AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
SymportersAnionsPlasma Membrane Neurotransmitter Transport ProteinsChlorellaProton-Phosphate SymportersSodium-Phosphate Cotransporter ProteinsSodium-Glucose Transporter 1SodiumAmino Acid Transport SystemsBiological TransportCarrier ProteinsAnion Transport ProteinsMembrane Transport ProteinsOrganic Anion TransportersAmino Acid SequenceMolecular Sequence DataMonosaccharide Transport ProteinsXenopus laevisModels, MolecularProtein Structure, SecondaryLeucineOocytesBinding SitesSodium Chloride SymportersOrganic Anion Transporters, Sodium-IndependentKineticsBacterial ProteinsSequence Homology, Amino AcidVoltage-Dependent Anion ChannelsProtein ConformationCell MembraneSodium-Bicarbonate SymportersVoltage-Dependent Anion Channel 1SuperoxidesChloridesAnion Exchange ResinsSodium-Potassium-Chloride SymportersBromidesVoltage-Dependent Anion Channel 24,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acidp-Aminohippuric Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidBicarbonatesSLC4A ProteinsSulfatesHydrogen-Ion ConcentrationSulfobromophthaleinProbenecidChloride ChannelsOrganic Anion Transport Polypeptide CIodidesIon ChannelsCalixarenesIon ExchangeThiocyanatesCationsSuperoxide DismutaseNitratesAcid-Base ImbalanceMembrane PotentialsCell Membrane PermeabilityAcid-Base EquilibriumIonsBiological Transport, ActiveCarbonatesFree RadicalsEstroneChromatography, Ion ExchangeHypotonic SolutionsPerchloratesElectric ConductivityOxidation-ReductionOxalatesErythrocytesPhosphatesXanthine OxidaseFree Radical Scavengers
TransportersTransporterCationBile acid:sodium symporterIodideNitrateSulfateDivalentCationsChloridePerchlorateCotransporterGlucoseTransportIonsAcetateElectrogenicStructuralChannelFunctionFormWaterBile acid:sodium symporter activityPerchlorateProteinsSodium:bicarbonateInorganic anionsPotassium-chlorideProteinThyroidInterproscanFamilyPolypeptidesMoleculesIodineHighlyInclude
Transporters4
  • Proteins of the DASS family are divided into two groups of transporters with distinct anion specificities: the Na+-sulfate (NaS) cotransporters and the Na+-carboxylate (NaC) cotransporters. (wikipedia.org)
  • Once in periplasmic space, glucose is transported into the cytoplasm by several systems, including the phosphoenolpyruvate-dependent phosphotransferase system (PTS), the ATP-dependent cassette (ABC) transporters, and the major facilitator (MFS) superfamily proton symporters. (encyclopedia.pub)
  • The SLC13 transporters belong to a larger group of associated transporters referred to as the divalent anion:Na symporter (DASS) family members (Transporter Classification Database no. two.A.47) (Saier et al. (idhinhibitor.com)
  • The manuscript represents an important contribution to an ongoing discussion about the substrate binding site and mechanism of the Bile Acid Sodium Symporter (BASS) family of transporters. (elifesciences.org)
Transporter3
  • 1] "Cloning and functional characterization of human sodium-dependent organic anion transporter (SLC10A6). (tcdb.org)
  • The human sodium iodide symporter (hNIS) is a theranostic reporter gene which concentrates several clinically approved SPECT and PET radiotracers and plays an essential role for the synthesis of thyroid hormones as an iodide transporter in the thyroid gland. (elsevierpure.com)
  • Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N. Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. (ucdenver.edu)
Cation4
  • In water, perchlorates will rapidly dissolve and completely dissociate into the perchlorate anion and the corresponding cation. (cdc.gov)
  • To maintain charge neutrality on the outside of cells every sodium cation is followed by a chloride anion. (hawaii.edu)
  • The difference between a cation and an anion is the net electrical charge of the ion. (welladjusted.co)
  • Sometimes, you can predict whether an atom will form a cation, or an anion based on its position on the periodic table. (welladjusted.co)
Bile acid:sodium symporter1
  • The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants. (elifesciences.org)
Iodide7
  • Nitrate and thiocyanate are polyatomic anions that can disrupt thyroid function by competitively inhibiting iodide uptake, similar to the action of perchlorate. (cdc.gov)
  • Nitrate, thiocyanate, and perchlorate can reversibly bind to the sodium-iodide symporter (NIS) protein resulting in reduced iodine absorption by the thyroid. (cdc.gov)
  • The iodide ions are transported into the follicular cells of the thyroid gland by the sodium/iodide symporter (NIS) and for each iodide anion (I-), NIS transports two sodium cations (Na+) into the cell. (mugesh-iisc.in)
  • Pseudohalides such as thiocyanate (SCN - ), hexafluorophosphate (PF6 − ), and monovalent anions such as nitrate (NO 3 - ), chlorate (ClO 3 - ), perchlorate (ClO 4 - ), and perrhenate (ReO 4 - ) are also substrates and block iodide translocation by competition for the iodide binding and transport site of NIS [6,10]. (solvobiotech.com)
  • 18)F-tetrafluoroborate ((18)F-TFB), a PET probe for imaging sodium-iodide symporter expression: Whole-body biodistribution, safety and radiation dosimetry in thyroid cancer patients. (americanelements.com)
  • Sodium-iodide symporters (NIS) actively transport iodide ions from the bloodstream into thyroid follicular cells against a sodium electrochemical gradient, which is maintained by the sodium-potassium pump (Na+/K+-ATPase). (myendoconsult.com)
  • Iodide ions are then transported to the apical membrane of the thyroid follicular cells by the action of pendrin, an anion exchanger protein. (myendoconsult.com)
Nitrate1
  • Nitrate anion can also form endogenously. (cdc.gov)
Sulfate1
  • Two other SLC13 members (NaS1 [SLC13A1] and NaS2 [SLC13A4]) transport, among other compounds, divalent anions sulfate and selenate (Busch et al. (idhinhibitor.com)
Divalent2
  • Divalent anion:Na+ symporters were found in bacteria, archaea, plant chloroplasts and animals. (wikipedia.org)
  • They have a substrate preference for divalent anions, which include tetra-oxyanions for the NaS cotransporters or Krebs cycle intermediates (including mono-, di- and tricarboxylates) for the NaC cotransporters. (wikipedia.org)
Cations3
Chloride3
  • There is also a growing body of evidence that the perchlorate anion may be reduced to chloride by plants. (cdc.gov)
  • A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process. (nih.gov)
  • Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. (musc.edu)
Perchlorate4
  • It is the perchlorate anion that is responsible for the potential adverse health effects. (cdc.gov)
  • In the remainder of this document, perchlorates will be used to refer to the solid salts and perchlorate anion (or simply perchlorate) will be used to refer to the anionic species that is monitored in the environment. (cdc.gov)
  • The perchlorate anion is highly mobile in wet soil and it is expected to ultimately partition to surface water and groundwater. (cdc.gov)
  • The in situ degradation of the perchlorate anion in the environment has not yet been demonstrated, although laboratory studies indicate that it undergoes biodegradation by a wide variety of microorganisms under anaerobic conditions. (cdc.gov)
Cotransporter1
  • We therefore examined whether FSL rats differed from control rats for the expression levels of the K + /Cl - cotransporter, KCC2, which transports Cl - ions out of neurons, thus creating the concentration gradient that allows Cl - influx through the anion channel associated with GABA A receptors. (wustl.edu)
Glucose2
  • Transport of Na+ and K+ coupled to active reabsorption of glucose, amino acids, other organic anions and PO3 4 ¯ through specific symporters. (pharmacy180.com)
  • The transport protein, called the glucose symporter, uses the sodium gradient to power glucose movement into the cell. (hawaii.edu)
Transport5
  • Unfortunately, it is hindered by lack of understanding of the 3D organization of hNIS and its relation to anion transport. (elsevierpure.com)
  • Organic Anion Transport Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • This graph shows the total number of publications written about "Organic Anion Transport Protein 1" by people in this website by year, and whether "Organic Anion Transport Protein 1" was a major or minor topic of these publications. (ucdenver.edu)
  • Below are the most recent publications written about "Organic Anion Transport Protein 1" by people in Profiles. (ucdenver.edu)
  • In addition to I-, NIS also mediates the transport of other anions. (solvobiotech.com)
Ions1
Acetate1
  • d) The disproportionately large HCO 3 ¯, acetate, PO 4 3 ¯, amino acid and other anion reabsorption create passive driving forces for Cl¯ to diffuse through the paracellular pathway (in between tubular cells), particularly in the later PT. (pharmacy180.com)
Electrogenic1
  • The Na+:anion coupling ratio is 3:1, indicative of electrogenic properties. (wikipedia.org)
Structural1
  • Glutamate/aspartate:Na+ symporter, GLAST or EAAT1, Structural rearrangements have been probed by Leighton et al. (lbl.gov)
Channel1
  • It can function as an uncoupled anion, water and/or urea channel (Vandenberg et al. (lbl.gov)
Function1
  • Examples of function annotation using dissectHMMER, including the function discovery of an uncharacterized membrane protein Q9K8K1_BACHD (WP_010899149.1) as a lactose/H+ symporter, are presented. (beds.ac.uk)
Form2
  • Halogen atoms are characterized by an electronic structure where they are missing one electron, so they readily form the anion X 2 . (welladjusted.co)
  • Halogens always form anions. (welladjusted.co)
Water1
  • This segment, also impermeable to water, continues to absorb salt, but here it is through a Na+Cl¯ symporter. (pharmacy180.com)
Bile acid:sodium symporter activity1
  • Predicted to enable bile acid:sodium symporter activity. (nih.gov)
Perchlorate13
  • [ 3 , 4 ] Perchlorate uses the sodium-iodide symporter, which is what usually moves iodide or other anions into the thyroid follicular cells or human milk in the mammary gland. (medscape.com)
  • Perchlorate, an anion, competes with iodide for the symporter and thus inhibits uptake of iodide. (medscape.com)
  • Perchlorate is a polyatomic anion that can disrupt thyroid function by competitively inhibiting iodide uptake. (cdc.gov)
  • Nitrate and thiocyanate are polyatomic anions that can disrupt thyroid function by competitively inhibiting iodide uptake, similar to the action of perchlorate. (cdc.gov)
  • Nitrate, thiocyanate, and perchlorate can reversibly bind to the sodium-iodide symporter (NIS) protein resulting in reduced iodine absorption by the thyroid. (cdc.gov)
  • It is the perchlorate anion that is responsible for the potential adverse health effects. (cdc.gov)
  • In the remainder of this document, perchlorates will be used to refer to the solid salts and perchlorate anion (or simply perchlorate) will be used to refer to the anionic species that is monitored in the environment. (cdc.gov)
  • The perchlorate anion is highly mobile in wet soil and it is expected to ultimately partition to surface water and groundwater. (cdc.gov)
  • The in situ degradation of the perchlorate anion in the environment has not yet been demonstrated, although laboratory studies indicate that it undergoes biodegradation by a wide variety of microorganisms under anaerobic conditions. (cdc.gov)
  • There is also a growing body of evidence that the perchlorate anion may be reduced to chloride by plants. (cdc.gov)
  • She participated in demonstrating that the environmental pollutant perchlorate (ClO4-) is actively transported by NIS, and that NIS mediates this translocation with a 1Na+:1ClO4- stoichiometry rather than the 2 Na+:1 anion stoichiometry that characterizes NIS-mediated I- transport. (thyroid.org)
  • Goals Perchlorate nitrate and thiocyanate are well-known inhibitors from the sodium-iodide symporter and could disrupt thyroid function. (techblessing.com)
  • Intro Monovalent anions such as for example perchlorate nitrate fluoroborate and thiocyanate are recognized to competitively inhibit iodide uptake and could disrupt thyroid function [1] [2]. (techblessing.com)
Proteins1
  • The relevance of the SLC26 family in maintaining anion equilibria is underlined by the causative role of mammalian SLC26 proteins in diseases such as congenital chloride diarrhea and cytotoxic brain edema. (cef-mc.de)
Sodium:bicarbonate1
  • Enables sodium:bicarbonate symporter activity. (zfin.org)
Inorganic anions1
  • The solute carrier family 26 (SLC26) facilitates the transport of a broad variety of organic and inorganic anions in cells. (cef-mc.de)
Potassium-chloride1
  • A subclass of symporters that specifically transport SODIUM CHLORIDE and/or POTASSIUM CHLORIDE across cellular membranes in a tightly coupled process. (nih.gov)
Protein2
  • The Leaf rust resistance 67 (Lr67) gene fits into the latter category as it confers partial resistance to multiple biotrophic fungal pathogens in wheat and encodes a Sugar Transport Protein 13 (STP13) family hexose-proton symporter variant. (bvsalud.org)
  • Low density lipoprotein related protein 1 (LPR-1), thrombospondin-1 (TSP-1), voltage dependent anion channel (VDAC) 1-2 and annexin A1 were considered to be of special interest and were analysed further by western blotting. (biomedcentral.com)
Thyroid3
  • Responding to her keen interest in endocrinology, and particularly thyroidology, she joined the laboratory of Dr. Nancy Carrasco, where she has been studying the role of the Na+/I- symporter (NIS) in physiology and pathophysiology, including its expression in tissues other than the thyroid. (thyroid.org)
  • To date there is no study specifically investigating the relationship between PTH levels and the effects of various monovalent anions that have traditionally been considered as thyroid-disrupting providers. (techblessing.com)
  • In the thyroid gland, iodide is concentrated or "trapped" by the sodium-iodide symporter (NIS), which utilizes the sodium gradient developed by the Na + ,K + -ATPase to move iodide through the basolateral plasma membrane of the thyroid follicular cell. (veteriankey.com)
Interproscan1
  • Sodium:alanine symporter family [Interproscan]. (ntu.edu.sg)
Family2
  • sodium/sulphate symporter family me. (nig.ac.jp)
  • The bile acid sodium symporter (BASS) family transports a wide array of molecules across membranes, including bile acids in humans, and small metabolites in plants. (feedspot.com)
Polypeptides1
  • The transport mechanism of mammalian SLC4/AE polypeptides is that of electroneutral Cl(-)/anion exchange, but trout erythroid Ae1 also mediates Cl(-) conductance. (nih.gov)
Molecules2
  • Uptake of -AM dyes by EMVs, including frank vacuoles, probably results from the action of intravesicular esterases, following diffusional entry of lipophilic neutral molecules or partially de-esterified anions. (biologists.com)
  • A symporter carries two different ions or molecules, both in the same direction. (edu.vn)
Iodine2
  • however, iodine is a chemical element whereas iodide is an anion [ 5 ]. (zrtlab.com)
  • Iodide (I ¯ ) - Iodide is the anion of iodine and typically binds to other elements to form a salt such as potassium iodide or sodium iodide. (zrtlab.com)
Highly1
  • The totally free radicals and reactive oxygen and also nitrogen types recognized to be fed on by melatonin include the highly harmful hydroxyl radical, peroxynitrite anion, as well as hypochlorous acid, among others. (almoheet-travel.com)
Include1
  • They have a substrate preference for divalent anions, which include tetra-oxyanions for the NaS cotransporters or Krebs cycle intermediates (including mono-, di- and tricarboxylates) for the NaC cotransporters. (wikipedia.org)