Angiogenesis mirs micro rna that regulates. Medical search. Frequent questions

CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
Using the GSE2223 and GSE59612 datasets, and RNA sequencing data of GBM from The Cancer Genome Atlas, differentially expressed (DE) genes including DE messenger RNAs (DEmRNAs) and DElncRNAs between GBM and normal controls were identified. (spandidos-publications.com)
Among the various targets and verified regulated genes identified by microarray, we confirmed the downregulation of Integrin a5 in vitro and in vivo. (uni-frankfurt.de)
miRNAs are small non-coding RNAs (~22 nucleotides in length) that regulate the expression of their target genes by translational repression or mRNA degradation ( 13 , 14 ). (spandidos-publications.com)
MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)
Gene expression modulating miRNAs are encoded in diverse genomic locations including intergenic regions, introns of protein-coding genes and introns/exons of noncoding RNA genes [ 36 ]. (biomedcentral.com)
Next, by the intersect of the targeted genes with an increase in their expression in epithelial to mesenchymal transition (EMT) of RPE cells, we tried to build a microRNA-mRNA integrative network. (ac.ir)
One of the challenges to understand miRNA-mediated regulation is to identify co-regulating miRNAs that simultaneously regulate their target genes in a network perspective. (biomedcentral.com)
Pathway enrichment analysis of target genes in the cooperatively regulating miRNAs revealed the mutually exclusive functional landscape of miRNA cooperativity. (biomedcentral.com)
We evaluate the miRNAs modules determined to be significantly cooperative by assessing the functional coherence of target genes co-regulated by the miRNA modules. (biomedcentral.com)
The ability of miRs to target multiple genes and biological signaling pathways has created intense interest in their potential clinical utility as predictive and diagnostic biomarkers, and as innovative therapeutic agents. (biomedcentral.com)
BCLC9-miR122 cells down-regulate expression of MYC, KLF4, FOXM1, AKT2 and AKT3 genes and up-regulate FOXO1 and FOXO3A gene expression. (oncotarget.com)
MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)
In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)

The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
isolated the lin-4 miRNA, they found that instead of producing an mRNA encoding a protein, it produced short non-coding RNAs, one of which was a ~22-nucleotide RNA that contained sequences partially complementary to multiple sequences in the 3' UTR of the lin-14 mRNA. (wikipedia.org)
miRNAs (miRs) are small, noncoding RNAs that bind mRNAs at their 3′-UTRs, leading to mRNA degradation or inhibition of protein translation. (elsevierpure.com)
It is likely that the intronic miRNAs are processed from the same primary transcript as the precursor mRNAs and thus, their expression levels are regulated by the expression of the host mRNA [ 39 ]. (biomedcentral.com)
Shariari F, Moradi S, Totonchi M, Satarian L, mowla S, Baharvand H. Constructing microRNA-mRNA Integrative Network of miR-204-5p and miR-211-5p in RPE Cells Going Through EMT. (ac.ir)
Mammalian microRNAs predominantly act to decrease target mRNA levels. (ac.ir)
MicroRNAs (miRNAs) play crucial regulatory roles in repressing mRNA translation or mediating mRNA degradation by targeting mRNAs in a sequence-specific manner [ 1 ]. (biomedcentral.com)
MicroRNAs (miRs) are regulators of gene expression by destabilizing and inducing degradation of messenger RNAs (mRNA) and/or repressing their translation [ 1 ]. (oncotarget.com)
MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
A microRNA strand is transferred to the Argonaute complex (AGO), forming an RNA-induced silencing complex (RISC), and guides it to pair with the target mRNA through binding of the microRNA seed sequence with the microRNA recognition site on the mRNA. (archivesofmedicalscience.com)

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
Additionally, as competitive endogenous RNAs (ceRNAs), lncRNAs and messenger RNAs (mRNAs) can regulate one other by competing for the shared microRNAs (miRNAs/miRs) ( 14 , 15 ). (spandidos-publications.com)
As a group, miRNAs are small (17-27 nucleotides) noncoding RNAs that govern gene expression in a post-transcriptional manner by binding directly to the 3′UTRs of target mRNAs, thereby repressing their translation or inducing their degradation [ 6 ]. (biomedcentral.com)
Through this mechanism, a single microRNA can alter the function of multiple mRNAs. (archivesofmedicalscience.com)

Based on the competing endogenous RNA hypothesis, DElncRNA‑micro RNA (miRNA)‑DEmRNA interactions were obtained by target gene prediction. (spandidos-publications.com)
In this study, the gene expression profile in GBM was analyzed using a microarray dataset and RNA-sequencing (RNA-Seq) datasets. (spandidos-publications.com)
Found in plants, animals and some viruses, miRNAs are involved in RNA silencing and post-transcriptional regulation of gene expression. (wikipedia.org)
However, only about 500 human microRNAs represent bona fide miRNA in the manually curated miRNA gene database MirGeneDB. (wikipedia.org)
Regulatory noncoding microRNAs (miRNAs) play a critical role in the regulation of gene expression [ 5 ] and are potential candidates for studying their role in the progression of PCa to androgen-independent stage. (biomedcentral.com)
with one experimental database to select microRNAs gene targets. (ac.ir)
Further analysis of the obtained target gene list demonstrated that these two microRNAs are mostly involved in maintaining RPE cells from going through EMT via regulation of cell adhesion and secretion subnetworks and also MAPK and TGF-β1 signaling pathways while preserving cells from apoptosis and neuronal fates. (ac.ir)
11. Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A. MicroRNAs can generate thresholds in target gene expression. (ac.ir)
MicroRNAs (miRNAs) are key components in post-transcriptional gene regulation in multicellular organisms. (biomedcentral.com)
For example, genetic evidences in previous research suggest that the lin-28 gene is cooperatively regulated by the lin-4 miRNA and another unidentified miRNA [ 8 ]. (biomedcentral.com)
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate several gene expressions, pathways, and complex biological networks at the cellular level acting either exclusively or together with other miRNAs. (justia.com)
MiRNAs regulate both transcriptional and post-transcriptional gene expression as well as regulate several circuits involved in tissue repair, inflammation, hypoxia-response, and angiogenesis. (justia.com)
In future these models will be helpful in mimicking hypoxic tumours, in studying gene expression, cellular signalling, angiogenesis and drug response more accurately than 2D and perhaps other 3D models. (westminster.ac.uk)

MicroRNAs (miRNAs) are small noncoding RNAs that can function as either powerful tumor promoters or suppressors in numerous types of cancer. (biomedcentral.com)

The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)
these miRs are also regulated in cardiac disease. (elsevierpure.com)
In this updated critical appraisal we report on the main miRs that play a key role in response to cardiac resynchronization therapy (i.e., responder vs nonresponder HF patients), focusing on the miR-mediated modulation of cardiac angiogenesis, apoptosis, fibrosis and membrane ionic currents. (elsevierpure.com)
Recent data suggested that microRNA-101a (miR-101a) exerted anti-fibrotic effects in post-infarct cardiac remodeling and improved cardiac function. (cyberleninka.org)
However, it is unclear how cerebral ischemic stroke regulates cardiac function, what are the direct effects of stroke on cardiac function, and what are the underlying molecular mechanisms. (justia.com)
There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)

MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. (wikipedia.org)
These are excised from much longer RNAs and prepared in the nucleus as brief hairpin pre-miRNA, and so are further prepared in the cytoplasm right into a double-stranded, 22-nucleotide RNA. (irjs.info)
One strand from the miRNA can be then preferentially included in to the RISC proteins complex, which ribonucleoprotein complicated binds to messenger RNAs and prevents their expressionCbut this regular processing can be dys-regulated in tumor [24]. (irjs.info)
In addition, we found that one miRNA in the miRNA association network could be involved in many cooperatively regulating miRNAs in a condition-specific and combinatorial manner. (biomedcentral.com)
On the system level, we identified cooperatively regulating miRNAs in the miRNA association network. (biomedcentral.com)
The primary microRNA (Pri-miRNA) is produced in the cell nucleus through the transcription of a DNA strand mediated by RNA polymerase II [ 2 ]. (archivesofmedicalscience.com)
After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
Pre-miRNA is exported to the cytoplasm by exportin-5 and cleaved by Dicer (an RNA degrading enzyme) and produces approximately 22 nucleotide RNA duplexes. (archivesofmedicalscience.com)

Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
It has been proven that the miR-183 expression is up-regulated in tumor tissues and patient serum in BC, which indicates its possibly an oncogenic role 15 , 16 . (nature.com)
Some miRNAs which have been examined in GBM and various other cancers attended to become characterized as oncogenic, or in a position to get tumor development through mechanisms such as for example treatment resistance, get away from the disease fighting capability or dys-regulation of angiogenesis. (irjs.info)
miRNAs which have become realized as oncogenic or tumor-driving, using their appearance usually elevated in GBM, consist of but aren't limited by miR-21, the miR cluster 17C92, miR-26a, and miRs-221 and -222 [29]C[33]. (irjs.info)
Tumor suppressor miRNAs are thought as those that lower development or invasion and so are generally down-regulated in GBM. (irjs.info)
MIR31HG , which encodes microRNA-31 (miR-31), is a novel non-coding tumor suppressor positioned adjacent to CDKN2A/B at 9p21.3. (oncotarget.com)
Different tumor types can also design their specific microenvironment by encouraging tumor angiogenesis and stimulating peripheral immune tolerance. (biomedcentral.com)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)

Included amongst the various classes of noncoding RNAs are members of the PIWI-interacting RNA (piRNA) family, the small nucleolar RNA (snoRNA) family, the large intragenic noncoding RNA (lincRNA) family, the long noncoding RNA (lncRNA) family, and the transcribed ultraconserved regions (T-UCR) family of the lncRNAs [ 3 - 5 ]. (biomedcentral.com)

BC-related differentially expressed microRNAs (DE-miRs) were recognized and assessed in the present study. (nature.com)

MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate cellular proliferation, differentiation, and apoptosis, through regulating BCL6. (biomedcentral.com)

The NONFH exosomes reduced the osteogenic differentiation of hBMSCs and angiogenesis of HUVECs. (biomedcentral.com)

The DEmRNAs were mainly enriched in tumorigenesis‑associated GO terms (angiogenesis, positive regulation of cell proliferation, positive regulation of fibroblast apoptotic processes and regulation of neutrophil migration) and pathways (Hippo signaling pathway, cancer pathways, and Wnt signaling pathway). (spandidos-publications.com)

A tube formation assay was used to study angiogenesis of human umbilical vascular endothelial cells (HUVECs). (biomedcentral.com)

The central dogma of molecular biology states that the transfer of genetic information within cells transpires sequentially from DNA to RNA to proteins, whose coding sequences comprise a paltry 1.5-2% of the human genome [ 2 , 3 ]. (biomedcentral.com)
It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)

Further, several pathway analyses tools were used to perform a more accurate and comprehensive analysis of the signaling pathways and biological processes being regulated by selected miRs in the EMT of the RPE cells. (ac.ir)

Previously, it has been demonstrated that certain transcriptional targets of SOX4 are associated with cancer development and progression and the processing of microRNAs (miRNAs/miRs) ( 12 ). (spandidos-publications.com)
TIME-related RNA or RNA regulators could be promising targets for anticancer immunotherapy. (biomedcentral.com)
Coherent but overlapping expression of microRNAs and their targets during vertebrate development. (ac.ir)

At this point, researchers started using the term "microRNA" to refer to this class of small regulatory RNAs. (wikipedia.org)
microRNAs (miRNAs) are little noncoding regulatory RNA substances with profound effects on many natural procedures. (irjs.info)
Recent data show aberrant and altered expression of regulatory noncoding micro (mi) RNAs in prostate cancer (PCa). (biomedcentral.com)

Hier de conclusie van deze review en daaronder een studie abstract met ranpirnasse uit 2002 met bijzonder goede resultaten op de mediane overlevingstijd. (kanker-actueel.nl)

This study investigated the role of long non‑coding RNAs (lncRNAs) in glioblastomagenesis progression. (spandidos-publications.com)
Regarding the important role of microRNAs in breast cancer, investigating the molecular mechanisms of miRs and their impacts on breast cancer progression is critical. (nature.com)
Dysregulation of microRNAs (miRs) can contribute to cancer development and progression. (spandidos-publications.com)
To understand the molecular mechanism of SOX4 in breast cancer development and progression, the present study aimed to identify miRNAs that regulate the expression of SOX4, which revealed miR-320 as a potential candidate. (spandidos-publications.com)
Transcripts targeted by the microRNA-16 family cooperatively regulate cell cycle progression. (ac.ir)
Atherosclerosis initiation and progression are driven by many pro-inflammatory and pro-thrombotic microRNAs. (archivesofmedicalscience.com)
MicroRNAs are powerful modulators of plaque progression and transformation into a vulnerable state, which can eventually lead to plaque rupture. (archivesofmedicalscience.com)

While there is some controversy surrounding recent research that claims that miR-155 may display anti-oncogenic or pro-immunological benefits (Cell Rep 2:1697-1709, 2012), most research seems to point to the importance of anti-miRs, with anti-miR-155 in particular, for cancer therapy. (biomedcentral.com)

MicroRNAs (miRNAs) are single-stranded, endogenously expressed, short, noncoding RNAs with a length of 18-25 nucleotides. (nature.com)

miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
Long non-coding RNA (lncRNA) is a type of RNA that contains over 200 nucleotides and that does not encode protein ( 5 , 6 ). (spandidos-publications.com)
5. Selbach M, Schwanhäusser B, Thierfelder N, Fang Z, Raya Khanin R, Rajewsky N. Widespread changes in protein synthesis induced by microRNAs. (ac.ir)
Although genetic and epigenetic aberrations that occur in components of the central dogma clearly elicit disease development in humans, recent findings also point to a prominent role for non-protein-coding regions of the genome in regulating cell and tissue homeostasis, as well as in contributing to the formation of human tumors. (biomedcentral.com)

The expression of HOX transcript antisense RNA lncRNA is increased in GBM and is significantly associated with high grade brain tumors ( 13 ). (spandidos-publications.com)

High expression of lncRNA H19 promotes cell migration and enhances angiogenesis ( 11 , 12 ). (spandidos-publications.com)
LncHERG is an lncRNA that acts as a competing RNA of miR-940. (spandidos-publications.com)

MicroRNA sequencing was conducted to identify potential regulators in the NONFH exosomes. (biomedcentral.com)

Cooperatively regulating miRNAs have been identified by network topology-based approach. (biomedcentral.com)
We showed that the secondary structures of pre-miRNAs in cooperatively regulating miRNAs are highly similar. (biomedcentral.com)

Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors. (ac.ir)
For instance, miR122 accounts for 72% of all miRs in the liver and it is undetectable in all other tissues analyzed [ 3 ]. (oncotarget.com)

The viability of GBM cells was significantly decreased following RNA interference with DLEU1 and TRAF4 production. (spandidos-publications.com)
miRNAs resemble the small interfering RNAs (siRNAs) of the RNA interference (RNAi) pathway, except miRNAs derive from regions of RNA transcripts that fold back on themselves to form short hairpins, whereas siRNAs derive from longer regions of double-stranded RNA. (wikipedia.org)

It was revealed that cellular oncogenicity is positively regulated by miR-183 by inhibiting the expression of PTEN. (nature.com)
This discrepancy might be partially due to the involvement of Dicer in other cellular processes like heterochromatin formation and to the fact that Dicer and Drosha target mainly different subsets of microRNAs. (uni-frankfurt.de)

Diagnostic value of microRNAs in asbestos exposure and malignant mesothelioma: systematic review and qualitative meta-analysis over welke aanpak bij mesothelioma eventueel zou kunnen werken. (kanker-actueel.nl)
Because aberrant microRNA (miR) promoter methylation contributes to cancer development, we investigated whether altered miR-30a-5p expression associates with DNA promoter methylation and evaluated the usefulness as clear cell RCC (ccRCC) diagnostic and prognostic markers. (biomedcentral.com)

Small interfering RNA demonstrated that silencing DLEU1 downregulated TRAF4. (spandidos-publications.com)
At the time, the lin-4 small RNA was thought to be a nematode idiosyncrasy. (wikipedia.org)
In 2000, a second small RNA was characterized: let-7 RNA, which represses lin-41 to promote a later developmental transition in C. elegans. (wikipedia.org)
The let-7 RNA was found to be conserved in many species, leading to the suggestion that let-7 RNA and additional "small temporal RNAs" might regulate the timing of development in diverse animals, including humans. (wikipedia.org)
A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila and human cells. (wikipedia.org)

MicroRNA-126 (miR-126) is endothelial cell (EC) specific and plays a key role in regulating EC function, controlling angiogenesis, and maintaining vascular integrity. (justia.com)

Dicer and Drosha are the major enzymes involved in microRNA processing. (uni-frankfurt.de)
Using siRNA targeting Dicer and Drosha, thereby downregulating a substantial number of microRNAs in EC, we demonstrate a crucial role of both enzymes in angiogenic processes. (uni-frankfurt.de)
Moreover, Dicer effects in vivo angiogenesis, a process which is unaffected by Drosha. (uni-frankfurt.de)

It may act as a competing endogenous RNA and influence tumorigenesis of GBM. (spandidos-publications.com)

Long noncoding RNAs are emerging as key players in various fundamental biological processes. (biomedcentral.com)

MiR-100-5p expression was upregulated in the NONFH exosomes and inhibited the osteogenesis of hBMSCs and angiogenesis of HUVECs by targeting BMPR2 and suppressing the BMPR2/SMAD1/5/9 signalling pathway. (biomedcentral.com)
Silencing miR-100-5p expression rescued the reduction in osteogenesis and angiogenesis caused by the NONFH exosomes by activating the BMPR2/SMAD1/5/9 signalling pathway. (biomedcentral.com)

We selected miR-183 for study among the considerably dys-regulated microRNAs in breast cancer. (nature.com)
In this review, we discuss the available RNA-based cancer immunotherapies targeting the TIME. (biomedcentral.com)
More importantly, we summarize the potential of various RNA-based therapeutics clinically available for cancer treatment. (biomedcentral.com)
RNA-dependent targeting of the TIME, as monotherapy or combined with other evolving therapeutics, might be beneficial for cancer patients' treatment in the near future. (biomedcentral.com)
The microRNA miR-155 is prominent in cancer biology. (biomedcentral.com)
Among microRNAs that have been linked to cancer, it is the most commonly overexpressed in malignancies (PNAS 109:20047-20052, 2012). (biomedcentral.com)
Genome-wide methylome and RNA sequencing data from a set of ccRCC and normal tissue samples from The Cancer Genome Atlas (TCGA) database were integrated to identify candidate CpG loci involved in cancer onset. (biomedcentral.com)
Study of MicroRNA expression profiles of esophageal cancer. (ac.ir)
miRs are key in cancer biomarker research due to their tissue specificity [ 2 ]. (oncotarget.com)

After selecting the data sets based on our criteria, quality control, and normalization, each data set of the microRNAs expression profile was analyzed. (nature.com)

The many RNAs of this class resembled the lin-4 and let-7 RNAs, except their expression patterns were usually inconsistent with a role in regulating the timing of development. (wikipedia.org)

Principles of microRNA-target recognition. (ac.ir)

Decreased osteogenesis and angiogenesis are considered the main factors in the pathogenesis of NONFH. (biomedcentral.com)

Without limitation, some embodiments comprise methods, systems, and/or compositions relating to microRNAs and/or cell based therapies and the use of the same in the research, diagnosis, or treatment of injury or disease. (justia.com)

This study tested the hypothesis that double overexpression of miR-19a & miR-20a (dOex-mIRs) in human induced pluripotent stem cell (iPS)-derived mesenchymal stem cells (MSCs) effectively preserved left-ventricular-ejection-fraction (LVEF) in dilated cardiomyopathy (DCM) (i.e., induced by doxorubicin) rat. (researchsquare.com)
There is a constant crosstalk between microRNAs derived from various cell sources. (archivesofmedicalscience.com)

Studying the cooperativity of miRNAs is a substantial step for understanding the contribution of co-regulating miRNAs towards a complex interplay between miRNAs. (biomedcentral.com)
MicroRNA biogenesis is quite complex [ 2 ]. (archivesofmedicalscience.com)

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