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  • SLC4A1
  • MBS7230564 is a ready-to-use microwell, strip plate Competitive ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Band 3 anion transport protein (SLC4A1) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • Cytoskeleton
  • The primary defect in SAO differs significantly from other forms of elliptocytosis in that it is a defect in the gene coding for a protein that is not directly involved in the cytoskeleton scaffolding of the cell. (wikipedia.org)
  • The lack of a cell wall also calls for increased support of the cell membrane(reinforced with sterols), which includes a rigid cytoskeleton composed of an intricate protein network and, potentially, an extracellular capsule to facilitate adherence to the host cell. (wikipedia.org)
  • binds
  • MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. (wikipedia.org)
  • regulation
  • Some of the proteins in snake venom have very specific effects on various biological functions including blood coagulation, blood pressure regulation, and transmission of the nervous or muscular impulse, and have been developed for use as pharmacological or diagnostic tools, and even useful drugs. (wikipedia.org)
  • They are involved in regulation of kinases and phosphatases, G protein associated factors and transcriptional factors. (wikipedia.org)
  • Regulation of protein activity mainly involves phosphorylation/dephosphorylation events, leading to its activation or inhibition. (wikipedia.org)
  • transporters
  • Cotransporters are a subcategory of membrane transport proteins (transporters) that couple the favorable movement of one molecule with its concentration gradient and unfavorable movement of another molecule against its concentration gradient. (wikipedia.org)
  • Renal
  • Mutations of kidney AE1 cause distal (type 1) renal tubular acidosis, which is an inability to acidify the urine, even if the blood is too acidic. (wikipedia.org)
  • cell
  • Monoclonal antibodies against the membrane domain of human red blood cell band 3 protein have been prepared and used in topographical studies of the arrangement of the polypeptide in the membrane. (semanticscholar.org)
  • Although the initial studies were done using human erythrocytes as a model senescent cell antigen has been found on all cells examined (Kay 1981). (springer.com)
  • Branch DR Gallagher MT, Mison AP Sy Siok Hian AL, Petz LD (1984) In vitro determination of red cell afloantibody significance using an assay of monocyte-macrophage interaction with sensitized erythrocytes. (springer.com)
  • The anion transport system of the red blood cell. (springer.com)
  • The internal framework of a eukaryotic cell, composed of protein filaments that provide structural support and drive the movement of the cell and its internal components, typically divided into three categories (microfilaments, intermediate filaments, and microtubules) based on the diameter and composition of the filaments. (thefreedictionary.com)
  • In healthy erythrocytes, cell volume is regulated by the transport of cations (Na + and K + ), which are pumped across the plasma membrane to maintain the osmotic potential and keep the cell correctly hydrated. (haematologica.org)
  • 4 Band 3 is the most abundant erythrocyte membrane protein and plays a central role in red cell structure and function. (haematologica.org)
  • 2) All of these antibodies react with regions of the protein located at the cytoplasmic surface of the red cell. (biochemj.org)
  • 4) Our results show that the C-terminus of the red-cell anion transport protein is located on the cytoplasmic side of the red-cell membrane. (biochemj.org)
  • Rather, the defect lies in a protein known as the band 3 protein, which lies in the cell membrane itself. (wikipedia.org)
  • The band 3 proteins aggregate on the cell membrane at the site of entry, forming a circular orifice that the parasite squeezes through. (wikipedia.org)
  • The increased rigidity of the erythrocyte membrane in SAO is thought to reduce the capacity of the band 3 proteins to cluster together, thereby making it more difficult for the malaria parasite to properly attaching to and enter the cell. (wikipedia.org)
  • Their N-terminal hydrophilic domains may interact with cytoskeletal proteins and therefore play a cell structural role. (wikipedia.org)
  • The bicarbonate is then excreted (in exchange for a chloride) from the cell by band 3. (wikipedia.org)
  • In mammals, it is present in two specific sites: the erythrocyte (red blood cell) cell membrane and the basolateral surface of the alpha-intercalated cell (the acid secreting cell type) in the collecting duct of the kidney. (wikipedia.org)
  • eAE1 is an important structural component of the erythrocyte cell membrane, making up to 25% of the cell membrane surface. (wikipedia.org)
  • These mutations are disease causing as they cause mistargetting of the mutant band 3 proteins so that they are retained within the cell or occasionally addressed to the wrong (i.e. apical) surface. (wikipedia.org)
  • AE1 was discovered following SDS-PAGE ( sodium dodecyl sulfate polyacrylamide gel electrophoresis ) of erythrocyte cell membrane. (wikipedia.org)
  • For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport of a monocarboxylate across the membrane. (wikipedia.org)
  • Because bilayers define the boundaries of the cell and its compartments, these membrane proteins are involved in many intra- and inter-cellular signaling processes. (wikipedia.org)
  • If a typical mammalian cell (diameter ~10 micrometers) were magnified to the size of a watermelon (~1 ft/30 cm), the lipid bilayer making up the plasma membrane would be about as thick as a piece of office paper. (wikipedia.org)
  • band
  • Western blot analysis showed the presence of a band 3-like protein of about 95 kDa, only in the adult epithelial extract, corroborating the immunocytochemical observations. (biomedsearch.com)
  • The finding of the presence of band 3-like protein in the MR cells of Pelobates, is similar to the observations made in the skin of other amphibian species. (biomedsearch.com)
  • Mild trypsin treatment of ghosts, which cleaves off the cytoplasmic portion of band 3 without affecting spectrin, actin, and protein 4.1, increased the intercompartmental hop rate of band 3 by a factor of 6, whereas it did not change the corral size and the microscopic diffusion rate within a corral. (nih.gov)
  • Monoclonal antibodies against human erythrocyte band 3 protein. (semanticscholar.org)
  • An immunoreactive form of the anion channel protein of erythrocytes, band 3, has been identified in the rat kidney. (semanticscholar.org)
  • the aging antigen itself is generated by the degradation of an important structural and transport membrane molecule, protein band 3 (Kay 1984). (springer.com)
  • Again, it is thought that the mutations responsible (Ser731Pro and His734Gln) affect the normal folding of band 3 and convert the protein into a cation conductor. (haematologica.org)
  • 4 Another mutation in band 3 has been identified as responsible for HSt Blackburn (Leu687Pro), in which affected erythrocytes share features of CHC and familial pseudohyperkalemia ( see below ), but the cation leak is not increased at low temperatures. (haematologica.org)
  • AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein. (wikipedia.org)
  • Associations of human erythrocyte band 4.2. (wikipedia.org)
  • AE3 is functionally similar to the Band 3 Cl−/HCO3− exchange protein but it is expressed primarily in brain neurons and in the heart. (wikipedia.org)
  • structural
  • One approach for obtaining high-resolution structural and functional information for biomembranes and their proteins is by static solid-state NMR of oriented systems. (ox.ac.uk)
  • 1988
  • Bosman GJCGM, Kay MMB (1988) Erythrocyte aging: A comparison of model systems for simulating cellular aging in vitro. (springer.com)
  • Biological
  • A complex mixture of proteins, enzymes, and various other substances with toxic and lethal properties serves to immobilize the prey animal, enzymes play an important role in the digestion of prey, and various other substances are responsible for important but non-lethal biological effects. (wikipedia.org)
  • Proteins constitute 90-95% of venom's dry weight and they are responsible for almost all of its biological effects. (wikipedia.org)
  • 2000
  • Mycoplasma pneumoniae cells have an elongated shape that is approximately 0.1-0.2 µm (100-200 nm) in width and 1-2 µm (1000-2000 nm) in length. (wikipedia.org)
  • cellular
  • 1 The cation leak results in deregulation of cellular volume, which can lead to morphological abnormality. (haematologica.org)
  • Members of the AE family are generally responsible for the transport of anions across cellular barriers, although their functions may vary. (wikipedia.org)
  • The cellular response in signal transduction cascades involves alteration of the expression of effector genes or activation/inhibition of targeted proteins. (wikipedia.org)