• Many studies have also shown an important activity of silver nanoparticles against bacterial biofilms. (mdpi.com)
  • Photo credit: Zack Eagles / Vanderbilt By dosing strep cultures with a mixture of milk sugars and antimicrobial peptides from human saliva, the researchers also showed that the sugars' ability to break down biofilms can also enhance the effectiveness of the other antimicrobial agents that breast milk contains. (labmanager.com)
  • REP3123 is a new narrow spectrum antibacterial agent that in vitro prevents the growth of C. difficile by in hibiting an essential enzyme inthe bacterial cell called methionyl tRNA synthetase, which blocks the organism from synthesizing proteins. (emaxhealth.com)
  • In assays against M. smegmatis the Galf 9-heptadecyl thioglycoside was found to be the most active compound with an in vitro potency of 1 µg/mL, comparable to the frontline anti-TB drug ethambutol (1-4 µg/mL). (edu.au)
  • In addition, the thioglycoside displayed excellent broad spectrum Gram positive anti-bacterial activity in vitro, but was not active at concentrations below 64 µg/mL against a Gram negative organism. (edu.au)
  • At 0.5 times the MIC, REP3123 was the most effective agent at preventing the production of spores in all strains (equal to or less than 1% of spores after 96 hours of treatment). (emaxhealth.com)
  • Astrophysicist Steinn Sigurdsson said "There are viable bacterial spores that have been found that are 40 million years old on Earth - and we know they're very hardened to radiation. (wikipedia.org)
  • This perspective describes the historical development in brief and recent advances on the preparation of small organometallic compounds as new classes of antibacterial agents with potential for clinical development. (rsc.org)
  • For the purpose of investigating the requirement for a galactofuranose glycan moiety for anti-bacterial activity, the aglycons of the more active galactofuranosyl compounds (Chapter 2) were introduced onto alternate furanose sugars. (edu.au)
  • This series of compounds (containing either sulfenamide or sulfonamide functionality) were prepared to investigate the requirement of a carbohydrate moiety for anti-bacterial activity. (edu.au)
  • VS could inhibit the growth of S. aurous and E. coli , and adding glycine or EDTA improved VS antibacterial activity presumably via instability of the cell wall and enhanced transport of VS through bacterial cell wall. (hindawi.com)
  • Since the early steps of isoprenoid biosynthesis pathway (mevalonate kinase) in eukaryotes resemble bacterial isoprenoid biosynthesis and regarding the fact that VS inhibits the mevalonate pathway in eukaryotic organisms [ 10 ], we examined the effect of VS as a nonselective mevalonate kinase inhibitor on bacterial isoprenoid biosynthesis and its impact on bacterial growth. (hindawi.com)
  • Replidyne's antibacterial candidate REP3123 is shown to in hibit growth and prevent spore-forming of the Gram-positive Clostridium difficile (C. difficile) bacterium without inhibiting other key organisms that are essential for normal intestinal functioning. (emaxhealth.com)
  • Bacterial peptide deformylase, which catalyzes the removal of the N-formyl group from N-terminal methionine following translation, is essential for bacterial protein synthesis, growth, and survival. (dovepress.com)
  • In this way, can determine which substance has the best antibacterial effect and which concentration should be used inside implants to avoid bacterial growth. (austinpublishinggroup.com)
  • This chapter provides an overview of the antibacterial agents currently marketed in the United States, with major emphasis on their mechanisms of action, spectra of activity, important pharmacologic parameters, and toxicities. (asmscience.org)
  • With minimal projected side-effects, owing to the lack of Galf residues in mammalian systems, hydrolytically-stable Galf analogues were selected as promising targets for the development of potential therapeutic agents against Galf containing pathogenic micro-organisms. (edu.au)
  • It is not surprising that some of the enzymes involved in isoprenoids biosynthesis could be targets for the development of novel antibacterial agents. (hindawi.com)
  • Interference with the incorporation of Galf into this polysaccharide was expected to compromise the physical integrity of the bacterial cell wall leading to cell death. (edu.au)
  • This disclosure fails to provide long-lasting means for release of dentrifice or other agents since the liquid dentrifice would be washed from the oral cavity with each use. (google.com)