• This review outlines the advantages and challenges of narrow-spectrum antibacterial agents, discusses the progress that has been made toward developing diagnostics to enable their use, and describes some of the narrow-spectrum antibacterial agents currently being investigated against some of the most clinically important bacteria including Clostridium difficile , Mycobacterium tuberculosis and several ESKAPE pathogens. (rsc.org)
  • Multi-drug resistance is a growing problem in the treatment of infectious diseases and the widespread use of broad-spectrum antibiotics has produced antibiotic resistance for many human bacterial pathogens. (mdpi.com)
  • During the last two decades, the number of antibacterial agents that have been discovered and introduced into the market has steadily declined and failed to meet the challenges posed by rapidly increasing resistance of the pathogens against common antibacterial drugs . (rsc.org)
  • This study was conducted to determine the Gram negative bacterial pathogens that infect the eyes of people whether wearing lenses or not & investigate the inhibitory effect of some antibiotics and compare them with the antibacterial effect of black & green tea extracts , honey (at 10%) and CFS of Lactobacillus casei that isolated from milk of healthy mother against the pathogens isolated from the eye by using the agar diffusion technique. (ijcmas.com)
  • With each new agent designed to overcome a resistance mechanism, pathogens inevitably establish new strategies to withstand the next antibiotic. (uspharmacist.com)
  • Few agents have been introduced since 2010 (TABLE 2) , and even fewer have activity against ESKAPE pathogens. (uspharmacist.com)
  • Antibacterial activity of Manuka honey has been documented for several bacterial pathogens, however there is no information on Clostridium difficile , an important nosocomial pathogen. (biomedcentral.com)
  • Though susceptibility of several bacterial pathogens to Manuka honey has been investigated, there is no data on C . difficile , and hence the current study investigated the antibacterial effect of Manuka honey against the organism. (biomedcentral.com)
  • METHODS Antibacterial activity was examined in vitro against a wide range of Gram negative and Gram positive pathogens. (bmj.com)
  • 21 22 To gain further insight into the mechanism by which resident bifidobacteria of the human microflora could exert a protective role against pathogens, we examined the antibacterial activity of bifidobacterium strains isolated from infant stools. (bmj.com)
  • Given the spectrum of causative bacterial pathogens, empirical therapy must be initiated with a broad spectrum regimen until smear or culture provides the identity of the causative organism. (bmj.com)
  • AKBA was found to be the most active compound showing an MIC range of 2-8 μg/ml against the entire gram positive bacterial pathogens tested. (biomedcentral.com)
  • Gram-positive bacterial pathogens such as Staphylococcus aureus , Streptococcus pneumonia and Enterococcus faecalis are clinically significant and the antibiotic resistance in these pathogens has become one of the major worldwide health problems. (biomedcentral.com)
  • Moxifloxacin is a new broad-spectrum antibacterial agent for treatment of respiratory tract infection of pathogens, including the major pathogens isolated in respiratory tract infections. (oup.com)
  • Common bacterial pathogens associated with the perpetuation of canine OE include Staphylococcus spp , Streptococcus , Pseudomonas, Proteus and Escherichia coli , with Staphylococcus pseudintermedius being the most frequent. (bmj.com)
  • The population genetics of drug resistance evolution in natural populations of viral, bacterial and eukaryotic pathogens. (bmj.com)
  • RESULTS Although the prevalence of bacterial pathogens decreased significantly with azithromycin treatment, a significant change in the distribution of specific bacterial pathogens could not be demonstrated. (bmj.com)
  • CF patients often receive antibiotics due to disease-associated susceptibility to bacterial infections by pathogens such as Pseudomonas aeruginosa and Staphylococcus aureus . (cysticfibrosisnewstoday.com)
  • While broad spectrum antibiotics play an invaluable role in the treatment of bacterial infections, there are some drawbacks to their use, namely selection for and spread of resistance across multiple bacterial species, and the detrimental effect they can have upon the host microbiome. (rsc.org)
  • Since ancient times, silver was known for its anti-bacterial effects and for centuries it has been used for prevention and control of disparate infections. (mdpi.com)
  • The considerable therapeutical problems of persistent infections caused by multidrug-resistant bacterial strains constitute a continuing need to find effective antimicrobial agents. (mdpi.com)
  • Whereas the natural agents that used in this study had higher inhibitory effect against bacteria that isolates from ocular infections than the selected antibiotics .Further in vivo studies for the confirmation the antibacterial effect of natural agents that were used in this study. (ijcmas.com)
  • Bacterial infections are best dealt with rapidly, but lab tests to determine the type of infection a patient has are slow. (medicalxpress.com)
  • It should be noted that about half of all drugs used to treat bacterial infections are beta-lactam antibiotics. (ahefv.com)
  • Therefore, to choose antibiotics for MRSA is much more difficult than for the treatment of other types of bacterial infections. (ahefv.com)
  • However, very often, MRSA is complicated by other types of bacterial infections. (ahefv.com)
  • They are effective in the prevention and treatment of bacterial infections, have saved the lives of millions of people and have become a significant breakthrough for medical science. (ahefv.com)
  • There was no effective treatment of bacterial infections prior to the discovery of antibiotics. (ahefv.com)
  • sexually transmitted infections: bacterial vaginosis, syphilis or gonorrhea. (ahefv.com)
  • C . difficile is an important nosocomial agent and currently accounts for 30-50% of hospital acquired infections with serious economic burden for many countries [ 3 , 4 ]. (biomedcentral.com)
  • The emergence of resistance to antimicrobial agents continues to evolve substantially, influencing the evaluation and treatment of infections in nosocomial and health care-associated settings and in the community. (biomedcentral.com)
  • Turmeric heals wounds and beneficial to keep bacterial infections at bay. (careinfo.in)
  • The supposed superiority of bactericidal agents over bacteriostatic agents is of little relevance when treating the vast majority of infections with gram-positive bacteria, particularly in patients with uncomplicated infections and noncompromised immune systems. (oup.com)
  • Despite the extensive use of antibiotic agents and the existence of vaccination programs, infectious diseases, particularly bacterial infections are still a major cause of death worldwide. (unimes.fr)
  • studies that assessed patients with broadly defined bacterial skin infections or pyoderma were included if results for patients with impetigo were reported separately. (bmj.com)
  • Targeting some elements in the bacterial cell wall can be an effective way to activate the immune system and fight chronic, treatment-resistant Pseudomonas aeruginosa infections, according to a study. (cysticfibrosisnewstoday.com)
  • Throughout the years, many antibacterial agents have been developed to help fight such life-threatening infections. (cysticfibrosisnewstoday.com)
  • Fighting treatment-resistant bacterial infections has become a major concern in the medical community. (cysticfibrosisnewstoday.com)
  • Spanish researchers have now evaluated the antibacterial potential of these immune-produced proteins - namely lysozyme and PGN Recognition Proteins (PGLYRPs) - to fight treatment-resistant infections. (cysticfibrosisnewstoday.com)
  • First only approximately one-third of AECOPD are due to bacterial infections. (bmj.com)
  • Researchers then tested three antibiotics - tobramycin , ceftazidime, and flucloxacillin - used to treat bacterial infections in CF. While the presence of tobramycin showed a dose-dependent effect on the growth rate of the strains, ceftazidime and flucloxacillin had highly variable results, leading to both higher and lower growth rates. (cysticfibrosisnewstoday.com)
  • Amoxicillin and clavulanate combination is used to treat bacterial infections in many different parts of the body. (biaxin2020.site)
  • Neo-Predef combines powerful anti-inflammatory, anesthetic, and antibiotic ingredients to treat ear and skin infections and conditions on cats, dogs, and horses. (vetdepot.com)
  • The emergence of bacterial resistance to commercial antibiotics is an issue of global importance. (rsc.org)
  • All natural agents showed varying effectiveness against the bacteria isolated from the eye , while the most of isolates were resisted to antibiotics , Honey & CFS of Lactobacillus casei were most effective against growth of all the test organisms. (ijcmas.com)
  • Owing to the substantial costs associated with drug development, the introduction of novel antibiotics has lagged behind the increase in bacterial resistance. (uspharmacist.com)
  • 9 As of June 2019, only 42 antibiotics were in clinical development, and just three in five agents entering phase III trials are approved. (uspharmacist.com)
  • Different types of antibacterials (except drugs included in the group of beta-lactam antibiotics) can be used to treat resistant staph infection. (ahefv.com)
  • If you want to buy antibiotics to treat MRSA at the lowest price, you can find cheap oral and IV antibacterials on online pharmacy. (ahefv.com)
  • When choosing antibiotics, such an important factor as the type of infectious agent should be considered. (ahefv.com)
  • The escalating trend of microbial resistance to essential antibiotics, especially multidrug resistance underscores the need for evaluating alternative potential therapeutic agents with antibacterial properties. (biomedcentral.com)
  • While the latest ESVAC reports presented data on the sales of veterinary antimicrobial agents (Grave and others 2012, ESVAC 2013), they provide little information on the diseases for which the antibiotics are being prescribed. (bmj.com)
  • Clinical response rates and bacterial eradication rates with moxifloxacin were not significantly affected by bacterial resistance to other antibiotics (i.e., penicillin, clarithromycin, or amoxicillin). (oup.com)
  • 1 Reports of such associations have raised the possibility that anti-infective treatments, such as a short course of antibiotics, might be able to prevent disease. (bmj.com)
  • Background The effectiveness of antibiotics in chronic obstructive pulmonary disease (COPD) exacerbations is still a matter of debate, especially in outpatients with an intermediate probability of bacterial infection. (bmj.com)
  • Conclusions We detected no evidence for the effectiveness of addition of antibiotics to prednisolone for COPD exacerbations of moderate severity and with intermediate probability of bacterial infection in this underpowered study. (bmj.com)
  • No evidence for effectiveness of addition of antibiotics to prednisolone for AECOPD with moderate severity and intermediate probability of bacterial infection was observed. (bmj.com)
  • 1-3 Management of AECOPD includes oral corticosteroids often combined with broad spectrum antibiotics to treat a presumed bacterial infection. (bmj.com)
  • 4 Some antibiotics, especially the macrolides, are also sometimes provided prophylactically for longer term use due to their anti-inflammatory, immunomodulatory or antiviral effects. (bmj.com)
  • 5 A short course of broad spectrum antibiotics during AECOPD is, however, mainly used for their antibacterial effect. (bmj.com)
  • Treatment of VZV pneumonitis includes respiratory isolation until skin lesions heal, intensive respiratory support, administration of antiviral agents, particularly acyclovir and related compounds, antibiotics, and active and passive immunisation. (bmj.com)
  • The evolution of pathogenic bacteria against commercially available antimicrobial agents has become a critical problem in modern era. (ijcmas.com)
  • Naturally occurring antibacterial agents are not able to overcome bacterial resistance, while Bacteriophages have a higher mutation and replication rate, so they can compete over the development of resistance of bacteria against antimicrobial agents. (ijcmas.com)
  • To address this crisis, pharmacists can take an active role in antimicrobial stewardship and foster understanding of how bacteria evade even the strongest available antimicrobial agents. (uspharmacist.com)
  • Unfortunately, bacteria adapt quickly, and the development of antimicrobial agents is truly a race against time. (uspharmacist.com)
  • 1 2 In 2014, it was estimated that China consumed 77 760 tons of antimicrobial agents for humans and the defined daily doses per 1000 inhabitants per day were approximately six times larger than in the UK, USA, Canada and Europe. (bmj.com)
  • Therefore, drugs for MRSA containing two antimicrobial agents have an extended range of antibacterial activity. (ahefv.com)
  • These antimicrobial agents will be covalently bound to a polymer matrix, to provide polymers with sustained antibacterial activity. (sbir.gov)
  • Antimicrobial agents and chemotherapy 2003;47(6):2030-5. (bmj.com)
  • Antimicrobial agents and chemotherapy 2016;60(6):3767-78. (bmj.com)
  • Incidence of suspected and documented mold infection, use of anti mold therapy, duration of hospitalization and death rate. (clinicaltrials.gov)
  • If the causative agent of the infection is known, the use of narrow-spectrum antibacterial agents has the potential to mitigate some of these issues. (rsc.org)
  • So if a doctor suspects a bacterial infection, she will probably prescribe a broad-spectrum antibiotic. (medicalxpress.com)
  • http://oto.sagepub.com/content/150/1_suppl/S1.long http://www.ncbi.nlm.nih.gov/pubmed/24491310?tool=bestpractice.com It is most commonly caused by bacterial infection. (bmj.com)
  • The type of antibacterial agent is chosen depending on the type of bacterium that caused the infection. (ahefv.com)
  • Relief of symptoms of bacterial infection occurs within a few days. (ahefv.com)
  • Acute infective conjunctivitis is an inflammation of the conjunctiva secondary to a bacterial or viral infection. (bmj.com)
  • A bacterial corneal ulcer was defined as an epithelial defect demonstrated by fluorescein staining, with a stromal infiltrate with or without a hypopyon and no other active ocular infection. (bmj.com)
  • Introduction Gonorrhoea is currently the second most common bacterial sexually transmitted infection and represents a serious public health threat. (bmj.com)
  • Serology -Anti-VZV IgM can be used to detect active disease, while the presence of anti-VZV IgG is a marker of previous infection/inoculation. (bmj.com)
  • respiratory failure may develop secondary to superimposed bacterial infection, with Streptococcus pneumoniae, Staphylococcus aureus, and Haemophilus influenzae commonly implicated. (bmj.com)
  • In the vaginal mucosa this response is a double-edged sword: it can help limit infection but may also lead to pathological damage and increased susceptibility to bacterial and viral infection. (virology.ws)
  • The outcome of this work may determine whether the use of antivirals to inhibit TVV replication, or anti-inflammatory agents, should accompany antibiotic therapy to prevent the complications associated with T. vaginalis infection. (virology.ws)
  • 9 Preventing further resistance requires not only persistent AMS to reserve existing agents, but also a fundamental understanding of antibiotic mechanisms of action and the strategies bacteria employ to resist these agents. (uspharmacist.com)
  • Among Gram-positive bacteria, the most prevalent causative agent of bacterial conjunctivitis, chloramphenicol sensitivity remains high. (bmj.com)
  • Ideally, new technologies should display broad spectrum activity against bacteria, viruses, fungi, etc. but should not encourage the emergence of antibiotic resistant bacterial strains. (sbir.gov)
  • When these compounds showed anti-bacterial activity against Salmonella and Francisella, we began testing efficacy against a variety of pathogenic bacteria, including Staphylococcus aureus, Enterococcus, and Streptococcus," said Chiu, who is now an assistant professor at the Department of Clinical Laboratory Sciences and Medical Biotechnology at National Taiwan University. (healthcanal.com)
  • Both surviving bacterial cell numbers and conjugant pair numbers were lower when ARB were PCD treated in final effluent from an urban wastewater treatment plant.In conclusion, the results of this study confirm the efficacy of PCD, but also highlight the importance of applying PCD treatment "long enough" to avoid post treatment recovery from sub-lethal injury and the highly undesirable transfer of antibiotic resistant genes amongst bacteria during wastewater treatment. (ulster.ac.uk)
  • The distinction between bactericidal and bacteriostatic agents appears to be clear according to the in vitro definition, but this only applies under strict laboratory conditions and is inconsistent for a particular agent against all bacteria. (oup.com)
  • The possible transmission of genes that encode the mechanisms of resistance between different bacterial species has led to the emergence of multiresistant bacteria. (unimes.fr)
  • 2 In addition to C trachomatis , azithromycin has antibacterial activity against many bacterial species including pathogenic bacteria that are routinely found in the conjunctiva. (bmj.com)
  • While Chlamydia has remained sensitive to macrolides and azalides including azithromycin, other bacteria may develop resistance, and there is some concern that large scale trachoma programmes may interfere with bacterial flora. (bmj.com)
  • The antibacterial activity of the oils was tested against standard strain Escherichia coli ATCC 25922 as well as 60 other clinical strains of Escherichia coli . (mdpi.com)
  • It became clear that these analogues had a unique anti-bacterial activity, and they appeared to be most potent against Staph aureus and other MRSA strains. (healthcanal.com)
  • The present study describes the antimicrobial activities of boswellic acid molecules against 112 pathogenic bacterial isolates including ATCC strains. (biomedcentral.com)
  • The majority (89%-97%) of the different bacterial strains with MICs for moxifloxacin ⩽2 mg/L were successfully eradicated. (oup.com)
  • Purpose The aim of the study is to compare the susceptibility to antibacterial agents of Escherichia coli strains isolated from adults and children. (bmj.com)
  • Overall, results showed that the antibacterial activity of these proteins alone was modest for the majority of the strains. (cysticfibrosisnewstoday.com)
  • The researchers tested two P. aeruginosa bacterial strains (named ATCC 27853 and ATCC 19429), and 10 different strains from the Scedosporium genus to test possible inhibitory or enhancing effects. (cysticfibrosisnewstoday.com)
  • The investigators chose these two bacterial strains based on their different phenotypes and sources of isolation (blood and urine samples, respectively). (cysticfibrosisnewstoday.com)
  • Results showed that physical contact inhibited both bacterial strains (about 60% inhibition) and fungal strains (100% inhibition). (cysticfibrosisnewstoday.com)
  • The researchers next assessed a possible indirect effect by diffusible media-soluble molecules from the two bacterial strains. (cysticfibrosisnewstoday.com)
  • While in direct physical contact, bacterial strains inhibited the fungal growth," the researchers wrote. (cysticfibrosisnewstoday.com)
  • Sulfonamides and urinary anti-infective agents were the antibiotic classes most likely to be prescribed without documentation. (bmj.com)
  • For successfully MRSA cure, this IV antibiotic can be administered in combination with other antibacterials from the rifamycin group (e.g. (ahefv.com)
  • When type of infectious agent is identified, a certain antibiotic is prescribed. (ahefv.com)
  • In total 185 (92.5%) of the 200 isolates expressed resistance to antibacterial agents. (biomedcentral.com)
  • Resistance of all bacterial isolates to chloramphenicol was 8.4% varying from 3.0% to 16.4% while that for ciprofloxacin and gentamicin was 16.4% and 14.0%, respectively. (bmj.com)
  • While chlamydia, the causative agent of trachoma, remains universally sensitive to azithromycin, there is concern that large scale programmes may alter the bacterial flora and induce resistance in streptococcal species. (bmj.com)
  • A single dose of azithromycin is extremely effective in eliminating the causative agent of trachoma, Chlamydia trachomatis , from an individual. (bmj.com)
  • The authors used culture media to isolate specific bacterial species, whose identification was performed with API 20 E galleries. (bmj.com)
  • In this study the effect of a single dose of azithromcyin on the prevalence, species distribution, and resistance of conjunctival bacterial flora was determined. (bmj.com)
  • Does a single dose of azithromycin alter the distribution of bacterial species found in the conjunctival flora? (bmj.com)
  • To evaluate the clinical efficacy and safety of topical polymyxin B, neomycin, and gramicidin for the treatment of suspected bacterial corneal ulceration at the Leiden University Medical Center. (bmj.com)
  • powder has powerful therapeutic efficacy on various bacterial and protozoal disease. (samu.co.kr)
  • Although bacteriostatic/bactericidal data may provide valuable information on the potential action of antibacterial agents in vitro, it is necessary to combine this information with pharmacokinetic and pharmacodynamic data to provide more meaningful prediction of efficacy in vivo. (oup.com)
  • Enrofloxacin, the main ingredient of Neotril-50 injection, is a quinolone-synthetic antibacterials containing fluorine(F) and that shows strong bactericidal efficacy against most of bacterial diseases like respiratory and digestive diseases caused by Mycoplasma as well as both of Gram-positive and Gram-negative like Actinobacillus, Pasteurella, E-coli, Salmonella, etc. (samu.co.kr)
  • Bacteriophages escaping from a dying bacterial cell (Streptococcus sp. (sciencephoto.com)
  • There are two types of bacterial resistance: intrinsic and acquired. (uspharmacist.com)
  • Two hundred and twenty-one (221) client-owned dogs of varying breeds with diagnosed bacterial and/or fungal OE were enrolled. (bmj.com)
  • When further testing two known bacterial signal molecules, called diffusible signal factor and pyocyanin, the researchers found that both molecules inhibited fungal germination (development from spores) and growth rate. (cysticfibrosisnewstoday.com)
  • This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development. (rsc.org)
  • A meta-analysis 2 concluded that while bacterial conjunctivitis is often self-limiting, antimicrobial use is associated with improved rates of clinical and microbiological remission. (bmj.com)
  • This effort yielded OSU-03012 (AR12), a compound that is currently in a Phase I clinical trial as anticancer agent at the OSU Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. (healthcanal.com)
  • Overall, 94% clinical success and 95% bacterial eradication was observed with moxifloxacin. (oup.com)
  • The distinction is more arbitrary when agents are categorized in clinical situations. (oup.com)
  • Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. (mdpi.com)
  • The antimicrobial polymer PHMB enters cells and selectively condenses bacterial chromosomes. (thefreedictionary.com)
  • Trichomonas vaginalis is a protozoan parasite that infects the genitourinary tract of ~250 million individuals each year, leading to bacterial vaginosis, increased susceptibility to human immunodeficiency virus (HIV) and human papillomavirus (HPV), and reproductive complications such as infertility, pregnancy loss, and preterm delivery. (virology.ws)
  • We characterized 200 S. aureus obtained from food handlers in different restaurants for antibacterial resistance and the carriage of virulence genes. (biomedcentral.com)
  • Therefore in the present study, we characterized S. aureus isolated from food handlers in Kuwait City restaurants for their susceptibility to antibacterial agents and the carriage of virulence associated genes. (biomedcentral.com)
  • In such cases, patients should be prescribed with drugs containing several antibacterial agents. (ahefv.com)
  • Treating patients with ozone therapy lessens the treatment time with an immense deal of variation and it eradicates the bacterial count more specifically. (thenakedscientists.com)
  • Design and setting Retrospective review of laboratory records for adult patients with suspected bacterial conjunctivitis between 2001 and 2012 attending the Royal Liverpool University Hospital. (bmj.com)
  • Participants Patients with suspected bacterial conjunctivitis. (bmj.com)
  • The medical records of all patients with a diagnosis of a suspected bacterial corneal ulcer between April 1995 and February 2002 were selected for retrospective review. (bmj.com)
  • This injectable drug includes antibacterial agents Dalfopristin and Quinupristin. (ahefv.com)
  • Treatment of the uncomplicated form is cleaning of the ear canal and application of topical anti-infective agents. (bmj.com)
  • Topical chloramphenicol remains a suitable first-line treatment for bacterial conjunctivitis. (bmj.com)
  • Prompt topical antimicrobial therapy is the cornerstone for successful treatment of bacterial corneal ulceration. (bmj.com)
  • On the basis of its broad antibacterial activity, we made the combination of polymyxin B, gramicidin, and neomycin the standard treatment of suspected bacterial corneal ulceration. (bmj.com)
  • Bacteriostatic agents (e.g., chloramphenicol, clindamycin, and linezolid) have been effectively used for treatment of endocarditis, meningitis, and osteomyelitis-indications that are often considered to require bactericidal activity. (oup.com)
  • 3 Treatment of canine OE frequently involves a variety of agents with antibacterial, antifungal and anti-inflammatory properties, the choice of which is most often driven by findings on otoscopic examination as well as cytological and/or culture results from ear canal exudates. (bmj.com)
  • For treatment of bacterial disease susceptible to Enrofloxacin in cattle, pig and dog, as follows - digestive disease like diarrhea due to coli-bacillosis and salmonellosis - respiratory disease due to Actinobacillus pleuropneumoniae, Pasteurella multocida, Mycoplasma hyopneumoniae, etc. (samu.co.kr)
  • The increased bacterial susceptibility to the combo treatment could result from particular changes in PNGs and their metabolism. (cysticfibrosisnewstoday.com)
  • CONCLUSION Repeated mass treatment of trachoma endemic areas with oral azithromycin will have an effect on bacterial flora. (bmj.com)
  • Susceptibility to antibacterial agents was determined by disk diffusion and Etest. (biomedcentral.com)
  • Although we previously studied the prevalence of staphylococcal enterotoxins in S. aureus isolated from food handlers in Kuwait city [ 10 ], their susceptibility to antibacterial agents were not investigated. (biomedcentral.com)
  • It was particularly gratifying to see that these compounds, originally designed as anticancer agents, work as a novel class of anti-bacterial agents based on the same principle in bacterial cells," said Chen. (healthcanal.com)
  • Antibacterial therapy is often indicated in bacterial scours due to E. coli and/or Salmonella. (revivalanimal.com)
  • It has been suggested that coronary heart disease may be associated with persistent bacterial or viral agents. (bmj.com)
  • Gepotidacin (GEP) is a novel, first in class triazaacenaphthylene antibacterial which inhibits bacterial DNA replication. (bmj.com)
  • AKBA can be further exploited to evolve potential lead compounds in the discovery of new anti-Gram-positive and anti-biofilm agents. (biomedcentral.com)
  • Re-Sorb ® does not contain antibacterial agents. (revivalanimal.com)
  • Some of the most effective oral drugs for MRSA are Bactrim, Cotrim, Septra, Sulfatrim, Sulmeprim (contain antibacterial agents Trimethoprim and Sulfamethoxazole), as well as Zyvox oral tablets (contain antibacterial agent Linezolid). (ahefv.com)
  • The team is already working with scientists at the Ohio State Center for Microbial Interface Biology, led by Dr. Larry Schlesinger, to use this technology to develop novel agents against tuberculosis, another public health threat facing similar issues with drug resistance. (healthcanal.com)
  • I would, however, argue that these authors' rational is based on vague assumptions and that robust evidence on the causality of the spread of antibacterial drug resistance in the community is needed before making such claim. (bmj.com)
  • 1995), and hypoglycemic, anticomplement and anti-HIV activities (Niyonzima et al. (bioline.org.br)
  • In addition, the silver nanoparticles are attracting much interest because of their potent antibacterial activity. (mdpi.com)
  • Acetyl-11-keto-β-boswellic acid (AKBA), which exhibited the most potent antibacterial activity, was further evaluated in time kill studies, postantibiotic effect (PAE) and biofilm susceptibility assay. (biomedcentral.com)
  • Galdiero, M. Silver Nanoparticles as Potential Antibacterial Agents. (mdpi.com)
  • Advantage of antibacterial cocktail drugs is that their active ingredients have different mechanisms of action. (ahefv.com)
  • He mixed together a unique combination of normal barrier cream , aloe vera, vitamin E and jojoba oil, and combined it with anti-bacterial agents and water repellent silicon. (thefreedictionary.com)
  • Interestingly, when the team used either lysozyme or PGLYRPs in combination with a permeabilizer compound (subinhibitory colistin - a compound that disrupts the permeability of the bacterial cell wall), the antibacterial activity was enhanced. (cysticfibrosisnewstoday.com)
  • In the oral cavity, NO is also formed via bacterial reduction of salivary nitrate to nitrite, mainly in the deep crypts in the posterior part of the tongue and subsequently via further chemical reduction of nitrite to NO. 10- 12 Thus, nitrite in the upper airways may serve an important host defence purpose, being a substrate for NO formation. (bmj.com)
  • The antibacterial activity of the aqueous, ethanol, methanol and petroleum ether Soxhlet extracts of sundried stem bark of Spathodea campanulata P. Beauv. (bioline.org.br)
  • The methanol extract showed the best antibacterial activity. (bioline.org.br)
  • This study was undertaken to determine the antibacterial activity of different extracts of S. campanulata using the standard antimicrobial zone of inhibition assay. (bioline.org.br)
  • Nitrate is reduced to nitrite by bacterial activity which takes place primarily in the oropharyngeal tract of healthy subjects. (bmj.com)
  • In spite of these therapeutic effects of boswellic acids, little is known about their antibacterial activity and the active principle responsible. (biomedcentral.com)
  • Increased uptake of propidium iodide and leakage of 260 and 280 nm absorbing material by AKBA treated cells of S aureus indicating that the antibacterial mode of action of AKBA probably occurred via disruption of microbial membrane structure. (biomedcentral.com)
  • 3. Being the most durable agent of all sulfonamides, it exerts sufficient therapeutic effect with just single dose per day. (samu.co.kr)
  • Bacterial conjunctivitis is common and often treated empirically with topical antimicrobials. (bmj.com)