Anthelmintic efficacy of ivermectin. Medical search. Frequent questions

Efficacy of albendazole (ABZ), levamisole (LVM) and ivermectin (IVM) against gastrointestinal nematodes (GIN) was evaluated in commercial goat farms in Gomba District, Uganda. (naro.go.ug)
Anthelmintic resistant cattle nematodes have been reported in different regions around the world. (thedairysite.com)
Emodepside belongs to a relatively new class of anthelmintics (depsipeptides) which achieve their antiparasitic effect against nematodes by a novel mechanism of action. (vin.com)
Its efficacy against gastrointestinal nematodes of cats has been extensively studied. (vin.com)
Importantly, emodepside was reported to show some efficacy against nematodes resistant to ivermectin, benzimidazoles, and levamisole in sheep, and nematodes resistant to ivermectin in cattle. (vin.com)
The study was conducted to investigate the efficacy of Albendazole, Tetramisole and Ivermectin for treatment gastrointestinal nematodes on naturally infected small ruminants. (cipav.org.co)
Efficacy of anthelmintics under study revealed that Albendazole, Ivermectin and Tetramisole had shown effective against gastrointestinal nematodes 95%, 97% and 99%, respectively. (cipav.org.co)
This study aimed to evaluate the efficacy of ivermectin, levamisole HCl and albendazole against gastrointestinal nematodes in naturally infected goats of government goat development farm, Sylhet, Bangladesh. (wayambajournal.com)
One injectable ivermectin (200Âµgkg-1 body weight, S/C) preparations (Techno Drugs Limited, Bangladesh) and two solid levamisole HCl, albendazole (7.5 mgkg-1 body weight, orally) preparations (Techno Drugs Limited and Square Pharmaceuticals Ltd, Bangladesh) were used for positive control of gastrointestinal nematodes as group A, B and C. Goats of group D was kept as control without giving any treatment. (wayambajournal.com)
The farm management practices along with results of the present study revealed the efficacy of multiple anthelmintic against gastrointestinal nematodes in goats. (wayambajournal.com)
regarding the seasonal presence of nematodes on pasture in temperate zones and anthelmintic efficacy, supports the use of dose-and-move strategies in temperate zones during summer and provides stochastic criteria for selecting the exact optimum time instant t (sub index 0) when these strategies should be applied. (ucm.es)
Lanusse, C. Clinical efficacy assessment of the albendazole ivermectin combination in lambs parasited with resistant nematodes. (ucm.es)
Donskow-Schmelter, K. Alternatives to anthelmintics for the control of nematodes in livestock. (ucm.es)
Roush, R.T. Slowing the spread of anthelmintic resistant nematodes of sheep and goats in the United Kingdom. (ucm.es)
Donald, A.D. The problem of anthelmintic resistance in nematodes. (ucm.es)
Then an overview of different techniques of in vitro and in vivo screening assays used to evaluate anthelmintic activity of the plant extracts against gastrointestinal nematodes is presented. (techagro.org)
In the present article, we will first review several isolation methods of different stages of parasite materials that are needed to perform in vitro bioassays and then an overview of different techniques of in vitro and in vivo screening assays used to evaluate anthelmintic activity of plant extracts against gastrointestinal nematodes is given. (techagro.org)
Use in young horses (under 2 years) as it has double action against nematodes and tapeworms due to the combination of the three actives ivermectin, praziquantel and pyrantel. (wanneroostockfeeders.com.au)
EQUIMAX ELEVATION Oral Paste for Horses has a double action against nematodes and tapeworms due to the unique combination of the three actives ivermectin, praziquantel and pyrantel. (wanneroostockfeeders.com.au)

After screening examination, a total of 80 small ruminant (36 Goats and 44 Sheep) were selected randomly, and grouped in to four treatment groups (n= 20) that is Albendazole, Tetramisole, Ivermectin and Control. (cipav.org.co)
However, the efficiency of Albendazole was lower than both Ivermectin and Tetramisole. (cipav.org.co)
Albendazole is a broad-spectrum anthelmintic. (medscape.com)
Keiser explains that WHO's twice-a-year mass administration of anthelmintic drugs (albendazole and mebendazole) to the population in Pemba rapidly reduces prevalence of helminth infections, but in the weeks and months after, people are simply re-infected back to the previous high levels. (swisstph.ch)
Adding ivermectin to albendazole has proven to be efficacious against the three common soil-transmitted helminth infections. (swisstph.ch)

10 Marketed under the tradename Profender®, this preparation is a unique combination of two active substances, emodepside and praziquantel: emodepside comes from a new class of active anthelmintic substances, while praziquantel, a convenient spot-on formulation for cats, controls cestodes. (vin.com)
Some products, like ZIMECTERIN® Gold (ivermectin/praziquantel), are backed by a 100 percent product satisfaction guarantee that can help make deworming decisions easier. (chronofhorse.com)
200 mcg ivermectin /kg bw (=91 mcg ivermectin per lb), and 1,5 mg/kg praziquantel /kg bw (0.68 mg praziquantel per lb) corresponding to 1.07g of gel per 100kg bodyweight in a single administration. (parasitipedia.net)
Read the articles on ivermectin safety and/or praziquantel safety in this site. (parasitipedia.net)
Broad Spectrum Allwormer The combination of ivermectin, pyrantel and praziquantel in EQUIMAX ELEVATION provides a broad-spectrum anti-parasiticide for total control of all equine worms, bots, lungworms, intestinal threadworms, tapeworms and skin parasites (summer sores and neck threadworms). (wanneroostockfeeders.com.au)

benzimidazoles/1-BZ (white drenches), levamisole/2-LV (yellow drenches) and macrocyclic lactones/3-ML (clear group including ivermectin, moxidectin and doramectin). (farmersjournal.ie)

Nansen, P. Anthelmintic resistance in nematode parasites of sheep in Denmark with special emphasis on levamisole resistance in Ostertagia circumcincta. (ucm.es)
Synergistic efficacy of anthelmintic combinations against nematode parasites of otherspecies has been reported and such strategies may be useful in the management of PE in horses. (edu.au)
Resistance to modern anthelmintics by ruminant nematode parasites is an increasing problem throughout the world. (fliphtml5.com)

In the district different anthelmintic drugs under different trade names and by different manufacturers were used to combat the problem encountered by parasitic diseases in small ruminant. (cipav.org.co)

In Ethiopia, various anthelmintics have been used in different parts of the country for the treatment of sheep and goats helminth parasites. (cipav.org.co)
This means that if this product does not achieve the expected efficacy against the mentioned parasites, it may be due to resistance and not to incorrect use, which is usually the most frequent cause of product failure. (parasitipedia.net)
Resistance of PE to macrocyclic lactones (MLs) is recognized in many countries and additional treatment options for these parasites are desirable to maintain the efficacy ofcontrol programmes. (edu.au)
Controls 39 stages of internal and external parasites with up to 99.9% efficacy. (angelopellets.com)
Generic Stromectol (Ivermectin) is used to treat infections brought on by sure parasites. (page.tl)
Dose confirmation and non-interference evaluations of the oral efficacy of a combination of milbemycin oxime and spinosad against the dose limiting parasites, adult cat flea (Ctenocephalides felis) and hookworm (Ancylostoma caninum), in dogs. (org.vn)
Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. (pharmaoffer.com)
Vermact contains the ingredient Ivermectin which is a substance that acts as a killing agent of malicious parasites. (hotmedz.com)

Faecal Egg Count Reduction Tests (FECRTs) for macrocyclic lactone (ML) and levamisole (LEV) drenches were conducted on two dairy farms in the subtropical, summer rainfall region of eastern Australia to determine if anthelmintic failure contributed to severe gastrointestinal nematode infections observed in weaner calves. (thedairysite.com)
Since the 1960s, there have predominantly been three classes of broad-spectrum anthelmintic drugs used to control helminths in mammals: benzimidazole/pro-benzimidazole (such as fenbendazole and febantel), tetrahydropyrimidines/imidazothiazoles (such as pyrantel, morantel/levamisole), and macrocyclic lactones (such as ivermectin and moxidectin). (vin.com)

Pour-on formulations of macrocytic lactones (eprinomectin, doramectin, ivermectin and moxidectin) are commonly used to treat different parasitic infections. (interchem.ie)
Individual systemic exposures to doramectin, ivermectin, and moxidectin in eight cows. (interchem.ie)
Holstein cows were housed on pasture and treated according to manufacturer recommendations with pour-on doramectin (2), ivermectin (2), moxidectin (2) or untreated (2). (interchem.ie)
1 In the case of doramectin, cow 2 received substantially less dose than the other treated cow and this raises substantial concerns for drug efficacy. (interchem.ie)
The AUC of doramectin for cow 2 was below the established efficacy level previously published. (interchem.ie)
Furthermore, the increase of avermectin and ivermectin-resistant insects has led to the development of a series of avermectin analogs including selamectin, abamectin, emamectin, and doramectin [ 5 ]. (biomedcentral.com)
Recent cases include: 8 ➤ A Georgia cow/calf herd suffering from severe gastroenteritis caused by ➤ In a study of 60 feedlot steers, cattle treated with CYDECTIN® (moxidectin) brown stomach worm (Ostertagia ostertagi) failed to respond to repeated had significantly lower strongyle egg counts and virtually no Ostertagia treatments of various avermectin dewormers, including ivermectin, infection, compared to animals treated with generic ivermectin.9 doramectin and eprinomectin. (fliphtml5.com)

While we have seen resistance in other anthelmintic classes,4 we had not seen it pop up in macrocyclic lactones until recently. (chronofhorse.com)
Tolerance of small strongyles to macrocyclic lactones (e.g. ivermectin , moxidectin ), manifested as a low but significant worm egg output after treatment (determined after fecal egg counts) is not yet widespread, but has been already reported in Europe (e.g. in the UK, Germany, Italy), the USA, and Brazil. (parasitipedia.net)
Resistance to macrocyclic lactones (e.g. ivermectin , moxidectin ) has been reported in the USA, UK and Australia. (parasitipedia.net)
These results demonstrate significant interindividual variability of drug exposure, resulting in underdosing based on previous studied efficacy levels for macrocytic lactones. (interchem.ie)

The prevalence of parasite populations resistant to commercial broad-spectrum anthelmintic drugs has been dramatically increasing and suggests the need to adopt new prophylaxis strategies. (techagro.org)

Ivermectin exerts its antiparasitic action by acting as a potent agonist at gamma-aminobutyric acid (GABA) receptors and potentiating the inhibitory signals sent to motor neurons, thus paralyzing the parasite. (medscape.com)
Consequently, the semisynthetic 22,23-dihydroavermectin B1 (ivermectin) (Fig. 1 ) was developed and introduced to the market for use as an antiparasitic agent [ 4 ]. (biomedcentral.com)
Ivermectin, an avermectin antiparasitic, has been recently identified to bind FXR-LBD and decrease serum glucose and cholesterol levels in mice 10 . (nature.com)

Anthelminthic agents include the macrocyclic lactone derivatives ivermectin and moxidectin, piperazine derivatives, and benzimidazole derivatives. (medscape.com)
Known allergy to study medications (i.e. benzimidazole or ivermectin). (who.int)

In a study of 42 female stocker calves, generic ivermectin products were significantly lesscattle overseas4, parasite resistance is now being documented with increasing frequency effective eight weeks post-treatment than a branded ivermectin dewormer.8in cattle in the United States. (fliphtml5.com)
Vermact 6 mg containing generic Ivermectin is a prescription pill and thus you need to take it by getting the consent of a doctor on their prescription. (hotmedz.com)
The 6mg dose of generic Ivermectin under the brand name Vermact is the base dose. (hotmedz.com)
It is a case where the Generic Ivermectin 6 mg becomes too much for your body to cope up with. (hotmedz.com)
Missing intake of doses at frequent intervals means that generic Ivermectin efficacy will become less. (hotmedz.com)

Additional studies in sheep, cattle, horses, and dogs have shown emodepside to display effective anthelmintic activity against trichostrongylids, ascarids, hookworms, trichocephalids, large and small strongyles as well as respiratory strongyles. (vin.com)

This essentially involves carrying out two faecal egg counts one or two weeks apart depending on the anthelmintic class used. (farmersjournal.ie)
2) evaluate the usefulness of a simplified faecal egg count reduction test (FECRT), where efficacies are based on the mean FECs of 10 at random collected faecal samples pre- and post-treatment per farm and (3) identify possible risk factors for reduced anthelmintic efficacy. (thedairysite.com)
Faecal egg count reduction test (FECRT) was used to monitor the evolution of ivermectin resistance on a Belgian cattle farm between 2006 and 2009. (thedairysite.com)
The effectiveness of the anthelmintics were evaluated by computing the mean faecal egg counts reduction for each treatment groups and 95% upper and lower confidence limits. (cipav.org.co)

It is registered to treat abamectin, moxidectin and ivermectin resistant ascarids. (wanneroostockfeeders.com.au)
These guidelines address transmission of intestinal ascarids and hookworms from dogs and cats to people and recommend counseling of dog and cat owners and well-timed preventive anthelmintic treatments for pets. (cdc.gov)

Sweeney, T. Gastrointestinal nematode infection in sheep-A review of the alternatives to anthelmintics in parasite control. (ucm.es)

Further studies are needed to clarify the state of efficacy of commonly used anthelmintics in the different farming systems in Uganda. (naro.go.ug)
We describe antitumor activities of vitamin E succinate (VES), an anti-oxidant and fenbendazole (FBZ), a commonly used veterinary anthelmintic. (researchgate.net)
a commonly used veterinary anthelmintic. (researchgate.net)
Anthelmintics belong to the pharmaceutical API subcategory used in the treatment of parasitic infections caused by helminths, commonly known as worms. (pharmaoffer.com)

Anthelmintic efficacy was determined by the Fecal Egg Count Reduction (FECR) test. (naro.go.ug)
This strategic approach to deworming entails administering anthelmintics (anti-parasite drugs) only as often as necessary to reduce fecal egg counts. (holistichorse.com)

Many anthelmintic compounds have been used in herpetological medicine. (vin.com)
Over time, some of these compounds were tested and became empirically recommended because of their efficacy and safety (Table 2). (vin.com)
1-3,5-9,12 Many references promoting the use of these anthelmintic compounds in reptiles are currently available. (vin.com)

The purpose of this study was to determine the efficacy of an abamectin (ABA) and morantel (MOR) combination(AMMO Allwormer) for the treatment of ivermectin (IVM) and ABA resistant PE. (edu.au)

Moxidectin, a macrocyclic lactone, is an anthelmintic indicated for the treatment of onchocerciasis due to Onchocerca volvulus in patients aged 12 years and older. (medscape.com)
The WHO has advised that it only be considered for the curative treatment of individuals in areas without transmission of onchocerciasis, in individuals leaving an endemic area, and in individuals with severe hyperreactive onchodermatitis if their symptoms are not adequately controlled with ivermectin. (medscape.com)
Critical reactions after mass remedy of onchocerciasis with ivermectin in an area endemic for Loa loa infection. (page.tl)

In horses, ivermectin is not labeled for control of encysted larval stages of small strongyles. (chronofhorse.com)
An analysis of five ranches with a history of IVM use was done to determine the efficacy and resistance of GIN to IVM treatment in horses from the Mexican southeast. (bvsalud.org)

Resistance to an anthelmintic class is identified if the treatment fails to kill at least 95% of worms present. (farmersjournal.ie)
The level of resistance varies hugely across farms, with some farms finding that upwards of 90% of worms have been killed by a treatment, whereas on the worst affected farms, the efficacy of treatment can be as low as 30% to 40%, or worse. (farmersjournal.ie)
The presence of ivermectin resistant Cooperia oncophora worms on this farm was first detected in 2006. (thedairysite.com)
It is important to maintain a diverse refugia of worms on farm as these will dilute any resistant worms which survive anthelmintic treatment, slowing down the development of resistance on farm. (moredun.org.uk)

The quicker resistance is identified, the more opportunities there will be to put a treatment programme in place in conjunction with your vet to try and prolong the lifetime use of these products and also protect anthelmintic classes which are effective, including the relatively new classes, monepantel/4-AD or orange drench and spiroindole/5-SI or purple wormer. (farmersjournal.ie)

By means of considering a number of age-dependent birth and death processes with killing, we analyse the impact of grazing strategies that are defined in terms of an intervention instant t0, which might imply a move of the host to safe pasture and/or anthelmintic treatment. (ucm.es)
There was no conclusive proof for a distinction in scientific effectiveness in terms of treatment or complete clearance between oral and topical ivermectin for the remedy of parasitic skin infections of scabies. (page.tl)

In 2005, an evaluation of the efficacy of heartworm preventive products was published by the Center for Veterinary Medicine, US Food and Drug Administration (FDA) that reported concerns of an increased number of reports by practicing veterinarians on lack of efficacy (LOE) of macrocyclic lactone (ML) preventive drugs [ 1 ]. (biomedcentral.com)

95%) of fecal eggs in all treated goats is indicative of anthelmintic resistance in the goat farming sector in Uganda. (naro.go.ug)

Horse paste contains 1.87% ivermectin. (angelopellets.com)

Stromectol tablets 3mg comprises ivermectin, an anthelmintic used to treat scabies, attributable to the parasitic mite Sarcoptes scabiei. (page.tl)

Laboratory-based assessment of insecticides efficacy was carried out using the method named "dosed contacting" using mature Musca domestica and 3-5days old laboratory and field species. (vetvrach-vnivi.ru)

Reduced efficacy was significantly associated with farm type and with a lower efficacy in beef herds compared to dairy herds. (thedairysite.com)

The aimof this work was to evaluate the efficacy of pyrethroid insecticides containing deltamethrin and cypermethrin against mature houseflies. (vetvrach-vnivi.ru)

In this study there were significantly fewer therapy failures within the ivermectin group at 7 days (26 sufferers seventy nine.three% cured with ivermectin in contrast with four 15.38% within the placebo group). (page.tl)
The global ivermectin (IVM) market size was significantly robust in 2021, and is expected to register rapid revenue CAGR over the forecast period. (reportsanddata.com)

However at the moment, the original ivermectin is quite expensive and not available for mass drug administration programmes for soil-transmitted helminths, but recently prequalified products might be a game changer. (swisstph.ch)
Anthelmintics act by either paralyzing or killing the helminths, thereby eliminating the infection. (pharmaoffer.com)
There are different classes of anthelmintics, each targeting specific types of helminths. (pharmaoffer.com)

Ivermectin and moxidectin should show a reduction of at least 95 percent. (holistichorse.com)

First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 195. (pharmaoffer.com)
Piperazine was first introduced as an anthelmintic in 195. (pharmaoffer.com)

This is an alarming situation, as the widespread use of ivermectin bears a risk of the emergence of drug resistance. (biomedcentral.com)

In conclusion, the results showed that a reduced efficacy observed in a FECRT are not only caused by AR but that the detection limit of the FEC technique used and the (in)correct administration of the anthelmintic drugs are confounding factors of major importance (El-Abdellati et al. (thedairysite.com)
These drugs may deserve to be tested for their efficacy in the control of prostate cancer using in vivo models. (researchgate.net)
Work is also ongoing to improve the efficacy of standard drugs using derivatives, or other formulations. (swisstph.ch)
For example, assisted by funding from the European Research Council, she is about to study the interplay between the human host microbiome and anthelmintic drugs. (swisstph.ch)
Strains of Dirofilaria immitis suspected of lack of efficacy (LOE) to macrocyclic lactone (ML) preventive drugs have been increasingly reported in dogs by practicing veterinarians since 2005 in the Lower Mississippi Delta region. (biomedcentral.com)

The milbemycins and avermectins are structurally related 16-membered macrolides with excellent anthelmintic and insecticidal activities (Fig. 1 ). (biomedcentral.com)
Another class is the avermectins, which includes ivermectin and moxidectin. (pharmaoffer.com)

NT005 trade name] is indicated together with ivermectin and/or diethylcarbamazine for the elimination of lymphatic filariasis. (who.int)

Additional detailed studies are required to clarify the current status of the efficacy of the anthelmintic widely used in different agro ecologies, animal species, and livestock management systems in Bangladesh. (wayambajournal.com)
In addition, we evaluated the efficacy of insecticides against flies in a livestock farm by comparing the number of insects in facilities before and after disinsection, which was carried out by treating the facilities with the aqueous solution or aqueous emulsion of preparations. (vetvrach-vnivi.ru)

Blood containing Mf from the canine field cases was used to infect and produce L 3 in Aedes aegypti for experimental infection of two groups of dogs, each of which contained two laboratory dogs, one treated with prophylactic ivermectin (12 μg/kg) monthly for 6 months at twice the label dose (6 μg/kg), and one untreated control. (biomedcentral.com)
stromectol interactions and intensity of Onchocerca volvulus an infection and efficacy of ivermectin in endemic communities in Ghana: a two-section epidemiological examine. (page.tl)
When using anthelmintics, it is crucial to follow the prescribed dosage and duration to ensure the effective elimination of the parasitic infection. (pharmaoffer.com)

There are only two marketed equine anthelmintics with an efficacy against S. westeri. (wikipedia.org)
Equine parasite resistance is becoming more of a concern as we continue to investigate how well each anthelmintic class and product is currently working," Dr. Cheramie says. (chronofhorse.com)

Eprecis® is the only injectable eprinomectin uniquely suited to be part of a sustainable anthelmintic strategy featuring zero milk withdrawal for the milking herd. (interchem.ie)

The use of anthelmintics has been practiced for a long time, and constitutes a considerable share of the costs spent by the country in the control of helminthosis (Biffa et al 2006). (cipav.org.co)
Traditional control of GIN has generated resistance to main anthelmintics, including ivermectin. (bvsalud.org)

Anatomy1

Organisms47

Diseases37

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment8

Phenomena and Processes3

Health Care5

Geographicals4

Nematodes19

Albendazole5

Praziquantel5

Benzimidazoles1

Nematode parasites3

Different anthelmintic1

Parasites8

Levamisole2

Doramectin7

Lactones4

Broad-spectrum1

Antiparasitic3

Benzimidazole2

Generic ivermectin5

Effective anthelmintic1

Faecal egg4

Ascarids2

Gastrointestinal nematode1

Commonly4

Fecal egg2

Compounds3

Morantel1

Onchocerciasis3

Horses2

Worms4

Wormer1

Treatment2

Veterinary1

Goats1

1.871

Scabies1

Assessment1

Lower efficacy1

Evaluate1

Significantly2

Helminths3

Reduction1

Piperazine2

Widespread1

Drugs5

Avermectins2

Diethylcarbamazine1

Livestock2

Infection3

Equine2

Eprinomectin1

Control2