• As a derivative of EDTA, dexrazoxane chelates iron and thus reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. (wikipedia.org)
  • New discovery: By conducting a meta-analysis of four large breast cancer trials including nearly 3,000 patients, the researchers have discovered that an abnormality on chromosome 17, called CEP17, is associated with a worse outcome for patients, but also that its presence is a highly significant indicator that the tumour will respond to anthracyclines. (wikipedia.org)
  • Anthracycline-induced congestive heart failure (CHF) is a rare but serious toxicity associated with this commonly employed anticancer therapy. (aacrjournals.org)
  • As a derivative of EDTA, dexrazoxane chelates iron and thus reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. (wikipedia.org)
  • Although the study included only those who received anthracyclines as children, the mechanism would likely be the same in adults, which Bhatia said her group plans to study. (medpagetoday.com)
  • Amrubicin was the first anthracycline derivative created by de novo synthesis and was first published in 1989 by scientists from Sumitomo. (wikipedia.org)
  • Both retrospective and prospective data show that the anthracyclines only benefit women with amplification of both the HER2 receptor and the topoisomerase IIa gene (Topo IIa), Dr. Slamon told an oral session at the San Antonio Breast Cancer Symposium. (medpagetoday.com)
  • The reason, he said, is that the Topo IIa protein is a "major target" of the anthracyclines and the Topo IIa gene is amplified only in a minority of women who are also HER2-positive. (medpagetoday.com)
  • Anthracyclines increase survival for HER2-positive tumors but not neg. (bio-medicine.org)
  • But, in an accompanying editorial in the journal, Dr. Charles Geyer Jr. and his colleagues from the National Surgical Adjuvant Breast and Bowel Project in Pittsburgh, said that it may not be as simple as determining who should get anthracyclines based just on HER2 status. (bio-medicine.org)
  • If validated, the results suggest that those who would require lower doses of anthracyclines -- typically children with acute lymphoblastic leukemia or non-Hodgkin's lymphoma -- and test positive for the genotype might be considered for a different chemotherapeutic class, Bhatia said. (medpagetoday.com)
  • She and her colleagues found that the rates of heart failure among adult patients receiving anthracycline therapy were significantly lower when the patients had an infusion of the drug that lasted six or more hours, compared to shorter infusions times. (rxpgnews.com)
  • Herein, we present a genome-wide approach for biomarker discovery with two validation cohorts to predict CHF from adult patients planning to receive anthracycline. (aacrjournals.org)
  • According to a study presented at the 2016 ESMO Congress, a technically negative trial in high-risk adult soft tissue sarcoma nonetheless produced a significant survival benefit for anthracycline-based neoadjuvant chemotherapy. (targetedonc.com)
  • Peng X, Chen B, Lim CC, Sawyer DB (2005) The cardiotoxicology of anthracycline chemotherapeutics: translating molecular mechanism into preventative medicine. (springer.com)
  • Note that this study suggests that the benefit seen with anthracyclines is limited to a small proportion of women with two genetic changes. (medpagetoday.com)
  • Anthracyclines have four mechanisms of action: Inhibition of DNA and RNA synthesis by intercalating between base pairs of the DNA/RNA strand, thus preventing the replication of rapidly growing cancer cells. (wikipedia.org)
  • The genotype no longer appeared to impact outcomes at the highest cumulative anthracycline doses, though, Bhatia reported at a press conference in advance of her presentation at the American Society of Clinical Oncology meeting here. (medpagetoday.com)