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  • proteins
  • Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. (nih.gov)
  • Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. (nih.gov)
  • Ankyrin (ANK) repeat containing proteins are evolutionary conserved and have functions in crucial cellular processes like cell cycle regulation and signal transduction. (hindawi.com)
  • The active ingredient, which comprises several DARPins (designed ankyrin repeat proteins), is also easy to produce. (thefreedictionary.com)
  • Conformation-dependent recognition of HIV gp120 by designed ankyrin repeat proteins provides access to novel HIV entry inhibitors," Journal of Virology 87(10): 5868-5881. (thefreedictionary.com)
  • The Rh antigens are expressed as part of an ankyrin complex in the red blood cell (RBC) membrane as a heterotrimer consisting of one molecule of Rh-associated glycoprotein (RhAG) and two molecules of Rh proteins. (thefreedictionary.com)
  • Heavier proteins in our SDS-PAGE assays that coimmunoprecipitate with each of the RPeL27 and RPeL43 proteins (Figure 2(b)) were later identified as POTE Ankyrin Family Member E- tubulin alpha 1A (POTEE-TUBA1A) and beta actin-beta actin-like 2 (ACTB-ACTBL2) complexes via the MALDI-TOF analysis (Table 2). (thefreedictionary.com)
  • gene
  • Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. (nih.gov)
  • PMID
  • This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localise sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system [ PMID: 12716895 ]. (ebi.ac.uk)
  • KCNQ2/KCNQ3 channels are preferentially localised to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3 [ PMID: 16735477 ]. (ebi.ac.uk)
  • fold
  • The ankyrin fold appears to be defined by its structure rather than its function since there is no specific sequence or structure which is universally recognised by it. (ebi.ac.uk)
  • domains
  • Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. (ebi.ac.uk)
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. (ebi.ac.uk)
  • brain
  • Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. (acris-antibodies.com)
  • Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Ankyrin-R knockout (KO) mouse brains probed with N388A/60 (left) and K58/35 (right) TC supe. (acris-antibodies.com)