• Wild-type (wt) p53 has been demonstrated to repress the bFGF gene, while mutant forms of the protein can activate it in vitro ( 11 ). (rupress.org)
  • We are thus interested in exploring WMJ-S-001's anti-lymphangiogenic mechanisms in lymphatic endothelial cell (LECs). (frontiersin.org)
  • In keeping with these observations, trans -resveratrol, but not cis -resveratrol, inhibits α v β 3 integrin-dependent endothelial cell adhesion and the recruitment of enhanced green fluorescent protein-tagged β 3 integrin in focal adhesion contacts. (aacrjournals.org)
  • A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. (cancer.gov)
  • Much less is known about the biological activity of cis -resveratrol that appears to exert antioxidant ( 12 ) and anti-inflammatory ( 13 ) activities similar to those exerted by the trans form. (aacrjournals.org)
  • The protein also contains type II repeats with epidermal growth factor-like homology and type III repeats that contain an RGD sequence. (wikipedia.org)
  • A 34 amino acid synthetic analog of human parathyroid hormone-related protein (PTHrP) (PTHrP(1-34) analog), with bone-growing and bone density conserving activities. (cancer.gov)
  • This may have profound implications for the design of synthetic antiangiogenic/angiopreventive phytoalexin derivatives. (aacrjournals.org)
  • it is a component of metalloenzymes and acts as an electron donor or acceptor, while iron forms complexes with proteins, such as flavin-iron enzymes, transferrin, ferritin, myoglobin or hemoglobin (responsible for oxygen transport), and with enzymes involved in electron transfer and oxidation-reduction reactions [ 1 ]. (mdpi.com)