Ankylosing spondylitis tumor necrosis factor alpha. Medical search. Frequent questions

1 Historically the therapeutic options in SpA have been limited, but recent studies have shown that biological blockade with the tumour necrosis factor α (TNFα) antagonists infliximab and etanercept is efficacious in ankylosing spondylitis 2, 3 and psoriatic arthritis. (bmj.com)
In people with diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis, the body produces too much TNF, which can cause the body's immune system to attack normal healthy parts of the body. (mydr.com.au)
Janssen Biotech Inc. has gained Food and Drug Administration approval for Simponi Aria (golimumab) to treat adults with active psoriatic arthritis or active ankylosing spondylitis. (chaindrugreview.com)
Longterm follow-up studies on these agents have shown sustained efficacy, with acceptable safety profiles, in treating rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, and inflammatory bowel disease. (pharmacytimes.com)
The US Food and Drug Administration (FDA) has approved an intravenous (IV) formulation of secukinumab (Cosentyx) for the treatment of adults with psoriatic arthritis (PsA), ankylosing spondylitis (AS), and nonradiographic axial spondyloarthritis (nr-axSpA). (medscape.com)
The glycoengineered antibody SA-D2E7 has reduced anti-drug immune respone, it specifically binds TNFα and can be potentially used in the treatment of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease and ulcerative colitis. (creativebiolabs.net)
Methods: IA was defined as a diagnosis of rheumatic arthritis (RA), ankylosing spondylitis/unspecified spondyloarthritis (AS/uSpA) or psoriatic arthritis (PsA). (lu.se)
If approved, ankylosing spondylitis will be the fourth indication for Humira, following rheumatoid arthritis (approved in April 2008), psoriasis vulgaris and psoriatic arthritis (filed for approval in September 2007), and Crohn's disease (filed for approval in September 2009). (eisai.com)
SIMPONI is approved in 85 countries for rheumatologic indications, including the European Union (EU), where SIMPONI received European Commission approval in October 2009 for the treatment of moderate-to-severe, active rheumatoid arthritis in combination with methotrexate, for the treatment of active and progressive psoriatic arthritis alone or in combination with methotrexate and for the treatment of severe, active ankylosing spondylitis. (jnj.com)
Like the reference product, Remsima is authorised for the treatment of patients with Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and psoriasis. (hospitalpharmacyeurope.com)
Golimumab, a new human tumor necrosis factor alpha antibody, administered every four weeks as a subcutaneous injection in psoriatic arthritis: twenty-four-week efficacy and safety results of a randomized, placebo-controlled study. (ima-press.net)
The European Medicines Agency (EMA) Committee for Medicinal Products for Human Use has recommended in favor of marketing the infliximab biosimilar product Zessly , from Sandoz GmbH, for treatment of rheumatoid arthritis, Crohn's disease, ulcerative colitis, ankylosing spondylitis, psoriatic arthritis, and psoriasis. (medscape.com)
Zessly should be initiated and supervised by qualified physicians experienced in the diagnosis and treatment of rheumatoid arthritis, inflammatory bowel diseases, ankylosing spondylitis, psoriatic arthritis, or psoriasis, the EMA advises. (medscape.com)

Inhibitors of tumour necrosis factor α (TNFα) have constituted a major advance in the treatment of ankylosing spondylitis (AS), and infliximab, etanercept, adalimumab and golimumab have all been proved to be efficacious in reducing signs and symptoms of AS. (bmj.com)
TNF-alpha inhibitors are used to treat a number of inflammatory conditions. (pharmacytimes.com)
Unlike earlier immunosuppressive agents, TNF-alpha inhibitors offer a targeted approach to therapy. (pharmacytimes.com)
4 The Centers for Disease Control and Prevention (CDC) recommends systematic testing and treatment of LTBI in patients initiating the use of TNF-alpha inhibitors. (pharmacytimes.com)
10 This case demonstrates the importance of screening for LTBI in patients receiving TNF-alpha inhibitors. (pharmacytimes.com)
The tumor necrosis factor (TNF)-alpha inhibitors adalimumab, infliximab, and etanercept are widely used for therapy of autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis, and psoriasis. (siemens-healthineers.com)
To retrospectively investigate and compare the effects of tumor necrosis factor alpha inhibitors (TNFi) on hepatic enzymes in ankylosing spondylitis (AS) patients. (mmp-signal.com)
Patients from the GLAS cohort treated with TNF-alpha inhibitors who had a serum trough level measurement during follow-up because of an increase in ax-SpA related symptoms between June 2015 and June 2018 were included. (rug.nl)
Secondly, to explore if these serum trough levels are associated with disease activity (DA) and/or change in DA.MethodsPatients from the GLAS cohort treated with TNF-alpha inhibitors who had a serum trough level measurement during follow-up because of an increase in ax-SpA related symptoms between June 2015 and June 2018 were included. (rug.nl)

[2] Radiographic axial spondyloarthritis is also known as ankylosing spondylitis (AS). (physio-pedia.com)
Ankylosing spondylitis and non-radiographic axial spondyloarthritis are inflammatory diseases of the spine. (mydr.com.au)
Is there a difference between spondyloarthritis and ankylosing spondylitis? (medicalnewstoday.com)
Ankylosing spondylitis (AS) is a common type of spondyloarthritis. (medicalnewstoday.com)
2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis. (nature.com)
http://dx.doi.org/10.1016/j.imlet.2013.05.004 Cortes A, Hadler J, Pointon JP, Robinson PC, International Genetics of Ankylosing Spondylitis Consortium (IGAS)Australo-Anglo-American Spondyloarthritis Consortium (TASC)Groupe Française d'Etude Génétique des Spondylarthrites (GFEGS)Nord-Trøndelag Health Study (HUNT)Spondyloarthritis Research Consortium of Canada (SPARCC)Wellcome Trust Case Control Consortium 2 (WTCCC2)et al (2013). (geneticsmr.com)
Key secondary endpoints at week 16 included ASAS 40 response, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) 50 response, ASAS partial remission and change from baseline in Spondyloarthritis Research Consortium of Canada (SPARCC) MRI Sacroiliac Joints Scoring. (jnj.com)
To investigate, in daily clinical practice, TNF-alpha inhibitor serum trough levels in patients experiencing an increase in axial spondyloarthritis (ax-SpA) related symptoms. (rug.nl)
abstract = "ObjectiveTo investigate, in daily clinical practice, TNF-alpha inhibitor serum trough levels in patients experiencing an increase in axial spondyloarthritis (ax-SpA) related symptoms. (rug.nl)
Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with spondyloarthritis. (cdc.gov)

Because of the central role of tumor necrosis factor alpha in the spondyloarthritides, we performed a randomized, double-blind, placebo-controlled trial of etanercept, a recombinant human tumor necrosis factor receptor (p75):Fc fusion protein, in patients with ankylosing spondylitis. (nih.gov)
Forty patients with active, inflammatory ankylosing spondylitis were randomly assigned to receive twice-weekly subcutaneous injections of etanercept (25 mg) or placebo for four months. (nih.gov)
Treatment with etanercept for four months resulted in rapid, significant, and sustained improvement in patients with ankylosing spondylitis. (nih.gov)
Recently biological blockade with the tumour necrosis factor alpha (TNFα) antagonists infliximab and etanercept has been shown to be effective in the treatment of SpA. (bmj.com)
Etanercept was discontinued, and the patient was referred to an infectious disease specialist, who made a diagnosis of acquired LTBI due to TNF-alpha inhibitor therapy with etanercept. (pharmacytimes.com)
Etanercept is a human tumour necrosis factor receptor p75 Fc fusion protein produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian expression system. (medicines.org.uk)

AS is a type of seronegative spondyloarthropathy, meaning that tests show no presence of rheumatoid factor (RF) antibodies. (wikipedia.org)
Increased tumor necrosis factor-alpha mRNA expression in whole blood from patients with rheumatoid arthritis: reduction after infliximab treatment does not predict response. (jrheum.org)
The prevalence and incidence of work disability in rheumatoid arthritis, and the effect of anti-tumor necrosis factor on work disability. (jrheum.org)
Clinical indications include rheumatoid arthritis, Crohn's disease, ankylosing spondylitis and psoriasis. (ox.ac.uk)
Treatment of polyarthritis (rheumatoid factor positive or negative) and extended oligoarthritis in children and adolescents from the age of 2 years who have had an inadequate response to, or who have proved intolerant of, methotrexate. (medicines.org.uk)
Patients with AS are typically negative for rheumatoid factor. (eisai.com)
To determine the prevalence of sexual dysfunction (FSD) among women with rheumatoid arthritis attending the Rheumatology Clinic in Universiti Kebangsaan Malaysia Medical Centre (UKMMC) and Hospital Putrajaya, Malaysia, and to determine its associations with potential clinical and disease activity factors. (mmp-signal.com)

Ankylosing spondylitis is a chronic, progressive inflammatory disorder primarily affecting the axial skeleton. (medscape.com)
Most patients have predominantly axial involvement (called axial ankylosing spondylitis). (msdmanuals.com)
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by involvement of primarily axial, but also peripheral joints. (bjbms.org)

Efficacy and safety of adalimumab in Chinese adults with active ankylosing spondylitis: results of a randomised, controlled trial. (geneticsmr.com)
In clinical studies in patients with active ankylosing spondylitis in Japan, Humira demonstrated excellent efficacy in improving the signs and symptoms of ankylosing spondylitis and tolerability equivalent to that observed in foreign studies. (eisai.com)

The signs and symptoms of ankylosing spondylitis often appear gradually, with peak onset between 20 and 30 years of age. (wikipedia.org)
HUMIRA is a prescription medicine used to reduce the signs and symptoms of ankylosing spondylitis in adults. (humira.com)
The signs and symptoms of ankylosing spondylitis differ from person to person. (epainassist.com)

Ankylosing spondylitis (AS) is a type of arthritis characterized by long-term inflammation of the joints of the spine, typically where the spine joins the pelvis. (wikipedia.org)
Anterior and posterior segment inflammation is greater with uveitis associated with ankylosing spondylitis than it is with idiopathic uveitis, especially if ocular surgery is performed. (medscape.com)
Ankylosing spondylitis ( AS ) is a type of arthritis in which there is a long-term inflammation of the joints of the spine. (findzebra.com)
Although the cause of AS is unknown, it is believed that immunological factors and other factors such as infection with specific bacteria play important roles in causing an immune disorder which induces inflammation of the ligaments and tendons where they attach to bone and eventually rigidity of the spine and other joints. (eisai.com)
Ankylosing spondylitis causes moderate to severe inflammation of the vertebrae that causes chronic pain and ultimately disability. (epainassist.com)
About SIMPONI ® (golimumab) SIMPONI is a human monoclonal antibody that targets and neutralises excess tumor necrosis factor (TNF)-alpha, a protein that when overproduced in the body due to chronic inflammatory diseases can cause inflammation and damage to bones, cartilage and tissue. (jnj.com)
It works by blocking the action of a protein called tumor necrosis factor-alpha (TNF-alpha), which is involved in the inflammation that causes these diseases. (writeupcafe.com)
Ankylosing spondylitis causes inflammation of the sacroiliac joint where the spine joins the pelvis or hip bone. (turmericforhealth.com)
Ankylosing spondylitis is characterized by inflammation in the lower end of the spine. (turmericforhealth.com)
The prime reason why curcumin can benefit in ankylosing spondylitis is that it is an anti-inflammatory agent and can help reduce inflammation, pain and stiffness in this condition. (turmericforhealth.com)
Curcumin inhibits the activity of inflammatory chemicals such as interleukin and tumor necrosis factor alpha and nuclear factor kappa B which aids in inhibiting inflammation. (turmericforhealth.com)
It works by inhibiting tumour necrosis factor alpha (TNF-alpha), a naturally occurring protein that promotes inflammation. (hospitalpharmacyeurope.com)
Interleukin-1 alpha is described as "pro-inflammatory" because it stimulates the activity of genes involved in inflammation and immunity. (medlineplus.gov)
Studies suggest that the effects of IL1A variations are probably related to the role of interleukin-1 alpha in promoting inflammation. (medlineplus.gov)
Variations in the IL1A gene have been studied as potential risk factors for several other disorders associated with abnormal inflammation. (medlineplus.gov)

Objective To assess the effectiveness of switching to a second tumour necrosis factor inhibitor (TNFi) in patients with ankylosing spondylitis (AS). (bmj.com)
The impact of smoking on response to tumor necrosis factor-α inhibitor" by HANDAN YARKAN TUĞSAL, GÖKÇE KENAR ARTIN et al. (tubitak.gov.tr)
Background/aim: To investigate the impact of smoking on disease activity, treatment retention, and response in patients with ankylosing spondylitis (AS) treated with their first tumor necrosis factor-α inhibitor (TNFi). (tubitak.gov.tr)
It is well established that TNF-alpha inhibitor use increases the risk of TB infection. (pharmacytimes.com)
Therefore, we set up a study using nationwide Swedish high-coverage administrative register data with the objective to identify patient groups with distinct persistence of subcutaneous tumor necrosis factor inhibitor (SC-TNFi) treatment in IA, using recursive partitioning, a statistical learning algorithm. (lu.se)
In this observational study in daily clinical practice, approximately half of ax-SpA patients who experienced an increase in symptoms had below therapeutic TNF-alpha inhibitor serum trough levels. (rug.nl)
The increase in DA was significantly larger in patients with below therapeutic drug levels compared to patients with therapeutic levels (AASDAS: 0.94 +/- 0.81 vs. -0.07 +/- 126, pConclusionIn this observational study in daily clinical practice, approximately half of ax-SpA patients who experienced an increase in symptoms had below therapeutic TNF-alpha inhibitor serum trough levels. (rug.nl)

Janssen said Simponi Aria is the only fully-human anti-tumor necrosis factor-alpha therapy administered via a 30-minute infusion. (chaindrugreview.com)
Infections and anti-tumor necrosis factor alpha therapy. (koreamed.org)

Adalimumab is a recombinant human anti-TNF-alpha IgG1 monoclonal antibody that blocks inflammatory activity of TNF-alpha. (medscape.com)
Adalimumab is a monoclonal antibody that neutralizes the activity of tumor necrosis factor alpha (TNF-α), a protein that plays a central role in inflammatory reactions in patients with autoimmune diseases. (eisai.com)
Adalimumab belongs to a class of medications known as tumor necrosis factor (TNF) blockers. (medicalnewstoday.com)

Go to Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy for complete information on this topic. (medscape.com)

Although the cause of ankylosing spondylitis is unknown, it is believed to involve a combination of genetic and environmental factors. (wikipedia.org)
The underlying cause of ankylosing spondylitis is still not known. (epainassist.com)

Here's everything about how occupational therapy can help in ankylosing spondylitis. (epainassist.com)
How can turmeric help in ankylosing spondylitis? (turmericforhealth.com)

At three and six months, 68% and 63% of patients were Assessments in Ankylosing Spondylitis (ASAS)20 responders, 49% and 46% ASAS40 responders, and 49% and 50% Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)50 responders, respectively. (nih.gov)
An improvement was defined according to the Assessments in Ankylosing Spondylitis (ASAS)-20 and BASDAI-50. (smj.org.sg)

We investigated whether infliximab, an anti-TNF-alpha therapy, may modify the lipid profile. (researchgate.net)
Infliximab is a chimeric monoclonal antibody against tumour necrosis factor alpha (TNF-α). (gabionline.net)
Infliximab is a tumor necrosis factor alpha blocker. (medscape.com)

ASAS/WHO ICF Core Sets for ankylosing spondylitis (AS): how to classify the impact of AS on functioning and health. (geneticsmr.com)
The primary endpoint of the study was an Assessment in Ankylosing Spondylitis (ASAS) 20 response at week 16. (jnj.com)

one of aggressive type of bc is triple-negative breast cancer (tnbc) that defined as without estrogen receptors, progesterone receptors, and human epidermal growth factor (her2). (icbcongress.com)
It specifically binds to TNF-alpha and blocks its interaction with p55 and p75 cell surface TNF receptors. (medscape.com)
Tumor necrosis factor (TNF)-alpha and TNF receptors in viral pathogenesis. (koreamed.org)
Golimumab neutralizes the biological activity of TNF-alpha by binding to it and blocking its interaction with cell surface TNF receptors. (bcbsnd.com)

Golimumab is a human anti-TNF-alpha monoclonal antibody that blocks the inflammatory activity of TNF-alpha. (medscape.com)
It is a monoclonal antibody that inhibits the function of the inflammatory protein tumour necrosis factor-alpha (TNF-alpha). (writeupcafe.com)
Trastuzumab is a monoclonal antibody that binds to and inactivates the human epidermal growth factor receptor 2 (HER2)/neu receptor. (gabionline.net)

Golimumab acts by binding to a specific protein in the body called tumour necrosis factor (TNF) alpha. (mydr.com.au)
Golimumab is a tumor necrosis factor (TNF) blocker. (bcbsnd.com)

The antibody-based targeted delivery of interleukin-4 and 12 to the tumor neovasculature eradicates tumors in three mouse models of cancer. (geneticsmr.com)

Ankylosing spondylitis is one of the seronegative spondyloarthropathies, a group of multisystem inflammatory diseases that affects the spine, peripheral joints, adjacent soft tissues, and extra-articular structures. (medscape.com)

Ankylosing spondylitis (AS) is a systemic rheumatic disease, meaning it affects the entire body. (wikipedia.org)
Ankylosing spondylitis (AS) is an auto-inflammatory spinal rheumatic disease. (icbcongress.com)
To assess the safety of anti-tumor necrosis factor (TNF)-alpha therapy in patients with rheumatic disease and chronic Hepatitis B virus (HBV) infection. (koreamed.org)

Diagnosis requires showing sacroiliitis on imaging Treatment is with nonsteroidal anti-inflammatory drugs and/or tumor necrosis factor antagonists or interleukin-17 (IL-17) antagonists and physical measures that maintain joint flexibility. (msdmanuals.com)

In an effort to contribute to improving the quality of life (QOL) of patients with ankylosing spondylitis, Abbott Japan and Eisai will work in tandem to bring Humira as a new treatment option for them. (eisai.com)

Ankylosing spondylitis is a rare form of progressive arthritis that causes stiffness of the spine and pain. (epainassist.com)
Unlike ankylosing spondylitis, which is another type of AxSpA, patients with nr-AxSpA may not present with traditional X-ray evidence of structural damage in sacroiliac joins the spine. (jnj.com)
Ankylosing spondylitis is arthritis that majorly affects the spine. (turmericforhealth.com)
This could be of relevance when ankylosing spondilitis leads to the growth of bones in the spine and their fusion. (turmericforhealth.com)
At baseline and at 5-year follow up, spinal radiographs were graded according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). (biomedcentral.com)
Ankylosing spondylitis (AS) is a chronic, inflammatory disease mainly affecting the sacroiliac joints and the spine, where it is characterized by pathological new bone formation and development of syndesmophytes. (biomedcentral.com)
Conventional x-ray is still considered the gold standard for assessing chronic spinal alterations in AS, with the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) considered as the most valid method for quantifying these changes [ 3 ]. (biomedcentral.com)

Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases. (ox.ac.uk)
Preclinical studies have identified and validated tumour necrosis factor alpha (TNFalpha) as a key disease molecule and therapeutic target for immunotherapeutic intervention in many immune-mediated inflammatory diseases. (ox.ac.uk)
This study was conducted to assess the therapeutic potential of intravenous pamidronate in nonsteroidal anti-inflammatory drug (NSAID) refractory or intolerant cases of ankylosing spondylitis (AS). (smj.org.sg)

Ankylosing spondylitis had been diagnosed five years before his presentation to our clinic, although symptoms had started around the same time as the colitis. (bmj.com)
What are the Symptoms of Ankylosing Spondylitis? (epainassist.com)
The early symptoms of ankylosing spondylitis have been found to affect younger adults usually. (epainassist.com)
Unlike other arthritic and rheumatic conditions, the symptoms of ankylosing typically appear between the ages of 20 to 40 years of age. (epainassist.com)

Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis: a comparison of the Rome, New York and modified New York criteria in patients with a positive clinical history screening test for ankylosing spondylitis. (koreamed.org)
Prevalence and clinical manifestations of ankylosing spondylitis in young Greek males. (geneticsmr.com)
Hence, there are both clinical and economic incentives for the identification of factors associated with treatment persistence. (lu.se)
Patients' clinical data, Bath Ankylosing Spondylitis Disease Activity (BASDAI) scores, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were all examined. (mmp-signal.com)

The recursive partitioning algorithm identified sex and treatment as factors associated with SC-TNFi treatment persistence in PsA and AS/uSpA. (lu.se)

Ankylosing spondylitis is characterized by joint pain and stiffness in the neck, lower back, and hips, as well as the hands and feet in some cases, followed by the development of fusion and rigidity of affected joints over time. (eisai.com)
Ankylosing spondylitis (AS) is a chronic inflammatory disease that manifests first as joint pain and stiffness in the neck, lower back, and hips, as well as hands and feet in some cases, followed by fusion and rigidity of affected joints over time. (eisai.com)
Ankylosing spondylitis can also cause stiffness and pain in other parts of the body, especially the large joints like shoulders, knees, and hips. (epainassist.com)
Curcumin possess painkiller activity which can aid in reducing pain and stiffness in ankylosing spondylitis. (turmericforhealth.com)

The presence of the HLA-B27 protein is also a risk factor for ankylosing spondylitis. (epainassist.com)
According to a 2002 study published in the Rheumatology Journal found that over 90 percent of people who were diagnosed with ankylosing spondylitis have this gene that expresses the HLA-B27 protein. (epainassist.com)
The IL1A gene provides instructions for making a protein called interleukin-1 alpha. (medlineplus.gov)
Interleukin-1 alpha is initially produced as a relatively long protein that is trapped within cells. (medlineplus.gov)
Another protein, called calpain, cuts (cleaves) this precursor protein to create a shorter, mature version of interleukin-1 alpha. (medlineplus.gov)
Each of these variations changes a single protein building block (amino acid) in interleukin-1 alpha. (medlineplus.gov)

Pain in AS can be caused by sacroiliitis , enthesitis, and spondylitis. (physio-pedia.com)

Systemic manifestations of ankylosing spondylitis occur in one third of patients. (msdmanuals.com)

Tumor necrosis factor inhibition in the treatment of refractory sarcoidosis: slaying the dragon? (jrheum.org)

Acute anterior uveitis (AAU) occurs in as many as 39% of patients at some time during the course of ankylosing spondylitis, particularly in persons with the HLA-B27 allele, and can precede the onset of spondylitis in half the cases. (medscape.com)
Late onset AS patients are characterized with lower human leukocyte antigen-B27 sequence, less inflammatory sign, delayed diagnosis, and less MTX and anti-tumor necrosis factor alpha drug usage. (bjbms.org)

[ 3 ] Patients with ankylosing spondylitis who have peripheral arthritis also have a higher prevalence of uveitis. (medscape.com)
Similar to AS, people with the gene HLA-B27 have a higher risk factor of developing enteropathic arthritis. (medicalnewstoday.com)

Smoking predicted progression in men whereas high Bath Ankylosing Spondylitis Metrology Index (BASMI) and exposure to bisphosphonates during follow up (OR 4.78, 95% CI 1.1 to 20.1) predicted progression in women. (biomedcentral.com)

[8] Syndesmophytes are one of the main features of spinal structural damage in ankylosing spondylitis. (physio-pedia.com)
Knowledge about predictors of new spinal bone formation in patients with ankylosing spondylitis (AS) is limited. (biomedcentral.com)

Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis. (geneticsmr.com)
Analysis of single nucleotide polymorphisms in Toll-like receptor 4 shows no association with ankylosing spondylitis in a Korean population. (cdc.gov)
Several variations (polymorphisms) in the IL1A gene have been found to influence the risk of ankylosing spondylitis. (medlineplus.gov)

HLA-B27 typing is not necessary to establish the diagnosis of ankylosing spondylitis, but it is a useful prognostic indicator in patients with uveitis. (medscape.com)

[14] Studies have shown factors such as genetic background gene called ( HLA-B27), microbial infection, endocrinal abnormalities and immune reaction related to the occurrence of AS. (physio-pedia.com)
Single nucleotide polymorphism (SNP) A/G variant rs10440635 close to the PTGER4 gene on human chromosome 5 has been associated with an increased number of cases of ankylosing spondylitis in a population recruited from the United Kingdom, Australia, and Canada. (findzebra.com)
Causative factors of ankylosing spondylitis are unknown but individuals with gene HLA-B27 tend to develop ankylosing spondylitis. (turmericforhealth.com)

AS outpatients who started TNF-α blocking therapy were included in the Groningen Leeuwarden Ankylosing Spondylitis (GLAS) study, an ongoing prospective longitudinal observational cohort study with follow-up visits according to a fixed protocol. (nih.gov)

The factors associated with treatment persistence in RA were less distinct but may comprise disease activity and concurrent conventional systemic disease-modifying anti-rheumatic drug (DMARD) treatment. (lu.se)

For ankylosing spondylitis, Zessly is indicated for treatment of severe, active disease in adults who have responded inadequately to conventional therapy. (medscape.com)

Patients with ankylosing spondylitis and the HLA-B27 antigen tend to develop uveitis at a younger age, have a longer duration of ocular disease, and have more recurrences. (medscape.com)

The most frequent manifestation of ankylosing spondylitis is inflammatory back pain, but disease can begin in peripheral joints, especially in children and women, and rarely with acute iridocyclitis (iritis, anterior uveitis). (msdmanuals.com)
Symptomatic noncompressive motoromyelopathy presents as early manifestation in ankylosing spondylitis. (geneticsmr.com)

Ankylosing spondylitis typically begins in adolescents and young adults but affects people for the rest of their lives. (turmericforhealth.com)

There are few effective treatments for ankylosing spondylitis, which causes substantial morbidity. (nih.gov)

Identifying ankylosing spondylitis (AS) patients who are likely to benefit from tumor necrosis factor-alpha (TNF-α) blocking therapy is important, especially in view of the costs and potential side effects of these agents. (nih.gov)
One of the cases treated with lamivudine before anti-TNF-alpha therapy for chronic hepatitis B treatment. (koreamed.org)
His hepatitis status was maintained stable after he initiated anti-TNF-alpha therapy. (koreamed.org)
Five of the cases started anti-TNF-alpha therapy without lamivudine. (koreamed.org)
Two of these five cases were received lamivudine during anti-TNF-alpha therapy due to elevation of HBV DNA titer without liver function test abnormality and then HBV DNA was normalized. (koreamed.org)
Occupational therapy can help people with ankylosing spondylitis. (epainassist.com)
Your doctor is likely to recommend this occupational therapy combined with physical therapy as part of your treatment plan for ankylosing spondylitis. (epainassist.com)
Physical therapy and healthy diet also benefit in ankylosing spondylitis. (turmericforhealth.com)

Having a family history of ankylosing spondylitis increases the risk of having the disease. (epainassist.com)

The human leukocyte antigen B27 (HLA-B27) allele is present in 90% of White patients with ankylosing spondylitis, but it is also present in up to 10% of the general population depending on ethnicity. (msdmanuals.com)

Anatomy37

Organisms13

Diseases31

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes40

Disciplines and Occupations1

Information Science3

Health Care3

Psoriatic arthritis13

Inhibitors9

Spondyloarthritis10

Etanercept6

Rheumatoid7

Axial3

Active ankylosing2

Signs and symptoms of ankylosing3

Inflammation15

Inhibitor7

Anti-tumor necrosis fact2

Adalimumab3

Spondyloarthropathy1

Cause of ankylosing2

Help in ankylosing2

Assessments in Ankylosing Spondylitis2

Infliximab3

ASAS2

Receptors4

Monoclonal3

Golimumab2

Antibody1

Seronegative spondyloarthropathies1

Rheumatic disease3

Antagonists1

HUMIRA1

Spine7

Therapeutic3

Symptoms4

Clinical4

TNFi1

Stiffness4

Protein6

Sacroiliitis1

Manifestations1

Inhibition1

Onset2

Arthritis2

Progression1

Spinal2

Polymorphisms3

Diagnosis1

Gene3

GLAS1

Systemic1

Treatment of severe1

Tend to develop1

Manifestation2

Typically1

Treatments1

Therapy8

Increases the risk1

Ethnicity1