• The association of blood levels of microRNAs (miRs) implicated in angiogenesis with circulating endothelial cells (CEC) and with angiogenic proteins was examined in patients administered drugs with anti-angiogenic activity. (biomedcentral.com)
  • 1990). To determine which of the structural motifs present in the 180-kD TSP1 polypeptide mediate the anti-angiogenic activity, a series of protease-generated fragments were tested using several in vitro and in vivo assays that reflect angiogenic activity. (rupress.org)
  • The majority of the anti-angiogenic activity of TSP1 resides in the central 70-kD stalk region which alone could block neovascularization induced by bFGF in the rat cornea in vivo and inhibit both migration in a modified Boyden chamber and [3H]thymidine incorporation stimulated by bFGF in cultured capillary endothelial cells. (rupress.org)
  • The definition of short peptides from each of these domains that are able to block the angiogenic process may be of use in designing targeted inhibitors of the pathological neovascularization that underlies many diseases. (rupress.org)
  • Previously, recombinant proteins consisting of suppressor of cytokine signaling 3 (SOSC3) fused to the fibroblast growth factor (FGF) 4-derived MTM were developed to inhibit inflammation and apoptosis. (freepatentsonline.com)
  • Physiologic and pathologic neovascularization in other tissues may also be initiated by release of stored angiogenic factors from the basement membrane. (nih.gov)
  • Previously developed hydrophobic CPPs-named membrane translocating sequence (MTS), membrane translocating motif (MTM) and macromolecule transduction domain (MTD)-are able to deliver biologically active proteins into a variety of cells and tissues. (freepatentsonline.com)
  • Thrombospondin-1 (TSP1) is a large modular matrix protein containing three identical disulfide-linked 180-kD chains that inhibits neovascularization in vivo (Good et al. (rupress.org)
  • An in Vivo Function for the Transforming Myc Protein: Elicitation of the Angiogenic Phenotype -- Ngo et al. (aacrjournals.org)
  • Several studies have focused on known protein mediators of angiogenic processes. (biomedcentral.com)
  • In principle, protein-based biotherapeutics offers a way to control biochemical processes in living cells under non-steady state conditions and with fewer off-target effects than conventional small molecule therapeutics. (freepatentsonline.com)
  • Furthermore, solubilization domains (SDs) have been incorporated into the aMTD-fused SOCS3 recombinant proteins to enhance solubility with corresponding increases in protein yield and cell-/tissue-permeability. (freepatentsonline.com)
  • These recombinant SOCS3 proteins fused to aMTD/SD having much higher solubility/yield and cell-/tissue-permeability have been named as improved cell-permeable SOCS3 (iCP-SOCS3) proteins. (freepatentsonline.com)
  • This result is comparable to the positive control, fibronectin, an ECM protein involved in all phases of tissue repair. (chalmers.se)
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • Peptide sequences were assigned to fragment ion spectra, and proteins were inferred from openly accessible protein databases. (elsevier.com)
  • Blood samples for plasma proteins were collected on days 1 (baseline), 8, and 15 of cycle 1, and days 1, 8, and 15 of cycle 2. (biomedcentral.com)
  • Blood levels of specific angioregulatory miRs are not associated with levels of angiogenic proteins. (biomedcentral.com)
  • A number of drugs with anti-angiogenic effects are in common use to treat cancer, and a number are under investigation. (biomedcentral.com)
  • Taken together, the present observations suggest that the angiogenic effects might be explained by the cell binding properties of amelogenin. (chalmers.se)
  • Angiogenic proteins also did not change significantly with treatment. (biomedcentral.com)