Anoikis resistance and metastasis in human cancers. Medical search. Frequent questions

SNCA inhibits epithelial-mesenchymal transition and correlates to favorable prognosis of breast cancer. (amedeo.com)
Knockdown of Snail inhibits epithelial-mesenchymal transition of human laryngeal squamous cell carcinoma Hep-2 cells through VDR signaling pathway. (biossantibodies.com)
MMP proteins Inhibitors,Modulators,Libraries represent one of the major markers of epithelial mesenchymal transition as well as metastasis. (microrna21.com)

Her work demonstrated the role of cancer stem cells in multistage of cancer from carcinogenesis to metastasis. (siscr.org)
While carcinogenesis induced by various chemicals and environmental agents including cigarette smoke, air pollution, and heavy metals has been extensively studied [ 7 - 9 ], relatively little has been carried out or known about the cancer risk caused by nanomaterial exposure, notably carbon nanotubes (CNTs) which share similar properties with asbestos fibers, a known human carcinogen [ 10 - 13 ]. (oncotarget.com)
Pan-cancer analysis of G6PD carcinogenesis in human tumors. (amedeo.com)
Prior to his clinical fellowship, he earned a Master of Science degree in Cancer Biology and Molecular Carcinogenesis at the University of Texas/MD Anderson Cancer Center and received dedicated basic science research training as a Women's Reproductive Health Research Scholar from Baylor College of Medicine and UT MD Anderson Cancer Center, Houston, Texas. (moffitt.org)
In this review, we summarize some recent findings on HPV-associated carcinogenesis, such as miRNAs in HPV-associated cancers, implication of stem cells in the biology and therapy of HPV-positive cancers, HPV vaccines, targeted therapy of cervical cancer, and drug treatment for HPV-induced intraepithelial neoplasias. (virosin.org)

In recent years, the Hedgehog (Hh) signalling pathway has emerged as a critical determinant of cancer initiation, progression and metastasis of an important subset of human cancers [ 3 - 5 ]. (biomedcentral.com)
Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. (frontiersin.org)
Belongs to the tetraspanin web involved in tumor progression and metastasis. (cusabio.cn)

Co-Occurrence of Familial Non-Medullary Thyroid Cancer (FNMTC) and Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Associated Tumors-A Cohort Study. (nih.gov)
Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice. (biossantibodies.com)
Colorectal cancer (CRC) progression and related mortality are highly associated with metabolic disorders. (thno.org)
Colorectal cancer (CRC) is the second leading type of cancer worldwide and is a common malignant tumor of the digestive system [ 1 ]. (thno.org)

and promoted the proliferation and invasiveness of breast cancer cells both in vivo and in vitro. (cancerindex.org)
Furthermore, in the cancer context, TBX3 directly represses the cell cycle regulators p19ARF/p14ARF, p21WAF1 and TBX2 as well as E-cadherin which encodes a cell adhesion molecule, to promote proliferation and migration. (wikipedia.org)
HCRP1 regulates proliferation, invasion, and drug resistance via EGFR signaling in prostate cancer. (beds.ac.uk)
Studies provide evidence that dysregulated overexpression of CEACAM6 plays a role in several of the hallmarks of cancer, including uncontrolled proliferation, anoikis resistance, immune evasion, invasion and metastasis. (cusabio.cn)
The miR-345-3p/PPP2CA signaling axis promotes proliferation and invasion of breast cancer cells. (amedeo.com)
EGFR is a key mediator of oncogenesis in NSCLCs, with its activation inducing tumor proliferation and growth, angiogenesis, invasion and metastasis, and inhibiting apoptosis ( 10 ). (spandidos-publications.com)
The aberrant glucose metabolism is associated with dramatically increased bioenergetics, biosynthetic, and redox demands, which is vital to maintain rapid cell proliferation, tumor progression, and resistance to chemotherapy and radiation. (biomedcentral.com)
Weinberg characterized "aberrant metabolic phenotype" with "autologous proliferation signaling, apoptosis resistance, evasion of proliferation inhibition, continuous angiogenesis, infiltration and migration, unlimited replication capacity, immune escape" in tumor cells. (biomedcentral.com)
Bae KM, Wang H, Jiang G, Chen MG, Lu L, Xiao L. Protein kinase C epsilon is overexpressed in primary human non-small cell lung cancers and functionally required for proliferation of non-small cell lung cancer cells in a p21/Cip1-dependent manner. (famri.org)

the expression level of ZNF326 was inversely associated with advanced pTNM stage (P = 0.002), positive lymph node metastasis (P = 0.004), poor prognosis in patients with breast cancer (P = 0.0097), and ER/PR/Her2 status (P = 0.013). (cancerindex.org)
In advanced stages, these cancerous cells spread to different parts of the body through our blood or lymph, in a process called metastasis. (researchmatters.in)
In Splitomicin this study, we used a paired colon cancer cell line model derived from a single patient, representative of the primary tumour (SW480) and its lymph node metastisis (SW620) (22). (petrocollapse.org)
Invasive micropapillary carcinoma of the breast (IMPC) is a rare subtype of breast cancer that has a high frequency of lymph node (LN) involvement and metastasis to distant organs. (jcancer.org)
This is due to the high propensity of lymph node (LN) involvement as well as early regional and distant metastasis seen in IMPC [ 1 - 5 ]. (jcancer.org)

The biological role and underlying mechanism of action of zinc-finger protein 326 (ZNF326) in malignant tumors, including breast cancer, are still not clear. (cancerindex.org)
Ovarian cancer is one of the most aggressive female reproductive tract tumors. (nature.com)
Evolving research in stem cells and cancer biology have provided strong evidence for the existence of cancer stem cells (CSCs) in various human solid tumors, including brain, breast, bone marrow, prostrate, colon, and lung [ 3 , 4 ]. (oncotarget.com)
HO-1 expression was higher in human primary and metastatic tumors compared with noncancerous tissue. (jci.org)
These results establish HO-1 as a mediator of ATF4-dependent anoikis resistance and tumor metastasis and suggest ATF4 and HO-1 as potential targets for therapeutic intervention in solid tumors. (jci.org)
Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. (oncotarget.com)
We detected PTK6 mRNA and protein expression in the immortalized normal MCF-10A human mammary gland epithelial cell line, and examined PTK6 expression and activation in a normal human breast tissue microarray, as well as in human breast tumors. (oncotarget.com)
However, in human breast tumors, striking PTK6 expression and phosphorylation of tyrosine 342 is observed at the plasma membrane. (oncotarget.com)
In vivo, inhibiting CDCP1 activity with an engineered blocking fragment (extracellular portion of cleaved CDCP1) lead to increased LD abundance in primary tumors, decreased metastasis, and increased ACSL activity in two animal models of TNBC. (cusabio.cn)
These treatment options can cure early and part of the intermediate tumors in certain degrees, but are not ideal for most of cancer in middle and late stages [ 2 ]. (biomedcentral.com)

Recombinant human/mouse/rat BMP-2 (355-BM) induces alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. (novusbio.com)
HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer. (beds.ac.uk)
Inhibition of PTP1B in D492 and HMLE affects cell-cell adhesion and induces anoikis-like effects. (cusabio.com)
2011. Human papillomavirus type 16 E6 induces cervical cancer cell migration through the p53/microRNA-23b/urokinase-type plasminogen activator pathway. (virosin.org)

Recent studies have underlined an important though less understood function of the Hh pathway in breast cancer malignancy. (biomedcentral.com)
Breast cancer is the most common malignancy globally for women. (jcancer.org)
Emerging data show the multiple roles of HO-1 in tumorigenesis from pathogenesis to the progression to malignancy, metastasis, and even resistance to therapy. (encyclopedia.pub)
Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. (biomedcentral.com)
This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment. (biomedcentral.com)

However, if these tumour cells are deprived of the matrix, they die a form of programmed cell death called anoikis. (researchmatters.in)
In the case of therapeutic options two and three by inducing lethal toxicity and thus killing the cancer cells, predominately via a form of programmed cell death termed apoptosis. (touchoncology.com)

The PxIxIT motif of the RCAN3 Inhibits angiogenesis and tumor progression in Triple Negative Breast Cancer in Immunocompetent Mice. (amedeo.com)

Regulation of lung cancer cell migration and invasion by reactive oxygen species and caveolin-1. (siscr.org)
These CSCs, which were found to overexpress tumor promoter caveolin-1 (Cav-1), displayed aggressive cancer phenotypes of apoptosis resistance and enhanced cell invasion and migration compared with their non-CSC counterpart. (oncotarget.com)
CEACAM6 promoted oral squamous cell carcinoma cell invasion, migration, cytoskeletal rearrangement, and metastasis via interaction with EGFR and enhancing it activation. (cusabio.cn)
This protein enhances cell motility, invasion and metastasis of cancer cells. (cancer-genetics.org)
It is characterized by aggressive growth, nerve invasion, and high rate of metastasis to distant organs. (researchsquare.com)
PI3Kinase and ERK may also participate in cancer cell migration and invasion by activating vari ous ECM degrading enzymes, such as the matrix metalloproteinase Inhibitors,Modulators,Libraries family proteins. (microrna21.com)

This study aimed to investigate the effects of angiopoietin-like 4 (ANGPTL4) on NADPH oxidase 4 (NOX4) expression and reactive oxygen species (ROS) production, which might provide new targets for improving outcomes in patients with hyperlipidemia-associated CRC metastasis. (thno.org)

Aberrant activation of the Hedgehog (Hh) signalling pathway has been unambiguously tied to cancer development and progression in a variety of solid malignancies, and the recent approval of vismodegib, an orally bioavailable small-molecule inhibitor of Smoothened, validates Hh signalling as a valuable therapeutic target. (biomedcentral.com)
This review will provide an update on the Hh signalling pathway and its role in the regulation of normal mammary development and the aetiology of breast cancer. (biomedcentral.com)
The Hh pathway is an evolutionarily conserved system for regulating patterning and cell fate from Drosophila to humans. (biomedcentral.com)
CAF can promote cancer progression by activating EMT through hedgehog (HH) pathway. (researchsquare.com)
Further analysis showed that higher expression of plakoglobin was able to promote activation of the PI3K/Akt/Bcl-2 pathway, which might protect the clusters from anoikis. (jcancer.org)
Activation of the PI3Kinase pathway in metastatic cancer cells due to the highly glycolytic state of the cells and aerobic glycolysis could also induce drug resistance http://www.selleckchem.com/products/Imatinib(STI571).html in cancer cells. (microrna21.com)
Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation of ATP but it is now clear that OXPHOS, at least in many tumour types, plays a critical role in delivering the bioenergetic and macromolecular anabolic requirements of cancer cells. (biomed.news)

Herein, this review updates the mechanisms of metabolic reprogramming involved in tumor chemo- and radio-resistance. (biomedcentral.com)

Clin Cancer Res (2021 Mar 1) 27:1399-1409. (nih.gov)
Cancers (Basel) 13(19), 2021. (mdanderson.org)

5 Although ovarian cancer in advanced stages initially appears to be chemotherapy sensitive as response rates to platinum-based therapy exceed 80%, long-term survival remains poor as a result of recurrence and emergence of drug resistance. (nature.com)
The SP assay identifies putative CSCs based on the high activity of the ATP-binding cassette transporter protein (ABC)G2, which is also implicated in drug resistance due to its role in the efflux of chemotherapeutics from the cell (16,17). (petrocollapse.org)
Nevertheless, BC might acquire drug resistance and sometimes relapse. (wjgnet.com)

Among these miRNAs, we focused on miRNA-31 (miR-31) because miR-31 was the only miR that has been reported to regulate tumor phenotype, an anti-metastatic effect in breast cancer. (nature.com)
Here, we have shown that activating transcription factor 4 (ATF4), a master transcriptional effector of the ISR, protects transformed cells against anoikis - a specialized form of apoptosis - following matrix detachment and also contributes to tumor metastatic properties. (jci.org)
Novel Targeted Therapies for Metastatic Thyroid Cancer-A Comprehensive Review. (nih.gov)
Targeting Integrins with Radiolabeled RGD Analogues for Radiotheranostics of Metastatic Radioactive Iodine Nonresponsive Thyroid Cancer: New Avenues in Personalized Medicine. (nih.gov)
Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells. (cusabio.cn)
PTK6 was identified in human metastatic breast cancer [ 2 ], and is overexpressed in the majority of human breast cancers and in most breast tumor cell lines [ 3 - 5 ]. (oncotarget.com)
Moreover, knockdown of ANGPTL4, NOX4, MMP-1, and MMP-9 or the treatment of antioxidants dramatically inhibited circulating OA-enhanced tumor cell extravasation and metastatic seeding of tumor cells in lungs, indicating that the ANGPTL4/NOX4 axis was critical for dyslipidemia-associated tumor metastasis. (thno.org)
As the SW480 and SW620 cell lines developed from the same genetic background, Splitomicin they provide an model to study the cellular changes that occur during cancer progression and development of a metastatic phenotype. (petrocollapse.org)
Metastatic spread is responsible for the majority of cancer-associated deaths and is affected by a variety of factors, including the deregulation of gene expression, signal transduction, and epigenetic modification, as well as epithelial-to-mesenchymal transition (EMT) and the transformation of tumor cells into stem/progenitor cells. (jcancer.org)

We investigated the mechanism of chemoresistance by analysis of microRNAs using the ovarian cancer cell line KFr13 and its PTX-resistant derivative (KFr13Tx). (nature.com)
In addition, lower levels of miR31 and higher expression of MET in human ovarian cancer specimens were significantly correlated with PTX chemoresistance and poor prognosis. (nature.com)
This study demonstrated miR31-dependent regulation of MET for chemoresistance of ovarian cancer, raising the possibility that combination therapy with a MET inhibitor and PTX will increase PTX efficacy. (nature.com)

Acquisition of anoikis resistance up-regulates caveolin-1 expression in human non-small cell lung cancer cells. (siscr.org)
Expression of CA125 and cisplatin susceptibility of pleural effusion-derived human lung cancer cells from Thai patient. (siscr.org)
The chronic CNM-exposed cells exhibited CSC-like properties as indicated by 3D spheroid formation, anoikis resistance, and CSC marker expression. (cdc.gov)
6 Following the initial demonstration of the important role for miR in human cancer, such as downregulation of miR-15a-miR-16-1 in chronic lymphocytic leukemia, 7 a number of cancers have been shown to exhibit distinct miR expression patterns related to various phenotypes with remarkable cytogenetic abnormalities. (nature.com)
ATF4-deficient human fibrosarcoma cells were unable to colonize the lungs in a murine model, and reconstitution of ATF4 or HO-1 expression in ATF4-deficient cells blocked anoikis and rescued tumor lung colonization. (jci.org)
HCRP1 expression status is a significant prognostic marker in oral and oropharyngeal cancer. (beds.ac.uk)
PurposePrevious studies indicate that breast cancer molecular subtypes differ with respect to their dependency on autophagy, but our knowledge of the differential expression and prognostic significance of autophagy-related biomarkers in breast cancer is limited.Methods Immunohistochemistry (IHC) was performed on tissue microarrays from a large popu. (researchgate.net)
To date, expression of PTK6 has not been extensively examined in the normal human mammary gland. (oncotarget.com)
These results revealed that ADAM9 down-regulates miR-1 via activating EGFR signaling pathways, which in turn enhances CDCP1 expression to promote lung cancer progression. (cusabio.cn)
This study explored the expression of Ln5 and the role of its relationships with PTEN, phospho-EGFR (p-EGFR) and phospho-Akt (p-Akt) in the prognosis of patients with non-small cell lung cancer (NSCLC). (spandidos-publications.com)
The depletion of ANGPTL4 significantly inhibited c-Jun-mediated transactivation of NOX4 expression, accompanied with reduced levels of ROS, MMP-1, and MMP-9, resulting in the disruption of OA-promoted CRC cell metastasis. (thno.org)
The coincident expression of NOX4 and ANGPTL4 in CRC tumor specimens provides the insight into the potential therapeutic targets for the treatment of dyslipidemia-associated CRC metastasis. (thno.org)
PTP1B is widely expressed in the human breast gland with highest expression in myoepithelial cells and fibroblasts. (cusabio.com)

Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the emergence of targeted and biologic therapies, have among the highest mortality rates. (researchgate.net)
For cancer to thrive, the tumour cells must develop resistance to anoikis. (researchmatters.in)
This may be due to a number of factors, including the molecular heterogeneity of breast tumours, intrinsic tumour resistance to conventional therapy, or inadequate therapy due to borderline pathological features. (biomedcentral.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Cancer stem cells (CSCs) may represent targets for carcinogenic initiation by chemical and environmental agents. (oncotarget.com)

Cancer Epidemiol Biomarkers Prev. (famri.org)

Mechanistically, co-immunoprecipitation and immunofluorescence assays both demonstrated that ZNF326 interacted with deleted in breast cancer-1 (DBC1) in breast cancer cells. (cancerindex.org)
Therefore, we concluded that ZNF326 is highly expressed in breast cancer, is associated with poor prognosis, and plays a vital role in promoting the malignant phenotype of breast cancer cells by interacting with DBC1. (cancerindex.org)
In 2014, she returned to Thailand to join Prof. Surapol Issaragrisil's laboratory at the SiSCR to pursue her interest in targeting cancer stem cells in cancer therapeutic discovery and development. (siscr.org)
Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes. (siscr.org)
Regulation of apoptosis by Bcl-2 cysteine oxidation in human lung epithelial cells. (siscr.org)
Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells. (siscr.org)
Hydroxyl radical mediates cisplatin-induced apoptosis in human hair follicle dermal papilla cells and keratinocytes through Bcl-2-dependent mechanism. (siscr.org)
Acquisition of cancer stem cell-like properties in human small airway epithelial cells after a long-term exposure to carbon nanomaterial s. (cdc.gov)
Cancer stem cells (CSCs) are a key driver of tumor formation and metastasis, but how they are affected by nanomaterial s is largely unknown. (cdc.gov)
The present study investigated the effects of different carbon-based nanomaterial s (CNMs) on neoplastic and CSC-like transformation of human small airway epithelial cells and determined the underlying mechanisms. (cdc.gov)
To identify miRNAs that potentially cause the resistance to taxanes, such as PTX, we performed microarray analysis of miRNAs in KFr13 and PTX-resistant KFr13Tx cells. (nature.com)
Here, we show that chronic (6-month) exposure of human lung epithelial cells to single-walled (SW) CNTs at the workplace-relevant concentration induced an emergence of lung CSCs, as indicated by the induction of CSC tumor spheres and side population (SP). (oncotarget.com)
Cav-1 not only promoted tumorigenesis in a xenograft mouse model but also metastasis of the transformed cells to neighboring tissues. (oncotarget.com)
Anchorage-independent survival after intravasation of cancer cells from the primary tumor site represents a critical step in metastasis. (bvsalud.org)
Here, we reveal new insights into how MUC13-mediated anoikis resistance, coupled with survival of colorectal tumor cells, leads to distant metastasis. (bvsalud.org)
So far, we know that abnormal and uncontrollable growth of cells in our body leads to cancer. (researchmatters.in)
They used human breast cancer cells and mice for the study. (researchmatters.in)
Retraction to: 2-Tellurium-bridged beta-cyclodextrin, a thioredoxin reductase inhibitor, sensitizes human breast cancer cells to TRAIL-induced apoptosis through DR5 induction and NF-kappaB suppression. (amedeo.com)
Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
PTK6 is expressed in normal prostate epithelial cells where it is largely localized to the nuclei, but in prostate cancers PTK6 nuclear localization is lost [ 7 ]. (oncotarget.com)
When human cells are exposed to environmental insults, DNA may be damaged. (ijofb.org)
Results Comparison of biological characteristics of the paired SW480 and SW620 cancer cell lines The morphology of SW480 and SW620 cells were analysed by phase contrast microscopy to reveal two cell morphologies (Fig. model of cancer progression. (petrocollapse.org)
Invading cancer cells can utilize different modes of migration including single cell migration and collective migration. (jcancer.org)
Re sistance against anoikis induced upon cell detach ment from the extracellular matrix, might also be involved in survival of migrating cancer cells. (microrna21.com)
In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)
In addition, metformin potentiated the antitumor efficacy of cytarabine (Ara-C) in vivo in an NCG immunodeficient mouse xenograft model by inhibiting the mitochondrial transfer and OXPHOS activity in the engrafted human AML cells. (biomed.news)
The energy metabolism of cancer cells. (biomedcentral.com)
2006. Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis. (virosin.org)
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. (famri.org)

These results suggest that MET inhibitors administered concurrently with PTX could prevent the development of resistance to PTX. (nature.com)
This study provides newer insights into developing AMPK and PHLPP2 inhibitors as potential drugs against cancer that can target the molecular mechanisms involved in the spread of cancer. (researchmatters.in)
Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR), including gefitinib and erlotinib, have become the standard first-line therapy for patients with advanced non-small cell lung cancers (NSCLCs) harboring activating EGFR mutations ( 4 , 5 ). (spandidos-publications.com)

HO-1 in Cancer Cell Survival" Encyclopedia , https://encyclopedia.pub/entry/14608 (accessed December 06, 2023). (encyclopedia.pub)

Paclitaxel (PTX) is widely used for the treatment of ovarian cancer. (nature.com)
Ovarian cancer is the leading cause of death among malignancies of the female reproductive system, resulting in ∼ 125 000 deaths annually. (nature.com)
3 , 4 The current therapy for ovarian cancer is debulking surgery followed by chemotherapy using carboplatin and paclitaxel (PTX). (nature.com)
In this study, we aimed to investigate the correlation between miR and sensitivity to PTX, and demonstrated that miR-31 was decreased in chemoresistant ovarian cancer. (nature.com)
Oral contraceptives and risk of breast cancer and ovarian cancer in women with a BRCA1 or BRCA2 mutation: A meta-analysis of observational studies. (amedeo.com)
Dr. Shahzad's clinical interests are in the surgical management of advanced gynecologic malignancies, including cytoreductive surgery for ovarian cancer, complex minimally invasive laparoscopic and robotic surgery for endometrial and cervical cancers as well as fertility sparing surgical techniques. (moffitt.org)

Cancers (Basel) (2020 Jul 29) 12. (nih.gov)
Cancers (Basel). (moffitt.org)

Loss of calponin h1 confers anoikis resistance and tumor progression in the development of high-grade serous carcinoma originating from the fallopian tube epithelium. (biossantibodies.com)
2004. HPV-18 confers resistance to TNF-alpha in organotypic cultures of human keratinocytes. (virosin.org)

Her research interest is in the area of cellular and molecular mechanisms of gene regulation and targeted therapy for cancer. (siscr.org)

Human papillomaviruses (HPVs) cause virtually all cervical cancers, the second leading cause of death by cancer among women, as well as other anogenital cancers and a subset of head and neck cancers. (virosin.org)

In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. (jcancer.org)

The integrated stress response (ISR) is a critical mediator of cancer cell survival, and targeting the ISR inhibits tumor progression. (jci.org)
The Molecular Landscape of Hürthle Cell Thyroid Cancer Is Associated with Altered Mitochondrial Function-A Comprehensive Review. (nih.gov)
In this study, we found that the induction of NOX4, followed by the increased ROS was essential for oleic acid (OA)-promoted CRC cell metastasis. (thno.org)
We hypothesised that if CSC are responsible for metastasis, then the SW620 cell line may be enriched in CSC compared to the SW480 cell line and therefore should be the more chemoresistant of the two cell lines. (petrocollapse.org)
We reported here that plakoglobin, as a key component in cell adhesion, can promote collective metastasis through facilitating IMPC clusters formation. (jcancer.org)
Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. (virosin.org)

However, late-stage CRC with distant metastasis has a 10-15% survival rate for cancer patients [ 2 ]. (thno.org)

ZNF326 promotes a malignant phenotype of breast cancer by interacting with DBC1. (cancerindex.org)
DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7. (cancerindex.org)
POP1 promotes the progression of breast cancer through maintaining telomere integrity. (amedeo.com)
A yes-associated protein 1-Notch1 positive feedback loop promotes breast cancer lung metastasis by attenuating the Bone morphogenetic protein 4-SMAD family member 1/5 signaling. (amedeo.com)
Correction to: tRNA-derived fragment tRFLys-CTT-010 promotes triple-negative breast cancer progression by regulating glucose metabolism via G6PC. (amedeo.com)

OS of jaw differs from the OS of the long bones in its biological behavior, presenting a lower incidence of metastasis and a better prognosis with approximately 40% 5-year survival rate as compared to 20% for nonjaw lesions. (ijofb.org)

Approximately half of women, who develop cervical cancer die from it. (virosin.org)

Interestingly, Hh ligand overexpression is associated with the BLBC phenotype and a poor outcome in terms of metastasis and breast cancer-related death. (biomedcentral.com)

Lung cancer is the leading cause of cancer-related death, and environmental and occupational exposure is a major cause of most cases [ 1 , 2 ]. (oncotarget.com)
Targeting RET-mutated thyroid and lung cancer in the personalised medicine era. (nih.gov)
Lung cancer is the leading cause of cancer-related death in the United States and throughout the world in both men and women ( 1 , 2 ). (spandidos-publications.com)
A total of 98 tissue samples were obtained from the tumor bank of Guangdong Lung Cancer Institute (Guangzhou, China) between 2004 and 2006. (spandidos-publications.com)

Reports from the Indian Council of Medical Research (ICMR) estimated 14.5 lakh new cancer cases in 2016, and this number is likely to go up to 17.3 lakhs in 2020. (researchmatters.in)
Incidence and Survival in Reproductive-Aged Women with Differentiated Thyroid Cancer: United States SEER 18 2000-2016. (nih.gov)
We used data from the 2016 DocStyles, a web-based survey of U.S. primary care providers, to examine skin cancer prevention counseling practices among 1506 providers. (cdc.gov)

SOCS1 acts as a ferroptosis driver to inhibit the progression and chemotherapy resistance of triple-negative breast cancer. (amedeo.com)
Chemotherapy in particular is also frequently associated with significant side effects, which are often perceived by patients as worse than the actual disease, and have in the past led to the termination of treatment, particularly in under-aged patients.16 However, even with treatment success, long-term adverse effects and treatment-induced secondary cancers are, with extended life expectancies, also becoming increasingly a problem. (touchoncology.com)
Radiotherapy and chemotherapy, as the routine treatment, face substantial challenges of resistance. (biomedcentral.com)

But how do they develop resistance? (researchmatters.in)
However, almost all patients eventually develop resistance to EGFR TKIs. (spandidos-publications.com)

The most appropriate Splitomicin and accurate method of identifying of CSCs remains a subject of intense debate, Furthermore, many researchers remain sceptical as to the role of this subpopulation in cancer initiation and progression. (petrocollapse.org)

Cav-2beta isoform yielded by alternative translation initiation desensitizes insulin receptor (IR) via dephosphorylation by PTP1B, and subsequent endocytosis and lysosomal degradation of IR, causing insulin resistance. (cusabio.com)

However, ovarian cancers often acquire chemotherapeutic resistance to this agent. (nature.com)

T-box transcription factor TBX3 is a protein that in humans is encoded by the TBX3 gene. (wikipedia.org)
The human TBX3 gene maps to chromosome 12 at position 12q23-24.1 and consists of 7 exons which encodes a 723 amino acid protein (ENSEMBL assembly release GRCh38.p12). (wikipedia.org)
A low-carbohydrate diet containing soy protein and fish oil reduces breast but not prostate cancer in C3(1)/Tag mice. (amedeo.com)
Protein tyrosine kinase 6 (PTK6, also called BRK) is a SRC-related intracellular tyrosine kinase expressed in normal epithelia and cancer. (oncotarget.com)

For example, it can interact with other transcription factors such as Nkx2-5, Msx 1/2 and Sox4 to assist it binding to its target genes to regulate heart development and it can interact with histone deacetylases (HDACs) 1, 2, 3 and 5 to repress p14ARF in breast cancer and with HDAC5 to repress E-cadherin to promote metastasis in hepatocellular carcinoma. (wikipedia.org)
ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop. (amedeo.com)
Correction to: SOX8 acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer. (amedeo.com)
Ehm2 transcript variant 1 inhibits breast cancer progression and increases E-cadherin stability. (amedeo.com)
Genetic and clinical characteristics of BRCA-associated hereditary breast cancer in the West region of Kazakhstan. (amedeo.com)
HMGN4 plays a key role in STAT3-mediate oncogenesis of triple-negative breast cancer. (amedeo.com)
Maternal soybean genistein on prevention of later-life breast cancer through inherited epigenetic regulations. (amedeo.com)
Aspirin Suppresses Breast Cancer Metastasis to Lung by Targeting Anoikis Resistance. (amedeo.com)
Despite the progress achieved in breast cancer screening and therapeutic innovations, the basal-like subtype of breast cancer (BLBC) still represents a particular clinical challenge. (biomedcentral.com)
In order to make an impact on survival in this type of aggressive breast cancer, new targeted therapeutic agents are urgently needed. (biomedcentral.com)
A number of recent publications have highlighted a role for Hh signalling in breast cancer models and clinical specimens. (biomedcentral.com)
Breast cancer remains the leading cause of cancer-related death among women worldwide and accounts for 23% of all cancers diagnosed in 2008 [ 1 ], totalling approximately 1.4 million cases globally. (biomedcentral.com)
With a lifetime risk of developing invasive breast cancer of 1 in 8, breast cancer is one of the top three cancers that caused the greatest economic impact worldwide in 2008 [ 2 ]. (biomedcentral.com)
Due to its frequency and cost, breast cancer represents a major public health concern. (biomedcentral.com)
Breast cancer (BC) is the most common cancer among women, and current available therapies often have high success rates. (wjgnet.com)
1 Emil Grubbe irradiated the first breast cancer in 18962 and mustard gas variants were first used therapeutically in 1946. (touchoncology.com)
Taking proanthocyanidin, a chemical found in grape seed extract, does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer. (medlineplus.gov)

As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
The objective of this review was to analyze the results from preclinical and clinical trials of these drugs for the treatment of cancer. (frontiersin.org)
Aslthough all these drugs have produced good results in preclinical studies of multiple cancers, the outcomes of clinical trials have not been similar. (frontiersin.org)

The role of BCSCs in cancer formation, growth, invasiveness, therapy resistance and tumor recurrence is becoming increasingly clear. (wjgnet.com)

In summary, the study of this tumor, particularly in its early stages, provides useful clues to further understanding the biology and progression of large bowel cancer. (bvsalud.org)
She obtained her postdoctoral training in the Department of Cancer Biology at The University of Texas MD Anderson Cancer Center, joined the Department of Genetics in 2002, where she established the Molecular Cytogenetics Facility as an Institutional specialty resource. (mdanderson.org)
7. Graduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan, ROC. (thno.org)
He completed his Gynecology Oncology fellowship training at the prestigious University of Wisconsin-Madison, School of Medicine and Public Health, alongside with PhD in endocrinology-reproductive physiology with special focus in cancer biology. (moffitt.org)
1 Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. (aacrjournals.org)

Induction of the ISR is critical for resistance to anoikis. (jci.org)
A few reports have suggested that induction of resistance against anoikis is also derived from ac tivation of the PI3Kinase signaling and extracellular signaling receptor kinase via various proteins involving TrkB, its ligand brain derived neurotrophic factor, and hepatocyte growth factor. (microrna21.com)
In cancer, EMT plays various roles in the maintenance of cancer stemness and induction of metastasis, and is inducible by different growth factors, hormones, and intracellular molecules. (microrna21.com)

This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. (cancerindex.org)
The T-box gene family consists of 17 members in mouse and humans that are grouped into five subfamilies, namely Brachyury (T), T-brain (Tbr1), TBX1, TBX2, and TBX6. (wikipedia.org)

In a new study, researchers from the Indian Institute of Science, Bengaluru, led by Prof. Annapoorni Rangarajan, have made some astounding discoveries on the molecular mechanism behind the spread of cancer, which can help better understand and treat the disease. (researchmatters.in)
However, the molecular mechanism involved in the regulation of hyperlipidemia-associated CRC metastasis remains unclear. (thno.org)
Nevertheless, a better understanding of the molecular events underlying the metastasis of IMPC will be important for its prevention, diagnosis, and treatment. (jcancer.org)
As the molecular mechanisms underlying chemo- and radio-resistance are still poorly understood, the alteration of glucose metabolism in cancer provides new ideas to explain chemo- and radio-resistance. (biomedcentral.com)

Constitutively active AR-V7, one of the major androgen receptor (AR) splice variants lacking the ligand-binding domain, plays a key role in the development of castration-resistant prostate cancer (CRPC) and anti-androgen resistance. (cancerindex.org)

Carcinoma-associated fibroblasts (CAF) play a pivotal role in cancer progression. (researchsquare.com)
Salivary gland carcinoma (SGC) is rare cancer, constituting 6% of neoplasms in the head and neck area. (genominfo.org)
Salivary gland carcinoma (SGC) is an uncommon neoplasm, which constitutes approximately 6 percent of cancers in the head and neck region [ 1 , 2 ]. (genominfo.org)
Invasive micropapillary carcinoma of the breast (IMPC) accounts for 5 % of all breast cancers, and displays relatively uncommon and distinct histomorphological features [ 1 ]. (jcancer.org)

Anatomy4

Organisms1

Diseases20

Chemicals and Drugs6

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes20

Disciplines and Occupations1

Information Science1

Epithelial-Mesenchyma3

Carcinogenesis5

Progression and metastasis3

Colorectal Cancer4

Proliferation9

Lymph5

Tumors10

Induces4

Malignancy5

Form of programmed cell2

Angiogenesis1

Invasion6

Reactive oxygen1

Pathway7

Involved in tumor1

20212

Drug resistance3

Metastatic9

Chemoresistance3

Expression13

Tumour3

Targets2

Biomarkers1

Cells29

Inhibitors3

20231

Ovarian cancer6

Basel2

Confers2

Targeted therapy1

Subset1

Clinicopathological1

Cell7

Distant1

Promotes5

Prognosis1

Cervical1

Phenotype1

Lung cancer4

20163

Chemotherapy3

Develop resistance2

CSCs1

Initiation1

Chemotherapeutic1

Protein4

Breast cancer17

Clinical3

Recurrence1

Biology5

Induction3

Gene2

Molecular4

Prostate cancer1

Carcinoma4