AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
VitronectinReceptors, VitronectinNeovascularization, PathologicAngiogenesis InhibitorsNeovascularization, PhysiologicAngiogenesis Inducing AgentsVascular Endothelial Growth Factor AReceptors, CytoadhesinIntegrin alphaVbeta3Endothelial CellsCell AdhesionIntegrinsGlycoproteinsFibronectinsEndothelium, VascularCell MovementPlasminogen Activator Inhibitor 1Integrin alphaVVascular Endothelial Growth FactorsEndothelial Growth FactorsCells, CulturedReceptors, Urokinase Plasminogen ActivatorVascular Endothelial Growth Factor Receptor-2LymphokinesOligopeptidesReceptors, FibronectinAngiogenic ProteinsLamininAngiogenesis Modulating AgentsIntegrin beta3Human Umbilical Vein Endothelial CellsHeparinExtracellular Matrix ProteinsChorioallantoic MembraneFibroblast Growth Factor 2CapillariesSignal TransductionCell ProliferationUmbilical VeinsUrokinase-Type Plasminogen ActivatorExtracellular MatrixMice, NudeCollagenBlood VesselsProtein BindingAllantoisAntigens, CD31Receptors, Vascular Endothelial Growth FactorCorneal NeovascularizationMice, Inbred C57BLCell Line, TumorPlatelet Membrane GlycoproteinsImmunohistochemistryAngiopoietin-2Angiopoietin-1ThrombospondinsTumor Cells, CulturedAmino Acid SequenceIschemiaReceptors, ImmunologicMolecular Sequence DataThrombospondin 1Plasminogen InactivatorsRNA, MessengerReceptor, TIE-2ChorionCell DivisionHindlimbBlood ProteinsMicrovesselsCell LineNeoplasm TransplantationFibrinogenReceptors, Cell SurfaceHypoxia-Inducible Factor 1, alpha SubunitNeoplasmsDrug CombinationsVascular Endothelial Growth Factor Receptor-1ProteoglycansEndostatinsMicrocirculationAntibodies, MonoclonalWound HealingBlotting, WesternChick EmbryoRecombinant ProteinsAngiostatinsRetinal NeovascularizationDisease Models, AnimalFibrinolysinIntercellular Signaling Peptides and ProteinsBinding SitesPeptide FragmentsUp-RegulationCarcinoma, Lewis LungApoptosisTransplantation, HeterologousComplement Membrane Attack ComplexXenograft Model Antitumor AssaysReverse Transcriptase Polymerase Chain Reaction
FibronectinThrombospondinIntegrinsLamininFibrinogenTumor metastasisMetastasisMoleculesMembraneWoundExtracellular matrixInflammationMediatesAdhesionBindsTransmembraneTherapeuticProgressionProteasesAdrenergicInteractsViralRegulationAdaptiveOccurDownstreamCellRoleCancerGrowthActivityActivationContributeBetaType
Fibronectin2
  • Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. (biossantibodies.com)
  • The CD51/CD61 complex mediates adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin. (thermofisher.com)
Thrombospondin2
  • Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. (biossantibodies.com)
  • CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis, and in this later capacity the TSP1-CD47 interaction inhibits nitric oxide signaling at multiple levels in vascular cells. (wikidoc.org)
Integrins5
  • Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
  • Integrins are heterodimeric cell surface receptors found in nearly all metazoan cell types, composed of non-covalently linked α and β subunits. (thno.org)
  • Integrins also function in pathological processes such as inflammation, wound healing, angiogenesis, and tumor metastasis. (thno.org)
  • Integrins are not constitutively active but rather exist in multiple activation states wherein ligand binding stability is related to the activation status of the receptor. (thno.org)
  • Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. (biossantibodies.com)
Laminin3
  • A specific inhibitor of PKCd, rottlerin, completely abrogated Go¨6976-dependent increase in PC12 cell adhesion to laminin as well as the activation of small GTPases, Rac1 and Cdc42, that are downstream of PKCd in adhesion receptor signaling. (mirnamimic.com)
  • Biological activities of laminin are mediated through binding to a subset of integrin family of cell adhesion receptors, a3b1, a6b1, a6b4, and a7b1 [2]. (mirnamimic.com)
  • In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)
Fibrinogen1
Tumor metastasis1
  • HABP1 can be cleaved by cell surface MMP-14/MT1-MMP, a protease important in angiogenesis and tumor metastasis (5). (rndsystems.com)
Metastasis1
  • Via direct actions on cancer cells and indirect actions on the tumor microenvironment, radiation has the potential to enhance epithelial-to-mesenchymal transition, invasion, migration, angiogenesis and metastasis. (biomedcentral.com)
Molecules5
  • Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). (rndsystems.com)
  • Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). (rndsystems.com)
  • Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10 - 16). (rndsystems.com)
  • Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
  • Gelatinases degrade molecules in the basal lamina around capillaries, facilitate angiogenesis and neurogenesis, and contribute to instigating cell death. (periobasics.com)
Membrane2
  • PEX blocks MMP-2 activity on the chick chorioallantoic membrane where it disrupts angiogenesis and tumor growth. (embl.de)
  • CD47 is a 50 kDa membrane receptor that has extracellular N-terminal IgV domain , five transmembrane domains , and a short C-terminal intracellular tail. (wikidoc.org)
Wound4
  • Beneficial impacts on skeletal muscle regeneration, wound healing and angiogenesis have been reported alongside renoprotective, anti-hypertensive and anti-inflammatory effects. (bvsalud.org)
  • Here, we show that although this receptor is present on most vascular and blood cells, the key regulatory function in tumor and wound angiogenesis is performed by β 3 integrin on bone marrow-derived cells (BMDCs) recruited to sites of neovascularization. (rupress.org)
  • Thus, β 3 integrin has the potential to control processes such as tumor growth and wound healing by regulating BMDC recruitment to sites undergoing pathological and adaptive angiogenesis. (rupress.org)
  • Latest research have proven the potential organic advantages of non-thermal atmospheric stress plasma (NTAPP), together with wound therapeutic, angiogenesis, and the proliferation of stem cells. (aabioetica.org)
Extracellular matrix1
  • CD51, an ~120 kDa surface molecule can also non-covalently associate with other beta subunits of the integrin family including beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. (thermofisher.com)
Inflammation2
  • Other reported functions of CD31 are neutrophil emigration to sites of inflammation, and angiogenesis. (biolegend.com)
  • [8] Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikidoc.org)
Mediates1
  • Transient receptor potential channel TRPV4 mediates TGF-β1-induced differentiation of human ventricular fibroblasts. (fgf-erk.com)
Adhesion1
Binds1
  • It is designed by mutating domain 1 of CD2 (D1-CD2), which naturally binds weakly to the receptor. (wikipedia.org)
Transmembrane1
  • CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)
Therapeutic1
  • Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment. (mytaq.com)
Progression1
  • This integrin may regulate angiogenesis and cancer progression. (assaygenie.com)
Proteases1
  • Found in several serine proteases and in ROR-like receptors. (embl.de)
Adrenergic2
  • One of two major pharmacologically defined classes of adrenergic receptors. (lookformedical.com)
  • The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS. (lookformedical.com)
Interacts1
  • PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
Viral1
  • In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. (assaygenie.com)
Regulation1
  • They are generally associated with allergic response, but they are involved in the regulation of many other functions , including angiogenesis (formation of new blood vessels), defense against pathogens, and tissue homeostasis. (jillcarnahan.com)
Adaptive1
  • The multiligand receptors that form the focus of this Perspective series have expectedly diverse functions, often conforming to potential gaps in the host response to invading pathogens that are not effectively manned by adaptive immunity. (jci.org)
Occur1
  • Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). (embl.de)
Downstream1
  • Thus, GAGs/PGs may modulate downstream signaling of key cellular mediators including insulin growth factor receptor (IGFR), epidermal growth factor receptor (EGFR), estrogen receptors (ERs), or Wnt members. (hindawi.com)
Cell2
  • Angiogenesis is dependent on the coordinated action of numerous cell types. (rupress.org)
  • Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
Role1
  • Its role in angiogenesis, in cancer and other diseases, is linked to the blood supply for problematic overgrowths. (wikipedia.org)
Cancer1
  • GAGs and PGs perform multiple functions in specific stages of the metastatic cascade due to their defined structure and ability to interact with both ligands and receptors regulating cancer pathogenesis. (hindawi.com)
Growth2
  • Elimination of the primary tumor, either by irradiation or by surgery, shifts the balance towards pro-angiogenesis and growth of the lung metastases (Table 1 ) (Camphausen et al. (biomedcentral.com)
  • Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). (mytaq.com)
Activity1
  • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. (embl.de)
Activation1
  • Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
Contribute1
  • This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)
Beta2
  • Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. (biossantibodies.com)
  • Integrin alpha-4/beta-1 is a receptor for VCAM1. (biossantibodies.com)
Type1