet.gov.ar)
The purified protein exhibited potent inhibitory effects against both methicillin-sensitive and methicillin-resistant staphylococcal strains, with minimal inhibitory concentrations (MICs) ranging from 1 to 2 µg/mL, and ultrastructural analysis revealed that APLss-induced concentration-specific changes in the morphological architecture of staphylococcal surface membranes. (bvsalud.org)
Furthermore, spectrophotometric and fluorescence microscopy revealed that incubating staphylococcal strains with sub-MIC and MIC of APLss significantly inhibited staphylococcal adherence to human vaginal epithelial cells and biofilm biomass formation. (bvsalud.org)
It turned out that standardized fruit extract at a 10% concentration in liquid culture inhibits the growth of streptococci (including Streptococcus pyogenes) responsible for upper respiratory tract infections and strains of Moraxella catharalis [39]. (researchgate.net)

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae. (umcutrecht.nl)

5,14 That prevalence of this infection increases with age is possibly due to a number of factors: the increasing age of the population, increasing number of patients on renal replacement therapy, increasing number of patients with immunosuppressive medications and increasing rates of bacteremia due to intravascular devices and other forms of instrumentation. (wheelessonline.com)
The most common sources are urinary tract infections and the transient bacteremia caused by genitourinary procedures. (wheelessonline.com)
We believe that the properties of our lysins and amurin peptides will make them suitable for targeting antibiotic-resistant organisms, such as MRSA, Pseudomonas aeruginosa and Acinetobacter baumannii , which can cause serious infections such as bacteremia and pneumonia. (kfor.com)

Diabetes increases susceptibility to various types of infections that cause considerable morbidity and mortality. (medscape.com)
Diabetes increases susceptibility to various types of infections. (medscape.com)
Rare cases of infection in the United States (1) have been caused by coagulase-negative staphylococci with reduced susceptibility to vancomycin (minimum inhibitory concentration {MIC} greater than or equal to 8 ug/mL) * (2). (cdc.gov)
Because the occurrence of fully vancomycin-resistant staphylococcal infection in a hospital could result in serious public health consequences, CDC and the Hospital Infection Control Practices Advisory Committee have developed interim guidelines to direct medical and public health responses when isolates of staphylococci with reduced vancomycin susceptibility are identified. (cdc.gov)
After repeat testing, if species identification and vancomycin test results are consistent, immediately contact the state health department (SHD) and CDC's Hospital Infections Program, National Center for Infectious Diseases, telephone (404) 639-6400, to report the occurrence of a 'presumptive' staphylococcal strain with reduced susceptibility to vancomycin and to obtain epidemiologic and laboratory assistance. (cdc.gov)
The methodology for susceptibility testing of the Company's anti-staphylococcal lysin, exebacase, will be described as an illustrative example of a modified AST method recently approved by the CLSI in order to assess the susceptibility of clinical trial isolates in the Company's Phase 1b/2 study of exebacase currently being conducted in France in patients with chronic prosthetic joint infections (PJI) of the knee. (kfor.com)
We screened the Nebraska Transposon Mutant Library of 1920 single-gene inactivations in S. aureus strain JE2, for increased susceptibility to the anti-staphylococcal antimicrobials (ciprofloxacin, oxacillin, linezolid, fosfomycin, daptomycin, mupirocin, vancomycin, and gentamicin). (frontiersin.org)

Chronic suppurative otitis media is often associated with MRSA, Pseudomonas and Staphyloccoi infection. (greenmedinfo.com)

Incision and drainage of any subcutaneous collections of pus (abscesses) is also an important component of treating wound infections. (cdc.gov)
Furuncles (boils) are skin abscesses caused by staphylococcal infection, which involve a hair follicle and surrounding tissue. (msdmanuals.com)
Paronychias are localized, superficial infections or abscesses of the perionychium (epidermis bordering the nails). (aafp.org)

Impetigo is a very contagious, superficial, bacterial skin infection that easily spreads among people in close contact. (mims.com)
This review aims at describing clinical, diagnostic and therapeutical features of major pyodermitis: impetigo, ecthyma, erysipelas, staphylococcal scalded skin syndrome and folliculitis. (scielo.br)

S. aureus infections are more prevalent in carriers than in noncarriers and are usually caused by the colonizing strain. (merckmanuals.com)
In summary, phage treatment of S. aureus infections inside the body may be fundamentally challenging, and more investigation is needed prior to proceeding to in-human trials. (bvsalud.org)

Contiguous spread of a polymicrobial infection from a skin ulcer (particularly a chronic ulcer) to adjacent bone is common in patients with diabetes. (medscape.com)
Background: biofilms are involved in chronic persistent infections, such as bovine mastitis, osteomyelitis and foreign body-related infections. (conicet.gov.ar)
Biofilms may be responsible, in part, of late reactivation of staphylococcal chronic infections after the initial disease has been cured. (conicet.gov.ar)
Salmonella infection or staphylococcal infections would not be associated with the chronic course or the gibbus deformity. (uab.edu)

Treatment options for these community MRSA infections include trimethoprim-sulfamethoxazole (oral) or vancomycin (intravenous). (cdc.gov)

A human chimeric monoclonal antilipoteichoic acid antibody (pagibaximab) has shown encouraging results for the prevention of staphylococcal infection in premature newborns in a phase 2 randomized, controlled trial. (medscape.com)
A recent article suggested the use of monoclonal anti CD20 antibody therapy (rituximab) which could induce long term remission (forty weeks) This was administered with four infusions of anti CD20 antibody given intravenously once a week. (vgrd.org)
Long term complete remission of severe pemphigus vulgaris with monoclonal anti CD20 antibody therapy and immunophenotype correlation. (vgrd.org)

Serious staphylococcal infections require treatment with parenteral penicillinase-resistant penicillin (eg, nafcillin, oxacillin) or first-generation or second-generation cephalosporins (eg, cephalexin, cefuroxime) plus clindamycin. (medscape.com)

Although cholecystitis is probably no more common in patients with diabetes than in the general population, severe, fulminating infection, especially with gas-forming organisms, is more common. (medscape.com)
Contamination of wounds with water (fresh or sea water) can lead to infections caused by waterborne organisms. (cdc.gov)
Though infections with these organisms are uncommon, even after floods, this possibility should be considered in patients who fail to respond to initial therapies described above. (cdc.gov)
Because recurrent skin and lung infections and marked elevation of IgE levels are the hallmarks of HIES, investigations have focused on defining a basic immune defect that leads to both recurrent infection with certain organisms (S aureus and Candida species) and elevated IgE synthesis in HIES. (medscape.com)
Paronychial infections develop when a disruption occurs between the seal of the proximal nail fold and the nail plate that allows a portal of entry for invading organisms. (aafp.org)
Infection usually is caused by bacterial organisms, but can also be due to viral or fungal organisms. (wheelessonline.com)
It is indicated for the treatment of infections caused by susceptible organisms involving the respiratory tract. (medscape.com)
It is indicated for the prophylaxis or treatment of mild to moderately severe upper respiratory tract infections caused by organisms susceptible to low concentrations of penicillin G. (medscape.com)

Therefore, we aimed to examine the varying effect of an antimicrobial peptidase lysostaphin (APLss) on staphylococcal adherence to host cells, biofilm biomass formation, and toxin production as a probable method for mitigating staphylococcal virulence. (bvsalud.org)

[ 1 ] The most common sites of infection in diabetic patients are the skin, soft tissues, urinary tract, and respiratory tract. (medscape.com)
Malignant otitis externa and rhinocerebral mucormycosis are two head-and-neck infections seen almost exclusively in patients with diabetes. (medscape.com)
Patients with diabetes have an increased risk of asymptomatic bacteriuria and pyuria, cystitis, and, more important, serious upper urinary tract infection . (medscape.com)
Sensory neuropathy, atherosclerotic vascular disease, and hyperglycemia all predispose patients with diabetes to skin and soft tissue infections. (medscape.com)
The incidences of staphylococcal and Klebsiella pneumoniae infections are greater in people with diabetes than in people without diabetes, and cryptococcal infections and coccidioidomycoses are more virulent in patients with diabetes. (medscape.com)
Patients with long-standing diabetes tend to have microvascular and macrovascular disease with resultant poor tissue perfusion and increased risk of infection. (medscape.com)
Hyperimmunoglobulin E syndrome (HIES) was first described as Job syndrome in 1966, when 2 patients were reported with eczematous dermatitis, recurrent staphylococcal boils, hyperextensible joints/recurrent bone fractures, and distinctive coarse faces. (medscape.com)
3, 4] In addition, tyrosine kinase 2 deficiency (tyk2) deficiency was reported in patients with HIES, but tyk2 deficiency is also characterized by severe viral and bacterial infections. (medscape.com)
However, patients with AR HIES are susceptible to viral infection characterized by severe Molluscum contagiosum and may develop severe neurological complications for unknown reasons. (medscape.com)
DOCK8 deficiency is now known to cause a combined immunodeficiency rendering the affected patients susceptible to viral, fungal, and bacterial infections. (medscape.com)
Patients with receptor defects of IFN-γ or IL-12 have disseminated atypical mycobacterial infections with incomplete granuloma formation and do not exhibit clinical features of HIES. (medscape.com)
Of these, 14.3% of patients had at least one episode of neutropenia, with no obvious cause other than the anti-TNF treatment. (bmj.com)
The time period between starting anti-TNF treatment and developing neutropenia ranged from 1 week (two patients) to 26 months, with a median of 3 months. (bmj.com)
Of the 19 patients, 16 who developed neutropenic episodes while receiving anti-TNF treatment have managed to stay on their original treatment. (bmj.com)
In our experience, patients gain so much benefit from anti-TNF treatment that they are reluctant to stop and are happy to continue, despite the potential risks of neutropenia. (bmj.com)
However, two of these patients have since had to stop anti-TNF, with one undergoing investigations into the aetiology of a pleural effusion, and another developing a resistant staphylococcal foot infection. (bmj.com)
There has been a small number of reports of cytopenias in patients receiving anti-TNF treatment. (bmj.com)
Only one of our patients who developed neutropenia developed a concomitant infection. (bmj.com)
The prevalence of neutropenia in patients receiving anti-TNF treatment in our experience is similar at 14.3%, so that it would be inconsistent and unsafe for us not to monitor regular full blood counts in these patients. (bmj.com)
We would recommend regular full blood counts in all patients receiving anti-TNF treatment, whether they are on concomitant methotrexate or not, and believe that guidelines need to be modified to take this into account. (bmj.com)
Patients with herpes simplex virus (HSV) infection or gonococcal upper airway disease also benefit from specific treatment. (medscape.com)
In immunocompromised patients, treatment of respiratory syncytial virus (RSV) and cytomegalovirus infections may be appropriate, especially if lower airway disease is suspected. (medscape.com)
Foscarnet or ganciclovir are recommended for the treatment of cytomegalovirus infections (CMV) in immunocompromised patients. (medscape.com)

Inadequate use of antimicrobials has led to widespread instances of suboptimal antibiotic concentrations around infection sites. (bvsalud.org)

We intend to address life threatening infections using therapeutic product candidates generated from our proprietary platform of DLAs. (kfor.com)

Since 2019, the Commission's infection prevention and control programme team has facilitated the implementation of a preoperative anti-staphylococcal bundle within the Surgical Site Infection Improvement (SSII) Programme. (hqsc.govt.nz)

It is a localized, superficial infection or abscess of the paronychial tissues of the hands or, less commonly, the feet. (aafp.org)

4. Section III, Editing and Interpreting Entries, Guides for the determination of the probability of sequence, Interpretation of "highly improbable", deleted diarrhea and gastroenteritis of infectious origin from the list of infections that may be accepted as "due to" any other disease. (cdc.gov)

it typically causes skin infections and sometimes pneumonia, endocarditis, and osteomyelitis. (merckmanuals.com)

An old antibiotic, fusidic acid, is receiving renewed attention in the United States for treatment of MRSA infections. (medscape.com)
MRSA and purulent or complicated cellulitis Cellulitis is acute bacterial infection of the skin and subcutaneous tissue most often caused by streptococci or staphylococci. (msdmanuals.com)

An estimated 700,000 deaths worldwide each year are attributed to antimicrobial-resistant infections. (kfor.com)
The emergence of antimicrobial resistance severely threatens our ability to treat bacterial infections. (frontiersin.org)

For treatment of infections caused by penicillinase-producing staphylococci. (medscape.com)

Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression. (greenmedinfo.com)
Overview of Bacterial Skin Infections Bacterial skin infections can be classified as skin and soft-tissue infections (SSTI) and acute bacterial skin and skin structure infections (ABSSSI). (msdmanuals.com)
Any disruption of the seal between the proximal nail fold and the nail plate can cause acute infections of the eponychial space by providing a portal of entry for bacteria. (aafp.org)

Inhibits Staphylococcal infections. (naturalon.com)

Crush injuries are more susceptible to infection than wounds from shearing forces. (cdc.gov)

Spectinamides are effective partner agents for the treatment of tuberculosis in multiple mouse infection models. (stjude.org)
Skeletal tuberculosis is thought to result from hematogenous dissemination from a primary site and occurs 6 months to 3 years after primary infection. (uab.edu)
Early diagnosis and treatment are important in prevention of tuberculosis (TB) infection. (academicjournals.org)

Vertebral osteomyelitis refers to an infection of the vertebral bones in the spine. (wheelessonline.com)
The most common primary spinal infection is pyogenic vertebral osteomyelitis. (wheelessonline.com)
Osteomyelitis following hematogenous spread of infection is the major mechanism by which adults and children contract vertebral osteomyelitis. (wheelessonline.com)

Use parenteral therapy initially in severe infections. (medscape.com)

Staphylococci are one of the most common causes of community- and hospital-acquired infection. (cdc.gov)

Infective Endocarditis Infective endocarditis is infection of the endocardium, usually with bacteria (commonly, streptococci or staphylococci) or fungi. (msdmanuals.com)

Most wound infections are due to staphylococci and streptococci. (cdc.gov)
from these locations, staphylococci can cause infection in the host and others. (merckmanuals.com)

These agents have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)
Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-Infective and Anti-cancer Drugs Academic Press. (uel.ac.uk)

Primary spinal infections are described as infections of the vertebrae that are not secondary to an operation. (wheelessonline.com)
Infection spreads into vertebral bodies by first seeding underneath vertebral end plates, which is followed by disc and nearby vertebrae involvement. (wheelessonline.com)

Efficacy of Aminomethyl Spectinomycins against Complex Upper Respiratory Tract Bacterial Infections. (stjude.org)
Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections. (stjude.org)
Few adequately designed clinical trials have addressed optimal treatment duration in lower respiratory tract infections. (unimib.it)

CONCLUSIONS: Overall, APLss dose-dependently inhibited adhesion to host cell surfaces and staphylococcal-associated virulence factors, warranting further investigation as a potential anti-staphylococcal agent with an antiadhesive mechanism of action using in vivo models of staphylococcal toxic shock syndrome. (bvsalud.org)

Such infections commonly originate from elsewhere in the body and spread to the spine and its musculoskeletal components. (wheelessonline.com)

Moreover, the ability of the skin to act as a barrier to infection may be compromised when the diminished sensation of diabetic neuropathy results in unnoticed injury. (medscape.com)

In this in vitro and animal study, we demonstrated that the activity of anti-staphylococcal phages is severely impaired in 0.5% plasma or synovial fluid. (bvsalud.org)

9] Recent progress in immunological research continues to find other gene mutations that can manifest as overlapping clinical features of HIES (high IgE, allergic symptoms, vulnerability to fungal and bacterial infection). (medscape.com)

Fluctuance and local purulence at the nail margin may occur, and infection may extend beneath the nail margin to involve the nail bed. (aafp.org)
Spinal infections involve pyogenic or granulomatous infections of the vertebral column, intervertebral discs, the dural sac or the epidural space. (wheelessonline.com)
Pyogenic infections of the spine most frequently involve the lumbar spine (58%), followed by the thoracic (30%) and cervical (11%) regions. (wheelessonline.com)
Spine infections are rare infections that can involve the intervertebral disc space (discitis), the vertebral bones, the spinal canal or adjacent soft tissues. (wheelessonline.com)
Risk factors for infections of the spine involve conditions that weaken the patient's immune system, such conditions include diabetes mellitus, use of immunosuppressant medications, cancer, HIV/AIDS, malnutrition, history of an organ transplant and intravenous drug abuse. (wheelessonline.com)

Fennel honey, propolis and bee venom significantly improve the immune response of rats to staphylococcal infection. (greenmedinfo.com)

The pectin in apples has been shown to inhibit the growth of both type A and type B staphylococcal enterotoxins. (naturalon.com)

No other protein was shown to mediate staphylococcal adhesion in this thesis. (lu.se)

The present invention relates to an anti-inflammatory topical treatment that is applied, for example, as a cream, ointment, foam, or via a patch, or via a composition-infused fabric, or the like. (justia.com)

Anatomy1

Organisms7

Diseases16

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes10

Health Care1

Staphylococcus11

Antibiotics7

Strains7

Streptococcus1

Bacteremia3

Susceptibility7

Pseudomonas1

Abscesses3

Impetigo2

Aureus infections2

Chronic4

Vancomycin1

Monoclonal3

Oxacillin1

Organisms8

Adherence1

Patients23

Antimicrobials1

Therapeutic1

20191

Superficial1

Disease1

Pneumonia1

MRSA2

Antimicrobial2

Treatment of infections caused1

Acute3

Inhibits1

Susceptible1

Tuberculosis3

Osteomyelitis3

Initially1

Hospital1

Infective Endocarditis1

Staphylococci2

Agents2

Vertebrae2

Respiratory tract3

Mechanism1

Commonly1

Skin1

Severely1

Fungal1

Involve5

Significantly1

Apples1

Protein1

Topical1