• Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. (t3db.ca)
  • The cDNA for the rat liver organic anion-transporting polypeptide "oatp" has been shown to encode transport of bromosulfophthalein (BSP) and bile salts in Xenopus oocytes (E. Jacquemin, B. Hagenbuch, B. Stieger, A. W. Wolkoff, and P. J. Meier. (elsevierpure.com)
  • Because oatp mRNA is expressed strongly in the kidney, we sought to determine whether renal oatp might play a role in the known secretion of a large variety of organic anions by the kidney. (elsevierpure.com)
  • Several organic anions known to be secreted by the classic secretory pathway, including paminohippurate (PAH), phenol red, and indigo carmine (10 uM) failed to inhibit oatp-mediated BSP transport. (elsevierpure.com)
  • Human organic anion transporter OATP4C1 is a member of the OATP family predominantly ex-pressed in the kidney, and contributes to the renal secretion of digoxin. (elsevierpure.com)
  • We showed previously that grapefruit and orange juices inhibited human enteric organic anion-transporting polypeptide (OATP)1A2 in vitro and lowered oral fexofenadine bioavailability clinically. (nih.gov)
  • Recently, we isolated a new complementary DNA (cDNA) encoding human liver-specific organic anion transporter (LST-1), representing the multispecificity of human liver. (nih.gov)
  • A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. (aspetjournals.org)
  • Desk 1 The SLC26 Multifunctional Anion Exchanger /Anion Route gene Family includes a one SulP polypeptide, YchM. (exposed-skin-care.net)
  • Impact of organic anion transporting polypeptide, P-glycoprotein, and breast cancer resistance protein transporters on observed tamoxifen and endoxifen concentration and adverse effects. (cdc.gov)
  • 1] "Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (tcdb.org)
  • The objective of the current study was to examine the kinetics of amoxicillin and cefaclor interactions with human renal transporters human organic anion transporter 1 (hOAT1), human peptide transporter 1 (hPepT1), and human peptide transporter 2 (hPepT2) in detail, both as substrates and as inhibitors. (aspetjournals.org)
  • To examine the relationship between H + -ATPase and the transport of anions, we investigated the effects of various inhibitors on the activity of the H + -ATPase, the transport of protons, and the transport of Cl - ions using plasma membrane vesicles prepared from barley roots. (elsevierpure.com)
  • 1. Shitara Y, Sugiyama Y. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions. (degruyter.com)
  • Human renal proximal tubule epithelial cells with over-expressed organic anion transporter 1 (RPTEC-OAT1) were exposed to serial dilutions of 5 AFFF (A-E), 5 SFFF (F-J), and 7 frequently detected PFAS in cell culture media for 6 - 24 hours. (cdc.gov)
  • The SLCO superfamily is comprised of the organic anion transporting polypeptides (OATPs). (guidetopharmacology.org)
  • Scholars@Duke publication: The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. (duke.edu)
  • Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene. (wikipedia.org)
  • Both drugs reduced in a concentration-dependent manner the transport of fluorescein on the classical organic anion system and transport of fluorescein-methotrexate on multidrug resistance-associated protein 2 (Mrp2). (aspetjournals.org)
  • We previously showed that users of OAT family constitutively internalize from and recycle back to the cell surface and Morin hydrate that inhibition of OAT activity by acute activation of protein kinase C (PKC) results from an accelerated internalization Morin hydrate of these transporters from your cell surface to intracellular compartments without affecting the total expression of the transporters (Zhang et al. (bio2009.org)
  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (nih.gov)
  • ATP-Binding Cassette Transporter Family C Protein 10 Participates in the Synthesis and Efflux of Hexosylceramides in Liver Cells. (nih.gov)
  • For instance, DTG decreases the renal clearance of metformin by inhibiting organic cation transporters in renal tubular cells. (medscape.com)
  • This gene is one member of a family of sulfate/anion transporter genes. (wikipedia.org)
  • The decomposition of the organic matter, the imbalance of the N, S, and C cycles, the excess in the cation uptake on anions and the N fixation by the legumes influence the concentration of protons [H + ] in the soil solution. (frontiersin.org)
  • Inhibition of Mrp2-mediated transport was abolished by 50 μM p -aminohippurate, indicating that adefovir and cidofovir entered the cells at the basolateral membrane on the classical organic anion transport system (OAT1). (aspetjournals.org)
  • Organic anion transporter-1 (OAT1) mediates the body's disposition of a diverse selection of environmental toxins and clinically essential medications. (bio2009.org)
  • In the kidney OAT1 and OAT3 make use of a tertiary transport mechanism to move organic anions across the basolateral membrane into the proximal tubule cells for subsequent exit across the apical membrane into the urine for removal. (bio2009.org)
  • The interactions of two antiviral, acyclic nucleoside phosphonates, adefovir and cidofovir, with xenobiotic transporters was studied in intact killifish ( Fundulus heteroclitus ) renal proximal tubules by using fluorescent substrates, confocal microscopy, and quantitative image analysis. (aspetjournals.org)
  • The role of drug transporters is evolving, revealing more drug interactions. (medscape.com)
  • Transporters aid hepatic, renal, and biliary clearance of drugs and may be susceptible to drug interactions. (medscape.com)
  • The influence of drug transporters on drug-drug interactions is complex and requires further understanding. (medscape.com)
  • The discovery that the activity of aluminium-activated malate transporters (ALMTs) can be regulated by GABA 18 represents a plausible mechanism by which GABA signals could be transduced in plants, providing a putative-but unproven-novel signalling link between primary metabolism and physiology 19 . (nature.com)
  • Drugs interacting with organic anion transporter-1 affect uptake of Tc-99m-mercaptoacetyl-triglycine (MAG3) in the human kidney: therapeutic drug interaction in Tc-99m-MAG3 diagnosis of renal function and possible application of Tc-99m-MAG3 for drug development. (bvsalud.org)
  • Renal uptake of Tc-99m-MG3 involves organic anion transporter ( OAT ). (bvsalud.org)
  • Moreover, organic material in decomposition, imbalance in N, S, and C cycles, excessive uptake of cations over anions and the uptake of nitrogen by leguminous crops all increase the concentration of H + and reduce soil pH (Figure 1 ). (frontiersin.org)
  • The phylogenetically ancient SLC26 gene family encodes multifunctional anion exchangers and anion channels transporting a wide selection of substrates, including Cl? (exposed-skin-care.net)
  • We tested an array of organic anions as candidate substrates by determining their ability to compete with tracer BSP for transport. (elsevierpure.com)
  • Because hOAT1 has been suggested to show rather limited capacity for organic anion transport, hOAT3 might play a large role in the human kidney. (aspetjournals.org)
  • Analysis of heterologous expression systems of rOAT1 in oocytes and culture cells revealed that rOAT1 has the ability to transport anionic drugs, such as β-lactam antibiotics, NSAIDs, methotrexate, and antiviral drugs, as well as various endogenous organic anions and exogenous substances. (aspetjournals.org)
  • A subclass of ORGANIC ANION TRANSPORTERS whose transport of organic anions is driven either directly or indirectly by a gradient of sodium ions. (umassmed.edu)
  • In particular, the organic anion transport pathway has been shown to mediate the elimination of various drugs. (aspetjournals.org)
  • The transport properties of rOAT1 are nearly identical to those of the classic PAH transporter. (aspetjournals.org)
  • Previous studies have suggested the involvement of organic anion and oligopeptide transporters in membrane transport of β-lactams. (aspetjournals.org)
  • Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. (t3db.ca)
  • From these properties of the Cl - transporter and the inhibition of H + transport activity by NIF, we suggest that H + -transport activity across the plasma membrane might be modulated by the transport of anions via a NIF- sensitive anion-permeable transporter that acts to collapse the inside- positive potential generated by H + -ATPase. (elsevierpure.com)
  • This cascade of events indirectly links organic anion transport to metabolic energy and the Na+ gradient allowing the entry Morin hydrate of a negatively charged substrate against both its chemical concentration gradient and the electrical potential of the cell (You 2002 Dantzler and Wright 2003 Srimaroeng et al. (bio2009.org)
  • first, organic anions are transported from the peritubular plasma by basolateral organic anion transporter(s) and subsequently effluxed into the tubular lumen by luminal transporter(s). (aspetjournals.org)
  • These results suggest an important role of hOAT3 in the excretion/detoxification of endogenous and exogenous organic anions in the kidney. (aspetjournals.org)
  • All of these isoforms are commonly expressed in the kidney, and their potential roles in renal handling of organic anions have been indicated. (aspetjournals.org)
  • 2010). NMR answer structures have already been resolved for the STAS BIIE 0246 supplier domain name of putative sulfate transporter Rv1739c from (Sharma et al. (exposed-skin-care.net)
  • auxotrophy inside a mutant from the ABC sulfate transporter complicated. (exposed-skin-care.net)
  • non-etheless, deletion in mycobacteria of ABC sulfate transporter complicated subunits will not prevent contamination. (exposed-skin-care.net)
  • rlst-1 also belongs to the same new gene family as human LST-1, located between the organic anion transporter family and the prostaglandin transporter. (nih.gov)
  • As the precise mechanisms of the effect of pravastatin on glucose metabolism and diabetes have not been clarified, we examined the roles of the organic anion transporter family on pravastatin-treated islet and adipocyte functions. (duke.edu)
  • Launch The organic anion transporter (OAT) family members mediates the body's disposition of the diverse selection of environmental poisons and clinically essential medications including anti-HIV therapeutics antitumor medications antibiotics antihypertensives and anti-inflammatories (You 2002 Dantzler and Wright 2003 Srimaroeng et al. (bio2009.org)
  • In fact, ABCB1 belongs to a family of 48 human ATP-dependent transporters, of which approximately 50% can confer resistance to one or another drug. (sciencewatch.com)
  • A sub-family of sequence-related ORGANIC ANION TRANSPORTERS. (bvsalud.org)
  • Investigations by our laboratory around the structure-function relationship of OATs have revealed that glycosylation is necessary for the targeting of these transporters to the plasma membrane (Tanaka et al. (bio2009.org)
  • Our first discovery, with my colleagues Igor Roninson and Ira Pastan, was that multidrug-resistant cancers overexpressed a gene that encoded an ATP-dependent transporter, termed P-glycoprotein, MDR1 or ABCB1. (sciencewatch.com)
  • Various anionic drugs have been indicated to be taken up into the proximal tubular cells by the classic p -aminohippurate (PAH) transporter. (aspetjournals.org)
  • This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. (nih.gov)