Anti cholinergic agents. Medical search. Frequent questions

Anticholinergics (anticholinergic agents) are substances that block the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system. (wikipedia.org)

Has also been used successfully in the treatment of tricyclic antidepressant-induced anticholinergic toxicity, but currently is rarely used because of potentially serious adverse effects (seizures, bronchospasm, bradycardia, asystole). (drugs.com)
if no response, repeat dose at 5- to 10-minute intervals until response occurs, adverse cholinergic effects develop, or a total dose of 2 mg has been administered. (drugs.com)
may repeat dose every 20 minutes until response occurs or adverse cholinergic effects occur. (drugs.com)

These agents inhibit the parasympathetic nervous system by selectively blocking the binding of ACh to its receptor in nerve cells. (wikipedia.org)
The effects of both extracts were almost totally inhibited by the anticholinergic agent atropine, suggesting that a principal pathway mediating this response may involve the parasympathetic nervous system. (cdc.gov)

Reversible acetylcholinesterase inhibitor agents such as physostigmine can be used as an antidote in life-threatening cases. (wikipedia.org)
The manufacturers state that physostigmine is used to reverse CNS effects resulting from clinical or toxic dosages of drugs (e.g., some antihistamines, antimuscarinics, antiparkinsonian agents, phenothiazines) capable of producing anticholinergic syndrome and from intoxication with certain plants (e.g. (drugs.com)
most clinicians advise against the routine use of physostigmine in tricyclic intoxication, and some clinicians recommend to reserve use only for life-threatening anticholinergic symptoms refractory to other treatment. (drugs.com)

By binding to the specific receptor sites, these agents appear to potentiate the effects of gamma-aminobutyric acid (GABA) and facilitate inhibitory GABA neurotransmission and other inhibitory transmitters. (medscape.com)
Treatment to reverse anticholinergic effects (e.g., delirium, prolonged somnolence) produced by atropine and/or scopolamine preanesthetic medications. (drugs.com)
See Reversal of Anticholinergic Effects under Uses and also see Rapid IV Administration under Cautions. (drugs.com)
To reverse anticholinergic effects of atropine or scopolamine preanesthetic medications, administer a dose twice that of the anticholinergic drug, on a weight basis. (drugs.com)
Whether PMs are also more prone to experience anticholinergic side effects needs to be further studied in larger patient populations. (nih.gov)
The methods seem appropriate and suggest that certain medications with anticholinergic effects are associated with risk of dementia. (sciencemediacentre.org)
In terms of clinical practice the message would remain about caution with medications with anticholinergic effects, particularly if several are used. (sciencemediacentre.org)
This paper ties in well with current advice for doctors to be careful when using drugs with anticholinergic effects in older people, those who are frail and others with numerous health conditions. (sciencemediacentre.org)
Constrictor effects were partially inhibited by a wide variety of the mediator blocking agents. (cdc.gov)

An acute anticholinergic syndrome is reversible and subsides once all of the causative agents have been excreted. (wikipedia.org)
Reversible anticholinesterase agent. (drugs.com)

Notes: If anti-hepatitis C virus (HCV) antibody is positive, a negative HCV ribonucleic acid (RNA) test is required for entry. (who.int)

It usually appears while consistently reported risk factors which the patient is still on the offending agent or were found to make some patients more appears for the first time when the drug is vulnerable to developing TD if treated with discontinued or its dose is reduced. (who.int)

By blocking the striatal cholinergic receptors, benztropine may help in balancing the cholinergic and the dopaminergic activity in the striatum. (medscape.com)
To compare measures of anticholinergic activity between metabolic phenotypes of the polymorphic enzymes cytochrome P450 2D6 (CYP2D6) and CYP2C19 in the elderly patients exposed to anticholinergic agents. (nih.gov)
Serum anticholinergic activity (SAA) was determined by a validated, 96-well format radio receptor assay and adjusted for ADS score. (nih.gov)
The cholinergic system is known to be critical for cognitive function and some treatments licensed for Alzheimer's dementia increase cholinergic activity. (sciencemediacentre.org)
There have been concerns about medicines with anticholinergic activity as in theory they can reduce cognitive function and several studies have shown that medicines with anticholinergic activity adversely affect cognition and can be associated with an increased risk of dementia. (sciencemediacentre.org)
Specifically mentioned are exposure to antidepressant, urological, and antiparkinson drugs rated as having higher anticholinergic activity (ACB score of 3). (sciencemediacentre.org)

Long-term nursing home patients (n = 80) with an anticholinergic drug scale (ADS) score ≥3 were recruited from 22 nursing homes in Norway. (nih.gov)
These preliminary findings suggest that elderly CYP2D6/CYP2C19 PMs with a high anticholinergic drug burden are at increased risk of elevated SAA. (nih.gov)
This study of a large number of patients to study anticholinergic drug classes in depth has used a specific score for anticholinergic burden (ACB). (sciencemediacentre.org)
The study findings are really about the need to study specific drug classes rather than total anticholinergic burden which is a reasonable conclusion. (sciencemediacentre.org)

This agent binds to the receptor sites on motor nerve terminals and inhibits the release of acetylcholine, which, in turn, inhibits the transmission of impulses at the neuromuscular junction. (medscape.com)
We suggest that paper dust extracts cause dose-related airway smooth muscle constriction possibly associated with the release of cholinergic as well as other mediators. (cdc.gov)

These agents produce symptomatic improvement in muscle strength by relieving spasticity and autonomic symptoms, or both in some patients. (medscape.com)
To the best of our knowledge, preva- definition of what constituted TD and, more lence rate of TD has not been recorded for importantly, the confounding effect of the patients from Arab countries diagnosed type, dosage and duration of the offending with psychosis and being treated with con- agents, and the duration of the illness itself, ventional neuroleptics. (who.int)

If dopaminergic agents are not effective against dystonia, anticholinergics can be used, but they offer only transient relief. (medscape.com)
Agents used to relieve rigidity and spasticity may prove effective against dysarthria, while methscopolamine bromide can deter excessive drooling. (medscape.com)