AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHumanitiesInformation ScienceNamed GroupsHealth CareGeographicals
Periodicals as TopicJournal Impact FactorPharmacologyPharmacology, ClinicalPublishingBibliometricsJournalism, MedicalPeer Review, ResearchAuthorshipDatabases, BibliographicPublicationsAbstracting and Indexing as TopicBibliography as TopicObesityDose-Response Relationship, DrugHormone AntagonistsPeer ReviewBiomedical ResearchDopamine AntagonistsExcitatory Amino Acid AntagonistsNeurokinin-1 Receptor AntagonistsNarcotic AntagonistsLibraries, MedicalRats, Sprague-DawleyBooksHistamine H2 AntagonistsLibrary Collection DevelopmentPiperidinesMuscarinic AntagonistsInterleukin 1 Receptor Antagonist ProteinMEDLINEGABA AntagonistsManuscripts as TopicBook SelectionResearchLibrary SurveysHistamine H1 AntagonistsAccess to InformationPurinergic P1 Receptor AntagonistsNicotinic AntagonistsHistory, 20th CenturyHistamine AntagonistsAdrenergic alpha-1 Receptor AntagonistsPurinergic P2 Receptor AntagonistsRadioligand AssayConflict of InterestWritingCopyrightSerotonin 5-HT3 Receptor AntagonistsHistory, 21st CenturyAdenosine A2 Receptor AntagonistsRats, WistarThinnessTime FactorsReference BooksResearch ReportScientific MisconductBody WeightInterlibrary LoansAdenosine A1 Receptor AntagonistsSerotonin 5-HT2 Receptor AntagonistsLibraries, DigitalAllied Health OccupationsDisease Models, AnimalAdrenergic AntagonistsBinding, CompetitiveAngiotensin Receptor AntagonistsSerial PublicationsReceptors, SerotoninAdrenergic alpha-AntagonistsEvidence-Based MedicineInsulinGABA-A Receptor AntagonistsPyridinesLigandsBenchmarkingResearch DesignReview Literature as TopicTerminology as TopicLeukotriene AntagonistsReceptors, G-Protein-CoupledPubMedDrug IndustryScienceGuinea PigsSignal TransductionBlood GlucoseAdrenergic alpha-2 Receptor AntagonistsRandomized Controlled Trials as TopicJournalismDrug InteractionsAdrenergic beta-2 Receptor AntagonistsCalcium Channel BlockersBiphenyl CompoundsReceptors, EndothelinGuidelines as TopicReceptors, N-Methyl-D-AspartateCells, CulturedXanthinesCalcium
Angiotensin II typeTherapeuticsReceptorPhysiology and PharmacologyDiabetic ratsMolecular and Cellular CardiologyDiabetesFrontiersCardiomyocytesBiophysical JournalRenalGlucoseClinicalCardiovascularIncreasesFoodUniversityTreatmentLeadershipEffectsInternational JournalMouseDownloadMedicineAmerican JournalMember
Angiotensin II type1
  • Chronic overexpression of MT or acute in vitro treatment with the flavoprotein inhibitor diphenyleneiodonium or the angiotensin II type I receptor antagonist losartan eliminated excess ROS production in diabetic cardiomyocytes. (diabetesjournals.org)
Therapeutics2
Receptor3
  • It has high affinity to the μ-opioid receptor, but unlike structurally related drugs such as 3-methylfentanyl and OPPPP, LY-88329 is a potent opioid antagonist. (wikipedia.org)
  • Because the therapeutic potential of globally acting CB 1 receptor antagonists in these conditions is limited due to their neuropsychiatric adverse effects, the recent development of peripherally restricted CB 1 receptor antagonists may represent a novel pharmacological approach in treating renal diseases. (degruyter.com)
  • The present study examined the combined effects of an antihypertensive (S-Amlodipine) and an insulin-sensitizing agent, peroxisome proliferator-activated receptor (PPAR) agonists (Pioglitazone and Ragaglitazar), on cardiovascular risk factors in aged diabetic and insulin-resistant Zucker fa/fa rats. (biomedcentral.com)
Physiology and Pharmacology1
Diabetic rats1
Molecular and Cellular Cardiology1
  • Journal of Molecular and Cellular Cardiology. (ku.dk)
Diabetes2
  • In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
  • Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. (earthtokathy.com)
Frontiers1
Cardiomyocytes1
  • KCNQ channels are involved in the regulatory volume decrease response in primary neonatal rat cardiomyocytes. (ku.dk)
Biophysical Journal1
  • Biophysical Journal. (ku.dk)
Renal3
  • A single oral gavage of tofogliflozin increased renal glucose clearance and lowered the blood glucose level in Zucker diabetic fatty rats. (aspetjournals.org)
  • Telemetric oxygen-sensitive carbon paste electrodes were implanted in Sprague-Dawley rats (250-300 g), either in renal medulla (n = 9) or cortex (n = 7). (kahasciences.com)
  • Renal and glycemic effects of high-dose chromium picolinate in db/db mice: assessment of DNA damage Mahmood S. Mozaffari, Babak Baban, Rafik Abdelsayed, Jun Yao Liu, Hereward Wimborne, Nancy Rodriguez, Worku Abebe The Journal of Nutritional. (nwlifescience.com)
Glucose3
  • Tofogliflozin also improved postprandial glucose excursion in a meal tolerance test with GK rats. (aspetjournals.org)
  • No blood glucose reduction was observed in normoglycemic SD rats treated with tofogliflozin. (aspetjournals.org)
  • In combination, S-Amlodipine and Pioglitazone significantly reduced blood glucose (115.1 ± 6.6 vs. 81.7 ± 4.2), BP (184.4 ± 5.0 vs. 155.1 ± 5.0), serum triglycerides (362.5 ± 47.5 vs. 211.1 ± 23.7) and glucose intolerance when compared with vehicle treated Zucker fa/fa rats. (biomedcentral.com)
Clinical6
  • Professor Danhof has been selected as an outstanding candidate for this award, given his life-long commitment and exceptional achievements in the field of clinical pharmacology. (eacpt.org)
  • He received further specialist training in clinical pharmacology as a visiting scientist at Stanford University Medical Center between 1983-1986. (eacpt.org)
  • In addition to his many research accomplishments and numerous awards, Dr. Danhof has shown genuine leadership in clinical pharmacology. (eacpt.org)
  • His work has formed the very base of Clinical Pharmacology, and has shaped the profession of Clinical Pharmacology. (eacpt.org)
  • With this letter we would like to endorse the nomination of Prof. Dr. Meindert Danhof for the EACPT Prize 2021 for Lifetime Achievement in Clinical Pharmacology. (eacpt.org)
  • Professor Danhof has been selected by the Board of the Dutch Society of Clinical Pharmacology and Biopharmacy as an outstanding candidate for this award, given his life-long commitment and exceptional achievements in the field of clinical pharmacology. (eacpt.org)
Cardiovascular1
Increases1
  • Results show that both site-specific upregulation (pharmacological or chemogenetic) and chronic downregulation (RNA interference) of MCH communication to the vHP increases impulsive responding in rats, indicating that perturbing this system in either direction elevates impulsivity. (nature.com)
Food2
  • Wistar rats) [155], failed to influence food intake during a 1 h ad libitum feeding period, moderate to high doses of CBD (4.4 mg·kg −1 , i.p. [58]. (researchgate.net)
  • Furthermore, there was less body weight gain and food intake with S-Amlodipine and Pioglitazone combination in Zucker fa/fa rats. (biomedcentral.com)
University1
  • Shortly after his postdoctoral training, he joined the University of Leiden, where he now is Professor Emeritus of Pharmacology in both the Faculty of Science and the Faculty of Medicine. (eacpt.org)
Treatment2
  • Treatment with the gap junction modifier rotigaptide (ZP123) reduces infarct size in rats with chronic myocardial infarction. (ku.dk)
  • Filipović D, Inderhees J, Korda A, Tadić P, Schwaninger M, Inta D, Borgwardt S. Metabolic Fingerprints of Effective Fluoxetine Treatment in the Prefrontal Cortex of Chronically Socially Isolated Rats: Marker Candidates and Predictive Metabolites . (uni-luebeck.de)
Leadership1
  • Journal of Leadership and Organizational Studies. (montclair.edu)
Effects1
  • Nevertheless, the study performed by Merroun and colleagues [33] suggested the lateral hypothalamus-derived orexin A as a mediator of the anorexigenic effects induced by CB1 antagonist AM251 as well [33]. (researchgate.net)
International Journal1
Mouse1
  • Tofogliflozin competitively inhibited SGLT2 in cells overexpressing SGLT2, and K i values for human, rat, and mouse SGLT2 inhibition were 2.9, 14.9, and 6.4 nM, respectively. (aspetjournals.org)
Download1
  • rats and download Bestimmung von skills, &, and philosophy as a oil. (quietisolation.de)
Medicine1
American Journal2
Member2