• The results revealed that berberine treatment downregulated the serum expression of inflammatory factors, including interleukin (IL)‑6, tumor necrosis factor‑α, IL‑10 and IL‑17A in mice with anoxia‑reoxygenation injury. (spandidos-publications.com)
  • Berberine treatment also decreased myocardial cell apoptosis following anoxia‑reoxygenation injury via regulating the expression of apoptosis‑associated genes. (spandidos-publications.com)
  • The body weight, blood lipid levels, blood pressure and heart rate were markedly improved in mice with anoxia‑reoxygenation injury following berberine treatment compared with untreated mice. (spandidos-publications.com)
  • The expression of p38 mitogen‑activated protein kinase (MAPK) and nuclear factor (NF)‑κB expression was downregulated in myocardial cells from in mice with anoxia‑reoxygenation injury following berberine treatment compared with untreated mice. (spandidos-publications.com)
  • These results suggest that berberine may be an effective treatment for anoxia‑reoxygenation injury. (spandidos-publications.com)
  • The epaulette shark ( Hemiscyllium ocellatum ), crucian carp ( Carassius carassius ), western painted turtle ( Chrysemys picta bellii ), and leopard frog ( Rana pipiens ) were exposed to anoxia and recovery, and small ncRNAs were sequenced from the brain (one of the most anoxia-sensitive tissues) prior to, during, and following exposure to anoxia. (frontiersin.org)
  • Certain vertebrates, such as freshwater turtles of the genus Chrysemys and Trachemys and crucian carp (Carassius carassius), have anoxia-tolerant hearts that continue to function throughout prolonged periods of anoxia (up to many months) due to successful balancing of cellular ATP supply and demand. (biomedsearch.com)
  • In contrast, anoxia per se results in limited changes to cardiac AP shape or ion current densities in turtle and crucian carp, suggesting that anoxic modifications of cardiac electrophysiology to reduce ATP demand are not extensive. (biomedsearch.com)
  • The crucian carp (Carassius carassius) has an exceptional ability to tolerate anoxia, being able to survive without oxygen for several months at low temperatures. (uio.no)
  • The aim of this study was therefore to examine if anoxia, and/or subsequent reoxygenation, affect the incidence of apoptotic cell death in the brain of crucian carp. (uio.no)
  • Regardless, anoxia followed by reoxygenation does cause some damage in the form of increased levels of apoptosis in the crucian carp telencephalon. (uio.no)
  • In contrast, the crucian carp ( Carassius carassius ) and some North American freshwater turtles of the genera Trachemys and Chrysemys can survive anoxia for hours to months depending upon the temperature. (springer.com)
  • Although the turtle and the crucian carp have both evolved strategies for anoxia survival, the mechanisms by which each defends their brain energy levels differ considerably. (springer.com)
  • In contrast, the crucian carp up-regulates glycolysis with only a slight reduction in neuronal activity which allows the crucian carp to maintain a degree of physical activity during anoxia. (springer.com)
  • The adaptation of the crucian carp and the turtle to anoxia represents two contrasting strategies for anoxia survival which may allow for insights into novel targets for therapeutic intervention in the ischemic mammalian brain. (springer.com)
  • The crucian carp (Carassius carassius) is one of very few vertebrates that can tolerate several months completely without oxygen (anoxia), a trait that enables this fish to survive under the ice in small ponds that become anoxic during the winter. (uio.no)
  • We have here characterized RNR in crucian carp, to search for adaptations to anoxia. (uio.no)
  • However, the radicals in crucian carp RNR small subunits, especially in the p53R2ii subunit, were very stable at 0 °C. A long half-life of the tyrosyl radical during wintertime anoxia could allow for continued cell division in crucian carp. (uio.no)
  • The amount of apoptotic cells did not increase significantly after 7 days of anoxia (at 9 °C). However, when the anoxic fish were given 1 day of reoxygenation at normal oxygen levels, a 170 % increase in the number of apoptotic cells was detected. (uio.no)
  • Previous studies have found indications of cell division in this fish after 7 days of anoxia. (uio.no)
  • One possibility is that anoxia initiates apoptotic pathways in the brain without leading to actual cell death until oxygen is restored. (uio.no)
  • In this review, I will investigate the role of adenosine in the naturally anoxia-tolerant freshwater turtle and goldfish and give an overview of pathways by which adenosine concentrations are regulated. (nih.gov)
  • Besides the expected induction of genes encoding enzymes involved in Suc metabolism and alcoholic fermentation, a large number of genes not related to these pathways were affected by anoxia. (plantphysiol.org)
  • Multiple pathways are involved in the anoxia response of SKIP3 including HuR-regulated RNA stability, NF-kappaB and ATF4. (ox.ac.uk)
  • Temporal activation of the NF-kappaB pathway under anoxia protected cells from negative consequences of the oxygen stress and involved the canonical signalling pathways that promote IkappaBA phosphorylation and degradation, and reduced mRNA level of the inhibitory protein IkappaBA followed by the translational repression of IkappaBA. (ox.ac.uk)
  • Clarification of the mechanisms that contribute to cell death during hypometabolic states such as stroke and anoxia may lead to novel strategies for therapy. (springer.com)
  • Neuronal mechanisms of the anoxia-induced network oscillations in the rat hippocampus in vitro. (inserm.fr)
  • We have found that anoxia-induced network oscillations (ANOs, 20-40 Hz, lasting for 1-2 min) can be reproduced in the intact hippocampi of postnatal day P7-10 rats in vitro, and we have examined the underlying mechanisms using whole-cell and extracellular field potential recordings in a CA3 pyramidal layer. (inserm.fr)
  • Of species tested, C. macellaria withstood the longest period of anoxia ( LT 50 of 9 h at 20 o C). In contrast, C. vicina was the least tolerant (LT 50 of 2.2 h at 40 o C). Overall, survival of P. regina showed the least response and C. macellaria showed the greatest response to temperature. (unl.edu)
  • Our data show a sharp shift to lighter δ 238 U values at the LPME that persist through the Early Triassic period, which indicates a protracted period of anoxia. (confex.com)
  • Here, we show that anoxia reduces expression of thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, in glioblastoma cells. (rupress.org)
  • Together, our results show that anoxia induced a greatly reduced rate of heterotrophic metabolism in Ammonia tepida on a time scale of less than 24 hours, these observations are consistent with a state of dormancy. (epfl.ch)
  • The analysis of whole single specimens or of their successive chambers may provide essential information about short-term environmental variability and/or the causes of anoxia. (biogeosciences.net)
  • Hearts from the reserpine-treated rats had higher left ventricular pressures, maximal rate of left ventricular pressure rise, and lactate output after 2 minutes of anoxia than the hearts from control rats. (ahajournals.org)
  • The protective effects of diltiazem were studied in isolated perfused rat hearts after 10, 20 and 30 minutes of anoxia and 10 minutes of reoxygenation. (onlinejacc.org)
  • Axon function in both WM tracts is resistant to anoxia with a subset of axons able to survive exclusively on energy generated by glycolysis. (begellhouse.com)
  • Although in 10 mM glucose, MONs and CC slices exhibit identical resistance to anoxia, 30 mM glucose unmasks the greater resistance of CC axons suggesting unmyelinated axons and/or the smallest axons with the thinnest myelin sheath are resistant to anoxia. (begellhouse.com)
  • These studies demonstrate that both marked and minor elevations in cardiac glycogen are associated with greater glycolytic reserve and improved mechanical resistance to anoxia. (ahajournals.org)
  • Activating transcription factor 4 (ATF4) is a mediator of the UPR and activates a gene expression program, promoting tumour growth and survival under anoxia. (ox.ac.uk)
  • Anemic anoxia takes place where there is not enough hemoglobin in a person's blood, or the hemoglobin present has become ineffective. (medicalnewstoday.com)
  • Anemic anoxia occurs when your blood can't carry enough oxygen around your body to keep your organs functioning properly. (healthline.com)
  • This lack of oxygen can cause anemic anoxia. (healthline.com)
  • Anemic anoxia results from a decrease in the amount of hemoglobin or RBCs in the blood, which reduces the ability to get oxygen to the tissues. (thefreedictionary.com)
  • Persistent environmental stresses such as hyperwarming and ocean anoxia may have delayed the biotic recovery [1,2, (confex.com)
  • In order to characterize the duration and extent of ocean anoxia after the LPME, we have measured the U isotope composition (δ 238 U) - a proxy for global ocean anoxia - in well-preserved marine carbonates across the Late Permian to the Middle Triassic at Zal (Iran). (confex.com)
  • The nature of the protracted global ocean anoxia might be a key and direct factor that caused the delayed biotic recovery from the LPME. (confex.com)
  • This impact of bioturbation on global biogeochemistry likely affected animal evolution through expanded ocean anoxia, high atmospheric CO2 levels and global warming. (tudelft.nl)
  • The results showed that rice, a species highly tolerant to anoxia, can readily break down starch under anaerobiosis concomitant with germination, while wheat does not germinate and fails to degrade starch present in the endosperm. (nih.gov)
  • Small ncRNA profiles were broadly conserved among species under normoxic conditions, and these expression patterns were largely conserved during exposure to anoxia. (frontiersin.org)
  • It has been reported that both anoxia and the transition from anoxia to re-oxygenation determine a strong imbalance in the cellular redox state involving the production of reactive oxygen species (ROS) and nitric oxide (NO). Plant cell cultures can be a suitable system to study the response to oxygen deprivation stress since a close control of physicochemical parameters is available when using bioreactors. (frontiersin.org)
  • Overall, the evaluation of cell defenses during anoxia and re-oxygenation in Arabidopsis cell cultures revealed that the immediate response involving the overproduction of reactive species activated the antioxidant machinery including ascorbate-glutathione system, α-tocopherol and the ROS-scavenging enzymes ascorbate peroxidase, catalase, and peroxidase making cells able to counteract the stress toward cell survival. (frontiersin.org)
  • From the results presented in this thesis and elsewhere, it is concluded that-the immediate cause of seedling death during anoxia is a shortage of substrate for glycolysis, and that the additional effect of ethanol accumulation in some species may reduce their subsequent rate of recovery. (st-andrews.ac.uk)
  • In anoxia, why can't humans be more like western painted turtles? (eurekalert.org)
  • Certain freshwater turtles and fish are extremely anoxia-tolerant, capable of surviving hours of anoxia at high temperatures and weeks to months at low temperatures. (nih.gov)
  • Apoptosis has been shown to be involved in mitochondrial dysfunction, and upregulating expression of SIRT1 can inhibit the apoptosis of cardiomyocytes induced by anoxia/reoxygenation (A/R). Therefore, the aim of this study was to test whether the protective effects of Cap against the injury to the cardiomyocytes are mediated by SIRT1. (hindawi.com)
  • Anoxia/reoxygenation (A/R) injury refers to a phenomenon in which ischemia/reperfusion (I/R) myocardial tissues aggravate the injury to myocardial structures and functions [ 1 ], which can lead to arrhythmia, heart hypofunction, cardiomyocyte apoptosis, and other disorders [ 2 ]. (hindawi.com)
  • Another possibility is that anoxia in itself does not induce apoptosis, but that the following reoxygenation causes increased apoptosis. (uio.no)
  • Despite the frequent inflows to the Baltic Sea during the period 2014-2016 approximately 18% of the bottom area was affected by anoxia and 28% by hypoxia during 2017. (smhi.se)
  • 2017. https://nursing.unboundmedicine.com/nursingcentral/view/Tabers-Dictionary/746744/all/anoxia. (unboundmedicine.com)
  • Low temperature pre-conditions fish heart for prolonged anoxia by changes in activity of excitation-contraction coupling genes and thereby allows sustained bradycardia and prolongation of ventricular action potential when oxygen shortage sets in. (biologists.org)
  • RNA interference was used to screen DAF-16-regulated genes that suppress the daf-2(e1370) -enhanced anoxia-survival phenotype. (genetics.org)
  • Genes induced (D) or repressed (E) by anoxia were plotted on the basis of their fold change following the anoxic treatment (horizontal axis) and the heat + anoxia treatment (vertical axis). (plantphysiol.org)
  • Red dots represent genes induced or repressed by either anoxia or heat, while blue dots represent genes that were not found to be heat responsive. (plantphysiol.org)
  • A, Heat map showing the expression of anaerobic genes showing a reduced expression in the combined heat + anoxia treatment. (plantphysiol.org)
  • Anoxia-induced Suc synthases showed a lower induction in presence of exogenous Suc, suggesting that induction of these genes might be related to an anoxia-dependent sugar starvation. (plantphysiol.org)
  • Hyperbaric oxygen therapy has been used in a number of conditions characterized by global ischemia (as opposed to focal ischemia of stroke), and anoxia, and leading to impairment of consciousness. (hbot.com)
  • Cell injury during periods of ischemia, hypoxia, or anoxia and reperfusion is caused not only by the loss of energy supply caused by deprivation of oxygen and glucose but also by oxidative stress. (jneurosci.org)
  • Inhibitory effect of anoxia on 125I-insulin binding by rat hepatocytes. (biomedsearch.com)
  • The inhibitory effect of anoxia on 125I-insulin binding was not due to any effect on 125I-insulin degradation or on cell viability. (biomedsearch.com)
  • In contrast, in anoxia, fewer diatoms were initially ingested and these were not assimilated or metabolized further, but remained visible within the foraminiferal cytoplasm even after 4 weeks. (epfl.ch)
  • In contrast, in rat optic nerve (RON), anoxia causes rapid and complete loss of function. (begellhouse.com)
  • These adaptations solve the main problem encountered during anoxia, which is to supply cells with enough ATP. (uio.no)
  • For this purpose, Arabidopsis cell suspension cultures grown in a stirred bioreactor were subjected to a severe anoxic stress and analyzed during anoxia and re-oxygenation for alteration in ROS and NO as well as in antioxidant enzymes and metabolites. (frontiersin.org)
  • Our observations of ongoing calcification under anoxic conditions mean that geochemical proxy data obtained from benthic foraminifera in settings experiencing intermittent anoxia have to be reconsidered. (biogeosciences.net)
  • Did anoxia terminate Ediacaran benthic communities? (whiterose.ac.uk)
  • Transcriptome analysis of anoxia-, heat-, and heat + anoxia-treated Arabidopsis seedlings. (plantphysiol.org)
  • H 2 O 2 (5 m m ) was added (2-h treatment) to the wells containing the seedlings followed by rinsing in fresh medium and transfer to anoxia (26 h). (plantphysiol.org)
  • We used the Affymetrix ATH1 GeneChip containing more than 22,500 probe sets to explore the anaerobic transcriptome of Arabidopsis seedlings kept under anoxia for 6 h in presence or absence of exogenous Suc. (plantphysiol.org)
  • to characterize the response of Arabidopsis seedlings treated for 6 h under anoxia in presence or absence of exogenous Suc. (plantphysiol.org)
  • We used anoxia to obtain a rapid anaerobic response and choose seedlings as they represent a very homogeneous plants material at a growth stage at which plants often experience low oxygen conditions ( Perata and Alpi, 1993 ). (plantphysiol.org)
  • Pea and rice seedlings were exposed to anoxia for 1 to 24 h and their tolerances and survival compared. (st-andrews.ac.uk)
  • Increasing amounts of K+ were lost from the roots of whole seedlings during anoxia, and seedling recovery on return to air was associated with the seedlings' ability to reabsorb most of the leaked K+. (st-andrews.ac.uk)
  • Aerobic respiration in the root tips was associated with both K+ uptake by pea seedlings, and the recovery and subsequent growth of pea and three varieties of rice after anoxia. (st-andrews.ac.uk)
  • Although some pea and rice seedlings appeared undamaged after anoxia, the subsequent growth rates of pea and rice, cv. (st-andrews.ac.uk)
  • Pea seedlings that were prevented from transpiring during anoxia were damaged earlier than controls, possibly because of an increase in the rate of accumulation of a toxic product of anaerobic metabolism in these seedlings. (st-andrews.ac.uk)
  • Two percent glucose merely delayed, and did not prevent, the onset of damage in whole pea seedlings during anoxia, nor did it enhance the subsequent growth of the seedlings. (st-andrews.ac.uk)
  • Fetal anoxia may occur from inadequate oxygenation of the mother, low maternal blood pressure, or abnormalities in the uterus, placenta, or umbilical cord that result in inadequate blood flow to the fetus. (britannica.com)
  • All the ascorbate-glutathione related parameters were altered during anoxia but restored during re-oxygenation. (frontiersin.org)
  • Oxygen deprivation stress in plant cells includes three different states characterized by different oxygen concentrations: hypoxia, anoxia, and re-oxygenation. (frontiersin.org)
  • Anoxia" means "total absence of oxygen," and in Lea's hands the term heralds aural environments that are full of the dreams of humanity yet may well be devoid of its living presence. (forcedexposure.com)
  • For the autumn period each profile in the dataset was examined for the occurrence of hypoxia (oxygen deficiency) and anoxia (total absence of oxygen). (smhi.se)