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  • exposure
  • Transcript and protein levels of all five HDACs rose by 1.3-4.6 and 1.7-3.5-fold, respectively, in skeletal muscle in response to 20 h of anoxia exposure. (carleton.ca)
  • Overall translational activity of the mRNA pool [cpm 35S-methionine incorporated per microgram poly(A)+ RNA] was altered by anoxia exposure in three organs, increasing by 38 and 18% in liver and kidney and decreasing by 42% in red muscle. (carleton.ca)
  • Anoxia exposure also led to qualitative changes in the protein products that resulted from in vitro translation. (carleton.ca)
  • Sodium dodecyl sulphate polyacrylamide gel electrophoresis revealed the presence of a novel 19.5-kDa polypeptide in liver of anoxia-exposed animals as well as increased amounts of two other proteins at 28.6 and 79.9 kDa.In heart a new translation product of 26.8 kDa was produced during the aerobic recovery period after anoxia exposure. (carleton.ca)
  • Anoxia exposure did not change the proteins produced by in vitro translation in white muscle. (carleton.ca)
  • The results suggest that anoxia exposure triggers rapid cellular responses in T. s. elegans that modify translatable mRNA populations in organs, leading to new protein transcripts. (carleton.ca)
  • anoxic
  • Poly(A)+ RNA was extracted from liver, red and white skeletal muscle, kidney and heart of control and anoxic turtles, as well as from heart and kidney of turtles allowed 24 h aerobic recovery (at 15°C) after anoxia exposure. (carleton.ca)
  • Anoxia stimulated the appearance of a 37.5-kDa protein in red skeletal muscle but anoxic red muscle also lost proteins of 40, 32, and 28.2 kDa that were present in aerobic controls. (carleton.ca)
  • muscle
  • In addition, HDAC activity in the muscle increased by 1.5-fold in response to 20 h of anoxia and levels of acetylated histone H3 (Lys 9 or Lys 23) decreased to 40-60% of control values. (carleton.ca)
  • cellular
  • Key to surviving anoxia is the shutting off of energy-utilizing cellular activities, such as the synthesis of proteins and perhaps most importantly reducing the activity of energy intensive ion pumps," according to Leslie T. Buck, a physiologist at University of Toronto's Zoology Department. (eurekalert.org)
  • species
  • Small ncRNA profiles were broadly conserved among species under normoxic conditions, and these expression patterns were largely conserved during exposure to anoxia. (frontiersin.org)
  • NMDA
  • Mathew Pamenter, a graduate student in the lab, had the idea to investigate a relatively newly discovered potassium channel (mitochondrial KATP channel) as a possible regulator of NMDA receptor activity during anoxia. (eurekalert.org)
  • oxygenation
  • Fetal anoxia may occur from inadequate oxygenation of the mother, low maternal blood pressure, or abnormalities in the uterus, placenta, or umbilical cord that result in inadequate blood flow to the fetus. (britannica.com)
  • causes
  • Because anoxia causes significant amounts of distress to the cardiovascular and respiratory systems, it is essential to identify and treat the problem with haste. (medicalmalpracticehelp.com)
  • Another possibility is that anoxia in itself does not induce apoptosis, but that the following reoxygenation causes increased apoptosis. (uio.no)
  • effects
  • T.M. Bosley, P.L. Woodhams, R.D. Gordon and R. Balozs, Effects of anoxia on the stimulated release of amino acid neurotransmitters in the cerebellum in vitro . (springer.com)
  • main
  • These adaptations solve the main problem encountered during anoxia, which is to supply cells with enough ATP. (uio.no)
  • activity
  • During anoxia, the turtle depresses neuronal activity which allows the turtle to significantly reduce its metabolism and enter a comatose-like state. (springer.com)