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  • regulatory
  • Our data indicates that this motif has a significant regulatory function, modulating interactions with more N-terminal parts of the Hox protein, eventually triggering the rib-repressing program. (biologists.org)
  • The GnRH regulatory region contains four conserved homeodomain binding sites (ATTA) that are essential for basal promoter activity and cell-specific expression of the GnRH gene. (pubmedcentralcanada.ca)
  • structures
  • The main emphasis of the presentation in this paper is on a detailed account of the practical use of a novel strategy for the computation of nuclear magnetic resonance structures of proteins with the combined use of the programs DIANA, CALIBA, HABAS and GLOMSA. (rcsb.org)
  • Receptors
  • The attachment of a virion particle with the surface of an individual cell is based upon the interaction between cell surface receptors and the particles composing the capsid or proteins on the surface of the virion. (jyi.org)
  • evidence
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • structural
  • The numerous members of this family are organized in several subgroups according to structural identities found within the proteins. (harvard.edu)
  • thus
  • Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure. (labome.org)
  • domain
  • binding domain present within the protein. (uniprot.org)
  • PDP: protein domain parser. (rcsb.org)
  • Most notably, fusion of COG133 to a protein transduction domain creates COG112, a modified apoE-mimetic peptide with significantly enhanced anti-inflammatory bioactivities in vitro, and improved therapeutic effects on EAE in vivo, which renders a nearly full remission from the disability. (duke.edu)
  • MADS Domain Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • allow
  • When fluorescent tags are appropriately attached to proteins they allow for the detection of their environment and changes therein. (flvc.org)
  • target
  • a href='/help/protein_existence' target='_top'>More. (uniprot.org)
  • These include limits on the size and lifetime of synthesized proteins and enzymes, attaching the tag at the target location on a peptide chain which will take advantage of the photochemical properties of the tag, and developing molecules that will readily exhibit environment-sensitive fluorescence. (flvc.org)
  • expression
  • or (cb) said test compound, upon binding in step (b) modulates the expression and/or activity of said protein or, if present, said subunit(s). (patentsencyclopedia.com)
  • and(b) determining whether said test compound, upon contacting in step (a) modulates the expression and/or activity of said protein. (patentsencyclopedia.com)
  • 12. The method of claim 1, wherein, prior to said contacting, (a') an ototoxic agent and/or an agent increasing the activity and/or the expression of said protein or subunit(s), is brought into contact with said protein or subunit(s) is/are administered to said cell or said animal. (patentsencyclopedia.com)
  • found
  • Using a murine experimental autoimmune encephalomyelitis (EAE) model of human multiple sclerosis, we found that a peptidomimetic of apoE protein, COG133, substantially reduces the clinical symptoms of EAE and promotes remission from the disability when administered before or after onset of disease. (duke.edu)
  • method
  • 6. The method of any one of claims 1, 2 or 5, wherein modulation involves modulating the reactive oxygen species (ROS) production of said protein, and wherein determining in step (c) comprises quantifying ROS production. (patentsencyclopedia.com)
  • 8. The method of claim 1, wherein said protein and, if present, said subunit(s) is/are comprised in a membrane preparation. (patentsencyclopedia.com)
  • 10. The method of any of claim 1, wherein said protein and, if present, said subunit(s) is/are comprised in a non-human animal. (patentsencyclopedia.com)
  • several
  • Schmidt, M. Alexander 2017-02-01 00:00:00 Bacterial pathogens have developed intriguing virulence mechanisms, including several sophisticated nanomachines, for injecting effector proteins to manipulate host immune signaling pathways for their own benefit. (deepdyve.com)
  • small
  • We identified the presence of two small sequences flanking the homeodomain that are phylogenetically conserved among Hox10 proteins and that seem to be specific for this group. (biologists.org)