• Current recommendations for ANCA-associated vasculitis (AAV) support its management within a dedicated clinical service. (springer.com)
  • In vitro studies have found that ANCAs can activate neutrophils, increase their adherence to endothelium, and induce their degranulation that can damage endothelial cells. (wikipedia.org)
  • It is a form of vasculitis (inflammation of blood vessels) that affects small- and medium-size vessels in many organs. (wikipedia.org)
  • NET induction activity was high in Sera A, B, and C but not in D. Additionally, we demonstrated the presence of anti-NET antibody (ANETA) in Sera B and C but not in A or D. (biomedcentral.com)
  • 2) hydralazine-induced reversal of epigenic silencing of MPO and proteinase3 (PR3) leading to increased expression of neutrophil autoantigens and (3) a break in tolerance in slow versus fast acetylators of hydralazine. (bmj.com)
  • Other more recent reports of widespread livedo and acral purpura due to vascular coagulation similar to that seen in livedoid vasculitis but with a much more rapid, widespread and intense onset have been linked to cocaine laced with levamasole. (oncologynurseadvisor.com)
  • The identified efficacy biomarkers may be useful as objective outcome measures for early phase proof-of-concept studies when assessing novel anti-inflammatory drugs in JDM and AAV, and likely in other inflammatory disorders. (luriechildrens.org)