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  • vitro
  • In vitro transwell matrigel invasion assay and annexin V anoikis assay in HCC cells were conducted to investigate LMO3 related biological functions. (springer.com)
  • Knockdown of LMO3 suppressed the invasion and anoikis inhibition of HCC cells in vitro. (springer.com)
  • cells
  • Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation. (cdc.gov)
  • Mcl-1 over-expression and knockdown studies in D6-MA and digitoxin exposed cells resulted in rescue and enhancement, respectively, indicating a facilitative role for decreased Mcl-1 expression in NSCLC anoikis. (cdc.gov)
  • In addition, D6-MA also targeted Mcl-1 degradation causing an increased anoikis in A549 lung cancer cells. (cdc.gov)
  • GSE treatment of cells led to their detachment within 12 hours, as occurs in anoikis, and caused a significant decrease in live cells mostly due to their apoptotic death. (aacrjournals.org)
  • Metastatic cells are resistant to anoikis and often have increased levels of the death receptor-inhibiting protein FLIP. (thefreedictionary.com)
  • Anoikis ensures that cells are unable to survive in inappropriate locations. (thefreedictionary.com)
  • Furthermore, EUG induces alteration on cellular architecture probably by perturb cytoskeleton dynamics leading to a cytoplasmic retraction, shrinkage, pyknosis and cell detachment culminating in anoikis , especially in MCF-7, SiHA and SK-MEL-28 cells. (thefreedictionary.com)
  • The presence of CTM supports the speculation that cells within CTM have a survival advantage via protection from anoikis (24-26). (thefreedictionary.com)
  • Polyphenon E, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic P[C. (thefreedictionary.com)
  • Knockdown of SKP2 expression sensitized cancer cells to anoikis, and a wobble mutant of SKP2 that is resistant to SKP2 small interfering RNA can rescue this effect. (aacrjournals.org)
  • Treatment of cells with phosphoinositidyl 3-kinase inhibitor (LY294002) and constitutively activator (insulin-like growth factor I) had significant effects on the anoikis of SKP2 RNA interference cells. (aacrjournals.org)
  • However, when tumour cells detach they resist anoikis, allowing them to migrate to new sites and seed new tumours. (oup.com)
  • MG-63 cells couldavoid anoikis through cell adhesion, and E-cadherin might play a role in this process. (waocp.org)
  • Colony formation, xenograft, and anoikis assays were conducted using cells in which MYBBP1A was either knocked down or overexpressed. (biomedcentral.com)
  • In addition we identify also a PKA/Src mechanism capable to protect cancer cells from anoikis. (uni.lu)
  • Our results reveal for the first time the role of the versatile PKA in cancer cells survival under chronic glucose starvation and anoikis and may be a novel potential target for cancer treatment. (uni.lu)
  • Moreover, suspended anoikis resistant TE-85 cells (TE-85ar) retained their sensitivity to chemotherapy as well. (beds.ac.uk)
  • Anoikis resistant tumor cells have circumvented the death signals generated by the lack of attachment affording them increased survival times while migrating to secondary sites. (beds.ac.uk)
  • An anoikis-resistant clone (HEK293ar), derived from anoikis-sensitive parental Human Embryonic Kidney 293 cells, survived anoikis by the formation of cell-cell contacts. (biomedcentral.com)
  • Upregulation of HAb18G/CD147 in suspended HEK293ar cells suppressed anoikis by mediating the formation of cell-cell adhesions. (biomedcentral.com)
  • degradation
  • expression with lentiviral short hairpin RNA sensitized IEC-Ras to anoikis and decreased PC degradation, but did not change PC synthesis. (dal.ca)
  • novel
  • These results identify a novel cardiac glycoside (CG) sensitizing anoikis mechanism and provide a promising anti-metastatic target for lung cancer therapy. (cdc.gov)
  • ovarian cancer
  • The mechanism of inhibition by foretinib involved (a) inhibition of c-Met activation and downstream signaling, (b) reduction of ovarian cancer cell adhesion, (c) a block in migration and invasion, (d) reduced proliferation mediated by a G 2 -M cell-cycle arrest, and (e) induction of anoikis. (aacrjournals.org)
  • protein
  • In this study, we show that metformin can induce instability of ΔNp63α protein, leading to subsequent anoikis. (aacrjournals.org)
  • Binding of CCN2 to EGFR suppresses the phosphorylation of c-Src and extracellular signal-regulated kinase but increases the expression of death-associated protein kinase, which leads to anoikis. (sigmaaldrich.com)
  • inhibition
  • These results suggest that LMO3 promotes HCC cell invasion and anoikis inhibition by interacting with LATS1 and suppressing Hippo signaling. (springer.com)
  • cell
  • Thus, our results suggest that EPS11 may be a potential candidate for human non-small cell lung carcinoma treatment via blocking filiform structure mediated adhesion and stimulating βIII-tubulin associated anoikis. (mdpi.com)
  • 2014). 'Correlation between E-Cadherin-Regulated Cell Adhesion and Human Osteosarcoma MG-63 Cell Anoikis', Asian Pacific Journal of Cancer Prevention , 15(19), pp. 8203-8207. (waocp.org)
  • role
  • As the negative pressure is thought to play a role in the anoikis process, these results have implications for both the path- ogenesis and therapeutics investigations of stenostic vessel diseases and the future vascular tissue engineering. (scirp.org)
  • p53 also plays a critical role in anoikis. (biomedcentral.com)