Animals and alternative methods in regulatory testing. Medical search. Frequent questions

16 National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. (nih.gov)
17 National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709, USA. (nih.gov)
Regulatory toxicology. (nih.gov)
Collaborative efforts between industry and the Institute for In Vitro Sciences (IIVS, Gaithersburg, USA) have focused on the transfer of several OECD Test Guideline methods to government laboratories in China and have supported the creation of an in vitro toxicology testing laboratory within the Zhejiang Institute for Food and Drug Control (Hangzhou, China). (iivs.org)
Risk assessment in Reproductive Toxicology: overview of guideline-based animal study test protocols, their use in testing strategies, parental versus fetal toxicity. (norecopa.no)
knowledge of internationally harmonized testing strategies in reproductive toxicology. (norecopa.no)
In order to support non-animal testing, People for the Ethical Treatment of Animals (PETA) India, in 2022, announced a grant of 7 lakh rupees in order to advance animal-free methods for toxicology testing. (thebusinessresearchcompany.com)
According to this draft, general cosmetics manufactured under certified GMP conditions and with substantiated safety as defined by risk assessment will be exempted from relevant toxicology tests, except in four cases. (chemlinked.com)
In February 2008, three federal agencies, the National Human Genome Research Institute, the National Toxicology Program, and the Environmental Protection Agency, announced the establishment of a five-year plan to investigate new technologies that would allow for the rapid testing of large numbers of chemicals while also providing results more applicable to humans. (aavs.org)
9 ) with the determination of the RC50 value being the marker reactivity of test chemicals as end point toxicology assays have of the potency of a chemical. (cdc.gov)

Moving toward species-relevant chemical safety assessments and away from animal testing requires access to reliable data to develop and build confidence in new approaches. (nih.gov)
These new ICE features allow users to explore the applications of an expanded data space and facilitate building confidence in non-animal approaches. (nih.gov)
GAITHERSBURG, MD, BRUSSELS, BE - The European Partnership for Alternative Approaches to Animal Testing (EPAA) has partnered with US based Institute for In Vitro Sciences (IIVS) to produce a series of training videos on non-animal testing methods for the safety evaluation of products and ingredients. (iivs.org)
Companies can pursue a number of approaches to ensure their cosmetics are safe without testing on animals. (pcrm.org)
Currently China is striving to adopt and implement non-animal, including in vitro, testing approaches for the safety assessment of cosmetics and ingredients. (iivs.org)
This commitment continues today, in partnership with global regulatory agencies that manage cosmetic safety, with animal advocacy groups and with leading animal alternative researchers in an effort to gain global acceptance of these new approaches. (marykay.ca)
As of today, using non-animal approaches such as in vitro tests on cells might be informative regarding certain elements of this definition, for instance to elucidate the endocrine mode of action of a chemical. (env-health.org)
That is why non-animal approaches such as in vitro tests cannot be used on their own to meet regulatory definitions of certain endpoints. (env-health.org)
The budget builds on the successes of human and animal food safety modernization activities and supports the agency's continued implementation of the New Era of Smarter Food Safety and other core food safety efforts to enable the FDA to strengthen data-driven approaches to protecting consumers, allocating regulatory oversight resources based on risk and improving the FDA's capacity to quickly respond to ongoing and evolving public health challenges. (news-medical.net)
The animal protection group Humane Society International/Korea condemns the steady increase in animal testing and calls for substantial and immediate action to position human-relevant approaches as the gold standard in Korean regulatory and bio-science testing. (hsi.org)
Despite available approaches without using animals, the number of newly opened animal testing facilities also increased from 2021 to 2022. (hsi.org)
While there are sporadic funding opportunities by central governments to study these non-animal approaches, HSI/Korea argues that a legislative system is necessary to support not only such research efforts, but also to ensure adaptation by regulatory authorities and use at the industrial level. (hsi.org)
The latest reforms in Chinese regulations have increased regulatory efficiency and transparency, resulting in better alignment with international approaches. (sigmaaldrich.com)
The program provides an overview of in vitro , in silico , and in chemico approaches and their many applications in basic, translational, and regulatory science to replace animals. (pcrm.org)
Current concepts and approaches on animal test alternatives. (cdc.gov)
Representatives from 40 states and from regulatory and public health agencies, water utility companies, and advocacy groups discussed approaches to avoiding unnecessary boil-water advisories (i.e., statements to the public advising persons to boil water before drinking it) and preventing and controlling waterborne cryptosporidiosis. (cdc.gov)

LUDWIGSHAFEN, Germany and GAITHERSBURG, Md., Oct. 23, 2012 /PRNewswire-USNewswire/ - BASF SE, the world's leading chemical company, has provided U.S. based Institute for In Vitro Sciences (IIVS) with equipment critical to replacing the use of animals for eye irritation testing of certain chemicals. (iivs.org)
Other tests assessing the effects of chemicals on internal systems involve force-feeding mice or rats chemicals for weeks, months, or their entire lives. (pcrm.org)
Tests for lung effects require forcing animals to inhale airborne chemicals or particles by shoving them into tiny tubes exactly the size of their bodies for hours a day, for weeks or months. (pcrm.org)
The selection of reference and proficiency chemicals is an important component of method validation and proficiency evaluations. (iivs.org)
Reference chemicals are a set of test substances used by a method developer to evaluate there liability and relevance of a new method, in comparison to reference data (usually to a validated reference method). (iivs.org)
Proficiency chemicals, as defined in OECD Guidance Document on Good In Vitro Method Practices, are defined post validation as a subset of the reference chemicals, or other chemicals with. (iivs.org)
Special attention is given to the interpretation of animal reproductive toxicity studies which form the basis for human risk assessment of chemicals. (norecopa.no)
To provide a state of the art review of current methods for in-vitro testing of safety and efficacy of chemicals (including drugs) as well as studying disease and more general medical research. (fsrm.ch)
Dr Wilkinson is a champion for the use of leading edge technology to replace animal testing for the development of safe drugs, nutraceuticals, chemicals and cosmetics. (fsrm.ch)
Today, European and national regulatory authorities assess the safety of chemicals on the basis of a variety of information, including scientific literature as well as tests performed in vivo (on living organisms such as rodents, fish, amphibians), in vitro on isolated cells or tissues, and increasingly in silico (using computer models). (env-health.org)
While all stakeholders engaged on chemicals share the goal to progressively eliminate tests performed on animals and core pieces of EU legislation on chemicals refer to this goal, it is unfortunately currently not possible to fully do without them for several reasons that are detailed further below. (env-health.org)
However, in vitro tests alone do not allow us to assess complex adverse effects that chemicals may have on an organism, for example, effects on the brain or the metabolism across generations. (env-health.org)
With the database, Hartung hopes that companies and regulators will find it easier to infer the toxic effects of untested substances by comparing them with structurally or biologically similar chemicals with known effects-a method called read-across. (scientificamerican.com)
That concept is already popular among chemical companies that seek alternatives to safety tests on animals , says Markus Wahl, a regulatory toxicologist at chemicals producer BASF in Ludwigshafen, Germany. (scientificamerican.com)
Currently, chemicals can go on the US market with little regulatory scrutiny. (scientificamerican.com)
The Draize eye test, for example, in which chemicals are applied to rabbits' eyes to check for harmful effects, is a "big lottery", he says. (scientificamerican.com)
Nearly half of animals used in 2022 were subjected to the most severe category of experiment in which they are denied anesthetic or tranquilizing drugs while being exposed to massive doses of chemicals or used for cancer or infectious disease studies that will result in their deaths. (hsi.org)
ICCVAM also works to promote the scientific validation and regulatory acceptance of testing methods that more accurately assess the safety and hazards of chemicals and products and that replace, reduce, or refine (enhance animal well-being and lessen or avoid pain and distress) animal use. (justia.com)
These technologies replace animal testing in end-use industries including pharmaceuticals, medical devices, chemicals and pesticides, food, and others. (thebusinessresearchcompany.com)
Regardless of the clear mandate from the public and international governments on this issue, the European Commission (EC) and the European Chemicals Agency (ECHA) are insisting on testing the chemicals used in cosmetics for which there's a possibility of workforce exposure during manufacturing processes. (peta.org.uk)
Yet across Europe, hundreds of animals, such as rats, mice, rabbits and guinea pigs, are used in toxicity (or "poison") tests for chemicals used in household products. (peta.org.uk)
In these tests, chemicals are applied to or injected into animals' skin or forced down their throats via a tube to check for side effects such as vomiting, tremors, organ failure, paralysis and even death. (peta.org.uk)
Regulatory accepted methods to assess skin sensitizing potential of chemicals are animal based tests, but increasing interest in animal welfare presses the development of animal-free methods. (tu-darmstadt.de)
The aim of this work was the development, establishment and validation of several alternative methods to animal testing to predict the skin sensitizing potential of chemicals. (tu-darmstadt.de)
Despite the fact that ECVAM recommended the Rat Skin TER Assay for use in all corrosivity tests, ICCVAM deemed this method unreliable in testing certain classes of chemicals, and suggested that traditional animal studies still be used. (aavs.org)
A restricted audience of 60 participants from 15 different countries attended this workshop in order to discuss the implications for animal welfare and the use of alternative methods of the EU strategy on chemicals namely "White Paper for a New EU Chemicals Policy" and to pave the way for launching ecopa as an official non-profit organization. (ecopa.eu)
In addition to experts from industry, academia, animal welfare and government institutions, a number of guests and speakers from DG Environment, the European Chemicals Bureau as well as government ministries of several European countries was present. (ecopa.eu)
Prof. Rogiers welcomed the participants and explained the need for the workshop and the potential impact and consequences of the White Paper for a New EU Chemicals Policy regarding additional animal testing which according to some estimates could reach up to 12.6 million animals over the next twenty years. (ecopa.eu)
Dr. Vogelgesang, DG Environment, explained that the EU Chemicals Policy is not a testing programme but essentially an effort to gather the necessary information on chemicals that is quite often readily available within industry and authorities. (ecopa.eu)
Animal testing is mandatory for the registration of chemicals and the authorization of plant protection products. (basf.com)
Of the tens of thousands of chemicals in commercial use, less than two percent have been thoroughly tested for their potential carcinogenicity, in part because the current chemical screening process is costly and time-consuming. (nih.gov)
According to the authors, their method provides a promising solution that could be used to prioritize chemicals for further cancer testing. (nih.gov)
Seventeen out of the 23 tested chemicals were pseudo-first order, and three were second order. (cdc.gov)
The reactivity of electrophilic authorities to develop alternative nonanimal-based methods chemicals to glutathione (GSH) was exploited by Schultz et al. (cdc.gov)
Basically, these are all concentrations of chemicals that should help to achieve a safe working environment but in different regulatory and cultural contexts 4 . (cdc.gov)

By combination of different assays or more specifically the combination of the outcome of different assay into a testing strategy or testing battery predictivities were increased and allowed the prediction of sensitizing and non-sensitizing substances with high probability. (tu-darmstadt.de)
The combinations of assays showed that predictivity compared to single assays can be increased and that for the number of tested substances these combinations are comparable to the local lymph node assay, the current gold standard to assess skin sensitizing potential. (tu-darmstadt.de)
We propose that integrated testing strategies should comprise complementary assays, providing measurements of a wide range of mechanistic events, to perform well-educated risk assessments based on weight of evidence. (lu.se)
PCR assays (NVO and other Orthopoxvirus laboratory developed tests [LDT]) represent the primary tool for monkeypox diagnosis. (cdc.gov)

Alternatives to animal experimentation. (norecopa.no)
These technologies have the potential to finally end animal experimentation - the journey has just begun. (eceae.org)
Prediction of Skin Sensitizers using Alternative Methods to Animal Experimentation. (lu.se)

Understandably, the use of animal experiments raises multiple moral questions. (env-health.org)
He describes his work in papers published on February 11 in Alternatives to Animal Experiments . (scientificamerican.com)
Fortunately, experiments on animals for cosmetics products and their ingredients have been consigned to the history books in many parts of the world. (peta.org.uk)
In addition to campaigning for the worldwide ban of animal-tested cosmetics, raising awareness of the cruelty that goes on in laboratories and putting pressure on governments and politicians to introduce compassionate legislation, PETA and its affiliates are also helping to develop non-animal testing methods that'll encourage companies to phase out horrific experiments on animals. (peta.org.uk)
In addition to replacement, the journal also features research that aims to reduce or refine in vivo experiments that are still carried out, as well as advocating for changes to global animal use policies. (sagepub.com)
In addition to the replacement of animals, it also covers work that aims to reduce the number of animals used and refine the in vivo experiments that are still carried out. (sagepub.com)
Subjecting animals to painful experiments to test cosmetics is inhumane and entirely unnecessary," said Buchanan, who serves as co-chair of the Congressional Animal Protection Caucus. (goodforyougirls.com)
Scientific advancements have created viable alternatives to these cruel experiments, while still ensuring that cosmetic products are safe for human use. (goodforyougirls.com)
Our goal is to replace animal experiments with animal-free alternative methods based on isolated human cells, tissues or computer models. (basf.com)

To assess whether and how exposure to chemical substances can impact our health and the environment, European and national regulatory authorities rely on the results from several testing methods, including animal testing, when performing their safety assessment. (env-health.org)
Important progress is currently being made in the development of in vitro and in silico tests, but they will not be fit to address the complexity of the assessment of adverse effects on organisms before a long time. (env-health.org)
To reduce the number of tests on animals, the REACH Regulation promotes alternative methods for the hazard assessment of substances. (ufz.de)
It clarifies that dossiers categories required for new cosmetic ingredient (NCI) registration and notification are the same, animal testing alternative methods data can be accepted under certain conditions, detailed test data, laboratory qualification analysis, etc. shall be attached if the safety assessment report is issued by an international authoritative safety assessment agency, etc. (chemlinked.com)
However, ICCVAM recommended that EpiDermTM be used only as part of a tiered assessment strategy, which may or may not involve animals. (aavs.org)
Our substances and finished products undergo extensive assessment and testing to ensure product efficacy and safety. (bayer.com)
To guide regulators faced with increasing amounts of data from non-guideline studies, the OECD formulated Guidance Document 211 (GD211) on method documentation for the purpose of safety assessment. (uni-konstanz.de)
For any regulatory submission of a medicinal product, data and risk assessment of potential leachables are required when single-use systems (SUS) are used in the manufacturing process. (sigmaaldrich.com)
A recent ban on the use of animal tests within the cosmetics industry has led to an urgent need for alternative animal-free test methods that can be used for assessment of chemical sensitizers. (lu.se)
In this MiniReview, we aim to summarize and give our view on the recent progress of method development for alternative assessment of chemical sensitizers. (lu.se)
Hazard Assessment and Regulatory Requirements. (cdc.gov)
Cyanobacteria , blue-green algae, are recommended for effects testing of antimicrobials in environmental risk assessments according to the European guidelines for risk assessment of medicinal products for human use (EMEA/CHMP/SWP/4447/00 corr 2). (janusinfo.se)

In September 2019, the USP Microbiology Expert Committee proposed the inclusion of recombinant factors for endotoxin testing in an existing chapter of the USP-NF that is harmonized across Europe, Japan and the US. (usp.org)

The global non-animal alternatives testing market size grew from $1.78 billion in 2022 to $1.94 billion in 2023 at a compound annual growth rate (CAGR) of 9.2% . (thebusinessresearchcompany.com)

The law will make it unlawful for cosmetic manufacturers to sell any cosmetic in California if the final product or any component of the product was tested on animals after Jan. 1, 2020, with some exceptions for regulatory requirements. (pcrm.org)
Rockville, MD, May 29, 2020 - The U.S. Pharmacopeia (USP) published a Compendial Notice and Prospectus today, reinforcing USP's commitment to the introduction of recombinant Factor C (rFC) - a synthetic alternative to naturally sourced reagents derived from horseshoe crabs - into the official text of the USP-NF . (usp.org)
SB 241, sponsored by Senator Linda Holmes (D-Aurora) and signed by Governor J.B. Pritzker on August 9, prohibits the import or sale of any cosmetic if the final product or any ingredient was tested on animals after January 1, 2020. (awionline.org)
METHOD: Data were obtained from a US internet panel survey of 3217 respondents during May-November 2020 (weighted by race/ethnicity, age, gender, and education to the US national population). (cdc.gov)

GAITHERSBURG, Md., May 28, 2013 - The Institute for In Vitro Sciences Inc., (IIVS) a world renowned leader in the validation, training, and application of non-animal test methods, announces the formation of ICARAA: Industry Council for the Advancement of Regulatory Acceptance of Alternatives. (iivs.org)
GAITHERSBURG, MD -August 28- The Institute for In Vitro Sciences (IIVS), with an established track record in the validation of alternatives to animal testing, is teaming up with BASF and Givaudan to validate an improved skin sensitization reactivity method to address the needs of toxicologists and regulators. (iivs.org)

We respect all legal requirements pertaining to animal welfare, compliance with which is verified both by regulatory authorities and by means of internal audits. (bayer.com)
EU Health Commissioner Tonio Borg has urged Chinese authorities to follow the European example and rid the cosmetics arena of animal testing and turn to alternative methods instead . (choosecrueltyfree.org.au)
In addition, CitroLife's product range is certified and approved by farmers, as well as scientific and regulatory authorities worldwide. (foodprocessing-technology.com)
The recommendations for use are based on WHO guidelines and on information from stringent regulatory authorities. (who.int)
The medicine may be authorised for additional or different uses by national medicines regulatory authorities. (who.int)

In 2013, the European Union banned the testing of cosmetics on animals in the EU, and the marketing or sale of cosmetics that have been tested on animals outside the EU. (pcrm.org)
Although companies can't sell animal-tested cosmetics in Europe, they can continue to test cosmetics on animals outside Europe and sell them in other markets. (peta.org.uk)
It's time to move past the cruel, inhumane practice of testing cosmetics on animals," said Cárdenas. (goodforyougirls.com)

While the skin sensitization hazard of substances can readily be identified using non-animal methods, the classification of potency into UN GHS sub-categories 1A and 1B remains challenging. (iivs.org)
The results, published alongside the description of the database, suggest that substances found to cause serious irreversible eye damage in one test have a 10% chance of being found harmless in a subsequent test. (scientificamerican.com)
By contrast, substances found to cause reversible irritation to rabbits' eyes have nearly a 60% chance of being found harmless in a later test. (scientificamerican.com)
Establishment and validation of the methods was performed with 54 test substances of known sensitizing potential, and the findings were compared to available human patch test data and murine local lymph node assay data. (tu-darmstadt.de)
The development of new methods to predict the protein reactive potential of sensitizing substances indicated that such compounds are able to react with proteins on the cell surface and that this reaction impacts the detection of such proteins by antibody staining. (tu-darmstadt.de)
An in vitro test to determine skin corrosion, Corrositex® uses a biomembrane and chemical detection system that changes color when in contact with corrosive substances. (aavs.org)
In contrast, ICCVAM has validated EPISKINTM for reduction purposes, suggesting that some substances may need to be tested on animals after using this method. (aavs.org)
Unfortunately, the Murine LLNA uses mice as a substitute to test substances topically. (aavs.org)
Uses specific strains of common bacteria to detect genetic changes caused by test substances. (aavs.org)
In addition to meeting legal and regulatory requirements, we have specified the responsible use of genetic engineering and strict, globally applicable safety measures in handling biological substances in corresponding corporate policies. (bayer.com)
The testing requirements for new substances would be increased to production amounts of 1 ton to improve innovation, but without a significant loss of protection. (ecopa.eu)
Regulatory frameworks within the European Union demand that chemical substances are investigated for their ability to induce sensitization, an adverse health effect caused by the human immune system in response to chemical exposure. (lu.se)
Bioaccumulation is assessed on the partition coefficient (n-octanol/water), usually reported as log K ow (also log P ow ) where substances with log K ow ≥ 4.5 are assessed as having a high potential for bioaccumulation (OECD test 107 or 117). (janusinfo.se)

Today Congresswoman Dina Titus (NV-01), a member of the Congressional Animal Protection Caucus, was joined by Rep. Brian Mast (R-FL) in sending a letter to Food and Drug Administration (FDA) Commissioner Robert Califf, M.D. requesting that the FDA develop and release Guidance for Industry on alternatives to animal testing. (house.gov)

However, completely getting rid of animal tests for chemical safety assessments overnight would constitute a serious threat to our health as well as wildlife. (env-health.org)
2) For cosmetics not subject to registration or filing (such as toothpaste and mouthwash), it is only necessary to provide the product safety commitments, and there is no need to provide test reports and safety assessments. (chemlinked.com)
We applaud Reps. Don Beyer (D-Va.), Vern Buchanan (R-Fla.), Ken Calvert (R-Calif.) Tony Cárdenas (D-Calif.), and Paul Tonko (D-NY) for driving a significant bipartisan effort that sets the stage for eliminating new cosmetics animal testing in favor of innovative, scientifically advanced safety assessments," said Lezlee Westine, president and CEO, PCPC. (goodforyougirls.com)

Encouraging developers of alternative test methods and testing strategies for skin sensitization to discuss their projects with ICCVAM and NICEATM to facilitate refinement of the methods to meet U.S. regulatory needs. (justia.com)
The role that ICCVAM should play in the development and evaluation of alternative skin sensitization test methods and testing strategies. (justia.com)
Request for Information: As noted above, ICCVAM is developing plans to augment and support activities that will advance the state of the science for alternative skin sensitization test methods and testing strategies. (justia.com)
As part of this process, ICCVAM is interested in receiving information on the state of the science regarding alternative test methods and testing strategies for skin sensitization and about activities of which ICCVAM may not be aware. (justia.com)
During development of its plan for advancing alternative skin sensitization test methods and testing strategies, ICCVAM will carefully consider the information and comments received in response to this notice and will also consult with ICATM partners and the OECD. (justia.com)
Background Information on ICCVAM and NICEATM: ICCVAM is an interagency committee composed of representatives from 15 Federal regulatory and research agencies that require, use, generate, or disseminate toxicological and safety testing information. (justia.com)
ICCVAM conducts technical evaluations of new, revised, and alternative safety testing methods and integrated testing strategies with regulatory applicability. (justia.com)
NICEATM provides scientific and operational support for ICCVAM and conducts independent validation studies and other activities to assess the usefulness and limitations of new, revised, and alternative test methods and strategies. (justia.com)
ICCVAM and NICEATM welcome the public nomination of new, revised, and alternative test methods and strategies for validation studies and technical evaluations. (justia.com)
The ICCVAM Authorization Act of 2000 (42 U.S.C. 285l-3) provides the authority for ICCVAM and NICEATM involvement in activities relevant to the development of alternative test methods. (justia.com)
As stated in the ICCVAM Authorization Act, ICCVAM acts to ensure that new and revised test methods are validated to meet the needs of Federal agencies, increase the efficiency and effectiveness and Federal agency test method review, and optimize utilization of scientific expertise outside the Federal Government. (justia.com)
In the U.S., the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) validates alternative methods, and recommends them for use to the scientific and federal regulators. (aavs.org)
The following are some of the validated alternatives approved by ICCVAM. (aavs.org)
however, ICCVAM concluded that in certain cases Corrositex® should be used in conjunction with animal tests. (aavs.org)
This test has been used for years prior to the passage of ICCVAM. (aavs.org)
On behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) requests public comments on nominations received for the three in vitro test methods proposed for detecting and quantifying botulinum neurotoxin (BoNT), and at second for an in vitro test method proposed for detecting non-endotoxin pyrogens. (gmp-compliance.org)

Allowing the pharmaceutical industry and government agencies to utilize high-tech alternatives to wasteful and inhumane animal tests will save time, money, and animals' lives. (house.gov)
Cosmetics testing on animals is inhumane, expensive, and at odds with the laws and regulations of many countries throughout the world," said AWI President Cathy Liss. (awionline.org)

The winners in 2021 were Carlo C. Lazado and Elisabeth Ytteborg at Nofima, Ås , for their studies of mucosal health in fish, using innovative strategies which reduce the number of experimental animals used. (norecopa.no)
METHODS: From Nov 7, 2021, to Feb 24, 2022, we conducted a public health investigation involving 15 agencies and medical centres in the USA. (cdc.gov)

The test, in use for decades, has been widely criticized for producing inconsistent results and raising animal-welfare concerns, but the Johns Hopkins team analysed 9,700 Draize results from the ECHA data to quantify the problem. (scientificamerican.com)
Congresswoman Titus has a long history of fighting for animal welfare in Congress and will continue to prioritize their safety. (house.gov)
Responsibility for animal welfare at Bayer lies with the Bayer Global Animal Welfare Committee. (bayer.com)
Washington, DC -The Animal Welfare Institute (AWI) and Cruelty Free International congratulate Illinois for joining California, Nevada, and more than 30 countries worldwide in banning the sale of animal-tested cosmetics. (awionline.org)
But sadly because these overseas markets offer lucrative investment opportunities to major brands, many still continue to overlook animal welfare in exchange for bigger profits. (choosecrueltyfree.org.au)

Advantages and disadvantages of using animals compared to in-vitro or in-silico methods. (fsrm.ch)
2) By Method: Cellular Assay, Biochemical Assay, In Silico. (thebusinessresearchcompany.com)
The need for alternatives to animal-based skin sensitization testing has spurred research on the use of in vitro, in silico, and in chemico methods. (cdc.gov)

The move away from animal tests-and the increased use of human-relevant methods to assess the safety of cosmetics and cosmetic ingredients-will ensure consumers can be assured safer cosmetics that are cruelty-free. (pcrm.org)
In the United States, California passed the Cruelty-Free Cosmetics Act, but the federal government does not require animal testing for cosmetics. (pcrm.org)
Until China removes these testing requirements, companies large and small are trying strategies to remain cruelty-free, such as manufacturing in China, avoiding manufacture of some kinds of cosmetics, creating separate product lines for the Chinese market, or avoiding selling their products in China altogether. (pcrm.org)
What could be more beautiful than cruelty-free wrinkle creams, eye shadows, and shampoos that protect both humans and animals? (pcrm.org)
I'm proud to support this legislation that will restore America's position as a world leader in cruelty-free safety methods that promote the well-being of humans and animals alike. (goodforyougirls.com)
Tragically, despite the availability of approved non-animal tests and existing ingredients that are safe for human use, we estimate that over half a million animals are still used annually in cruel and unnecessary cosmetics testing worldwide," said Monica Engebretson, North America campaign manager for Cruelty Free International. (awionline.org)
On 12 November 2013, we wrote to all the companies on the Choose Cruelty Free List in relation to the issue of animal testing in China. (choosecrueltyfree.org.au)

For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. (wikipedia.org)
Alternatives to Laboratory Animals (ATLA) is an established peer-reviewed journal dedicated to the Three Rs - the reduction, refinement and replacement of animals in research and testing. (sagepub.com)
ATLA is a peer-reviewed journal, intended to cover all aspects of the development, validation, implementation and use of alternatives to laboratory animals in biomedical research and toxicity testing. (sagepub.com)
This was ominous for the laboratory animals as it would mean even more products would be animal-tested, even if they were sold via e-commerce channels. (choosecrueltyfree.org.au)

Scientists at BASF and Givaudan have developed the Kinetic Direct Peptide Reactivity Assay (Kinetic DPRA), a non-animal test to predict allergic reactions in the skin known as sensitization. (iivs.org)

The aim of this study was to assess the capacity of the FET test in predicting acute fish toxicity and to define the applicability domain of the FET test for regulatory purposes. (ufz.de)
They cooperate with other international bodies to evaluate the accuracy and applicability of new alternative methods. (aavs.org)

Mary Kay is committed to the elimination of animal testing and is a strong advocate of utilizing alternative methods to substantiate the safety of our ingredients and products. (marykay.ca)

We do not conduct animal testing on our products or ingredients, nor do we ask others to do so on our behalf, except when absolutely required by law. (marykay.ca)
The non-animal alternatives testing is testing products and services that do not involve testing on animals to determine the safety and efficacy of products and ingredients used in any industry sector. (thebusinessresearchcompany.com)
Major companies have turned their backs completely on animal testing and no longer use ingredients that were tested on animals - and a number of animal tests have been completely replaced with superior, cheaper and more effective non-animal methods. (peta.org.uk)
The 2013 ban was the culmination of a vigorous and long-standing public campaign against animal-tested cosmetics - not just for finished products but also for their ingredients, which was critical. (peta.org.uk)
Despite the remarkable progress that's been made, ingredients used in cosmetics may still be tested on animals in the EU under REACH , the world's largest chemical testing programme. (peta.org.uk)
This means that animals will, in fact, continue to suffer and die in tests for cosmetics ingredients. (peta.org.uk)
PETA and its affiliates are determined to uphold the public's opposition to cosmetics testing and support the advancement of innovative, humane testing methods by pushing the ECHA to fulfil the spirit of the law by never testing cosmetics ingredients on animals - no matter what the circumstances are. (peta.org.uk)
There are thousands of ingredients that have already been proved safe for use in household products as well as an increasing number of alternative testing methods for new ingredients that don't use animals and are more reliable. (peta.org.uk)
PETA is urging the UK government to end these animals' suffering by banning all animal-testing for household products and their ingredients. (peta.org.uk)
Ingredients may be force-fed to rats, dripped into the eyes of rabbits, or rubbed onto the bare skin of animals for an extended period. (awionline.org)

S126: Modern Regulatory Methods for Skin Sensitization: Bye-Bye Buehler? (nih.gov)
Communicating information about the availability of funding or other resources to stakeholders that are developing alternative test methods and testing strategies for skin sensitization. (justia.com)
Conducting, cosponsoring, and/or participating in workshops to review the state of the science and soliciting or providing input for future activities on development and validation of test methods and testing strategies for skin sensitization. (justia.com)
Therefore several methods reflecting different parts of the complex sensitization process have been used. (tu-darmstadt.de)
This method ( 10 ) mea- chemical-induced skin sensitization is the ability of a chemical, sured the depletion of the peptides after treatment with excess either as such or after ex/in cutaneo activation, to covalently electrophile for 24 h and adopted the percent depletion (dp) as react with a carrier protein or peptide ( 6 ), resulting in an the reactivity index of a given chemical. (cdc.gov)

Only few cell-based test methods are described by Organisation for Economic Co-operation and Development (OECD) test guidelines or other regulatory references (e.g., the European Pharmacopoeia). (uni-konstanz.de)

SEOUL-South Korea's annual statistics on scientific use of animals reveal a record-high 4,995,680 in 2022, continuing an alarming upward trend. (hsi.org)
The 2022 statistical information also shows that animals are used most frequently in areas such as regulatory testing, basic research and translational research. (hsi.org)
The winners in 2022 were Anita Solhaug, Mona Gjessing and Hilde Sindre from the BIO-Direct cell model team at the Norwegian Veterinary Institute , for their work on developing cell lines to reduce the number of research animals used to study fish health. (norecopa.no)
Orthopoxvirus Testing Challenges for Persons in Populations at Low Risk or Without Known Epidemiologic Link to Monkeypox - United States, 2022. (cdc.gov)

In 2010 Norecopa established a prize for outstanding efforts to advance "the 3Rs" ( Replacement, Reduction & Refinement ) in connection with animal research. (norecopa.no)
The Committee agreed that, despite the considerable progress that had been made in investigating Variola virus, significant components of this research, most notably the refinement and use of an animal model developed in 2001 and the development of antiviral drugs, were unlikely to be completed by the end of 2002. (who.int)

Johnson & Johnson is committed to ensure the ethical treatment of animals used in laboratory settings to advance patient safety and well-being. (jordanshoe-au.com)

The two organizations will work collaboratively on a number of projects focused on cosmetic safety testing designed to promote in vitro (non. (iivs.org)
From simple cell cultures to 3D models of human skin, liver, and other organs, there are many methods available to assess cosmetic safety. (pcrm.org)
In a typical year, Mary Kay spends millions of dollars and conducts more than 300,000 tests to ensure that Mary Kay ® product meets the highest standards of quality, safety and performance. (marykay.ca)
For more than two decades, we have been a global leader in helping to develop alternative testing methods for product safety. (marykay.ca)
Scientists and Managers working in the pharmaceutical, nutraceuticals, cosmetics, tobacco or chemical industry where animal testing has been or still is used to test product safety and efficacy. (fsrm.ch)
Why is animal testing still being used for chemical safety testing today, while alternative methods already exist and more are being developed? (env-health.org)
The database will provide "helpful supporting evidence", he says, but he adds that European regulators accept the results of read-across (in place of animal-safety tests) only occasionally. (scientificamerican.com)
Hartung, a long-time promoter of alternatives to animal-based safety testing, hopes to change that. (scientificamerican.com)
The FDA has focused our budget request on some of today's most urgent needs such as human and animal food safety, medical device security and e-cigarette oversight. (news-medical.net)
43 million in additional investments in food safety modernization, including animal food safety oversight. (news-medical.net)
Building on the modernized food safety regulatory framework created by the FDA Food Safety Modernization Act, this funding will allow the agency to improve prevention-oriented food safety practices, strengthen data sharing and predictive analytics capabilities and enhance traceability to more quickly respond to outbreaks and recalls for human and animal food. (news-medical.net)
The budget request advances mutual reliance efforts as part of the New Era of Smarter Food Safety by providing significant funding to state animal food programs. (news-medical.net)
Stringent regulations related to safety, efficacy, and quality are projected to act as a major challenge for players operating in the non-animal alternative testing market. (thebusinessresearchcompany.com)
While the federal validation of non-animal alternative test methods continues to be a slow and frustrating process, new laws and public concerns about safety, have pushed the need for better and cheaper alternative methods. (aavs.org)
Animal studies are legally required and essential from a scientific viewpoint for assessing the safety and efficacy of our products. (bayer.com)
In cases where human toxicity data are not available the Acceptable Daily Intake (ADI) is determined by division of the No Observed Adverse Effect Level (NOAEL) for animal toxicity by a safety factor. (openrepository.com)
the legislation would end safety testing of cosmetic products on animals and prohibit the sale of products developed using animal testing in the United States. (goodforyougirls.com)
This reintroduction builds on the decades' long effort to promote non-animal alternatives and move closer to eliminating the need for animals in product safety testing. (goodforyougirls.com)
Animal-free strategies in food safety & nutrition: What are we waiting for? (ilsi.org)
Commissioned by the Alternatives to Animal Testing in Food Safety, Nutrition and Efficacy Studies Task Force. (ilsi.org)
For the animals in question this means a miserable and often shortened existence as these products are tested in the name of safety regulations. (choosecrueltyfree.org.au)

The Humane Cosmetics Act is bipartisan legislation that will protect animals from being subjected to unnecessary testing by banning the production and sale of animal-tested cosmetics," said Calvert. (goodforyougirls.com)

Although biological activity in an animal model does not ensure an effect in humans, many drugs, treatments and cures for human diseases are developed in part with the guidance of animal models. (wikipedia.org)
Homologous animals have the same causes, symptoms and treatment options as would humans who have the same disease. (wikipedia.org)
The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model. (wikipedia.org)
Instead, companies have developed new, humane testing methods to ensure that their products don't harm humans or animals. (peta.org.uk)
These testing procedures take less time and money, and the results are more applicable to humans. (awionline.org)

For example, testing according to OECD Technical Guideline 236 (fish embryo acute toxicity test (FET)) has been suggested as one of the alternative methods to toxicity testing in adult fish. (ufz.de)
To address these issues, an annotated toxicity test method template (ToxTemp) was developed (i) to fulfill all requirements of GD211, (ii) to guide the user concerning the types of answers and detail of information required, (iii) to include acceptance criteria for test elements, and (iv) to define the cells sufficiently and transparently. (uni-konstanz.de)

She felt that the founding of such an independent non-governmental organisation (NGO), wanting to play a crucial role in the development, promotion and application of alternative methods to the use of experimental animals in research and regulatory testing came at the right time and at the right place. (ecopa.eu)
WHO regions and advised by some 10 scientific academic experts from such areas as public health, fundamental applied research and regulatory agencies, was subsequently established and has met three times. (who.int)

An in vitro test for detecting eye irritants, the BCOP test method uses tissues obtained from slaughterhouses to replace the use of live animals. (aavs.org)
Meanwhile, more than a dozen non-animal alternatives, such as those using human cells and tissues, are readily available and accepted by the FDA and international regulatory agencies. (awionline.org)
We tested various specimens (blood, cerebrospinal fluid, intraocular fluid, serum, and tissues) from the organ donor and recipients by serology, RT-PCR, immunohistochemistry, metagenomic next-generation sequencing, and host gene expression, and conducted a traceback of blood transfusions received by the organ donor. (cdc.gov)

There are more than 40 in vitro methods approved by international regulatory bodies. (pcrm.org)

The government organizations enforce laws and regulations, raise funds to support non-animal testing methods such as tests on human volunteers, and advanced computer-modeling techniques, and also fund studies with human volunteers. (thebusinessresearchcompany.com)
In countries such as China (mainland) regulations require that most imported cosmetic products must undergo animal testing prior to being sold retail to consumers. (choosecrueltyfree.org.au)
Hong Kong still has no mandatory animal testing regulations for e-commerce or retail. (choosecrueltyfree.org.au)
Pan-Asian regulatory expert Dr Tommy Kong outlines current cosmetic import regulations in China . (choosecrueltyfree.org.au)
HSI's #BeCrueltyFree campaign update on the latest news from China re a proposed review of animal testing regulations . (choosecrueltyfree.org.au)
Our standards for animal care and use are intended to meet or exceed all applicable regulations. (jordanshoe-au.com)

As long as alternative methods validated and accepted for regulatory use are not available, and without the full implementation of a precautionary approach, animal tests are the only viable way to assess whether or not a chemical is hazardous to our health or the environment. (env-health.org)
Experts from research and industry provide you with information about the different tests, their implementation, regulatory background and the latest developments in these fields. (gmp-compliance.org)
Our Humane Cosmetics Act would institute national restrictions on animal testing for cosmetics, all while supporting the development and implementation of testing alternatives that will ensure the continued growth of the U.S. cosmetics industry. (goodforyougirls.com)

Currently there are two bills introduced at the National Assembly, the Act on the Promotion of Development, Dissemination, and Use of Alternatives to Animal Testing Methods, sponsored by Assembly member In-soon Nam and the Act on the Vitalization of Development, Dissemination, and Use of Alternatives to Animal Testing Methods, sponsored by Assembly member Jeoung-Ae Han. (hsi.org)
Data from these tests may nevertheless be used to support regulatory decisions or to guide strategies to assess compounds (e.g., drugs, agrochemicals) during research and development if they fulfill basic requirements concerning their relevance, reproducibility and predictivity. (uni-konstanz.de)
The announcement is the latest step in an effort to introduce more methods for detection of bacterial endotoxins, an important early step in the process for vaccine development and other injectable therapeutics. (usp.org)
USP is also making draft guidelines on rFC testing available for developers of COVID-19 vaccine and therapies as part of the Trust Accelerated program while continuing work on the development of a standalone compendial standard on this topic. (usp.org)
It is stated on several occasions in the White Book that the use of non-animal test methods will be maximised and test programmes minimised while the development of new non-animal test methods will be encouraged. (ecopa.eu)
More specifically in the 6th Framework Programme, providing the EU research accents for the coming 6 years, no key topic on the development of alternative methods is being present. (ecopa.eu)

To eliminate unnecessary government-mandated animal testing and facilitate greater use of modern alternative methods, we request that the FDA develop and release Guidance for Industry on how alternatives to animal testing can be used to meet regulatory requirements. (house.gov)
Some of these cruel and unnecessary tests have been funded by taxpayers. (house.gov)
Cosmetics testing on animals is cruel, unnecessary, and outdated, and Congress should finally put a stop to it," said Beyer, "Much of the cosmetics industry has already moved to more scientifically sound methods that do not result in animal cruelty. (goodforyougirls.com)
This cruel practice continues even as scientific advancements have created viable alternatives that make animal testing unnecessary," said Tonko. (goodforyougirls.com)
Compared to molecular tests, Raman spectroscopy analyses can more effectively discriminate malignant features, thus reducing unnecessary surgeries. (bvsalud.org)

For instance, under the EU regulation on classification, labelling and packaging (CLP) regulation, the identification of hazards such as carcinogenicity, endocrine disruption, or reproductive toxicity includes the requirement for positive evidence coming from tests performed in vivo . (env-health.org)
Additional funding and legislative proposals will focus specifically on better protecting mothers, infants and young children through contamination limits in food, product testing requirements, notification of anticipated significant interruptions in the supply of infant formula or essential medical foods, as well as modernization of dietary supplement regulation. (news-medical.net)

Gain vital knowledge of regulatory frameworks to make yourself aware of the arena you will end up working in and how this differs from that of traditional pharmaceutical products. (sunderland.ac.uk)
It closed the final loophole: in 2009, these abhorrent tests were banned in Europe, but products tested elsewhere could still be imported. (peta.org.uk)
Because of this, the only way to be completely sure that you aren't indirectly supporting animal testing is to continue to purchase products only from companies that don't test on animals. (peta.org.uk)
Following the ban on animal-tested cosmetics in Europe, ending animal tests for household products is the next logical step - and would save countless lives. (peta.org.uk)
Federal agencies have accepted ICCVAM's recommendation to use this test for identification of products that may cause severe or permanent eye damage. (aavs.org)
For us, product stewardship means that our products satisfy the highest quality standards and are safe for people, animals and the environment when properly used. (bayer.com)
This includes advising on the application of rFC-based test methods for these products. (usp.org)
Variation is a common feature among all animal-sourced products. (usp.org)
The addition of rFC to the pharmacopeia is in keeping with USP's commitment to seeking alternatives to animal-based products wherever possible. (usp.org)
Non-animal tests are faster and more relevant to human health, and that's why the Personal Care Products Council supports the bill. (goodforyougirls.com)
Cosmetics manufacturers test their products to determine potential human hazards. (awionline.org)
we won't accredit any company that allows their products to be animal tested, anywhere in the world. (choosecrueltyfree.org.au)
Imported products can continue to be direct mailed by foreign companies to consumers in the Chinese mainland for personal use with no animal testing requirement. (choosecrueltyfree.org.au)
Imported products can be sent to Hong Kong by foreign companies, then an agent there can direct mail to consumers in the Chinese mainland for personal use, with no animal testing requirement. (choosecrueltyfree.org.au)
Determine the regulatory status of these products, whether they fall fully or partially under REACH. (reachteam.eu)

Single fiber tensile testing was used to assess and validate the performance efficacy of KeraMatch V on damaged bleached European hair. (gcimagazine.com)
To confirm consumer-perceivable efficacy of KeraMatch V, additional performance studies were conducted through half-head conditioner salon testing on panellists with damaged hair by licensed cosmetologists. (gcimagazine.com)
Overall, KeraMatch V is an optimally designed, natural gluten free vegetable protein blend with performance efficacy comparable to an animal-derived hydrolysed keratin protein, and thus a suitable solution for various vegan hair care applications. (gcimagazine.com)

The Physicians Committee's Summer Immersion is designed to educate the next generation of scientists committed to advancing science ethically using nonanimal methods for research and testing. (pcrm.org)

and the optimisation and validation of novel or existing methods for use as non-animal alternatives. (sagepub.com)
This method was first validated by the European Coalition on the Validation of Alternative Methods (ECVAM) as a complete replacement for animal tests. (aavs.org)
NICEATM received nominations for validation studies on each of the above test methods, which have the potential to reduce or replace animal use for regulatory testing. (gmp-compliance.org)
To date, no such alternative assay has yet completed formal validation. (lu.se)

They seek data generated through alternative test methods for detecting and quantifying BoNT, including but not limited to three test methods nominated by BioSentinel Pharmaceuticals, Inc. (BioSentinel). (gmp-compliance.org)

The kinetic direct peptide reactivity assay (kDPRA) is a modification of the DPRA (OECD TG 442C) wherein the reaction kinetics of a test substance towards a synthetic cysteine-containing peptide is evaluated. (iivs.org)
Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. (ufz.de)

In 2018, FDA approved the first drug that used an endotoxin test based on the recombinant Factor C (rFC) reagent. (usp.org)

We support and participate in efforts to obtain regulatory acceptance of alternative testing methods. (jordanshoe-au.com)

As a global leader in the Life Science industry, we have a team of regulatory experts from around the world to help you to stay on top of current trends and future quality and regulatory opportunities as well as supporting with potential regulatory challenges. (sigmaaldrich.com)

In addition, the department is looking for data generated through alternative test methods for identifying non-endotoxin pyrogens, including but not limited to the monocyte activation test (MAT), which was nominated by Biotest AG. (gmp-compliance.org)
Data on non-endotoxin pyrogens tested in the rabbit pyrogen test (RPT) are requested for comparison. (gmp-compliance.org)
Please pay attention to ECA's course about "Endotoxin and Pyrogen Testing", 28 and 29 June 2011 in Heidelberg. (gmp-compliance.org)
As a synthetic reagent, rFC provides an alternative to Limulus amebocyte lysate (LAL) and Tachypleus amebocyte lysate (TAL) - reagents sourced from the blood of horseshoe crabs and used for endotoxin tests. (usp.org)
The new guidelines for the rFC reagent will now be proposed as a standalone chapter in the USP-NF, rather than combined with the other endotoxin tests. (usp.org)

In partnership with states, the FDA will expand efforts to modernize, harmonize and transform the U.S. animal food inspection system to become more comprehensive and prevention oriented. (news-medical.net)
the nation's monkeypox testing capacity, which we have increased from 6,000 specimens a week at the beginning of the response to 80,000 a week through a partnership with commercial laboratories that make orthopox tests available in their facilities. (cdc.gov)

Globally, studies such as organ-on-a-chip or organoid are receiving increasing attention because they have been shown to sometimes real-world predict human-biology based outcomes more accurately than the results that are obtained from animal models. (hsi.org)
The agencies predict that success of these high throughput mechanisms would result in a "reduction or replacement of animals in regulatory testing. (aavs.org)

For all these areas, there are immediately available alternatives to animal methods or non-animal methodologies that can be applied, such as human cell-based skin testing methods. (hsi.org)
HSI/Korea's director of government affairs, Borami Seo, said: "This report shows that Korean bio-science is stuck in the past, heavily relying on animal testing despite new human mimetic methodologies emerging without animal use. (hsi.org)

Mapping of in vitro assay targets to toxicity endpoints of regulatory importance uses literature-based mode-of-action information and controlled terminology from existing knowledge organization systems to support data interoperability with external resources. (nih.gov)
Mary Kay does not support animal testing. (marykay.ca)
We urge lawmakers to pass legislation that will support science without animal suffering. (hsi.org)
The support from the government and non-governmental organizations boosts the growth of the non-animal testing market. (thebusinessresearchcompany.com)
The constant support from the government drives the growth of the non-animal testing market. (thebusinessresearchcompany.com)
Hundreds of successful cosmetics companies of all sizes rely on non-animal testing methods and support globally consistent standards. (awionline.org)
B-Lands Consulting provides extensive regulatory support for business across the world. (reachteam.eu)

however, it is estimated that cosmetics testing to satisfy Chinese regulatory requirements account for potentially 75 percent of animals killed for cosmetics testing globally. (pcrm.org)

All medicines and treatments go through stringent testing in the lab (pre-clinical research) and in small groups of patients (clinical research). (thebusinessresearchcompany.com)

An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human. (wikipedia.org)
citation needed] Animal models serving in research may have an existing, inbred or induced disease or injury that is similar to a human condition. (wikipedia.org)
The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human. (wikipedia.org)
Many so-called "animal models" try to mimic a certain aspect or symptom of a human disease by artificially harming animals. (eceae.org)
Many animal models of human diseases including Alzheimer's disease or cancer are generated by genetic engineering. (eceae.org)
Genes that have been found to be associated with a certain disorder in human patients are knocked out or inserted into the genome of mice, rats or other animals. (eceae.org)
The NIH reports that 90 percent of drugs that pass these animal tests fail in human trials because they are toxic or ineffective. (house.gov)
This NHK basal cytotoxicity method uses human cells to estimate starting doses for in vivo acute oral toxicity tests, reducing the number of animals used for each test. (aavs.org)
A model of reconstructed human epithelium, developed to test skin corrosion. (aavs.org)
I started as a mathematician but very quickly switched into neurobiology, psychology, and animal models of human disease. (lu.se)

For decades, guinea pigs, rats, mice, and rabbits have been poisoned and killed in tests for the purpose of selling cosmetics. (pcrm.org)
Replacing the use of rabbits in skin corrosivity tests, the Rat Skin TER Assay utilizes rat skin samples instead. (aavs.org)

Discuss the essential regulatory considerations which highlight the processes and protocols undertaken in the highly regulated cosmetic industry. (sunderland.ac.uk)
Researchers working in academia or industry developing new methods of in-vitro testing. (fsrm.ch)
In the recent past, scientific experts from academia and industry have increasingly criticized animal-based disease models. (eceae.org)
The Life Science industry operates in one of the world's most regulated environments with an increase in regulatory requirements and complexity. (sigmaaldrich.com)
Together with seven other partners from science and industry, we have therefore made an appeal to politicians and campaigned for the targeted promotion of alternative methods. (basf.com)

The most common and painful are the Draize skin and eye tests. (pcrm.org)
Every year countless animals, including thousands of dogs and puppies, are used in painful and deadly toxicity tests performed to earn FDA approval for new drugs and medical devices. (house.gov)
Illinois' new law provides additional incentives for cosmetics companies to invest in non-animal alternatives to help them stay competitive in a changing global market while sparing animals from painful tests. (awionline.org)

At an award ceremony being held in London today, two groups shared the £50,000 Lush Training Prize for making 'outstanding contributions' to training researchers in non-animal methods. (iivs.org)

Animal models representing specific taxonomic groups in the research and study of developmental processes are also referred to as model organisms. (wikipedia.org)
The consistency of a synthetic can make manufacturing and testing processes easier to control and because rFC can be made in unlimited quantities, it is more sustainable. (usp.org)

This course introduces relevant aspects of chemistry, physiology and dermatology as well as the regulatory marketing and business framework for cosmetics. (sunderland.ac.uk)
During the course you will also become aware of the diverse global legislative and regulatory framework surrounding cosmetics and perfumes, and acquire fundamental knowledge of the physiology of the skin, eye, nail, oral cavity and hair, alongside the role of the endocrine system. (sunderland.ac.uk)
Proposed as part of the Circular Economy Action Plan, the new EU regulatory framework for batteries seeks to develop a circular, sustainable and safe European battery value chain that is able to compete with other global players on an equal footing. (basf.com)

Anatomy14

Organisms12

Diseases4

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment90

Psychiatry and Psychology1

Phenomena and Processes66

Disciplines and Occupations10

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science16

Named Groups1

Health Care38

Geographicals1

Toxicology10

Approaches16

Chemicals35

Assays4

Experimentation3

Experiments9

Assessment12

20191

20231

20204

Institute for In Vitro Sciences2

Authorities5

Cosmetics on animals3

Substances13

Congressional Animal Protection Caucus1

Assessments3

ICCVAM16

Inhumane2

20212

Welfare5

Silico3

Cruelty-free7

Laboratory animals4

BASF1

Applicability2

Substantiate the safety1

Ingredients10

Sensitization5

European Pharmacopoeia1

20224

Refinement2

Ethical Treatment of Animals1

Safety21

Sale of animal-tested cosmetics1

Humans5

Toxicity Test2

Research and regulatory2

Tissues3

Vitro Methods1

Regulations6

Implementation3

Development6

Unnecessary5

Regulation2

Products15

Efficacy3

Nonanimal1

Validation4

Pharmaceuticals1

OECD2

20181

Acceptance1

Challenges1

Endotoxin5

Partnership2

Predict2

Methodologies2

Support7

Estimated that cosmetics1

Stringent1

Human10

Rabbits2

Industry5

Painful3

Researchers1

Processes2

Framework3