• Orlistat (brand names Xenical/Alli) was first introduced in the UK and Europe in 1998 and is currently the main treatment option for those prescribed anti-obesity medication. (biomedcentral.com)
  • In Northern Ireland, during 2009/2010 orlistat accounted for approximately 80% of prescriptions for anti-obesity medication increasing to 99% following the withdrawal of sibutramine. (biomedcentral.com)
  • Obesity is a major health risk associated with numerous debilitating conditions, including type 2 diabetes, cardiovascular disease and hypertension [ 1 ]. (biomedcentral.com)
  • In response to this, efforts to control and treat obesity have also been vigorously pursued, ranging from raising awareness about lifestyle changes to the discovery and development of safe and effective anti-obesity drugs. (eurekaselect.com)
  • In 1999, sibutramine (brand name Reductil) was introduced as an anti-obesity treatment option but was subsequently removed in January 2010 because of the risk of cardiovascular disease [ 5 ]. (biomedcentral.com)
  • Sharma B, Henderson DC: Sibutramine: current status as an anti-obesity drug and its future perspectives. (wikipedia.org)
  • Tziomalos K, Krassas GE, Tzotzas T: The use of sibutramine in the management of obesity and related disorders: an update. (wikipedia.org)
  • Stock MJ: Sibutramine: a review of the pharmacology of a novel anti-obesity agent. (wikipedia.org)
  • Despite intense research, an effective pharmacological treatment of obesity is still lacking. (biomedcentral.com)
  • In recent years, pharmacological treatment for obesity has been increasing against a backdrop of decreasing choice of available anti-obesity medications. (biomedcentral.com)
  • Fifteen well written reviews make this special volume an excellent compilation of recent developments in anti-obesity treatment. (eurekaselect.com)
  • It's true that no anti-obesity drug had been approved in 13 years prior to the FDA approval of Belviq and Qsymia, but only one of these drugs is truly set up for immediate success -- Belviq. (fool.com)
  • In 2006, Rimonabant (brand name Acomplia) was marketed as an anti-obesity drug but was removed in November 2008 because of the risk of psychiatric side effects [ 6 ]. (biomedcentral.com)
  • Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. (drugbank.ca)
  • Educational material to improve the understanding of the role of anti-obesity medication, for patients and practitioners, is recommended. (biomedcentral.com)
  • While 25.0% of people are obese, only 1.3% (2.1% of females, 0.6% of males) received anti-obesity medication. (biomedcentral.com)
  • Onset of obesity in both the developing and the developed world has reached epidemic proportions. (eurekaselect.com)
  • It is therefore reasonable to hypothesize that the attenuation of the activity of this system would have therapeutic benefit in treating disorders that might have a component of excess appetitive drive or over-activity of the endocannabinoid system, such as obesity, ethanol and other drug abuse, and a variety of central nervous system and other disorders. (drugbank.ca)
  • One option is the use of anti-obesity medication the prescription of which has increased dramatically in recent years. (biomedcentral.com)
  • Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. (eurekaselect.com)
  • This book should be useful to clinicians and medicinal chemists involved in ant-obesity research and therapy. (eurekaselect.com)
  • Despite this, little is known about the individual and GP practice factors that influence the prescription of anti-obesity medication. (biomedcentral.com)
  • Multi-level logistic regression analysis was used to investigate factors associated with the prescription of anti-obesity medication in Northern Ireland using a population primary care prescribing database (~1.5 million people aged 16+ years) during 2009/10. (biomedcentral.com)
  • Prescribing of anti-obesity medication reflected obesity prevalence across urban/rural areas and deprivation. (biomedcentral.com)
  • There was an unexplained two-fold difference, between the 25th and 75th percentile, in the GP practice prescription of anti-obesity medication. (biomedcentral.com)
  • While the prevalence (and presumably the health consequences) of obesity worsens with age, younger females are more likely to be prescribed anti-obesity medication. (biomedcentral.com)
  • Despite the potential benefits of using anti-obesity medication a history of safety fears and a variety of side effects may have hampered their use [ 5 , 12 ]. (biomedcentral.com)
  • Limited animal studies have investigated the anti-obesity effects of inorganic NO 3 as a primary hypothesis (Roberts et al. (excli.de)
  • During diet-induced obesity (DIO), many subsets of adaptive immune cells within the gut adopt a pro-inflammatory phenotype, primarily demonstrated by T cells producing pro-inflammatory cytokines, such as interferon-γ (IFNγ) 7 , 8 . (nature.com)
  • It was speculated that this mechanism would protect the rodents, at least in part, from diet-induced obesity ( 10 ). (diabetesjournals.org)
  • Indeed, several rodent studies have demonstrated that BAT activation and recruitment by prolonged exposure to cold or β-adrenergic stimulation ameliorates diet-induced obesity and improves its associated complications, such as disturbed glucose and lipid homeostasis ( 5 , 6 ). (diabetesjournals.org)
  • In recent years, it has been shown that humans have active brown adipose tissue (BAT) depots, raising the question of whether activation and recruitment of BAT can be a target to counterbalance the current obesity pandemic. (jci.org)
  • Obesity is associated with pathological expansion of white adipose tissue (WAT) and is the leading cause of morbidity and mortality worldwide. (pcom.edu)
  • In light of this finding, researchers have begun investigating a newly identified type of adipose tissue in an attempt to combat obesity. (pcom.edu)
  • Celastrol was shown to protect against obesity and metabolic dysfunction through activation of the transcription factor HSF1, which regulates metabolic programs in adipose tissue and muscle [ 8 ]. (biomedcentral.com)
  • The mechanisms underlying the development of obesity may include enzymatic/receptor and hormonal changes (i.e., lipoprotein lipase, hormone sensitive lipase, very low-density lipoprotein (VLDL) receptor, insulin, growth hormone, catecholamine) in the skeletal muscles and adipose tissues. (frontiersin.org)
  • The natural phytochemicals present in foods, including anthocyanins, might play a role in attenuating obesity by producing a decrease in weight and adipose tissue. (hindawi.com)
  • Obesity is an abnormal excess accumulation of fat in adipose tissue due to an imbalance between energy intake and energy expenditure. (hindawi.com)
  • It has been reported that the anthocyanins might play a role in attenuating obesity by producing a decrease in weight and adipose tissue [ 4 ]. (hindawi.com)
  • Recruitment of brown adipose tissue (BAT) has emerged as a potential tool to combat obesity and associated metabolic complications. (diabetesjournals.org)
  • Detection of uncoupling protein 1(UCP1) in RWAT was confirmed qualitatively by both immunohistochemistry and immunofluorescence using a rabbit anti rat UCP1 antibody which showed the appearance of a marked increase of this protein in the adipose tissue. (dovepress.com)
  • The rise in the incidence of obesity has led to a major interest in the biology of white adipose tissue. (psu.edu)
  • Increases in the secretion of a number of adipokines occur in obesity, underpinning inflammation in white adipose tissue and the development of obesity-associated diseases. (psu.edu)
  • Objective-Plasminogen activator inhibitor-1 (PAI-1) production by adipose tissue is increased in obesity, and its circulating levels are high in type 2 diabetes. (psu.edu)
  • In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. (springer.com)
  • Currently, no appetite-suppressing drugs are approved specifically for the treatment of obesity. (nih.gov)
  • Bray GA. Use and abuse of appetite suppressant drugs in the treatment of obesity. (jamanetwork.com)
  • This review will provide a comprehensive overview of the recent advances on bioactive pure compounds isolated from different seaweed sources focusing on their potential use as drugs to treat or prevent hypertension and obesity. (mdpi.com)
  • China's demand for Anti-Obesity Drugs has grown at a fast pace in the past decade. (marketpublishers.com)
  • Antiobesity drugs may not be optimal for treating obesity. (hindawi.com)
  • Therefore, a better understanding of the mechanisms of obesity is urgently needed along with the development of new antiobesity drugs. (hindawi.com)
  • This review offers an overview of physiological agents, current therapeutics, as well as medications, which have been extensively used and those agents not currently available or non-classically considered anti-obesity drugs. (scielo.br)
  • Peptide drugs are particularly exciting for chronic disease applications because they metabolize to natural amino acids and thus are intrinsically devoid of the chemical toxicity issues that have plagued many of the earlier anti-obesity and anti-diabetic drugs,' said Edward T. Maggio, M.D., CEO of Aegis Therapeutics. (csjalbany.org)
  • Anti-obesity medication or weight loss drugs refer to all pharmacological agents that reduce or control weight. (hotvsnot.com)
  • This review summarizes data on currently used antiobesity drugs and new compounds under clinical development. (unboundmedicine.com)
  • Three antiobesity drugs are currently accepted for long-term use. (unboundmedicine.com)
  • Other drugs can induce weight loss, e.g. some antidepressants, antiseizure agents, and antidiabetic drugs. (unboundmedicine.com)
  • A1 - Zieba,Remigiusz, Y1 - 2007/10/19/ PY - 2007/05/16/received PY - 2007/09/28/accepted PY - 2007/11/1/pubmed PY - 2008/2/5/medline PY - 2007/11/1/entrez SP - 612 EP - 26 JF - Postepy higieny i medycyny doswiadczalnej (Online) JO - Postepy Hig Med Dosw (Online) VL - 61 N2 - This review summarizes data on currently used antiobesity drugs and new compounds under clinical development. (unboundmedicine.com)
  • This enzyme is a target for anti-inflammatory drugs and anti-metastatic agents. (lsu.edu)
  • Eligible studies were randomized trials of overweight children and adolescents assessing the effect of nonsurgical interventions on obesity outcomes. (nih.gov)
  • Anti-obesity pharmacological treatment is indicated when body mass index (BMI) is over 30 kg/m 2 , or when morbidities are associated to overweight (BMI over 25 kg/m 2 ) when dieting, physical activities and behavioral changes have proved unsuccessful (1). (scielo.br)
  • Treatment of wild-type HFD C57BL/6 mice with the local gut anti-inflammatory, 5-aminosalicyclic acid (5-ASA), reverses bowel inflammation and improves metabolic parameters. (nih.gov)
  • Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota. (greenmedinfo.com)
  • Here, we demonstrate that IgA levels are reduced during obesity and the loss of IgA in mice worsens IR and increases intestinal permeability, microbiota encroachment, and downstream inflammation in metabolic tissues, including inside the VAT. (nature.com)
  • C57BL/6 mice were fed a high-fat diet to induce obesity. (naturalnews.com)
  • In fact, these studies showed that the amount of OB-3 entering the blood stream of the mice was four times greater when the agent was administered nasally. (csjalbany.org)
  • The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. (springer.com)
  • The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. (springer.com)
  • Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area. (springer.com)
  • Here we show that the gut immune system is altered during high-fat diet (HFD) feeding and is a functional regulator of obesity-related insulin resistance (IR) that can be exploited therapeutically. (nih.gov)
  • The invention also relates to a method of identifying an insulin secretagogue agent for diabetes. (google.co.uk)
  • The intestinal immune system is emerging as an important contributor to obesity-related insulin resistance, but the role of intestinal B cells in this context is unclear. (nature.com)
  • Examinations were performed, including general physiological characteristics, obesity-related biochemical parameters, and insulin-signaling pathway-related proteins in the hypothalamus. (hindawi.com)
  • The mechanism responsible for the antiobesity effect of CPAE may be related to suppression of energy intake via regulation of insulin-signaling pathway in the hypothalamus. (hindawi.com)
  • These metabolic adaptations to prolonged exposure to mild cold may lead to improved glucose metabolism or prevent the development of obesity-associated insulin resistance and hyperglycemia. (diabetesjournals.org)
  • Current obesity treatments such as surgical procedures and anti-obesity medications have serious and undesirable side effects. (pcom.edu)
  • An analysis of all clinical trials over ten-week long is also presented for medications used in the management of obesity, as well as data about future medications, such as a the inverse cannabinoid agonist, rimonabant. (scielo.br)
  • Information presented in this review offer an overview of physiological agents, current therapeutics, as well as medications widely used in the past and no longer available. (scielo.br)
  • For reauthorization criteria for weight reduction medications, see Aetna Pharmacy CPB on Antiobesity Agents. (aetna.com)
  • Immunomodulatory glycans found on the surface of helminth parasites and in human breast milk are being investigated for their anti-inflammatory and immunosuppressive mechanisms. (pcom.edu)
  • On the other hand, although it is obvious that macroalgae represent promising sources of antihypertensive and anti-obesity compounds, it is also clear that further efforts are required to fully understand their cellular mechanisms of action, to establish structure-inhibition relationships and mainly to evaluate them in pre-clinical and clinical trials. (mdpi.com)
  • Therefore, we investigated the effects and mechanisms of Cyclocarya paliurus (CP) aqueous extract (CPAE) on obesity. (hindawi.com)
  • Obesity induces a chronic phenotypic pro-inflammatory shift in bowel lamina propria immune cell populations. (nih.gov)
  • As with all chronic medical conditions, effective management of obesity must be based on a partnership between a highly motivated patient and a committed team of health professionals. (medscape.com)
  • Antidiabetic;Orlistat is an antiobesity agent. (frbiz.com)
  • Led by active ingredients of anticancer, antidiabetic, and hormone replacement formulations, hormones and related agents will post the fastest growth in value among all pharmaceutical chemicals. (freedoniagroup.com)
  • Together, these data suggest that guggulsterone may exert anti-obesity effects not only by decreasing adipogenesis and promoting lipolysis in WAT, but also by inducing white to beige transdifferentiation thereby increasing thermogenesis and promoting weight loss. (pcom.edu)
  • We recently described an important role played by the TGF-β/Smad3 signaling pathway in modulating the appearance of brown adipocytes in traditional white fat, and its implications to thermogenesis, mitochondrial energetics, energy expenditure, and protection from diabetes and obesity. (frontiersin.org)
  • Used to treat diabetes and obesity, Dexfenfluramine decreases caloric intake by increasing serotonin levels in the brain's synapses. (pharmacycode.com)
  • The rise in the worldwide incidence of obesity and, by a tight correlation, diabetes is proof that we are failing as a populace to obey the energy balance equation. (frontiersin.org)
  • Because of this "energy-wasting" process, BAT activation results in increased EE, which could reverse or protect against obesity. (diabetesjournals.org)
  • Obesity has reached epidemic proportions, but little is known about its influence on the intestinal immune system. (nih.gov)
  • Obesity is reaching global epidemic proportions as a result of factors such as high-calorie diets and lack of physical exercise. (nature.com)
  • Onset of obesity in both the developing and the developed world has reached epidemic proportions. (eurekaselect.com)
  • Obesity is a major public health problem approaching epidemic proportions worldwide. (hindawi.com)
  • Our data suggests that LNnT has the ability to directly induce transdifferentation of white to beige adipocytes and indirectly induce beiging by activating anti-inflammatory M2 macrophages. (pcom.edu)
  • Obesity is a problem of significant public health concern both in this and other western countries. (clinicaltrials.gov)
  • Obesity is a global health concern. (greenmedinfo.com)
  • Natural News ) A recent study from South Korea's Mokpo National University revealed that Caulerpa okamurae can be used for managing obesity and its accompanying metabolic disorders. (naturalnews.com)
  • Diet, exercise, and behavioral modification should be included in all obesity management approaches for body mass index (BMI) of 25 kg/m 2 or higher. (medscape.com)
  • Xenical is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. (drugs.com)
  • It is used in the management of obesity as a short-term adjunct in a comprehensive regimen of weight reduction, which includes diet and exercise. (nccs.com.sg)
  • This program will consist of a series of four video vignettes presenting interviews with clinical experts who will explore some of the most pressing issues in the management of patients with obesity. (thedoctorschannel.com)
  • For Aetna's clinical policy on surgical management of obesity, see CPB 0157 - Obesity Surgery . (aetna.com)
  • The present invention comprises a transdermal drug delivery device comprising a reservoir comprising a releasably stored dosage of a pharmaceutically active agent and a translucent film adjacent to at least a portion of the reservoir, wherein the translucent film comprises at least one inorganic ultraviolet-absorbing. (google.ca)
  • 15 . A transdermal drug delivery device according to claim 1 , wherein the pharmaceutically active agent may undergo ultraviolet light induced degradation. (google.ca)
  • The Clore Laboratory staff members are internationally recognised drug discovery experts and opinion leaders within the fields of obesity, diabetes and metabolic disease. (buckingham.ac.uk)
  • Anti-obesity Drug Discovery and Development is focused on this very important area of healthcare research. (eurekaselect.com)
  • In 2006, Rimonabant (brand name Acomplia) was marketed as an anti-obesity drug but was removed in November 2008 because of the risk of psychiatric side effects [ 6 ]. (biomedcentral.com)
  • The combination of Albany Medical College's highly effective peptide with Aegis' non-invasive Intravail peptide delivery technology promises to lead to the first orally-active peptide anti-obesity and diabetes drug. (csjalbany.org)
  • A closely related type of drug is a serotonin-dopamine releasing agent (SDRA). (wikipedia.org)
  • National Institutes of Health Consensus Development Conference statements: gastrointestinal surgery for severe obesity. (jamanetwork.com)
  • Oolong tea polysaccharide and polyphenols prevent obesity development. (greenmedinfo.com)
  • The development of new antibiotics under the FDA's Qualified Infectious Disease Product program, coupled with an increasing patient volume for new hepatitis C treatments, will keep revenues of anti-infective chemicals rising. (freedoniagroup.com)
  • The Albany Medical College and Aegis Therapeutics have announced an agreement designed to speed the development and commercialization of an anti-obesity peptide that could also benefit those with Type 2 diabetes. (csjalbany.org)
  • Sister Patricia Grasso, CSJ, (Sister John Damien) associate professor of medicine at Albany Medical College, is the head of a team of researchers who have been working since 1997 on creating an anti-obesity peptide that would also be effective in treating Type 2 diabetes. (csjalbany.org)