Anti obesity effect diet induced metabolic syndrome is central obesity. Medical search. Frequent questions

In obese subjects, adipokines and miokines interact to promote reticulum stress, insulin resistance, metabolic inflexibility and endothelial dysfunction. (benthamscience.com)
CR favorably impacted metabolic profiles of obesity (i.e., lower body weight, plasma glucose and plasma insulin) in obese mice, but the addition of Cur and/or Pip into the CR diet resulted in no further measurable benefit on total body weight. (springer.com)
The first is through its anti‐androgenic effect, thus influencing expression of the genes possibly involved in this condition and the second might be through lowering the insulin resistance that is usually present in some patients with HS. (cassiopaea.org)
The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
Nonalcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are multidisciplinary liver diseases that often accompany type 2 diabetes or metabolic syndrome, which are characterized by insulin resistance. (hindawi.com)
Accordingly, insulin sensitizers, antioxidative agents, Niemann-Pick C1-like 1 (NPC1L1) inhibitors, RAS blockers, and drugs that target the central nervous system may represent candidate pharmacotherapies for NAFLD and possibly NASH. (hindawi.com)
Although clinical evidence for RAS blockers and incretin-based agents (GLP-1 analogs and dipeptidyl peptidase-4 inhibitors) is also lacking, these agents are promising in terms of their insulin-sensitizing and anti-inflammatory effects without causing weight gain. (hindawi.com)
Enhanced sympathetic tone, desyn- chronization of tissue circadian clocks, abnormal secretion of hormones, and obesity are relevant to insulin resistance during sleep disturbances. (vdocuments.mx)
Notably, recent experimental studies have strongly implicated ceramides in the development of numerous metabolic diseases such as insulin resistance, diabetes, cardiomyopathy, hepatic-steatosis, and atherosclerosis. (frontiersin.org)
Accumulation of neutral lipids, such as triglycerides, in key insulin target tissues, has been postulated to inhibit metabolic functions, however, they are less likely to be deleterious. (frontiersin.org)
Enhancing ceramide degradation also endows these metabolic benefits, and adiponectin exerts their antidiabetic, cardioprotective, and insulin-sensitizing actions through activating its receptors, which are ligand-activated ceramidases ( 23 ). (frontiersin.org)
As it is apparent in this series, numerous studies have shown that manipulation of ceramide synthesis or degradation pathways in rodents through pharmacologic and genetic interventions have profound effects on insulin sensitivity ( 6 , 12 , 26 , 27 ). (frontiersin.org)
The growing prevalence of obesity is strongly associated with low-grade systemic inflammation, dyslipidemia, insulin resistance and diabetes, and lifestyle factors including diet are known to play a critical role in the development and progression of T2D [ 2 - 4 ]. (biomedcentral.com)
Based on these observations, it has been hypothesized that n-3 LcPUFAs may also have beneficial effects in T2D, glucose metabolism and insulin sensitivity. (biomedcentral.com)
To the best of our knowledge, short-chain fatty acids (SCFAs), bile salt hydrolase (BSH), metabolic endotoxemia and the endocannabinoid (eCB) system are essential in regulating the initiation and progression of MS through the normalization of adipogenesis and the regulation of insulin secretion, fat accumulation, energy homeostasis, and plasma cholesterol levels. (biomedcentral.com)
Conclusion The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD. (cranberryinstitute.org)
Experiments conducted here demonstrate that diet-induced obesity and testosterone deficiency, combined with testosterone deficiency treatment, exacerbate the detrimental effects on metabolic (blood glucose, insulin) and proinflammatory (cytokine expression) responses in adipose tissue. (militarymuscle.co)
Raising SCFA levels in the intestine contributes to the beneficial effects of berberine to lower insulin resistance, obesity, diabetes, and other metabolic disorders. (pcosnutrition.com)
Considering high prevalence rates of metabolic diseases linked by insulin resistance, we performed a systematic review of existing literature which addressed the role of probiotics in modulating insulin sensitivity in animals and humans. (biomedcentral.com)
Searches for original articles published in English from 1990 to January 2020 were made in the electronic database of PubMed from the National Library of Medicine, using Medical Subject Headings to identify longitudinal studies conducted in animals and humans which reported effects of probiotics in a variety of insulin resistance parameters. (biomedcentral.com)
Five showed benefits in insulin resistance parameters and in two others no effect was detected. (biomedcentral.com)
Available data regarding the effects of certain probiotics do not guarantee sustained amelioration of insulin resistance in humans. (biomedcentral.com)
With scientific evidence suggesting their role in inflammation, insulin sensitivity, and fat and energy metabolism, inhibition of endocannabinoids may be a tool in reducing the prevalence of metabolic syndrome and augmenting the benefits of physical exercise. (medscape.com)

Obesity can induce type 2 diabetes mellitus, dyslipidemia, cardiovascular disease and other chronic disorders with high social and health costs. (benthamscience.com)
A research review found that ginger could benefit obesity and related metabolic disorders. (medicalnewstoday.com)
The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. (frontiersin.org)
Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. (frontiersin.org)
Its oils are rich sources of unsaturated fatty acids, such as monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids, which are previously associated with the prevention of health disorders because of their anti-inflammatory effects and cell membrane properties and structure 2 . (nature.com)
Therefore, effective treatment of type 2 diabetes and metabolic syndrome should target not only the cardiometabolic abnormalities, but also the associated liver disorders. (hindawi.com)
In the last decade, it has been shown that metformin, thiazolidinediones, vitamin E, ezetimibe, n-3 polyunsaturated fatty acids, renin-angiotensin system (RAS) blockers, and antiobesity drugs may improve hepatic pathophysiological disorders as well as clinical parameters. (hindawi.com)
Notably, NAFLD appears to be an early predictor of metabolic disorders, particularly among normal-weight individuals [ 7 ]. (hindawi.com)
The possibility that "faulty" circuits could be remodeled by BDNF is an exciting concept for new therapies for obesity and eating disorders. (hyperthermicwellness.com)
Sleep disorders are treated using anti-insomnia drugs that target ionotropic and G protein-coupled receptors (GPCRs), including g -aminobutyric acid (GABA) agonists, melatonin agonists, and orexin receptor antagonists. (vdocuments.mx)
A deeper understanding of the effects of these medications on glucose metabolism and their underlying mechanisms of action is crucial for the treatment of diabetic patients with sleep disorders. (vdocuments.mx)
In this review we focus on the bene ﬁ cial impact of sleep on glucose metabolism and suggest a possible strategy for therapeutic intervention against sleep-related metabolic disorders. (vdocuments.mx)
The epidemic of obesity is one of the major causes of these metabolic disorders. (frontiersin.org)
2015). This alcohol-induced intestinal inflammation may be at the root of multiple organ dysfunctions and chronic disorders associated with alcohol consumption, including chronic liver disease, neurological disease, GI cancers, and inflammatory bowel syndrome. (nih.gov)
11]. metabolic disorders including dyslipid This was a crosssectional study. (who.int)

Some members of Rhododendron genus are traditionally used as medicinal plants for arthritis, acute and chronic bronchitis, asthma, pain, inflammation, rheumatism, hypertension and metabolic diseases. (medsci.org)
Metabolic syndrome (MS) comprises central obesity, increased plasma glucose levels, hyperlipidemia and hypertension, and its incidence is increasing due to changes in lifestyle and dietary structure in recent years. (biomedcentral.com)
MS can be defined by the presence of abdominal obesity and any 2 of the following factors: increased fasting plasma glucose, increased TGs, reduced HDL cholesterol, and hypertension. (biomedcentral.com)
In recent years, the increased prevalence of obesity has reached epidemic proportions, and presents a critical public health problem worldwide because of the substantial health risks associated with increased mortality from type 2 diabetes (T2D), hypertension, and cardiovascular diseases, as well as the incidence of some cancers [ 2 ]. (biomedcentral.com)
Researchers discovered that there were not only zero benefits from consuming "diet" foods and drinks containing these artificial sweeteners (known as "non-nutritive sweeteners," since they offer no calories), but they were associated with "increases in weight and waist circumference, and higher incidence of obesity, hypertension, metabolic syndrome, type 2 diabetes and cardiovascular events. (draxe.com)
These meta-analyses consistently show that depression increases the risk of overall mortality (RR = 1.81) and the development of cardiovascular-related outcomes, such as heart disease (RR = 1.81), diabetes (RR = 1.60), hypertension (RR = 1.42), stroke (RR = 1.34) and obesity (RR = 1.58). (biomedcentral.com)
nonsmokers included those and hypertension, all of which are as with metabolic syndrome who were who had never smoked and those who sociated with cardiovascular disease referred to the Endocrinology Clinic of had not smoked for 5 years. (who.int)

describe how low skeletal muscle mass and abdominal obesity additively increase the risk of incident type 2 diabetes, independently from glycometabolic parameters. (tomwademd.net)
Evidence linking depression to metabolic syndrome abnormalities indicates that depression is especially associated with its obesity-related components (for example, abdominal obesity and dyslipidemia). (biomedcentral.com)

The first step in the therapeutic strategy against obesity should be the correct diagnosis of its causes and the promotion of lifestyle changes including physical exercise and a healthy diet. (benthamscience.com)
As a result, nutrition affects the incidence, natural progression and therapeutic response of malignant diseases, both in humans and in preclinical animal models. (nature.com)
Here we discuss the molecular mechanisms through which alimentary cues modulate metabolic, microbial and neuroendocrine circuitries and thus affect the probability of developing premalignant lesions that progress to clinically manifested disease and the response to therapeutic intervention. (nature.com)
Therapeutic options and their main effects on NAFLD and NASH. (hindawi.com)
Thus, preventative and therapeutic strategies to reduce the morbidity and mortality caused by metabolic diseases are significant. (biomedcentral.com)
As a traditional Chinese medicine, Rhizoma coptidis has excellent therapeutic effects on various diseases, but the underlying systematic molecular mechanisms are still far from being fully elucidated. (springer.com)
Understanding the mechanisms of alcohol-induced intestinal inflammation can aid in the discovery of therapeutic approaches to mitigate alcohol-induced organ dysfunctions. (nih.gov)

Some researchers believe that essential oils may also help counteract more than 20 chronic diseases and health conditions that obesity may contribute to. (medicalnewstoday.com)
However, the consumers still associate dietary FA with fat deposition and increased occurrence of metabolic diseases such as obesity and atherosclerosis. (nature.com)
Previous studies already demonstrated that some fatty acids are linked with inflammatory response, preventing metabolic diseases. (nature.com)
To better understand the role of dietary FA on metabolic diseases, for the first time, a study to identify key transcription factors (TF) involved in lipid metabolism and inflammatory response by transcriptome analysis from liver samples of animal models was performed. (nature.com)
An increased proportion of omega (n)-6:n-3 PUFA, which is observed typically in Western diets, leads to a wide range of pathologies, such as cardiovascular, inflammatory, autoimmune, and diabetic diseases. (nature.com)
Social-ecological environment, dietary pattern, metabolic state and lifestyle including exercise, are mutually interacting and form a global burden of non-communicable diseases. (heraldopenaccess.us)
This results in a spectrum of cellular dysfunction, that underlies various metabolic diseases. (frontiersin.org)
Herein we discuss and summarizes recent findings that implicate ceramides as a key contributor to adipocyte dysfunction underlying metabolic diseases and how depletion of ceramides can be exploited to improve metabolic health. (frontiersin.org)
Metabolic diseases represent a significant health burden that impacts millions of households worldwide. (frontiersin.org)
In this review, we intend to provide a perspective on ceramides and ceramide metabolites in the maintenance of adipose tissue homeostasis and how adipose tissue ceramides contribute to the development of metabolic diseases. (frontiersin.org)
MS is closely related to lifestyle and central obesity, serving as a risk factor for metabolic diseases, such as type 2 diabetes and cardiovascular disease. (biomedcentral.com)
Moreover, diseases related to systemic or local inflammation, including infections, cerebrovascular accidents, and obesity, have been proposed as risk factors for the development of AD. (biomedcentral.com)
Most neurodegenerative diseases are related to age, thus the most vulnerable population is elderly individuals, who are more likely to suffer from AD when external factors are present, such as obesity, which exacerbates inflammation [ 3 ]. (biomedcentral.com)
Despite advances in drugs, inflammation has not been eradicated in neurodegenerative diseases, and research on how to counteract its effects is ongoing. (biomedcentral.com)
Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)
Metabolic syndrome (MetS) is associated with several degenerative diseases, including retinal degeneration. (molvis.org)
Obesity and overweight affect, worldwide, over 1.7 billion people and is associated with premature mortality, chronic diseases and increase in health costs. (bvsalud.org)
Based on long-term trials of 6-12 months, researchers state that high-protein diets are "thought to also prevent obesity and obesity-related diseases, such as metabolic syndrome, nonalcoholic fatty liver disease, type 2 diabetes, and cardiovascular diseases. (medscape.com)
Although several past studies have quantified the impact of individual risk factors in Japan, to our knowledge no study has assessed and compared the effects of multiple modifiable risk factors for non-communicable diseases and injuries using a standard framework. (who.int)

Obesity is a multifactorial disease that is currently developing a threatening tendency towards becoming the main cause of chronic disease in the world. (benthamscience.com)
One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
Its ability to provide relief of chronic pain, to induce an increase in appetite, to alleviate nausea, and to ease anxiety are only some of the common uses for it. (medscape.com)
Profound and debilitating fatigue is the most common complaint reported among individuals with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 diabetes, celiac disease, chronic fatigue syndrome, and rheumatoid arthritis. (wikipedia.org)
Obesity is a chronic, multifactorial, relapsing disorder characterized by excess body weight and defined as a body mass index (BMI) of ≥ 30 kg/m2. (msdmanuals.com)
The ABOM stresses obesity be considered a chronic disorder that requires lifelong treatment and follow-up. (msdmanuals.com)
Despite professional society guidelines recommending that obesity be treated as a chronic disease by emphasizing the use of lifestyle modification in conjunction with pharmacotherapy, antiobesity medications are uncommonly prescribed in most clinical practices. (tomwademd.net)
Hearing loss is a highly prevalent disabling chronic condition, with more than 466 million people worldwide affected by this condition [ 3 ]. (biomedcentral.com)
Effects of chronic consumption of specific fruit (berries, citrus and cherries) on CVD risk factors: a systematic review and meta-analysis of randomized controlled trials. (cranberryinstitute.org)
Obesity is a complex chronic disease defined as excessive or abnormal fat accumulation that adversely affects health [ 1 ]. (biomedcentral.com)
This review summarizes the mechanisms by which chronic alcohol intake leads to intestinal inflammation, including altering intestinal microbiota composition and function, increasing the permeability of the intestinal lining, and affecting the intestinal immune homeostasis. (nih.gov)

We hypothesize that combined genetic and dietary factors may influence AA effects on metabolism. (researchsquare.com)
We aimed to explore whether AA effects on metabolism are influenced by the combination of genetic and dietary factors. (researchsquare.com)
We hypothesize that beneficial effects of AA on metabolism might be influenced by combinations of genetic and environmental factors. (researchsquare.com)
Therefore, we first used a genetically predisposed mouse model to investigate whether AA effects on metabolism might be influenced by particular genetic and diet. (researchsquare.com)
In this study, we examined AA effects on metabolism in wild-type (WT) mice and GLUT10 G128E mice fed with a normal diet (CD) or HFD, as we previously showed that GLUT10 G128E mice are highly sensitive to HFD-induced T2DM 9 . (researchsquare.com)
Curcumin (Cur), a possible anti-obesity compound, and piperine (Pip), a plausible enhancer of Cur's bioavailability and efficacy, may be candidate agents for controlling body fat, metabolism and low grade inflammation. (springer.com)
Other studies suggest that certain dietary components found in spices may exert a beneficial effect on metabolism. (springer.com)
Culture condition of crops affects the metabolites of products and consequently, consumers' metabolism. (heraldopenaccess.us)
We hypothesized that a gut-brain axis integrates all of the primary physiological components known to be affected in the metabolic syndrome, that, in addition to regulating glucose homeostasis, blood pressure, food intake and body weight, it also likely controls cholesterol metabolism. (anti-agingfirewalls.com)
To explore the mechanism by which intermittent fasting (IF) exerts prolonged effects after discontinuation, we examined mice that had been subjected to 4 cycles of fasting for 72?hours and ad libitum feeding for 96?hours per week (72hIF), followed by 4 weeks of ad libitum feeding, focusing on expression of genes for lipid metabolism in the skeletal muscle and histone acetylation in the promoter region. (tomwademd.net)
High fructose in the diet alters liver metabolism, making it store more fat, affecting both liver health and whole-body metabolism. (worldhealth.net)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Host-microbial interactions in the human microbiome drug metabolism by gut bacteria share metabolic pathways for anti-cancer drug metabolism. (antiwaft.com)
Lactic acid bacteria, specifically lactobacillus and Bifidobacterium are the most documented probiotics that appear to have beneficial effects of reducing fat mass, regulating glucolipid metabolism. (biomedcentral.com)
Research on intestinal microbiota has grown considerably, as well as the interest on probiotics' supplementation effects on metabolism. (biomedcentral.com)
Consistent beneficial results for intestinal barrier function, immune system and metabolism were reported in animals may encourage long-term randomized clinical trials in people with obesity and cardiometabolic risk. (biomedcentral.com)

Additionally, these diets have been shown to reduce cardiovascular disease risk factors , such as blood triglycerides and blood pressure. (medscape.com)
ABSTRACT There is accumulating evidence suggesting that inflammation is the bridging link between cardiovascular disease and metabolic syndrome. (who.int)

Adipocytes, the key components of the adipose tissue, have unique ability to store excess energy in the form of triglycerides, sense systemic energy demands, and secrete factors (lipids, peptides, cytokines, and adipokines) to regulate other metabolic tissues. (frontiersin.org)
In obesity the inherent capacity of adipose tissue to store and sense nutrients is compromised, causing spillover of the intermediate lipid metabolites into circulation and resulting in their ectopic deposition in tissues not suitable for lipid storage, a phenomenon known as lipotoxicity. (frontiersin.org)
It is considered the counterpart of the hormone leptin , produced by adipose tissue , which induces satiation when present at higher levels( ref ). (anti-agingfirewalls.com)
report on studies with male mice indicating that the metabolic benefits of intermittent fasting result in part from promotion of histone acetylation in lipid oxidation genes of muscle and adipose tissue. (tomwademd.net)
There are several factors that act and interact in the regulation of food intake and energy deposition, contributing to the development and maintenance of obesity, including: endocrinal, adipose, intestinal and neuronal factors 2 . (bvsalud.org)
Diagnosis of metabolic a 24hour dietary recall for 3 days (2 which originates from excess visceral syndrome was based on World Health workdays and 1 holiday) by a trained adipose tissue [2]. (who.int)

Furthermore, AA attenuates the predisposition of GLUT10 G128E mice to HFD-triggered eWAT inflammation, adipokine dysregulation, ectopic fatty acid accumulation, metabolic dysregulation and body weight gain, as compared with WT mice. (researchsquare.com)
Obesity is frequently associated with WAT inflammation, which contributes to further ectopic fat accumulation and finally T2DM 5 . (researchsquare.com)
It is plausible that supplementing the high fat diet of CR mice with Cur + Pip may increase loss of body fat and suppresses HFD induced inflammation. (springer.com)
External factors, including systemic inflammation, such as that observed in obesity, are likely to interfere with the brain's immune processes and further promote disease progression. (biomedcentral.com)
The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. (biomedcentral.com)
In fact, researchers have begun to discover that alcohol, particularly if consumed chronically and in larger amounts, induces a process initiated in the gut that promotes inflammation throughout the body (Patel et al. (nih.gov)
The factors that can modify alcohol-induced gut inflammation and organ damage and the resulting pathologies that are a consequence of gut-derived inflammation are described. (nih.gov)
Inflammation is one of Sina Hospital, Tabriz from April 2007 tional intake data were collected using the features of metabolic syndrome, to April 2008. (who.int)

Obesity was firstly described in 2000 as a cardiometabolic disease, even before Metabolic Syndrome, type 2 diabetes mellitus and coronary disease were considered as such. (benthamscience.com)
Type 2 diabetes mellitus (T2DM) is a major medical problem worldwide, and its development is highly affected by complex interactions between genetic and environmental (dietary and lifestyle) factors 1 . (researchsquare.com)
Gut dysbiosis is a major contributor in diet-related obesity and type 2 diabetes mellitus [9, 10]. (deepdyve.com)
ABSTRACT The Arab world is experiencing an epidemic of obesity and type 2 diabetes mellitus. (who.int)
There are alarming data related to the rising prevalence of obesity and type 2 diabetes mellitus in children of Arab ethnicity. (who.int)

Genetic, physiological and psychological factors, as well as dietary habits, physical activity, lifestyle and social and environmental factors are responsible for the significant increase in the prevalence of obesity and its consequences [ 1 - 4 ]. (medsci.org)
The alarming increase in the prevalence of obesity or MetS is likely to further exacerbate the risk for ophthalmic abnormalities associated with obesity. (molvis.org)

Anemia, defined as a decreased quantity of circulating red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population. (anr.fr)
Depression has been shown to subsequently increase the risk of, for example, cardiovascular, stroke, diabetes and obesity morbidity. (biomedcentral.com)

Dietary bioactive compounds capable of improving metabolic profiles would be of great value, especially for overweight individuals undergoing a caloric restriction (CR) regimen. (springer.com)
Our goal was to evaluate whether the beneficial effect of CR on reduction of HFD-induced obesity could be further potentiated by concurrent supplementation with dietary Cur, with or without the addition of Pip. (springer.com)
Short-term dietary supplementation with BO and FO improved biomarkers associated with T2D/metabolic syndrome. (biomedcentral.com)
For example, some dietary factors may alter gut microbiota interactions and affect cancer development and response to cancer treatment [22]. (deepdyve.com)

Consequently, inhibition of endocannabinoids may be a tool in reducing the prevalence of metabolic syndrome and augmenting the benefits of physical exercise. (medscape.com)
Over the past two decades, the prevalence of metabolic abnormalities such as type 2 diabetes and metabolic syndrome (MetS) has been increasing worldwide together with the escalating obesity pandemic [ 1 - 3 ]. (hindawi.com)

A number of potential implications for clinical practice are derived from the cardiometabolic state underlying obesity and its comorbidities. (benthamscience.com)
Obesity has become a global health crisis affecting over 1.5 billion people, resulting in metabolic and cardiovascular comorbidities as well as hypogonadic conditions characterized by decreased testosterone production or enhanced aromatase degradation of testosterone. (militarymuscle.co)

dose effect of environmentally responsive phytochemicals, respectively, ranging widely over basic metabolic pathways and secondary metabolite biosynthesis. (heraldopenaccess.us)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
Even more excitingly, the Verrucomicrobium A. These results provide a major step towards identifying the cellular and molecular mechanisms through which sex alters the microbiome impacts longevity in model organisms is that the net effect of all these pathways shapes life span in older animals. (antiwaft.com)
Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)

Current studies suggest that manipulation of the gut microbiota could be a promising approach for the prevention and management of metabolic syndrome [ 7 ]. (biomedcentral.com)
Here, we have reviewed recent studies concerning the role of the gut microbiota in metabolic syndrome and the effects of probiotic bacterial strains and prebiotics on the prevention or treatment of metabolic syndrome, such as their anti-obesity and anti-inflammatory effects and their ability to improve glycemic control and modulate serum lipids. (biomedcentral.com)
Gut microbiota can you buy skelaxin over the counter usa induce IGF-1 and promote bone formation and growth. (antiwaft.com)
Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. (antiwaft.com)
In another study, supplementation with Lactobacillus plantarum reduced fat mass and serum lipid profile concurrently with downregulation of lipogenic gene expression in the adipocytes, and modulated gut microbiota composition, resulting in reductions in the bodyweight of high fat diet (HFD) fed obese mice [ 13 ]. (biomedcentral.com)
Diversity and stability of the microbiota are affected by genetic and environmental factors. (biomedcentral.com)

Berberine also reduced cholesterol, TG, and LDL in patients with metabolic syndrome. (pcosnutrition.com)
We carried out a cross-sectional study of 195 patients with metabolic syndrome. (who.int)

Inherited neuropathies in which autonomic or sensory features predominate, conditions in which the neuropathy is part of a multiple-organ disturbance, and neuropathies with specific metabolic dysfunction are not discussed. (medscape.com)

Protective effects of thymoquinone (TQ), a phytochemical compound with antioxidant and anticancer influences, were investigated on sperm parameters, testicular structures, and sexual hormones in BL-treated mice. (bvsalud.org)
We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
Here we show that AA has greater metabolic impacts on HFD-fed GLUT10 G128E mice than HFD-fed WT mice. (researchsquare.com)
AA plays an important role in improving WAT development and HFD-induced metabolic dysregulation in GLUT10 G128E mice. (researchsquare.com)
47 eight-week-old male C57BL/6 mice were fed a high fat diet (HFD) for 23 weeks to induce obesity. (springer.com)
Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1β and KC/GRO. (springer.com)
Our previous study sought to evaluate whether Cur and/or Pip could potentiate CR's effect on body weight reduction in mice made obese by feeding a high-fat diet (HFD) [ 10 ]. (springer.com)
The effect of Cur and/ or Pip on telomere length in obese mice undergoing CR is not known. (springer.com)
In the present study, we further investigated whether Cur and/or Pip could improve metabolic profiles in obese mice subjected to CR on a HFD. (springer.com)
In this study, the effects of R. oldhamii leaf extract on inhibiting the free fatty acid (FFA)-induced accumulation of fat in HepG2 cells and on improving fatty liver syndrome in mice with high fat diet (HFD)-induced NAFLD were investigated. (medsci.org)
For the in vivo assay, C57BL/6 mice were randomly assigned to three groups ( n = 5), including the normal diet group, the HFD group and the HFD+EtOAc group. (medsci.org)
In addition, the EtOAc fraction of R. oldhamii leaf significantly improved fatty liver syndrome and reduced total cholesterol (TC) and triglyceride (TG) in HFD-induced NAFLD mice at a dosage of 200 mg/kg BW. (medsci.org)
Another study using an AD mice model induced by Aβ 1-42 injection has demonstrated that ginsenoside Rb1 (GsRb1) reduces neuroinflammation in the hippocampus [ 8 ]. (biomedcentral.com)
Additional studies have revealed a potential mechanism of action of anti-Aβ antibodies via experiments on transgenic mice overexpressing mutant human amyloid precursor protein (PDAPP) under the control of the mini-promoter of platelet-derived growth factor (PDGF) [ 9 ]. (biomedcentral.com)
Defining mechanisms that contribute can you buy skelaxin over the counter usa to sexual dimorphism in metabolic syndrome in mice. (antiwaft.com)
A metagenome-wide association study of gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice. (antiwaft.com)

Microbial community assembly and metabolic end-products. (antiwaft.com)
Moreover, it is well recognized that the excessive use of broad-spectrum antibiotics can affect the relative proportions of gut microbial populations and foster bacterial resistance [24]. (deepdyve.com)

Percent body fat, plasma inflammatory markers associated with obesity (interferon (IFN)-γ, interleukin (IL)-10, IL-12 p70, IL-1β, IL-6 and KC/GRO), plasma Cur metabolites and liver telomere length were measured. (springer.com)
On the other hand, there is growing evidence for the involvement of other lipid metabolites in inducing this metabolic outburst ( 3 - 5 ). (frontiersin.org)

Increased evidence indicates that berberine (BBR), a natural plant product, has beneficial effects on NAFLD, though the mechanisms are not completely known. (mdpi.com)
Li and colleagues identify mechanisms that may account for the weight-loss-inducing effects of berberine. (tomwademd.net)
Alkaloids, especially berberine, coptisine and palmatine, are responsible for multiple pharmacological effects of Rhizoma coptidis. (springer.com)
While berberine may be new to the polycystic ovary syndrome (PCOS) community, nothing is new about the numerous benefits of this potent supplement. (pcosnutrition.com)
The effects of berberine have been compared to metformin in women with PCOS. (pcosnutrition.com)
Berberine users reported much less side effects (mild GI discomfort) than metformin. (pcosnutrition.com)
Berberine possesses anti-inflammatory properties. (pcosnutrition.com)

Sciacovelli and associates report on the successful use of semaglutide to treat obesity induced by resection of craniopharyngioma. (tomwademd.net)
10 The stimulation of BAT can potentially increase total daily energy expenditure (i.e. burn more calories) and is seen as a possible target to treat obesity. (totalhealthmagazine.com)

Reduce symptoms of irritable bowel syndrome (IBS) (an intestinal disorder that causes pain in the belly, gas, diarrhea, and constipation). (mskcc.org)

Since NAFLD is closely associated with obesity, diabetes, and MetS, it is unknown whether the relationship between NAFLD and all-cause mortality and cardiovascular death, if any, is independent of cardiometabolic risk factors (Figure 1 ) such as MetS and type 2 diabetes. (hindawi.com)
In this study, we investigated the additional effect of impaired glucose tolerance (IGT), an essential component of MetS, on retinal degeneration using the WNIN/GR-Ob rat model. (molvis.org)

While awaiting the release of new drugs, topiramate, alone or combined with phentermine, has been proposed as a novel anti-obesity drug, showing relevant effects not only on weight loss but also on cardiometabolic alterations and biomarkers, even though new studies should clarify the mechanisms of these findings. (benthamscience.com)
This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
In Endocrine Reviews , Akalestou and others survey mechanisms of weight loss after obesity surgery, which include changed food selection. (tomwademd.net)
Mechanisms underlying the resistance to diet-induced obesity in germ-free (GF) model organisms has provided strong support for a can you buy skelaxin over the counter usa causal role of hepatic mTORC2 in aging. (antiwaft.com)

Obesity is mostly a multifactorial disease due to obesogenic environments, psychosocial factors and genetic variants. (biomedcentral.com)

Thus, the EtOAc fraction of R. oldhamii leaf and its derived phytochemicals have great potential in preventing FFA-induced fat accumulation. (medsci.org)
These results demonstrated that the methanolic extracts from R. oldhamii leaf have excellent inhibitory activities against fat accumulation and anti-NAFLD activities and thus have great potential as a natural health product. (medsci.org)
Obesity is a condition when fat accumulation is excessive to the extent that it produces adverse health consequences [ 1 ]. (medsci.org)
Obesity is a multifactorial, highly complex medical condition involving abnormal or excessive body fat accumulation that can cause health impairment. (molvis.org)

In conclusion, this preliminary study shows that Ghrelin exerts a strong stimulatory effect on GH (growth hormone) secretion in humans releasing more GH than GHRH. (anti-agingfirewalls.com)
Results of the present study revealed that supplementing CrPic and biotin alone or in a combination exerts anti-diabetic activities, probably through modulation of PPAR-γ, IRS-1 and NF-κB proteins. (cambridge.org)

Quantitative and qualitative aspects of nutrition have a profound effect on leukocytes and thereby affect proinflammatory carcinogenic effects or anticancer immune responses. (nature.com)
Hence, many effects of nutrition on the development and progression of cancer lack 'specificity' in their association, and such alimentary cues also affect the risk of developing metabolic syndrome, a prelude to arteriosclerosis and neurodegeneration ( Fig. 1 ). (nature.com)
In general, nutrition affects cancer development somewhat indirectly. (nature.com)
During his session "Helping Kids Thrive In A Metabolical World," Dr. Lustig explored metabolic syndrome as a primary threat to population health, the impact of poor metabolic health on pediatric immunity and development, and the paramount role of proper nutrition. (worldhealth.net)
Usually, the first-line intervention is a combination of nutrition, physical activity, and behavior change support, not just diet. (medscape.com)
clinical nutrition as a specialty goes here HN - 2008 BX - Nutrition FX - Diet FX - Food DH - Child Nutrition DI - 052504 MN - SP6.021.062 MS - Nutrition of children aged 2-10 years. (bvsalud.org)
check also tag CHILD or specific HN - 2008 FX - Adolescent Nutrition FX - Infant Nutrition DH - Maternal Nutrition DI - 052505 MN - SP6.021.072 MS - Nutrition of a mother which affects the health of the INFANT as well as herself. (bvsalud.org)

Nonalcoholic fatty liver disease (NAFLD) is a globally observed metabolic disease with high prevalence both in adults and children. (mdpi.com)

Promising results of fecal transplantation have also emerged from clinical trials including obese individuals with metabolic disturbances [ 9 ]. (biomedcentral.com)

With both factors acting to modulate many aspects of metabolic and neural functioning - including central nervous system function. (militarymuscle.co)

The relationship between obesity and hearing loss among the middle-aged and older population remained unclear. (biomedcentral.com)
Of note, however, it remains unclear whether there is a paradox pertaining to the relationship between obesity and hearing loss, with the relevant longitudinal data limited. (biomedcentral.com)

However, evidence for the significance and beneficial effects of AA in T2DM is thus far inconclusive. (researchsquare.com)

Effect of cranberry supplementation on liver enzymes and cardiometabolic risk factors in patients with nafld: a randomized clinical trial. (cranberryinstitute.org)
Background We aimed to evaluate the effect of cranberry supplementation on serum liver enzymes, hepatic steatosis, and cardiometabolic risk factors in patients with non-alcoholic fatty liver (NAFLD). (cranberryinstitute.org)
The results suggest that supplementation with different doses of Lacticaseibacillus paracasei K56 has certain effect on reducing body fat and glycosylated hemoglobin, especially at a dose of 10 9 CFU/day. (biomedcentral.com)

The current status of controversy regarding the use of certain preservatives in cosmetic products makes it necessary to seek new ecological alternatives that are free of adverse effects on users. (bvsalud.org)
Very importantly no significant adverse effects were recorded and blood tests regularly taken during the trial period have remained within the normal range for all patients. (cassiopaea.org)
Still, some studies show that high doses of caffeine [2] can induce adverse side effects such as gastrointestinal distress, which can be associated with diarrhea. (nchc.org)
Childhood obesity has wide-ranging adverse effects on immune status, including an impact on responses to vaccination and infection. (worldhealth.net)
Proponents of diet drinks claim that no adverse effects have been proven and that aspartame-laced products contribute to weight loss. (draxe.com)

While genetic factors have been associated with T2DM in population studies 2 , the effect sizes of identified variants are typically very small. (researchsquare.com)
In addition to their marginal effects, many genetic factors are thought to alter susceptibility by environmental factors, such as high-fat diet (HFD), accelerating the development of T2DM 3 . (researchsquare.com)
Such complex interactions between various genetic risk factor combinations and specific diet or lifestyle characteristics make clinical studies on the effects of AA on T2DM difficult to design. (researchsquare.com)
Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
This review summarizes the major pathological factors linking obesity to diabetes, focussing on current epidemiological data related to obese diabetic patients in the Arab world, the etiology of the disease and the genetic determinants of diabetes and obesity. (who.int)
Replication studies identify several genetic variants in Arabs with obesity-linked diabetes. (who.int)

Finally, our own experience with topiramate is described, focusing on its effects upon weight loss and inflammatory markers. (benthamscience.com)
Recent studies have shown a relationship between inflammatory markers and modifiable lifestyle factors including fitness, diet, exercise and smoking. (who.int)

Ultimately, obesity results from a long-standing imbalance between energy intake and energy expenditure, including energy utilization for basic metabolic processes and energy expenditure from physical activity. (msdmanuals.com)

Bleomycin (BL) is a powerful chemotherapy drug that has devastating effects on spermatogenic function and may make cancer survivors at risk of infertility. (bvsalud.org)
First, at the population level, overnutrition and imbalanced diets are typically associated with other health-compromising factors that include, but are not limited to, consumption of tobacco and alcohol, decreased physical activity and exposure to environmental toxicants, all of which not only are established risk factors for cancer development but also are linked to poor education and low income. (nature.com)
Obesity increases the risk of a number of health problems, including coronary disease, particular types of carcinoma, respiratory system complications and osteoarthritis of small and large joints [ 1 ]. (medsci.org)
Mongraw-Chaffin and coauthors find a strong graded association of body mass index and diabetes with self-reported COVID-19 that suggests obesity and diabetes might play a role in risk for symptomatic SARS-CoV-2 infection, beyond their co-occurrence with socioeconomic factors. (tomwademd.net)
Consuming too much sugar can lead to weight gain, which is a risk factor for obesity . (militarymuscle.co)
Consumption of too many sweetened beverages and highly processed foods may lead to weight gain and may increase your risk for obesity and other health problems. (militarymuscle.co)
Bipolar disorder is a common condition, affecting 1 to 4% of the population worldwide, and a serious illness because of the suicidal risk during depressive and manic episodes. (anr.fr)
We estimated the effects of 16 risk factors on cause- specific deaths and life expectancy in Japan. (who.int)
We applied a comparative risk assessment framework to estimate effects of excess risks on deaths and life expectancy at age 40 y. (who.int)

Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. (cassiopaea.org)

Also, obesity is associated with greater job absenteeism, loss of productivity, and higher health care costs. (msdmanuals.com)
The annual cost of health care in the United States related to obesity is estimated to be $150 billion. (msdmanuals.com)
In 2014, an estimated 600 million adults were obesity according to the World Health Organization. (medsci.org)
Ghrelin is a hormone deeply involved in a very important current health condition, obesity, and it also plays critical roles in other key processes including neural functioning and learning. (anti-agingfirewalls.com)
describe the case of a young woman whose body weight increased by over 30 percent with no concomitant worsening of her metabolic health. (tomwademd.net)
Type 2 diabetes (T2D) is a major health concern in the United States with an estimated 18.3 million adults having physician-diagnosed diabetes, an additional 7.1 million adults having undiagnosed diabetes and about 81.5 million having prediabetes, also referred to as metabolic syndrome [ 1 ]. (biomedcentral.com)
Having plenty of these types of foods in your diet is critical to your health. (drkeithsown.com)
Recently, accumulating evidence has been supporting the "obesity paradox," or the possible health benefits of being overweight. (biomedcentral.com)
Renowned pediatric neuroendocrinologist with decades of experience treating childhood obesity, Robert Lustig, MD, brought his expertise in pediatric metabolic health to the stage. (worldhealth.net)
The downstream benefits of metabolic health include good mental and immune health. (worldhealth.net)
Obesity is associated with a number of health problems, including diabetes , heart disease, and certain types of cancer. (militarymuscle.co)
In addition to negatively impacting testosterone levels, consuming too much sugar can have a number of negative effects on overall health. (militarymuscle.co)
It's important to limit your sugar intake and maintain a healthy diet to support overall health and well-being. (militarymuscle.co)
However, safe and effective treatments for obesity are scarce and new strategies are needed to mitigate its substantial health effects. (biomedcentral.com)
Growing rates of obesity represent a global lifestyle-related health problem [ 1 ]. (biomedcentral.com)
On the other side of the coin, a large community of health-conscious, anti-aspartame health practitioners and consumers are convinced that the U.S. Food and Drug Administration has turned a blind eye to one of the most dangerous food additives ever discovered. (draxe.com)
Consequently, depression largely affects public health and involves high societal costs. (biomedcentral.com)
Epidemiological studies suggest that the prevalence and severity of obesity have increased to epidemic proportions worldwide, making it a global public health problem. (molvis.org)

A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. (cassiopaea.org)

In the United States, obesity and its complications cause as many as 300,000 premature deaths each year, making it second only to cigarette smoking as a preventable cause of death. (msdmanuals.com)

metabolic syndrome, type 2 diabetes, cardiovascular lesions and malignancies. (benthamscience.com)
However, the hypoglycemic effect was comparatively less than that of a 1,000 mg/day dose of metformin, an approved medication for type 2 diabetes. (emedihealth.com)
The objective of the present study was to evaluate anti-diabetic effects of chromium picolinate (CrPic) and biotin supplementations in type 2 diabetic rats. (cambridge.org)
The type 2 diabetic rat model was induced by high-fat diet (HFD) and low-dose streptozotocin. (cambridge.org)

Their main role is in cell-signaling, and, because they are hydrophobic, their main actions are limited to paracrine (cell-to-cell) or autocrine (same cell), rather than systemic, effects. (medscape.com)

That inflammatory response, in turn, exacerbates alcohol-induced organ damage, creating a vicious cycle and leading to additional deleterious effects of alcohol both locally and systemically. (nih.gov)

However, this inflammatory response has a dual function: it can play a protective role by increasing Aβ degradation and clearance, but it can also contribute to Aβ and tau overproduction and induce neurodegeneration and synaptic loss. (biomedcentral.com)

Furthermore, mutations of melanocortin receptors are strongly correlated with human obesity( ref ) and alterations in cholesterol transport are a common occurrence in obesity and the metabolic syndrome( ref ). (anti-agingfirewalls.com)
We found that a gut-brain axis including ghrelin, glucagon-like peptide 1 (GLP-1) and the central melanocortin system directly regulates the hepatic synthesis and re-uptake of cholesterol( ref ). (anti-agingfirewalls.com)
A side effect of taking oral contraceptive pills (OCPs) (birth control), is that they can increase cholesterol, TG, and c-reactive protein levels. (pcosnutrition.com)
It is also used for obesity, altitude sickness, aging skin, high levels of cholesterol or other fats in the blood, and many other purposes, but there is no good scientific evidence to support many of these other uses. (medlineplus.gov)
In fact, research demonstrated that the polyphenol catechins in green tea gives it biological and medicinal qualities, including its anti oxidant, antimicrobial, blood thinning, and cholesterol lowering and anti-cancer activities, as well as its ability to promote weight loss. (totalhealthmagazine.com)

Anatomy13

Organisms8

Diseases59

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment67

Psychiatry and Psychology10

Phenomena and Processes67

Anthropology, Education, Sociology and Social Phenomena5

Technology, Industry, Agriculture13

Information Science3

Named Groups7

Health Care43

Geographicals13

Insulin23

Disorders15

Hypertension7

Abdominal2

Therapeutic7

Diseases20

Chronic11

Metabolism16

Cardiovascular disease2

Adipose6

Inflammation8

Diabetes mellitus5

Increase in the prevalence of obesity2

Morbidity2

Dietary4

Prevalence of metabolic2

Comorbidities2

Pathways4

Microbiota6

Patients with metabolic2

Dysfunction1

Mice17

Microbial2

Metabolites2

Berberine7

Treat obesity2

Intestinal1

MetS2

Mechanisms5

Multifactorial disease1

Accumulation4

Exerts2

Nutrition7

High prevalence1

Disturbances1

Modulate1

Relationship between obesity2

Beneficial effects1

Supplementation3

Adverse5

Genetic6

Inflammatory markers2

Basic metabolic1

Risk9

Greater metabolic1

Health18

Elevated liver1

Complications1

Type4

Systemic1

Exacerbates1

Neurodegeneration1

Cholesterol5