• Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. (wikipedia.org)
  • In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. (wikipedia.org)
  • The assembly of AQP4 monomers into tetramers is similar to other aquaporin channels. (wikipedia.org)
  • Conclusions Our data suggest that there is no need to routinely display anti-AQP4 antibody positive NMOSD individuals with a typical demonstration for onconeural antibodies. (healthyguide.info)
  • Pathogenetic antibodies focusing on the water channel protein aquaporin-4 (AQP4) are found in the majority of individuals with NMO [3]. (healthyguide.info)
  • Regarding to these modified criteria, an NMOSD diagnosis could be established in lack of anti-AQP4 antibodies also. (healthyguide.info)
  • Demographic and clinical data, including anti-AQP4 antibody status, were from individuals records. (healthyguide.info)
  • Eighteen (78.3%) were woman, and 13 (56.5%) were anti-AQP4 antibody positive. (healthyguide.info)
  • Serum anti-neuromyelitis optica (NMO)/aquaporin-4 (AQP4) antibody was positive and was confirmed by repeat serology (cell-based assay, Mayo Clinic). (neurology.org)
  • 11 ] Similarly, the seropositivity of Anti-MOG+ cases was 20% for AQP4 seronegative cases in the study. (lww.com)
  • Since the symptoms correlate with the location of the demyelinating lesion, it is often difficult to distinguish between multiple sclerosis (MS), aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder (AQP4-NMOSD), and monophasic acquired demyelinating syndrome (ADS). (annchildneurol.org)
  • Neuromyelitis optica-related disorder (NMORD) consists of a spectrum of diseases characterized by recurrent optic neuritis and/or myelitis, with most cases being associated with a pathogenic antibody against aquaporin-4 (AQP4-Abs) or antibodies targeting the myelin oligodendrocyte glycoprotein (MOG-Abs). (bioworld.com)
  • Preliminary study on the association of AQP4 promoter polymorphism with anti-aquaporin-4 antibody positivity in southern Han Chinese patients with idiopathic demyelinating disorders of central nervous system. (cdc.gov)
  • If you buy Antibodies supplied by MyBioSource they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Biotin conjugates can be detected by horseradish peroxidase, alkaline phosphatase substrates or anti biotin conjugated antibodies. (il-12p40.com)
  • Keywords: Aquaporin-4, Neuromyelitis optica spectrum disorders, NMOSD, Onconeural antibodies, Paraneoplastic Background Neuromyelitis optica (NMO) is definitely a rare, immune-mediated, demyelinating disorder of the central nervous system (CNS), typically showing with relapsing optic neuritis (ON) and/or? (healthyguide.info)
  • Paraneoplastic neurological syndromes (PNS) are remote control effects of cancer tumor and frequently are connected with high concentrations of so-called well-characterized onconeural antibodies (anti-Hu, Yo, Ri, CV2/CRMP5, Ma1, Ma2, and amphiphysin) that help establish the medical diagnosis [6]. (healthyguide.info)
  • However, CSF tested positive for anti-NMDA receptor antibodies (semiquantitative indirect fluorescent antibody, ARUP Laboratories). (neurology.org)
  • We report the diagnostic process of a rare patient with a combined central and peripheral demyelinating disease with antibodies against paranodal protein neurofascin 186 (anti-NF186)-the patient presented with weakness in both lower limbs. (neuralpress.org)
  • With antibody titers in the Ro52-seropositive SjS samples approximately 1,000 times higher than the healthy controls, not only was Ro52 the most informative, but detection of anti-Ro52 antibodies under these non-equilibrium conditions was improved compared to the standard 2 hour LIPS format. (biomedcentral.com)
  • We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. (frontiersin.org)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a severe autoimmune encephalitis mediated by anti-NMDA receptor antibodies. (biomedcentral.com)
  • Tissue or cell-specific expression of the Nek1 protein was never reported, since no anti-Nek1 antibodies were available then, and the association of Nek1 with pleiotropic abnormalities including PKD was not made in mice until later [ 4 ]. (biomedcentral.com)
  • We aimed to validate the prevalence of anti-aquaporin 5 (AQP5) IgG in a non-Korean cohort and to optimize the method to screen the anti-AQP5 IgG. (mdpi.com)
  • The third new patent granted in Canada (CA2975170) is on the use of OLEPENT ® cosmetic peptides in maintaining water hydration by increasing the expression of a water channel protein called aquaporin 5 (AQP5). (digezyme.com)
  • Tonicity-responsive enhancer-binding protein (TonEBP), which is also known as nuclear factor of activated T cells 5 (NFAT5), was discovered 20 years ago as a transcriptional regulator of the cellular response to hypertonic (hyperosmotic salinity) stress in the renal medulla. (nature.com)
  • Association Between the Single Nucleotide Polymorphism and the Level of Aquaporin-4 Protein Expression in Han and Minority Chinese with Inflammatory Demyelinating Diseases of the Central Nervous System. (cdc.gov)
  • She was treated with 1 g of methylprednisolone daily for 5 days followed by a prednisone taper without benefit. (neurology.org)
  • She received intravenous immunoglobulin (IVIG) at a dose of 0.4 g/kg for 5 days and methylprednisolone (30 mg/kg/day) for 3 days. (annchildneurol.org)
  • The patient was treated with methylprednisolone (1 g/day) for 5 days. (annchildneurol.org)
  • The discovery of NMDAR autoantibodies in 2007/8 by Josep Dalmau and his group and the since-emerging recognition and definition of Autoimmune Encephalitis (AE) for a widening spectrum of neurological disorders ( 4 , 5 ) have especially moved the field, because AE can be well diagnosed as a result of presenting with severe neurologic symptoms. (edupony.com)
  • A 52-year-old male with, known case of systemic hypertension with hypothyroidism, presented with urinary retention for 10 days, and progressive weakness of both lower limbs for 4−5 days. (vjim.org)
  • 2 3 4 5 6 ] However, a more recent population-based survey conducted in urban Mangalore has shown a prevalence of 8.3/100,000 for MS and 2.6/100,000 for neuromyelitis optic spectrum diseases (NMOSD). (lww.com)
  • Other performances that aquaporin-4 is involved in are synaptic plasticity, astrocyte migration, regulation of extracellular space volume, and the homeostasis of potassium. (wikipedia.org)
  • Validation of the anti-Ro52 QLIPS test in a new, independent cohort of SjS and control serum samples showed 66% sensitivity and 100% specificity. (biomedcentral.com)
  • Here we provide laboratory data that suggests imatinib affects aquaporin 2 (AQP2) expression proposing a theory behind imatinib associated FR. (asn-online.org)
  • Consequently, diagnostic criteria have been revised lately, introducing the word neuromyelitis optica range disorders (NMOSD) [5]. (healthyguide.info)
  • The idea that mild encephalitis (ME) may be under-recognized though clinically relevant for severe mental disorders (SMI) ( 2 ), was not well accepted when first published in 2001 ( 3 ), but is gaining more support now ( 3 - 5 ). (edupony.com)
  • Journal of neuroimmunology 2015 Sep 286 13-5. (cdc.gov)
  • Most important, the early stages of AE are associated with various and varying, initially pure psychiatric syndromes, with neurological symptoms appearing only later in more severe stages, in addition to psychiatric syndromes ( 4 , 5 ). (edupony.com)
  • Aquaporin-4's overall function is to provide fast water transportation as well as maintain homeostatic balance within the central nervous system. (wikipedia.org)
  • Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
  • It is known to upregulate Aquaporin-3, the important water & glycerin channels in the epidermis. (geekandgorgeous.com)
  • Serum paraneoplastic panel and anti-NMDA receptor antibody tests were negative. (neurology.org)
  • In very rare instances, anti-NMDA receptor encephalitis can present with a solitary brain lesion. (biomedcentral.com)
  • Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis was first described by Dalmau, et al. (biomedcentral.com)
  • We herein report a case of anti-NMDA receptor encephalitis initially presenting with focal seizures and. (biomedcentral.com)
  • However, thoracic spinal MRI shows T1 equal signal, and T2 high signal lesions in thoracic vertebrae 5-7 mainly involve white matter. (neuralpress.org)
  • Predicated on scientific records, NMOSD medical diagnosis was verified regarding to recently modified criteria [5]. (healthyguide.info)
  • 3 ] found that 74% of T2DM patients had one or more skin problems, with the highest amount being dry skin (47%), followed by infection (10%), diabetic foot (5%), hair loss, and diabetic dermopathy (4%), respectively. (hindawi.com)
  • A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. (wikipedia.org)
  • Aquaporin-4 is the most common aquaporin in the brain, spinal cord, and optic nerve. (wikipedia.org)
  • Expression and localization of aquaporins 3 and 7 in bull spermatozoa and their relevance to sperm motility after cryopreservation. (researchmap.jp)
  • the staining score was defined as sum of these scores used to categorize the AQP3 expression as negative (0 through 2), weak (3 through 5) or strong (6 or more). (dsmc.or.kr)
  • Results: A total of 180 (40.3%) patients were identified as AQP3-positive (staining score >2), including 86 (19.2%) cases of strong expression (stating score >5). (dsmc.or.kr)
  • Further, the unique ability of DMPBD to cause significant decrease in the expression of cell adhesion molecules (P-selectin, E-selectin and L-selectin) as evaluated by flow cytometric studies on pancreatic carcinoma cells, points to the molecule's specific function as an anti-metastatic agent. (digezyme.com)
  • A medium-amount of 5% Glycerin is enhanced by hydrators working in synergy with glycerin: a new-generation molecule called Isosorbide Dicaprylate and a sugar trio, trade named Aquaxyl, help the transportation of glycerin throughout the epidermis (by upregulating Aquaporin-3) and strengthen the skin barrier by stimulating the skin's own ceramide production. (geekandgorgeous.com)
  • Unlike cholesterol ,which is really just used for hydrating the skin and repairing the skin barrier, beta-sitosterol has uses in anti-aging products as well. (skintypesolutions.com)
  • A 7-year-old girl (patient A) visited the emergency room (ER) of a local hospital for diplopia, impaired vision, eye movement disorder, and mild neck stiffness that had lasted for 5 days. (annchildneurol.org)
  • After treatment, cells are washed, fixed, permeablized, and incubated with anti-aquaporin 2 antibody and Alexa Flor Goat anti-rabbit IgG 488. (asn-online.org)
  • Nek1 is a mammalian ortholog of the fungal kinase NIMA (never in mitosis A in Aspergillus nidulans ), which functions in DNA damage responses, regulates G2-M phase progression, and helps keep chromosome transmission to daughter cells faithful [ 5 ]-[ 10 ]. (biomedcentral.com)
  • The patent discloses a concentration-dependent in-vitro anti-tumorigenic activity of (E)-1-(3,4-dimethoxyphenyl) butadiene on cancer cells (pancreatic, prostate and ovarian carcinoma). (digezyme.com)
  • Materials Today Electronics , 5 , Article 100056. (au.dk)
  • Vella J, Zammit C, Di Giovanni G, Muscat R, Valentino M. The central role of aquaporins in the pathophysiology of ischemic stroke. (benthamscience.com)
  • The Aquaporin 4 antibody of the central nervous system indicates the disease is of an optic neuromyelitis pedigree. (neuralpress.org)
  • The aquaporin-4 tetramers accumulate to transform into orthogonal arrays of particle (OAPs) in the cell plasma membrane. (wikipedia.org)
  • Long-term changes in plasma anti-Müllerian hormone concentration and the relationship with superovulatory response in Japanese Black cattle. (researchmap.jp)
  • 5 Institute of Genetics and Department of Human Genetics, Zhejiang University School of Medicine, Hangzhou, China. (jci.org)
  • Many noncoding RNAs (ncRNAs) have been identified in asthmatic ASMCs in recent years [ 5 ]. (ersjournals.com)
  • Anticancer Research, 35(5), 2775-2782. (dsmc.or.kr)
  • Aside from AGEs and oxidative stress, DM is correlated with the disruption of anti-inflammatory response in which cytokine plays a key role [ 6 ]. (hindawi.com)
  • Role of aquaporin-4 in cerebral edema and stroke. (benthamscience.com)
  • [ 5 ] which means that a history of episodes of decreased vision in the same or the fellow eye may be elicited. (medscape.com)
  • Evidence that interferon-tau secreted from Day-7 embryo in vivo generates anti-inflammatory immune response in the bovine uterus. (researchmap.jp)