Anti cancer activity. Medical search. Frequent questions

The nutritional agent capsaicin displayed robust growth-inhibitory activity in a diverse array of human cancers. (worldhealth.net)
Additionally, poha isolates compounds were evaluated for their growth inhibitory effects with U251MG glioblastoma and MDA-MB-231 breast cancer cells that harbor aberrantly-active signal transducer and activation of transcription 3 (STAT3), compared to normal NIH-3T3 mouse fibroblasts. (nih.gov)
The ethanol extract of propolis of Alagoas showed significant results for antimicrobial activity, and inhibitory activity for Staphylococcus aureus and Candida krusei. (blogspot.com)
The anti-microbial activity of the isolates against Streptococcus mutans associated with caries, and the mucosal pathogens Staphylococcus aureus, Candida albicans and Enterococcus faecalis was determined by determining inhibitory zones on agar plates. (researchsquare.com)
Additionally, 2HF inhibited efflux of doxorubicin and increased its accumulation in the cells, but did not add to the transport inhibitory effect of anti-Rlip antibodies alone. (oncotarget.com)
Results showed that both plants possess a promising and dose dependent inhibitory activity with IC50of extract A 28.52 and 26.47 μg/ml on MCF7 and A549 cells respectively, and that of extract B was 41 and 27.9 μg/ml on MCF7 and A549 cell lines, respectively. (phcogj.com)
The results showed that the obtained complex could induce and stabilize G-quadruplex structure as well as exhibit potent inhibitory activity against telomerase. (telomerescience.com)
Several compounds showed low nanomolar or sub-nanomolar cell growth inhibitory activity. (bvsalud.org)

Blockade of interactions between PD-1 and PD-L1 enhances immune function in vitro and mediates antitumor activity in preclinical models. (nih.gov)
Compounds 2b, 2c and 6b exhibited significant antitumor activity against human breast cancer MCF 7 cell line. (ijpsonline.com)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of TYRA-300 in cancers with FGFR 3 activating gene alterations, including locally advanced/ metastatic urothelial carcinoma of the bladder and urinary tract and other advanced solid tumors. (survivornet.com)
Phase 2 will evaluate the preliminary antitumor activity of TYRA-300 in cancers with FGFR3 activating gene alterations, including locally advanced/metastatic urothelial carcinoma of the bladder and urinary tract and other advanced solid tumors. (survivornet.com)

As of February 24, 2012, a total of 207 patients--75 with non-small-cell lung cancer, 55 with melanoma, 18 with colorectal cancer, 17 with renal-cell cancer, 17 with ovarian cancer, 14 with pancreatic cancer, 7 with gastric cancer, and 4 with breast cancer--had received anti-PD-L1 antibody. (nih.gov)
Among patients with a response that could be evaluated, an objective response (a complete or partial response) was observed in 9 of 52 patients with melanoma, 2 of 17 with renal-cell cancer, 5 of 49 with non-small-cell lung cancer, and 1 of 17 with ovarian cancer. (nih.gov)
In an ovarian cancer cell line, all betulinic acid derivatives prepared showed weaker cytotoxicity than betulinic acid. (go.jp)
BRCA1 and BRCA2 genes are associated with hereditary breast/ovarian cancer (HBOC) syndrome. (cdc.gov)
Participants carrying a P/LP variant had 5.95-fold increased odds of a personal history of breast cancer and 18.3-fold increased odds of ovarian cancer. (cdc.gov)

Metformin, a widely used oral anti-diabetic drug, enhanced the anti-prostate cancer activity of abiraterone and enzalutamide, a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2016 has shown. (renalandurologynews.com)

Then, global structure-activity relationships are discussed for ruthenium and osmium metallodrugs with respect to in vitro antiproliferative/cytotoxic activity and in vivo tumor-inhibiting properties, as well as pharmacokinetics. (rsc.org)
Cytotoxic activity of a-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells. (academicjournals.org)
Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity. (academicjournals.org)
Our investigation revealed that the cytotoxic activity was significantly affected by N3-alkyl substituents. (irost.org)

In contrast, metformin inhibited AR, AR-V7, and PSA expression in a dose-dependent manner and induced apoptosis in prostate cancer cells. (renalandurologynews.com)
The anticancer activity of red ginseng is higher than that of white ginseng due to the production of active anticancer ginsenosides during the steaming process, resulting in apoptosis/paraptosisinduction and angiogenesis inhibition. (novapublishers.com)
Our results show that 2HF induced apoptosis in both histological types of lung cancer and inhibited proliferation and growth through suppression of CDK4, CCNB1, PIK3CA, AKT and RPS6KB1 (P70S6K) signaling. (oncotarget.com)
These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
Grape-related anti-tumoral activity encompasses a wide array of biological mechanisms and cellular targets, eventually leading to inhibition of cell growth and to enhanced apoptosis in several cancer cell lines, including lung, colon, breast, bladder, leukemia and prostate tumors. (oatext.com)
The anti-tumor effects of TMZ and DOX were mediated in part by selective induction of apoptosis. (nature.com)
In the present study, we investigated a combinatorial approach using two natural dietary polyphenols, luteolin and EGCG , and found that their combination at low doses (at which single agents induce minimal apoptosis) synergistically increased apoptosis (3-5-fold more than the additive level of apoptosis) in both head and neck and lung cancer cell lines . (cancertreatmentsresearch.com)
In vitro cytotoxicity studies showed that complex Ru-Se inhibited the cancer cell growth through apoptosis. (telomerescience.com)

The DPPH, ABTS+, OH radical, Iron (II) chelation and FRAP assays exhibited that methanol extract show a modulate antioxidant activity. (greenmedinfo.com)
These results suggest for the first time thatmethanol extract presents anti-adhesion and anti-proliferative proprieties. (greenmedinfo.com)
The propolis extract showed high activity with a higher percentage than 75% inhibition of tumor cells OVCAR-8, SF-295 and HCT116. (blogspot.com)
The anticancer activities of two Lebanese plant extract Micromeria fruticose (A) and Teucrium polium (B) and their fractions were tested against MCF7 and A549 cancer cell lines using MTT assay. (phcogj.com)

It was also discovered that when the mushroom was combined with the chemotherapy drug doxorubicin, an otherwise drug-resistant human liver cancer became treatable. (depkewellness.com)
The differential responses of gBS tumors and normal neuronal cells to sustained treatments with anti-cancer drugs temozolomide (TMZ) and doxorubicin (DOX) were investigated. (nature.com)
Cancers such as doxorubicin are commonly used in cancer leukaemia, colorectal, breast, lung, and so on are chemotherapy. (who.int)

Considering the above facts, the goal of the present study was to combine disubstituted pyrimidines with 1,3,4-thiadiazole residues in order to develop hybrid molecules with potential of enhanced activity and to test their antioxidant and antitumor activities. (ijpsonline.com)

10. Jothimani M, Loganathan L, Palanisamy P, Muthusamy K. Regulatory pathways of colorectal cancer and their synergistic cross-talk mechanism. (ac.ir)
1990. The effect of mild stress on DMH-induced colorectal cancer. (cdc.gov)
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. (lu.se)

We next utilized S100A9 knockout (KO) mice to address the question of whether the anti-tumor effect of tasquinimod is mediated through inhibition of S100A9. (aacrjournals.org)
These data suggest that the anti-MM effect of tasqunimod is indeed mediated through inhibition of S100A9. (aacrjournals.org)
Therefore, we suggest that silibinin prevents the EGFR signaling pathway and may be used as an effective drug for the inhibition of metastasis of human breast cancer. (iiarjournals.org)
It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
Complete inhibition of cytopathic anti-SARS-CoV activity. (cdc.gov)
Combination BRAFV600E inhibition with the multitargeting tyrosine kinase inhibitor axitinib shows additive anticancer activity in BRAFV600E-mutant anaplastic thyroid cancer. (cdc.gov)

It has a wide potent anticancerous agents coined as Acetogenins which play a key role towards many varieties of cancer, Acetogenins are potent inhibitors of NADH oxidase of the plasma membranes of cancer cells. (ingentaconnect.com)
The aim of the present study was to evaluate the phytochemical composition, antioxidant and anticancer activity ofaqueous and methanol extracts against Human glioblastoma cells U87MG. (greenmedinfo.com)
Based on the significant antibacterial activity, the sorting of bacterial cells against the compounds (MID6 and MID9) was analyzed by flow cytometry. (degruyter.com)
The results illustrated that certain cells (MCF-7 and HS-1 cells) demonstrate increased sensitivity to the two essential oils, and the anticancer effects of myrrh is superior to frankincense. (spandidos-publications.com)
All isolated poha compounds (aerial parts and fruits) were evaluated for their anti-inflammatory activity with lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells, and tumor necrosis factor alpha (TNF-α)-activated nuclear factor-kappa B (NF-κB) with transfected human embryonic kidney cells 293. (nih.gov)
In a study published in the journal Cancer Research , they reported that increasing vitamin D levels can help suppress a signaling pathway linked to the growth and spread of melanoma cells . (lecanadian.com)
Melanoma is a form of skin cancer that begins in cells known as melanocytes. (lecanadian.com)
We know when the Wnt/Beta-catenin pathway is active in melanoma , it can dampen down the immune response, causing fewer immune cells to reach the inside of the tumor, where they could potentially fight the cancer better," explained Newton-Bishop. (lecanadian.com)
In a separate experiment with mice, the team found that increasing VDR expression on melanoma cells reduced the activity of the Wnt/Beta-catenin pathway and slowed down tumor growth. (lecanadian.com)
Although vitamin D on its own won't treat cancer, we could take insights from the way it works to boost the effects of immunotherapy, which uses the immune system to find and attack cancer cells. (lecanadian.com)
Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. (lu.se)
Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). (lu.se)
miRs are considered as next-generation medicine of recent times, and their targeting by naturally occurring flavonoids in cancer cells could be deemed as a signature step. (lu.se)
We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future. (lu.se)
Here, we investigated the effect of silibinin (a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle) on the epidermal growth factor (EGF) ligand-induced CD44 expression in human breast cancer cells. (iiarjournals.org)
The levels of CD44 mRNA and protein expression were greatly increased by EGF and by TGF-α in SKBR3 and BT474 breast cancer cells. (iiarjournals.org)
In a previous study, we also reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression is inhibited by silibinin through inactivation of the RAF/MEK/ERK pathway ( 6 ), as well as augmenting the cell cycle arrest at the G 2 /M phase through the induction of p21 and the reduction of cyclin B1 in breast cancer cells ( 7 ). (iiarjournals.org)
Here, we also studied the effect of silibinin on EGFR ligand-induced CD44 expression, which is a hallmark of metastasis in various cancer cells. (iiarjournals.org)
In this study, we investigated the effect of silibinin on EGFR signaling pathway and EGF ligand-induced CD44 expression in breast cancer cells. (iiarjournals.org)
Nevertheless, its activity in normal T cells underlines the need for extensive toxicological investigation. (iiarjournals.org)
Temozolomide is an oral drug used to slow or stop the growth of cancer cells in the body. (uwindsor.ca)
MedlinePlus) This drug has is an alkylating agent that stops the cells from making new DNA (Cancer Research UK) with a reasonable blood-brain barrier penetration. (uwindsor.ca)
Overexpression of miR-21 decreases the sensitivity of gastric cancer cells to trastuzumab, which is a humanized monoclonal antibody targeting human epidermal growth factor receptor 2. (oncotarget.com)
This study is a continuation of our earlier findings involving poly(ε-caprolactone) (PCL)-poly (ethylene glycol) (PEG) nanoparticles (PEG-PCL NPs), which were coated with trastuzumab to target gastric cancer cells with HER2 receptor over-expression using anti-miRNA-21 antisense oligonucleotides (AMO-21). (oncotarget.com)
It enhances the activity of NK cells and has been found to initiate T cell responses against microbial pathogens and tumors. (depkewellness.com)
In this study, we have for the first time incorporated cells from the most devastating brain cancer (glioblastoma) from primary brain tumor tissue from our patients into the BS. (nature.com)
In conclusion, cytotoxicity against tumor cells, cytokine-mediated immunomodulatory properties, and broad-spectrum antimicrobial activity suggest that the Ps-1Pb and Ps-2Pa represent templates for design of non-hemolytic analogs for tumor therapy and for treatment of infections in cancer patients produced by multidrug-resistant pathogens. (ulster.ac.uk)
In this study, we investigated whether FBZ has anti-cancer activity in HL-60 cells, a human leukemia cell line, and assessed its relationship with the production of reactive oxygen species (ROS). (kjvr.org)
FBZ treatment at 0.25-1 μM significantly decreased the metabolic activity of HL-60 cells. (kjvr.org)
To investigate the anti-cancer mechanism of FBZ, HL-60 cells were treated with FBZ in the absence or presence of N-acetyl cysteine (NAC), an inhibitor of ROS production. (kjvr.org)
This study provides evidence that FBZ has anti-cancer activity in HL-60 cells provided, in part, via ROS production. (kjvr.org)
12. Cheng Y, Li L, Pan S, Jiang H, Jin H. Targeting frizzled-7 decreases stemness and chemotherapeutic resistance in gastric cancer cells by suppressing Myc expression. (ac.ir)
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. (ac.ir)
Our laboratory has a long-standing interest in immune signaling and cell metabolism underlying the differentiation and function of T cells, a central cell type in adaptive immunity and cancer immunotherapy. (stjude.org)
We found that FK866 shows anti-proliferative activity in three PDAC cell lines , as well as in Jurkat T-cell leukemia cells . (bvsalud.org)
Our best cell anti-proliferative compounds were the 2,4,6-trimethoxybenzamide analogue of FK866 ((E)-N-(4-(1-(2,4,6-trimethoxybenzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl) acrylamide ) (9), the 2,6-dimethoxybenzamide (8) and 2-methoxybenzamide (4), which exhibited an IC50 of 0.16 nM, 0.004 nM and 0.08 nM toward PDAC cells , respectively. (bvsalud.org)
and promotes antiproliferation of human cancer cells. (cdc.gov)
Anticancer activity against human lung A549 cells and HL-60 leukemia cells was also evaluated. (cdc.gov)
therefore, we investigated a potential link between CysLT2 signaling and the tumor suppressor 15-PGDH in colon cancer cells. (lu.se)
We observed a significant up-regulation of 15-PGDH after treatment with LTC 4 , a CysLT 2 ligand, in colon cancer cells at both the mRNA and protein levels, which could be reduced by a CysLT 2 antagonist or a JNK inhibitor. (lu.se)
Furthermore, we also observed that LTC 4 , via the CysLT 2 /JNK signaling pathway, increased the expression of the differentiation markers sucrase-isomaltase and mucin-2 in colon cancer cells and that down-regulation of 15-PGDH totally abolished the observed increase in these markers. (lu.se)
In conclusion, the restoration of 15-PGDH expression through CysLT 2 signaling promotes the differentiation of colon cancer cells, indicating an anti-tumor effect of CysLT 2 signaling. (lu.se)

Potent leads were taken for the study through literature survey, major types of cancer targets were identified, the natureceuticals and the cancer protein were subjected to docking analysis, further with the help of the dock score and other descriptor properties top ranked molecules were collected, commercial drug was also selected and identified as a Test compound for the study. (ingentaconnect.com)
Blocking of S100A9 with tasquinimod demonstrates a potent anti-myeloma activity. (aacrjournals.org)
Flavonoids have cardioprotective, antioxidant, anti-inflammatory, anti-cancer and antimicrobial properties, and are one of the most potent nutraceuticals in food and phytopharmaceutical products [11,12]. (oatext.com)
Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer. (bvsalud.org)

Antibody-mediated blockade of PD-L1 induced durable tumor regression (objective response rate of 6 to 17%) and prolonged stabilization of disease (rates of 12 to 41% at 24 weeks) in patients with advanced cancers, including non-small-cell lung cancer, melanoma, and renal-cell cancer. (nih.gov)
Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis ) activities whereas, none of the other microalgae were bioactive against the conditions tested for. (frontiersin.org)
British researchers have found that vitamin D helps fight a serious form of skin cancer known as melanoma. (lecanadian.com)
These findings point to new ways of using vitamin D to reduce Wnt/Beta-catenin pathway activity and boost the immune system's ability to fight melanoma. (lecanadian.com)

Xie Y, Wawng L, Hussain A. Metformin enhances the anti-prostate cancer activity of abiraterone and enzalutamide. (renalandurologynews.com)
Methyl jasmonate enhances antioxidant activity and flavonoid content in blackberries (Rubus sp. (cdc.gov)

One of the Pharmacognosy dissertations focused on plant-derived natural products with potential anti-inflammatory and cancer chemopreventive activities. (nih.gov)

In vitro anticancer activity of some plants used in Moroccan traditional medicine. (academicjournals.org)

2,5-Disubstituted-1,3,4-thiadiazoles represent one of the most active classes of compounds possessing wide spectrum of biological activities. (ijpsonline.com)
Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp. (mdpi.com)
They play pivotal roles in regulation of various biological and pathological processes, including various cancers. (lu.se)
Digalloyl-resveratrol (di-GA) is a synthetic compound aimed to combine the biological effects of the plant polyhydroxy phenols gallic acid and resveratrol, which are both radical scavengers and cyclooxygenase inhibitors exhibiting anticancer activity. (nature.com)
Anthocyanins, flavanols, flavanols and resveratrol are the most important grape polyphenols because they possess many biological activities such as antioxidant, cardioprotective, anticancer, anti-inflammation, antiaging and antimicrobial properties. (oatext.com)
Flavonoids are the main groups of soluble phenolics in grapes as well as major contributors of the biological activities in products derived from grapes [10,11]. (oatext.com)
Therefore, it is paramount to understand the principles of biological activity, bioavailability and metabolism of grape flavonoids in relation to human health. (oatext.com)
Although there has been considerable progress in the research on G. procumbens , to date there is no review paper gathering the reported biological activities of G. procumbens . (frontiersin.org)
Hence, this review aims to provide an overview of the biological activities of G. procumbens based on reported in vitro and in vivo studies. (frontiersin.org)
The present review aims to provide an overview of the biological activities of G. procumbens with reference to the available literature. (frontiersin.org)
However, the presence of the ligand Phen-Se did not appear to have a significant effect either on G-quadruplex binding or on biological activity. (telomerescience.com)
SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)
Four different paclitaxel mimetics have successfully been synthesized and tested for their biological activity in five breast-derived cell lines. (lu.se)

Bosset JF, Collette L, Calais G. Chemotherapy with preoperative radiotherapy in rectal cancer. (novapublishers.com)
My research will add to more understanding to chemotherapy treatment of cancer. (uwindsor.ca)
Before the 1980s, fewer than 100 cases of PJP were reported annually in the United States, occurring in patients who were immunosuppressed (eg, cancer patients receiving chemotherapy and solid-organ transplant recipients receiving immunosuppressants). (medscape.com)

Several scientific researches have been focalized on anti-inflammatory, anti-proliferative, antioxidant and other pharmacological activities of parsley. (greenmedinfo.com)

GSE-related anti-cancer activity mostly relies on the induced increase in reactive oxygen species, followed by the orchestrated down- and up-regulation of several key-molecular pathways, including MAPK kinases, PI3K/Akt, NF-kB, cytoskeleton proteins and metalloproteinases. (oatext.com)

The agar well diffusion method was used to assess the antibacterial and antifungal activities of partially pure fungal taxol against human and fungal pathogens. (degruyter.com)
Frankincense is an aromatic resin obtained from trees of the genus Boswellia and has been hypothesized to exhibit a number of health supporting properties, including the treatment of rheumatoid arthritis and anti-inflammatory, antibacterial, antifungal and anticancer activities ( 5 - 8 ). (spandidos-publications.com)

Taken together, our data suggest that targeting S100A9 with tasquinimod results in a strong anti-tumor effect in pre-clinical models of MM. This effect is associated with reduced angiogenesis in the BM. (aacrjournals.org)

Recently published in Pharmacology & Therapeutics , a leading medical review journal in the field of pharmacology, the article chronicles the growth-suppressive activity of sustained-release capsaicin drugs, including solid dispersion systems, liposomes, phospholipid complexes, and nanoparticles. (worldhealth.net)
Targeted cancer therapeutics. (academicjournals.org)
Seema Patel, Arun Goyal, Recent developments in mushrooms as anti-cancer therapeutics: a review, 3 Biotech. (depkewellness.com)

These compounds have been characterized on the basis of elemental analysis, IR, 1 H NMR and MS. Compounds have been evaluated for their anticancer and antioxidant activities. (ijpsonline.com)
Most of the isolated natural compounds showed activity with these assays. (nih.gov)
Optimisation and characterisation of various extraction conditions of phenolic compounds and antioxidant activity in olive seeds. (academicjournals.org)
Supercritical CO2 extraction and purification of compounds with antioxidant activity. (academicjournals.org)
Determination of antioxidant activity was performed using the DPPH assay (1.1-diphenyl-2-picrylhydrazyl), FTC (ferric thiocyanate) and determination of phenolic compounds by Follin method. (blogspot.com)
The antioxidant activity of the FTC method was 80% to 108.3% hydrogen peroxide kidnapping, the DPPH method showed an EC50 3.97 mg/mL, the content of total phenolic compounds was determined by calibration curve gallic acid, resulting from 0.0005 mg/100 g of gallic acid equivalent. (blogspot.com)
In fact, three of the predicted compounds had thesame structure with known anticancer compounds(HSCORE=1). (edu.et)
Predicted compounds were also shown to havering structures and functional groups deemed important foranticancer activity.CONCLUSIONS: Given the findings, there is apromising anticancer activity by thetraditionally used medicinal plants and apotential for the predicted phytochemicals to bepursued as possible hits or me-too drugs. (edu.et)
A structure-activity relationship for the estimation of rate constants for the gasphase reactions of OH radicals with organic compounds. (cdc.gov)

Cancer, inflammation, and the evolution of antibiotic-resistant pathologies, together with other human diseases, are continuously stimulating the search for new bioactive molecules from natural sources. (frontiersin.org)
Breast cancer is one of the most common female malignancies in many industrialized countries and it comprises a remarkably heterogeneous group of diseases ( 1 ). (iiarjournals.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The dietary consumption of grape and its products is associated with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers. (oatext.com)
Cancer is a notable deadly disease involving such as fluorouracil, methotrexate and several other diseases. (who.int)

Here, using pre-clinical models of MM, we investigated the anti-tumor effect of tasquinimod. (aacrjournals.org)
The anti-tumor effect of tasquinimod was initially evaluated in vivo in a syngeneic MM model. (aacrjournals.org)
A novel series of 2-arylquinazolinones 7a-o bearing trans -stilbene moiety were designed, synthesized, and evaluated against human breast cancer cell lines including human breast adenocarcinoma (MCF-7 and MDA-MB-231) and human ductal breast epithelial tumor (T-47D). (irost.org)
Despite advances in the early detection of breast cancer and the advent of novel targeted therapies, there is still a high failure rate, mainly due to tumor invasion and metastasis ( 2 , 3 ). (iiarjournals.org)
Enhanced Anti-tumor. (cancertreatmentsresearch.com)
A novel recombinant human Frizzled-7 protein exhibits anti-tumor activity against triple negative breast cancer via abating Wnt/β-catenin pathway. (ac.ir)
The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a key enzyme in PGE 2 catabolism, converting it into its inactive metabolite 15-keto- PGE 2 , and is often down-regulated in cancer. (lu.se)

Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area. (academicjournals.org)
The study aimed to evaluate the antimicrobial activity, antioxidant, toxicity and phytochemical screening of the Red Propolis Alagoas. (blogspot.com)
Antimicrobial activity was evaluated by disk diffusion method. (blogspot.com)

The anticancer activity of betulinic acid and its 3- O -acylated derivatives were then evaluated in vitro against human lung carcinoma (A549) and human ovarian (CAOV3) cancer cell lines. (go.jp)
10 μg/ml against A549 cancer cell line tested and showed better cytotoxicity than betulinic acid. (go.jp)

The researchers found that human tumors with low VDR gene expression grew more rapidly and displayed reduced expression of proteins involved in promoting immune-mediated anti-cancer activity. (lecanadian.com)
Low VDR expression also corresponded to higher expression of genes that promote the growth and spread of cancer, particularly a gene cluster that controls a signaling pathway called Wnt/Beta-catenin. (lecanadian.com)
Evaluating the association of rs6983267 polymorphism of the CCAT2 gene with thyroid cancer susceptibility in the Iranian Azeri population. (cdc.gov)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)

Adhesion assay was realized on different protein matrices (fibrinogen, fibronectin and poly-L-lysine) and the anti-proliferative effect was performed. (greenmedinfo.com)
Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)

On the basis of fresh weight of fruit, Hull Thornless also had significantly higher anthocyanin, total phenolic content, antioxidant and antiproliferation activity than other two cultivars. (cdc.gov)

The human breast cancer cell lines SKBR3 and BT474 were obtained from American Type Culture Collection (Manassas, VA, USA). (iiarjournals.org)
Recent findings indicate that reishi mushrooms may increase NK cell cytotoxicity against cancer cell lines. (depkewellness.com)
More interestingly, combination treatment with either extracts A or B and cisplatin, significantly boosted the cytotoxic effect of cisplatin against the two cancer cell lines. (phcogj.com)
The effect of sFzd7 was evaluated on AGS gastric and SW480 colon cancer cell lines expressing high levels of Fzd7 receptor. (ac.ir)
15. Schmuck R, Warneke V, Behrens H-M, Simon E, Weichert W, Röcken C. Genotypic and phenotypic characterization of side population of gastric cancer cell lines. (ac.ir)

Previous studies have shown that myrrh exhibits cytotoxic, analgesic, anti-inflammatory, anticancer, antiparasitic and hypolipidemic activities ( 1 - 4 ). (spandidos-publications.com)

Cancer therapy with natural products and medicinal plants. (academicjournals.org)
BACKGROUND: The merits of ethnomedicine-led approachto identify and prioritize anticancer medicinal plants havebeen challenged as cancer is more likely to be poorlyunderstood in traditional medicine practices. (edu.et)
Thus, this study combined an ethnobtanical studywith ligand based in silico screening to identify relevantmedical plants and predict their anticancer potential based ontheir phytoconstiutents reported in scientific literatures.METHODS: First, relevant medicinal plants were identifiedthrough an ethnobotanical survey. (edu.et)
Then, theirphytochemicals were subjected to in silico evaluation, whichincluded a hybrid score similarity measure, rule of five, Ghose-Viswanadhan-Wendoloski (GVW)-indices and structural featurescriteria, to predict their anticancer activity and drugability.RESULTS: A total of 18 medicinal plants and 265phytoconstituents were identified. (edu.et)
Medicinal plants used by traditional medical practitioners (TMP) to treat cancers are considered safe when used alone or combined with conventional therapy to ensure their effectiveness and eliminate the toxic effects of orthodox medicines. (who.int)
Using cytotoxic and antioxidant studies, the study attempted to assess some of the commonly used medicinal plants used to cure cancer among Yoruba people in Ogun, Oyo, Osun, and Lagos (South-West, Nigeria). (who.int)

The MTT assay was used to examine the cytotoxic effects of fungal taxol against the human liver cancer cell line HepG2. (degruyter.com)
National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)

These findings indicate that the Ru-Se complex may be a potential telomerase inhibitor and a viable drug candidate in antiangiogenesis for anticancer therapies. (telomerescience.com)
FK866 ((E)-N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl) acrylamide ) is a well-known NAMPT ( nicotinamide phosphoribosyltransferase ) inhibitor with anti- cancer activities, but it failed in phase II clinical trials. (bvsalud.org)

Background: Little is known regarding the potentially chemopreventive activity of cyanidin-3-O-β-glucopyranoside (Cy-g), the main anthocyanin present in the juice of pigmented oranges, apart from its antioxidant activity. (iiarjournals.org)

These data suggest the ingestion of poha berries may have some effect on the prevalence of colon cancer. (nih.gov)
Cancer prevalence and its rate of incidence are constantly rising since the past few decades. (lu.se)

Ps-1Pb and Ps-2Pa (5μg/mL) significantly inhibit production of the anti-inflammatory cytokine IL-10 and the multifunctional cytokine IL-6 from lipopolysaccharide (LPS)-stimulated peritoneal macrophages from C57BL/6 mice and enhance the production of the pro-inflammatory cytokine IL-23 from both unstimulated and LPS-stimulated macrophages. (ulster.ac.uk)
NAC significantly recovered the decreased metabolic activity of HL-60 induced by 0.5 and 1 μM FBZ treatments. (kjvr.org)
Frizzled-7, the most common receptor of the Wnt signaling pathway, was significantly over-expressed in gastric (GC) and colorectal (CRC) cancers and stimulated tumorigenesis. (ac.ir)

Cancer Biol. (academicjournals.org)

L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)

More than 50 FK866 analogues were synthesized that introduce substituents on the phenyl ring of the piperidine benzamide group of FK866 and exchange its buta-1,4-diyl tether for 1-oxyprop-3-yl, (E)-but-2-en-1,4-diyl and 2- and 3- carbon tethers. (bvsalud.org)

Paclitaxel (taxol) is the most well-known taxane, and it is employed in the treatment of a wide range of human cancers, including ovarian, breast, lung, prostate, and head and neck cancers [ 6 ]. (degruyter.com)
The expression of CD44 and its variants is associated with poor prognosis in breast cancer. (iiarjournals.org)
In particular, the splice variants of CD44v6 are associated with aggressiveness of cancer and correlate with poor prognosis in breast cancer ( 11 ). (iiarjournals.org)
Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer. (depkewellness.com)
Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
At present, Taxol is used in the treatment of ovarian, breast and non-small cell lung cancer. (lu.se)

A strategy to overcome these drawbacks is the development of different delivery systems, such as encapsulating capsaicin in long-acting sustained release drug delivery systems could allow for more consistent capsaicin levels that could be more efficient as anti-cancer agents. (worldhealth.net)
Metformin, a widely used oral anti-diabetic drug, enhanced the anti-prostate cancer activity of abiraterone and enzalutamide. (renalandurologynews.com)
Our findings are basis of proposing 2HF as therapeutic or preventative drug for lung cancer. (oncotarget.com)
Ghost cancer cell fighting with anti-cancer drug under normal confocal microscopy and super-resolution STED. (lu.se)

In this multicenter phase 1 trial, we administered intravenous anti-PD-L1 antibody (at escalating doses ranging from 0.3 to 10 mg per kilogram of body weight) to patients with selected advanced cancers. (nih.gov)
Anti-PD-L1 antibody was administered every 14 days in 6-week cycles for up to 16 cycles or until the patient had a complete response or confirmed disease progression. (nih.gov)

8. Phesse T, Flanagan D, Vincan E. Frizzled7: a promising Achilles' heel for targeting the Wnt receptor complex to treat cancer. (ac.ir)

Prevention concluded that further in vitro testing of antiviral drugs exhibit in vitro anti-SARS-CoV activity. (cdc.gov)

With your help we are able to advance research, improve cancer education and connect patients with life-saving resources. (aicr.org)
Because metformin has been reported to reduce prostate cancer-related death in patients with prostate cancer and type 2 diabetes , researchers at the University of Maryland in Baltimore sought to explore the effects of metformin with abiraterone or enzalutamide in preclinical models. (renalandurologynews.com)
The authors noted that further studies are warranted to evaluate the clinically efficacy of metformin in combination with either of these agents in patients with prostate cancer. (renalandurologynews.com)
Clinical trials of ginseng as a treatment for Alzheimer's patients support its beneficial activity without side effects, demonstrating that ginseng might be a promising medicine for Alzheimer's disease. (novapublishers.com)
In patients treated for cancer in the head and neck region, a marked increase in Lactobacillus has previously been reported. (researchsquare.com)
The aim of this study was therefore to identify Lactobacillus isolates from patients with head and neck cancer and to determine their acid-producing capacity and anti-microbial activity. (researchsquare.com)
Conclusion: The most frequent species Lactobacillus species isolated from patients with head and neck cancer were L. paracasei, L. casei/rhamnosus and L. fermentum of which L. paracasei showed the best acid-producing capacity. (researchsquare.com)
In a recent study, the acid-producing capacity of 211 Lactobacillus strains isolated from patients with cancer in the head and neck region pre-treatment, during treatment and six and 12 months post treatment was analyzed. (researchsquare.com)
In addition, only a small percentage of products reach the market after clinical testing, making it difficult to produce much needed new treatments for cancer patients 1 . (nature.com)
Overexpression of FZD7 is associated with poor survival in patients with colon cancer. (ac.ir)
The recent epidemic has shown that knowledge is lack- allow rapid screening of commercially available antiviral ing regarding the clinical management and treatment of agents, enabling those with in vitro evidence of activity to infected patients. (cdc.gov)
Genetic markers associated with adverse reactions of radioiodine therapy in thyroid cancer patients. (cdc.gov)
Changes in antioxidant status and DNA repair capacity are corroborated with molecular alterations in malignant thyroid tissue of patients with papillary thyroid cancer. (cdc.gov)
Evaluation of ABO/Rh blood group distributions in papillary thyroid cancer patients. (cdc.gov)

This study will examine whether or not capsaicin can inhibit the spread of small cell lung cancer to distant organs, as well as how it works. (aicr.org)

Anticancer Effect in Human Glioblastoma and Antioxidant Activity ofL. (greenmedinfo.com)

Anatomy3

Organisms3

Diseases23

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Psychiatry and Psychology1

Phenomena and Processes18

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Named Groups1

Health Care15

Geographicals1

Inhibitory8

Antitumor activity4

Ovarian cancer5

20161

Cytotoxic activity4

Apoptosis8

Extract4

Doxorubicin3

Antioxidant and antitumor activities1

Colorectal cancer3

Inhibition6

Cells42

Potent4

Melanoma4

Enhances2

Potential anti-inflammatory1

Vitro anticancer activity1

Biological13

Chemotherapy3

Pharmacological activities1

Reactive oxygen1

Antifungal2

Angiogenesis1

Therapeutics3

Compounds9

Diseases5

Tumor7

Antimicrobial activity3

A5492

Gene4

Protein2

Phenolic1

Cell Lines5

Exhibits1

Medicinal plants6

Assay2

Inhibitor2

Chemopreventive1

Prevalence2

Significantly3

Biol1

Cytotoxicity1

Analogues1

Breast8

Drug4

Antibody2

Receptor1

Exhibit in vitro1

Patients14

Inhibit1

Glioblastoma1