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  • mouse
  • We have identified polymorphic microsatellite markers for the mouse strains used and performed a genomewide scan on 237 females from a gene-segregating backcross between a high breeder and a relatively poor breeder. (genetics.org)
  • The high-breeder mouse strain we used is the inbred NFR/N mouse (MHC haplotype H-2q), which has extraordinary good breeding properties. (genetics.org)
  • The Jackson Laboratory is committed to setting quality standards in animal care and ensuring that these standards are maintained throughout all of our mouse colonies. (jax.org)
  • The Animal Health Program at JAX ensures the health of our mouse colonies by preventing the entry of pathogens and minimizing opportunities. (jax.org)
  • Learn what is in the name of genetically engineered and mutant mouse strains. (jax.org)
  • This project investigates the large phenotypic variation that exists between two mouse strains derived from common ancestors. (edu.au)
  • In addition, some recently developed laboratory mouse strains are derived wholly from other Mus species or other subspecies, such as M. spretus ). (jax.org)
  • Mouse strain names should be registered through the Mouse Genome Database (MGD) at http://www.informatics.jax.org/mgihome/submissions/amsp_submission.cgi . (jax.org)
  • e.g. , mouse strain 129P1/J). (jax.org)
  • Care should be taken that mouse and rat strains do not overlap in strain designations. (jax.org)
  • Note: a few historical examples exist of similar mouse and rat strain designations and these are allowed to stand, with their substrain designations identifying them as unique). (jax.org)
  • MR imaging of the mouse involves tradeoffs due to the size of the animal. (frontiersin.org)
  • lactation
  • Such strains are often denoted "high breeders," and they carry genes ensuring large litter size, high stress resistance during pregnancy, and good nursing properties during the lactation period. (genetics.org)
  • doses
  • Subsequently, in experimental animal stu- Bisphenol A (BPA), an endocrine disruptor, has still been the dies, exposureofpregnantanimals to BPA ata low focusofattentionofscientistsinthe fieldofenvironmental doses (2-20 μg/kg) altered the development of male health since the last century. (deepdyve.com)
  • Therefore, in order to maximize the detection of toxicities, animals are treated with very high doses of chemicals. (centerforethicalscience.org)
  • differ
  • This allows researchers to determine how much of a trait is genetically determined (remains the same across members of the strain) and how much is learned or environmentally influenced (can differ between members of the strain). (sparknotes.com)
  • research
  • The use of animal models for research is controversial. (encyclopedia.com)
  • Laboratory codes are assigned by the Institute of Laboratory Animal Research (ILAR) ( http://dels.nas.edu/global/ilar/lab-codes ). (jax.org)
  • models
  • Epilepsy animal models are used widely to test the influence of environmental and genetic factors on seizure mechanisms. (biomedcentral.com)
  • unique
  • An inbred strain should be designated by a unique brief symbol made up of uppercase, Roman, letters, or a combination of letters and numbers beginning with a letter. (jax.org)
  • growth
  • Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight. (taconic.com)
  • Tools
  • Rat strain names should be registered through the Rat Genome Database (RGD) at http://rgd.mcw.edu/tools/strains/strainRegistrationIndex.cgi . (jax.org)
  • lower
  • Chief amongst these choices is whether to image ex-vivo , where superior resolution and contrast are available, or in-vivo , where resolution and contrast are lower but the animal can be followed longitudinally. (frontiersin.org)
  • individuals
  • It should be borne in mind that genetic drift means that there may still be unknown genetic differences between individuals within strains. (jax.org)
  • Strains can be termed inbred if they have been mated brother x sister for 20 or more consecutive generations, and individuals of the strain can be traced to a single ancestral pair at the 20th or subsequent generation. (jax.org)
  • determine
  • A new test using protozoa - single-celled organisms - has been developed by U.K. researchers, who say it has "great potential" for reducing the use of animals to determine the safety of cosmetics. (centerforethicalscience.org)
  • often
  • In animal systems, parasitism often changes the sex ratio of infected hosts, which can increase the probability of their transmission. (cambridge.org)