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  • Garcinia
  • In a study in Zucker rats, which are genetically predisposed to obesity, Garcinia cambogia extract containing HCA showed that high doses led to significant suppression of epididymal fat accumulation, but also had high testicular toxicity. (wikipedia.org)
  • adipose tissue
  • Obesity is associated with pathological expansion of white adipose tissue (WAT) and is the leading cause of morbidity and mortality worldwide. (pcom.edu)
  • In light of this finding, researchers have begun investigating a newly identified type of adipose tissue in an attempt to combat obesity. (pcom.edu)
  • diabetes
  • High blood pressure, type 2 diabetes mellitus and obesity are risk factors for heart diseases . (medindia.net)
  • Hossain P, Kawar B, El-Nahas M (2007) Obesity and diabetes in the developing world, a growing challenge. (springer.com)
  • mechanism
  • WAT provides no protective mechanism against obesity due to the lack of UCPJ. (pcom.edu)
  • The present chapter focuses on the safety and efficacy of commonly used herbal medicines in the management of obesity through covering their beneficial effects and mechanism of action. (springer.com)
  • protein
  • The compound was found to potently induce body-fat loss while preserving protein stores in animals which is the ultimate goal of an anti-obesity agent as body protein loss is an undesired but inevitable (to some degree) side effect of fat loss via calorie restriction. (wikipedia.org)
  • weight loss
  • Agents that increase energy expenditure and weight loss by neural and chemical regulation. (curehunter.com)
  • Together, these data suggest that guggulsterone may exert anti-obesity effects not only by decreasing adipogenesis and promoting lipolysis in WAT, but also by inducing white to beige transdifferentiation thereby increasing thermogenesis and promoting weight loss. (pcom.edu)
  • induce
  • Our data suggests that LNnT has the ability to directly induce transdifferentation of white to beige adipocytes and indirectly induce beiging by activating anti-inflammatory M2 macrophages. (pcom.edu)
  • mechanisms
  • Immunomodulatory glycans found on the surface of helminth parasites and in human breast milk are being investigated for their anti-inflammatory and immunosuppressive mechanisms. (pcom.edu)
  • further
  • Further, red bell pepper has anti-tumor promoting activities and thus it prevents the growth of tumor. (medindia.net)