The US Food and Drug Administration (FDA) has approved Auvelity (dextromethorphan HBr -bupropion HCl) extended-release tablets for the treatment of major depressive disorder (MDD) in adults, the first and only oral N-methyl D-aspartate (NMDA) receptor antagonist approved for the treatment of MDD. (psychiatrictimes.com)
Auvelity's oral NMDA receptor antagonist and sigma-1 receptor agonist activity, which targets glutamatergic neurotransmission, provides clinicians a long sought after new mechanistic approach which may benefit the millions of patients living with this serious condition," said Dan V. Iosifescu, MD, professor of psychiatry at the New York University School of Medicine, and Director of the Clinical Research Division at the Nathan Kline Institute for Psychiatric Research. (psychiatrictimes.com)
1. Axsome Therapeutics announces FDA approval of AUVELITY™, the first and only oral NMDA receptor antagonist for the treatment of major depressive disorder in adults. (psychiatrictimes.com)
Background Ticagrelor can be an mouth platelet P2Con12 receptor antagonist that is recommended for sufferers experiencing myocardial infarction, both with and without persistent ST portion elevation. (bio-biz-navi.com)
Pancreatic β-cell IL-1 expression is increased and interleukin-1 receptor antagonist (IL-1Ra) expression reduced in patients with type 2 diabetes. (diabetesjournals.org)
7,11 Esketamine, an N-methyl D-aspartate (NMDA) receptor antagonist, an ionotropic glutamate receptor in the brain, was granted fast track review and a breakthrough therapy designation by the FDA. (ahdbonline.com)
7,11,12 This is the first NMDA receptor antagonist to receive FDA approval for treatment-resistant depression, with a new delivery system via a nasal spray. (ahdbonline.com)
The panel makes a conditional recommendation for interleukin (IL)-6 receptor antagonist monoclonal antibody treatment and high-flow nasal oxygen or continuous positive airway pressure in patients with hypoxaemic respiratory failure. (bvsalud.org)
NMDA2
The approval of Auvelity represents a milestone in depression treatment based on its novel oral NMDA antagonist mechanism, its rapid antidepressant efficacy demonstrated in controlled trials, and a relatively favorable safety profile. (psychiatrictimes.com)
Esketamine, the S-enantiomer of racemic ketamine, is a nonselective, noncompetitive antagonist of the NMDA receptor. (ahdbonline.com)
Dopamine2
Since adenosine A2A blocking drugs (antagonists) do not act directly on dopamine receptors, they may be able to reduce "off" time (changes in the ability to move as a levodopa dose wanes) by 30 to 60 minutes per day without worsening dyskinesia. (parkinson.org)
Dopamine antagonist medications treat this abnormality. (wikibooks.org)
Tumor5
Etanercept and infliximab are U.S. Food and Drug Administration-approved tumor necrosis factor (TNF) antagonists. (nih.gov)
Dysregulation of apoptosis of tumor cells plays an important role in the pathogenesis of pancreatic cancer and their resistance to therapies [ 5 ]. (oncotarget.com)
Methods: We present 2 patients with lymphocytic enterocolitis refractory to usual medical therapy who were treated with tumor necrosis factor antagonists. (johnshopkins.edu)
Conclusions: Tumor necrosis factor-α antagonists such as infliximab or adalimumab may be a new treatment option for patients with severe refractory lymphocytic enterocolitis not responding to corticosteroids. (johnshopkins.edu)
Radiolabeled antagonists of specific peptide receptors identify a higher number of receptor binding sites than agonists and may thus be preferable for tumor targeting. (bio-biz-navi.com)
Serotonin2
The standard antiemetic regimen currently recommended for prevention of chemotherapy-induced emesis includes a serotonin (5-HT3) antagonist and a corticosteroid. (brad.ac.uk)
[1] If this is not sufficient, a serotonin antagonist such as cyproheptadine may be used. (wikipedia.org)
Agonists4
Virtually all H1-antihistamines function as inverse agonists at the histamine H1-receptor, as opposed to neutral antagonists, as was previously believed. (wikipedia.org)
Objectives: Review of current evidence on potential differences regarding the cardiovascular risk profile of gonadotropin-releasing hormone (GnRH) agonists compared to GnRH antagonists. (uni-luebeck.de)
Overall, a decreased incidence of cardiovascular events was reported for GnRH antagonists compared to GnRH agonists. (uni-luebeck.de)
Conclusion: GnRH antagonists have a lower risk of treatment related cardiovascular events compared to GnRH agonists. (uni-luebeck.de)
Selective2
We first utilized two pharmacological brokers W146 a selective antagonist for S1P1 (Gaengel et al. (researchassistantresume.com)
The H2 antagonists are highly selective, do not affect the H1 receptors, and are not anticholinergic agents. (medscape.com)
Symptomatic3
The purpose of this study was to describe symptomatic sinus aspergilloma in RA patients treated with TNFα antagonists. (biomedcentral.com)
Among 550 RA patients treated with TNFα antagonists, six (1.1%) had symptomatic maxillary aspergilloma diagnosed by computed tomography before or during TNFα antagonist therapy. (biomedcentral.com)
With the approval of new products and the takeover of markets for obsolete symptomatic therapies, the neuroprotection market value will rise by the year 2025 when it will constitute a major and important component of the CNS market. (researchandmarkets.com)
Treatment18
TMX treatment enhanced efficacy of TRA-8 therapy on tumorigenesis in vivo . (oncotarget.com)
Is There a Role for 5-HT3 Receptor Antagonists in the Treatment of Opioid-Induced Pruritus? (nih.gov)
5-Hydroxytryptamine 3 (5-HT 3 ) receptor antagonists are potentially effective for treating OIP and may be a valuable treatment option if further controlled studies are encouraging. (nih.gov)
These individuals may need treatment with a psychologist in addition to speech therapy. (wikibooks.org)
In March 2019, the FDA granted Breakthrough Therapy designation for Auvelity for the treatment of MDD. (psychiatrictimes.com)
LN-145 is a ready-to-infuse, autologous TIL therapy that utilizes an autologous TIL manufacturing process, as originally developed by the NCI and further optimized by Iovance for the treatment of patients with metastatic NSCLC. (moffitt.org)
Patients of childbearing potential or those with partners of childbearing potential must be willing to practice an approved method of highly effective birth control during treatment and for 12 months after receiving all protocol-related therapy. (moffitt.org)
Furthermore, the majority of treatment failures in patients who received the NK1 antagonist occurred within the first 8¿12 h of chemotherapy, whereas the treatment failures in patients who received a 5-HT3 antagonist were more evenly distributed over time. (brad.ac.uk)
Background: Androgen deprivation therapy (ADT) plays a crucial role in treatment of advanced prostate cancer (PCa). (uni-luebeck.de)
In phase 3 clinical trials, we saw this therapy provide sustained improvement to patients with treatment-resistant depression. (ahdbonline.com)
Hormonal therapy is treatment that decreases the effect of testosterone on prostate cancer. (medlineplus.gov)
Because dual therapy with ceftriaxone plus azithromycin is the only recommended gonorrhea treatment, increases in azithromycin and cephalosporin MICs are cause for concern that resistance to these antimicrobial agents might be emerging. (cdc.gov)
The percentage of isolates with elevated cefixime MICs increased during 2009-2010, then decreased during 2012-2013 after treatment recommendations were changed in 2010 to recommend dual therapy (with a cephalosporin and a second antibiotic) and a higher dosage of ceftriaxone. (cdc.gov)
Subsequently, the treatment recommendations were changed again in 2012 to no longer recommend cefixime as part of first-line therapy (leaving ceftriaxone-based dual therapy as the only recommended therapy). (cdc.gov)
Therapy for HAE can be generally divided into 2 approaches, acute (or "on-demand") treatment of attacks and prevention of attacks, which is broken down into short-term prophylaxis (STP) and long-term prophylaxis (LTP). (ajmc.com)
7 The medications' FDA-approved indications (acute treatment or prophylaxis of HAE), availability as home therapy, pediatric age groups, and routes of administration (these may differ in other countries) are provided in Table 1 , 8,9 followed by summaries of the new guideline recommendations. (ajmc.com)
At the conclusion of the session, the participant will be able to describe Diagnostic and Statistical Manual of Mental Disorders 5th edition , DSM-5 assessment criteria for opioid use disorder, discuss the evidence for opioid use disorder medication assisted treatment with types of medications and settings used in medication assisted therapy. (cdc.gov)
The aim of this prospective comparative clinical study was to evaluate the effect of oral anticoagulants on peri- and post-operative bleeding during simple single tooth extractions , comparing patients in treatment with vitamin K antagonists (VKAs) and patients assuming direct oral anticoagulants (DOACs). (bvsalud.org)
Efficacy1
To evaluate the efficacy of opioid antagonists in promoting long-term smoking cessation. (cochrane.org)
Patients27
47 patients who developed new or worsening heart failure during TNF antagonist therapy. (nih.gov)
After TNF antagonist therapy, 38 patients developed new-onset heart failure and 9 patients experienced heart failure exacerbation. (nih.gov)
Ten patients younger than 50 years of age developed new-onset heart failure after receiving TNF antagonists. (nih.gov)
After TNF antagonist therapy was discontinued and heart failure therapy was started in these 10 patients, 3 had complete resolution of heart failure, 6 improved, and 1 died. (nih.gov)
In a fraction of patients, TNF antagonists might induce new-onset heart failure or exacerbate existing disease. (nih.gov)
Currently, liver transplantation is the only definitive therapy for cirrhosis and it is not available to most patients. (sbir.gov)
Patients with luminal inflammatory disease receiving IM or aTNF-based first maintenance therapy, following induction with steroids, exclusive enteral nutrition (EEN), or aTNF, were included. (ecco-ibd.eu)
In 2008, the Food and Drugs Administration required manufacturers of TNFα antagonists to strengthen their warnings about the risk of serious fungal infections in patients with rheumatoid arthritis (RA). (biomedcentral.com)
Before the introduction of TNFα antagonists, a retrospective study showed a twofold increase in the risk of serious infections among RA patients compared with non-RA patients [ 1 ]. (biomedcentral.com)
RA patients may experience reactivation of latent infection such as tuberculosis, which is the most commonly reported granulomatous infection in patients treated with TNFα antagonists [ 6 ]. (biomedcentral.com)
A recent warning issued by the Food and Drugs Administration and supported by the American College of Rheumatology Drug Safety Committee draws attention to histoplasmosis and other invasive fungal infections, including fatal cases, reported in RA patients taking TNFα antagonists (FDA Alert 9/4/2008). (biomedcentral.com)
Associations between aldosterone antagonist therapy and risks of mortality and readmission among patients with heart failure and reduced ejection fraction. (jamanetwork.com)
The cell transfer therapy used in this study involves patients receiving an NMA lymphocyte depleting preparative regimen, followed by infusion of autologous TIL, then finally followed by the administration of IL-2. (moffitt.org)
Using data obtained in 2 Phase II clinical trials of aprepitant in patients receiving chemotherapy based on the highly emetogenic chemotherapeutic agent cisplatin, we compared the time course of antiemetic effect of aprepitant, a 5-HT3 antagonist, or a combination of both. (brad.ac.uk)
Over the entire observation period (up to 7 days post-cisplatin), patients who received the NK1 antagonist had a superior prevention of emesis. (brad.ac.uk)
However, in the first 24 h after cisplatin, emesis occurred in fewer patients who received the 5-HT3 antagonist than in patients who did not receive this class of drug. (brad.ac.uk)
1. In 24 patients who were undergoing coronary arteriography for the assessment of ischaemic heart disease, the relationship between the systemic and coronary vascular responses to acute intravenous digoxin administration (500 μg) and concurrent drug therapy with the calcium antagonist verapamil (group I) or a β‐adrenoceptor antagonist (group II) or neither of these agents (group III) was examined. (biu.ac.il)
In this preliminary report, we aim to describe the epidemiology, clinical characteristics, and outcomes of adult critically ill COVID-19 patients, requiring invasive mechanical ventilation (iMV), and receiving IL-6RA and steroids therapy over the last 11 months. (biomedcentral.com)
On July 6, 2021, the World Health Organization (WHO) rapid evidence appraisal for COVID-19 therapies (REACT) working group developed a prospective meta-analysis of IL-6RAs in patients hospitalized for COVID-19 and showed that 28-day all-cause mortality rate was lower among patients who received IL-6RAs compared with those who received usual care or placebo [ 12 ]. (biomedcentral.com)
Dive into the research topics of 'Cardiovascular side effects in patients undergoing androgen deprivation therapy: superiority of gonadotropin-releasing hormone antagonists? (uni-luebeck.de)
These therapies act on different targets within the contact/kinin system (CKS) to reduce bradykinin production or its effects, decrease angioedema, and improve outcomes in patients with HAE. (ajmc.com)
7 While every patient with HAE should have access to on-demand therapy for acute attacks, not all patients require prophylaxis. (ajmc.com)
Current therapies to reduce obstruction, such as α1-adrenoceptor antagonists and 5α-reductase inhibitors, are not effective in all patients. (lu.se)
patients were enrolled following inclusion and exclusion criteria and divided into VKAs and DOAC group according to the anticoagulation therapy . (bvsalud.org)
Included patients underwent a simple single dental extraction with elevators and forceps with a maximum surgical time of 15 minutes, without anticoagulation therapy discontinuation. (bvsalud.org)
CLINICAL RELEVANCE Patients assuming DOACs can be treated similarly to patients in VKAs therapy with INR index between 2 and 3. (bvsalud.org)
Opioid10
This article reviews the current understanding of the mechanism of opioid-induced pruritus (OIP) and various pharmacological therapies. (nih.gov)
Opioid antagonists are a type of drug which blunts the effects of narcotics such as heroin and morphine, and might help reduce nicotine addiction by blocking some of the rewarding effects of smoking. (cochrane.org)
Our review identified eight trials of naltrexone, a long-acting opioid antagonist. (cochrane.org)
The available evidence does not suggest that opioid antagonists such as naltrexone assist smoking cessation. (cochrane.org)
Opioid (narcotic) antagonists are of particular interest to investigators as potential agents to attenuate the rewarding effects of cigarette smoking. (cochrane.org)
We searched the Cochrane Tobacco Addiction Group Specialised Register for trials of naloxone, naltrexone and other opioid antagonists and conducted an additional search of MEDLINE using 'Narcotic antagonists' and smoking terms in April 2013. (cochrane.org)
We considered randomised controlled trials comparing opioid antagonists to placebo or an alternative therapeutic control for smoking cessation. (cochrane.org)
We also reviewed, for descriptive purposes, results from short-term laboratory-based studies of opioid antagonists designed to evaluate psycho-biological mediating variables associated with nicotine dependence. (cochrane.org)
Anticholinergic1
They are effective in the relief of allergic symptoms, but are typically moderately to highly potent muscarinic acetylcholine receptor (anticholinergic) antagonists as well. (wikipedia.org)
Oral anticoagulants2
Spontaneous mediastinal hematoma during therapy with oral anticoagulants]. (pneumotox.com)
Should we fear direct oral anticoagulants more than vitamin K antagonists in simple single tooth extraction? (bvsalud.org)
Medications2
H1 antagonists, also called H1 blockers, are a class of medications that block the action of histamine at the H1 receptor, helping to relieve allergic reactions. (wikipedia.org)
Depression treatments on the horizon include new medications, electrical and magnetic stimulation of the brain and long-term cognitive behavioral therapy for stress management. (sciencedaily.com)
Antiemetic2
Advances in antiemetic therapy for chemotherapy-induced emesis have resulted in improved protection against symptoms occurring within 24 h of chemotherapy. (brad.ac.uk)
The neurokinin-1 (NK1) antagonist aprepitant represents a new class of antiemetic currently in clinical development. (brad.ac.uk)
Cancer10
Pancreatic cancer is highly malignant with limited therapy and a poor prognosis. (oncotarget.com)
We investigated the effects of calmodulin(CaM) antagonists, trifluoperazine(TFP) and tamoxifen(TMX), on TRA-8-induced apoptosis and tumorigenesis of TRA-8-resistant pancreatic cancer cells, and underlying mechanisms. (oncotarget.com)
Altogether, we have demonstrated that CaM antagonists enhance TRA-8-induced apoptosis of TRA-8-resistant pancreatic cancer cells by increasing DR5 expression and enhancing recruitment of apoptotic signal while decreasing survival signals in DR5-associated DISC. (oncotarget.com)
Our studies support the use of these readily available CaM antagonists combined with TRAIL-activating agents for pancreatic cancer therapy. (oncotarget.com)
The only potentially curative therapy for pancreatic cancer is surgical resection. (oncotarget.com)
Given the importance of Wnt signaling in ovarian cancer, more systematic studies combined with clinical studies are requisite to probe the precise mechanistic interactions of Wnt antagonists in ovarian cancer. (edu.au)
This review outlines the latest progress on the Wnt antagonists and ovarian cancer-specific regulators such as micro-RNAs, small molecules, and drugs regulating these Wnt antagonists in ovarian tumourigenesis. (edu.au)
Radiation therapy works best for treating prostate cancer that has not spread beyond the prostate. (medlineplus.gov)
Proton therapy is another kind of radiation therapy used to treat prostate cancer. (medlineplus.gov)
Hormone therapy is mainly used for cancer that has spread beyond the prostate, but it can also be used along with surgery and radiation to treat advanced cancers. (medlineplus.gov)
Initiation1
Early initiation of TNF-antagonist (aTNF) therapy for Crohn's disease (CD) is associated with greater clinical and endoscopic improvement but trialing an immunomodulator (IM) first remains common in paediatrics. (ecco-ibd.eu)
Heart Failure1
To describe adverse event reports of heart failure after TNF antagonist therapy. (nih.gov)
Clinical trials1
TRAIL-activating therapy has been promising, however, clinical trials have shown resistance and limited responses of pancreatic cancers. (oncotarget.com)
Emesis3
The difference in the time course of emesis blockade observed with two different classes of receptor antagonists provides substantial evidence for involvement of separate pathophysiological mechanisms in chemotherapy-induced vomiting. (brad.ac.uk)
Naylor, R.J., Aapro, M, Hesketh, P.J., Van Belle, S. (2003) Differential involvement of neurotransmitters through the time course of cisplatin-induced emesis as revealed by therapy with specific receptor antagonists. (brad.ac.uk)
H2 antagonist that may be a useful adjunct in reducing emesis volume. (medscape.com)
Symptoms5
Otorhinolaryngological symptoms must be evaluated before starting or switching TNFα antagonists. (biomedcentral.com)
In 1995, most persons who reported exposure to anticoagulant rodenticides did not develop symptoms or require specific therapy. (cdc.gov)
Symptoms typically resolved rapidly with atropine therapy. (cdc.gov)
Dosage and duration of calcium folinate rescue primarily depend on the type and dosage of methotrexate therapy, the occurrence of toxicity symptoms, and the individual excretion capacity for methotrexate. (janusinfo.se)
Behavioral change and drug therapy can help prevent or control symptoms. (msdmanuals.com)
Study5
This study aimed to determine if early aTNF is superior to IM maintenance therapy in paediatric luminal CD. (ecco-ibd.eu)
Among children with CD enrolled in the inception cohort study between 01/2014 and 12/2018, 464 met inclusion criteria and received IM (n=284) or aTNF (n=180 of whom 88 received steroids or EEN induction) as first maintenance therapy (Table 1). (ecco-ibd.eu)
We extracted data in duplicate on the study population, the nature of the drug therapy, the outcome measures, method of randomisation, and completeness of follow-up. (cochrane.org)
In their study, the researchers examined a range of NTSR1 antagonists to determine which one would be most effective for both imaging and therapeutic purposes. (medicalnewstoday.com)
Comparative Evaluation of Dimensional and Occlusal Accuracy of Non-Working Antagonist Casts: A Study on Dif. (medscimonit.com)
Anticoagulant2
Massive sublingual hematoma secondary to anticoagulant therapy complicated by a traumatic denture: a case report. (pneumotox.com)
Unusual complications in the course of anticoagulant therapy. (pneumotox.com)
Risks1
Risks should be minimized by taking known cardiovascular risk factors into account before initiating therapy. (uni-luebeck.de)
Inflammatory1
Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)
Cancers1
Brachytherapy may be combined with external beam radiation therapy for more advanced cancers. (medlineplus.gov)
Drug therapy1
Variability in vasomotor responses to digoxin is not clearly related to concurrent drug therapy with verapamil or a β‐adrenoceptor antagonist. (biu.ac.il)
Anticoagulation3
Sublingual haematoma: an unusual complication of oral anticoagulation therapy: about one case]. (pneumotox.com)
Upper airway obstruction by sublingual hematoma: a complication of anticoagulation therapy with acenocoumarol. (pneumotox.com)
Upper-airway obstruction as a complication of oral anticoagulation therapy. (pneumotox.com)
Infection1
Therapy should be initiated by a health care provider experienced in the management of HIV infection. (who.int)