Western Blot: Annexin A2 Antibody (1G7) [H00000302-M02] - MDA-MB-231 subclones whole cell lysates were loaded with 30 ug/lane. (novusbio.com)
Western Blot: Annexin A2 Antibody (1G7) [H00000302-M02] - ANXA2 monoclonal antibody (M02), clone 1G7 Analysis of ANXA2 expression in HepG2. (novusbio.com)
Immunocytochemistry/ Immunofluorescence: Annexin A2 Antibody (1G7) [H00000302-M02] - Analysis of monoclonal antibody to ANXA2 on HeLa cell. (novusbio.com)
Member of the annexin2
Annexin A1 (ANXA1), the first member of the annexin superfamily, is a Ca 2+ -dependent phospholipid-binding protein with two distinct regions: a variable N-terminal domain and a conserved C-terminal domain [ 10 ]. (biomedcentral.com)
This gene encodes a member of the annexin family. (novusbio.com)
Proteins4
Annexin A1 belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 Dalton and are preferentially located on the cytosolic face of the plasma membrane. (wikipedia.org)
Annexins constitute a family of calcium-dependent membrane-binding proteins and can be classified into two groups, depending on the length of the N-terminal domain unique for each individual annexin. (ed.ac.uk)
Steroid treatment increased gene expression of two proteins involved in membrane repair, annexins A1 and A6. (nih.gov)
Identification of UT-A1- and AQP2-interacting proteins in rat inner medullary collecting duct. (nih.gov)
Protein10
Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. (wikipedia.org)
Annexin A1 protein has an apparent relative molecular mass of 40 kDa with phospholipase A2 inhibitory activity. (wikipedia.org)
Higher expression of annexin A1 during pathological conditions could increase the strength of TCR signalling through the mitogen-activated protein kinase signalling pathway, thereby causing a state of hyperactivation of T cells. (wikipedia.org)
The N-terminal domain of annexin A1 can adopt an alpha-helical conformation and has been implicated in mediating the membrane aggregation behavior of this protein. (ed.ac.uk)
Annexin A1 (ANXA1) is a membrane protein that plays a role in innate and adaptive immunity by controlling the biosynthesis of inflammation, prostaglandins, and leukotriene mediators. (assaysolution.com)
Annexin A1 (ANXA1), a Ca 2+ -regulated phospholipid-binding protein, has been demonstrated to be implicated in the progression and prognosis of many cancers. (biomedcentral.com)
Protein annexin A1 (ANXA1) and peroxisome proliferated-activated receptors (PPAR) control inflammation, as both inhibit development of inflammation and accelerate its resolution. (usp.br)
Protein of the annexin family exhibiting lipid interaction and steroid-inducibility. (nih.gov)
In a second experiment, we will perform the transplantation of scaffolds, with or without the treatment with the annexin A1 (AnxA1) protein and the immunosuppressant, cyclosporin. (fapesp.br)
Low density lipoprotein related protein 1 (LPR-1), thrombospondin-1 (TSP-1), voltage dependent anion channel (VDAC) 1-2 and annexin A1 were considered to be of special interest and were analysed further by western blotting. (biomedcentral.com)
Peptides3
The binding of peptides to membranes was confirmed by surface pressure (Langmuir film balance) measurements using phosphatidylcholine/phosphatidylserine monolayers, which show a significant increase after injection of rat annexin A1 N-terminal peptides. (ed.ac.uk)
Lamellar neutron diffraction with human and rat annexin A1 N-terminal peptides reveals an intercalation of the helical peptides with the phospholipid bilayer, with the helix axis lying parallel to the surface of membrane. (ed.ac.uk)
Anti-Inflammatory and Pro-Resolving Actions of the N-Terminal Peptides Ac2-26, Ac2-12, and Ac9-25 of Annexin A1 on Conjunctival Goblet Cell Function. (harvard.edu)
Anti-inflammatory4
The main mechanism of glucocorticoids' anti-inflammatory effects is to increase the synthesis and function of annexin A1. (wikipedia.org)
Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, annexin A1 may have potential anti-inflammatory activity. (wikipedia.org)
Upon induction by modified NSAIDS and other potent anti-inflammatory drugs, annexin A1 inhibits the NF-κB signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid apoptosis. (wikipedia.org)
Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease. (ucdavis.edu)
Membrane2
Although the calcium-independent interaction of the annexin A1 N-terminal domain has been known for some time, there was no structural information about the membrane interaction of this secondary membrane-binding site of annexin A1. (ed.ac.uk)
The results are consistent with the hypothesis that the N-terminal domain of annexin A1 can serve as a secondary membrane binding site in the process of membrane aggregation by providing a peripheral membrane anchor. (ed.ac.uk)
CD1231
In contrast, HCL variant is typically negative for CD25, CD123, and annexin A1, as well as negative for BRAF V600E. (medscape.com)
Restores1
In addition, RWP restores Annexin A1 levels, thus involving activation of proresolutive pathways. (nih.gov)
CREB1
Exposure of MCF-7 breast cancer cells to high physiological levels (up to 100 nM) of estrogen lead to an up-regulation of annexin A1 expression partially through the activation of CREB, and dependent on activation of the estrogen receptor alpha. (wikipedia.org)
Gene1
The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia. (wikipedia.org)
Inflammation1
Annexin A1 alleviates kidney injury by promoting the resolution of inflammation in diabetic nephropathy. (nih.gov)
Phagocytosis2
Annexin A1 promotes neutrophil detachment and apoptosis, and phagocytosis of apoptotic neutrophils by macrophages. (wikipedia.org)
Influence of annexin A1 upon phagocytosis and expression of peroxissome proliferator activated receptor gamma in microglial cells. (usp.br)
Immune system2
Altered annexin A1 expression levels through modulation of the immune system effects the initiation and spread of breast cancer, but the association is complex and conclusions of published studies often conflict. (wikipedia.org)
Many studies have emphasized a well-established function of Annexin-A1 (ANXA1) in the immune system, including the regulation of microglial activation. (thno.org)
Anexina A12
Influência da anexina A1 sobre a fagocitose e a expressão de receptor ativado por. (usp.br)
A proteína anexina A1 (ANXA1) e os receptores ativados por proliferadores de peroxissomo (PPAR) controlam a inflamação, pois ambos inibem o desenvolvimento da inflamação e aceleram sua resolução. (usp.br)
Promotes1
Annexin A1 has important opposing properties during innate and adaptive immune responses: it inhibits innate immune cells and promotes T-cell activation. (wikipedia.org)
Neutrophils2
In resting conditions, human and mouse immune cells such as neutrophils, monocytes, and macrophages contain high levels of annexin A1 in their cytoplasm. (wikipedia.org)
Annexin I in the cytosol of resting neutrophils was translocated to the plasma membranes upon addition of opsonized zymosan (OZ). Maximum translocation could be detected 1 min after stimulation with OZ, and decreased thereafter. (bgu.ac.il)
Mechanism1
The mechanism regulating the translocation of annexin I is not clear. (bgu.ac.il)
The activation of T cells results in the release of annexin A1 and the expression of its receptor. (wikipedia.org)
Unique1
The marked translocation of annexin I was unique to OZ, since formyl-Met-Leu-Phe induced only slight translocation of annexin I to the plasma membranes, and phorbol 12-myristate 13-acetate had no effect at all. (bgu.ac.il)
Cell1
Following cell activation (for example, by neutrophil adhesion to endothelial-cell monolayers), annexin A1 is promptly mobilized to the cell surface and secreted. (wikipedia.org)
Cells3
In vitro and in vivo analyses show that exogenous and endogenous annexin A1 counter-regulate the activities of innate immune cells, particularly extravasation and the generation of proinflammatory mediators, which ensures that a sufficient level of activation is reached but not exceeded. (wikipedia.org)
Subcellular fractionation studies demonstrated that annexin I could not be detected in the granule fractions in either resting or activated cells, but was found in association with the phagosome fraction. (bgu.ac.il)
Annexin I is not phosphorylated in resting or stimulated cells. (bgu.ac.il)
Structure1
This study used circular dichroism spectroscopy to show that a rat annexin A1 N-terminal peptide possesses random coil structure in aqueous buffer but an alpha-helical structure in the presence of small unilamellar vesicles. (ed.ac.uk)
Potential1
Annexin A1 has been of interest for use as a potential anticancer drug. (wikipedia.org)