Anti-PCNA Mouse Monoclonal Antibody (1D7), 200 ul - 1 vial is backordered and will ship as soon as it is back in stock. (dnamethsoc.com)
Monoclonal Anti-PCNA antibody has been used in immunocytochemistry and western blotting. (scientificlabs.co.uk)
1, PCNA Monoclonal Antibody (1D7) (red) was diluted at 1:200 (4°C, overnight). (abbkine.com)
The cells were then intracellularly stained with 5 µg/ml anti-DNA-PKcs phospho (Thr2609) (clone 10B1) antibody in blocking buffer overnight at 4°C followed by staining with Alexa Fluor® 488 conjugated goat anti-mouse IgG antibody (clone Poly4053) for one hour at room temperature. (biolegend.com)
These effects were blocked by anti-TNF-α antibody or by pretreatment with an inhibitor of NF-κB signaling. (aacrjournals.org)
Immunohistochemical analysis of paraffin embedded Jurkat cell pellets, untreated (left) or etoposide-treated (right), using Phospho-Histone H3 (Ser10) Antibody, PCNA (PC10) Mouse mAb, Cleaved Caspase-3 (Asp175) Antibody and Survivin (71G4B7E) Rabbit mAb. (cellsignal.com)
Monoclonal antibody is produced by immunizing animals with a recombinant Protein A-PCNA fusion protein, or with a synthetic peptide corresponding to residues surrounding Cys60 of human Survivin. (cellsignal.com)
Moreover, miltuximab, a chimeric anti-GPC1 antibody, was shown to be safe and well tolerated when radiolabeled in a clinical trial 21 . (nature.com)
ANA, anti-mitochondrial antibody (AMA)/anti-liver-kidney microsomal antibody (LKM), anti-smooth muscle antibody (ASMA), antineutrophil cytoplasmic antibody (ANCA) assays were performed by indirect immunofluorescence method (IIF) (Euroimmune AG, Luebeck, Germany). (unboundmedicine.com)
Follow-up tests for anti-Th/To antibodies are recommended if limited cutaneous SSc is clinically suspected, and testing for anti-PM/Scl antibody reactivity is recommended if SSc-AIM overlap syndrome is suspected. (rheumatologyadvisor.com)
Antigen8
Proliferating cell nuclear antigen (PCNA) controls the production of the leading and lagging strands, that are required for the duplication of DNA. (scientificlabs.co.uk)
Proliferating cell nuclear antigen (PCNA) is a ring-shaped homotrimer protein that is located at the center of the faithful duplication of eukaryotic genomes. (scientificlabs.co.uk)
Proliferating cell nuclear antigen (PCNA) was originally identified by immunofluorescence as a nuclear protein whose appearance correlated with the proliferative state of the cell. (ihcworld.com)
Proliferating Cell Nuclear Antigen, commonly known as PCNA, is a protein that acts as a processivity factor for DNA polymerase in eukaryotic cells. (abbkine.com)
PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the cell cycle. (abbkine.com)
Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
Proliferating cell nuclear antigen (PCNA) is a member of the DNA sliding clamp family of proteins that assist in DNA replication (6). (cellsignal.com)
The vagaries of science, and no doubt Witko-Sarsat's own open-mindedness, led the team to focus on proliferating cell nuclear antigen (PCNA), a maestro of DNA replication which had long been considered to be restricted to the cell nucleus. (inserm.fr)
Antibodies10
Of the patients with positive autoantibodies, 60.6% (80/132) were diagnosed as PBS and 1.5% (2/132) were diagnosed as AIH (positive anti-LC-1 and anti-LKM1 antibodies). (unboundmedicine.com)
Follow-up tests for anti-SS-A/Ro and anti-SS-B/La antibodies are recommended for Sjogren syndrome, SLE, subacute lupus erythematosus, neonatal lupus, or congenital heart block. (rheumatologyadvisor.com)
Follow-up tests for anti-Sp100 are recommended if primary biliary cholangitis is clinically suspected, and follow-up for anti-MJ/NXP-2 antibodies is recommended if dermatomyositis is clinically suspected. (rheumatologyadvisor.com)
If the pattern is observed in the serum of patients with these conditions, follow-up testing for anti-NOR90(hUBF) antibodies is recommended. (rheumatologyadvisor.com)
If SSc is clinically suspected, it is recommended to perform a follow-up test for anti-RNApol III antibodies. (rheumatologyadvisor.com)
Apoptosis1
Administration of POS extract reversed the ACR-induced epididymides weight loss with improved semen quality and count, ameliorated the ACR-decreased testicular lesion scoring, testicular oxidative stress, testicular degeneration, Leydig cell apoptosis and the dysregulated PCNA and Caspase-3 expression in a dose-dependent manner. (biomedcentral.com)
Cyclin2
PCNA /cyclin has been localized by in situ hybridization to the short arm of human c h romosome 20 with a peak of grains over band 20p13. (ihcworld.com)
PCNA gene is present in single copy and has 6 exons. (ihcworld.com)
Transient receptor potential (TRP) channels contribute to the regulation of intracellular calcium, which can promote cancer hallmarks in cases of dysregulation of gene transcription and calcium-dependent pro-proliferative or anti-apoptotic mechanisms. (dovepress.com)
We have also confirmed that non-steroidal anti-inflammatory drug activated gene (NAG-1) is a major molecular target of AST during its antitumorigenic action, which has a strong correlation with the PI3K-Akt signaling pathway during its action ( 9 ). (spandidos-publications.com)
Proteins2
A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. (umassmed.edu)
The results have shown that DDB2 Wt recognize and repair the UV-induced lesions in plasmidic DNA transfected in the cells, whereas a delay in these processes were observed in the presence of DDB2 PCNA- , as also confirmed by the different extent of co-localization of DDB2 Wt and some NER proteins (such as XPG), vs the DDB2 mutant form. (biomedcentral.com)
Protein3
Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (3). (cellsignal.com)
Previously we have shown that DDB2, a protein involved in the Global Genome Repair, interacts directly with PCNA and, in human cells, the loss of this interaction affects DNA repair machinery. (biomedcentral.com)
Immunohistochemical1
The objective of this study was to evaluate clinical and microscopic features of squamous cell carcinomas using immunohistochemical analysis and assessing biological markers of angiogenesis and tumor vascular activity (anti-CD31, anti-CD34, Factor VIII), cell proliferation (Ki-67), and loss of cell suppression (p53). (bvsalud.org)
Antioxidant3
The fruit of this palm tree is widely used because of its anti-inflammatory and antioxidant properties. (mdpi.com)
Despite the fact that a common and clear definition of "berries" is not shared among different scientific areas, the phytochemical pattern of these fruits is mainly characterized by anthocyanins, flavanols, flavonols, and tannins, which showed antioxidant and anti-inflammatory properties in humans. (mdpi.com)
Moringa species are well-known for their antioxidant, anti-inflammatory, anticancer, and antihyperglycemic activities. (frontiersin.org)
We have previously demonstrated that the interaction between DDB2 and PCNA is important to remove DNA lesions by NER. (biomedcentral.com)
Human2
In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
To this end, human kidney 293 stable clones, expressing DDB2 Wt or DDB2 PCNA- , were co-transfected with pmRFP-N2 and UV-irradiated pEGFP-reported plasmids. (biomedcentral.com)
Between obtaining her dissertation in 1995 and her Inserm position in 1999, Witko-Sarsat focused on her research subject, initiated in the US, which was to decipher the mysterious role of proteinase 3 (PR3), a target of the anti-neutrophil autoantibodies involved in vasculitis - particularly Wegener's disease. (inserm.fr)
In the ENA profile results of these patients, the most common profile detected was anti-Ro-52 (65.9%, 27/41), followed by anti-SSA (34.1%, 14/41), anti-SSB (22.0%, 9/41) and anti-CENP-B (12.2%, 5/41) autoantibodies , respectively. (unboundmedicine.com)
Mouse2
The MSDS of Anti-PCNA for Mouse is available from Karlan upon request. (dnamethsoc.com)
The potential anti-angiogenic effect of formononetin was examined in nude mouse xenografts. (spandidos-publications.com)
Mice2
The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
Also, purslane exerted anti-fertility effect in female rats by disrupting ovulation and female fertility hormones [ 18 ], while it diminished aging alterations in female reproductive system in aged mice [ 19 ]. (biomedcentral.com)
Therefore, despite the existing anti-RAAS medicines, finding a novel downstream molecule exclusively targeting to inhibit neointimal formation and vascular remodeling may be a promising strategy for the treatment of vascular restenosis after angioplasty in hypertension. (hindawi.com)
O objetivo deste estudo foi avaliar clínica e microscopicamente o carcinoma epidermoide através de análise imuno-histoquímica, avaliando imunomarcadores tumorais angiogênicos e de atividade vascular tumoral (anticorpos anti-CD31, anti-CD34, Fator VIII), de proliferação celular (Ki-67) e de perda de supressão celular (p53). (bvsalud.org)
Controls1
PCNA controls establishment of sister chromatid cohesion during S phase. (ihcworld.com)
Expression1
Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
Directly1
The team had therefore put its finger on a mechanism that could enable the development of anti-inflammatories that are more targeted than corticosteroids, because they directly attack the neutrophil - the orchestral conductor of inflammation. (inserm.fr)
Found2
The outcome being that in 2010 she called into question another dogma: that PCNA is not just found in the cell nucleus. (inserm.fr)
HBsAg and anti-HCV test results of the patients were found to be negative. (unboundmedicine.com)
Shown1
In addition, a mutant form unable to interact with PCNA (DDB2 PCNA- ), has shown a reduced ability to interact with a UV-damaged DNA plasmid in vitro. (biomedcentral.com)
Repair1
Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex. (umassmed.edu)
Agent1
Haskap berry is a rich source of anthocyanins and (poly)phenols with a notable enrichment of cyanidin-3-O-β-glucoside (C3G), a potent anti-inflammatory agent. (researchgate.net)