• Inhibiting angiogenesis requires treatment with anti-angiogenic factors, or drugs which reduce the production of pro-angiogenic factors, prevent them binding to their receptors or block their actions. (wikipedia.org)
  • An international peer-reviewed journal for original articles and reviews on the cellular and molecular mechanisms that regulate angiogenesis in physiological and pathological conditions. (cancerindex.org)
  • An unmoderated mailing list designed mainly for PhD level scientists and medical doctors actively engaged in research on tumor angiogenesis inhibitors and their possible clinical applications. (cancerindex.org)
  • However, successful clinical application of angiogenesis inhibitors, irrespective of monotherapy or combination therapy, requires long-term administration, but most of these entering clinical trials are costly, large molecular weight proteins requiring parenteral administration ( 3 , 5 ). (aacrjournals.org)
  • We incorporated tumour growth, angiogenesis and vessel remodelling at tissue level, by coupling tumour cell phenotypes and endothelial cell behaviour in response to local chemical and haemodynamical microenvironment. (cancerindex.org)
  • Presently, we investigate the antitumor activity of the small-molecule angiogenesis inhibitor axitinib (AG-013736) and its potential for combination with metronomic cyclophosphamide. (aacrjournals.org)
  • Antitumor activity of angigenesis inhibitor TNP-470 was evaluated in 9 human cultured cell lines. (nii.ac.jp)
  • competitive inhibitor of ATP in other protein kinase reactions. (sigmaaldrich.com)
  • The crystal structure of the human Pg-derived angiogenesis inhibitor, angiostatin, complexed to VEK-30, a peptide from the group A streptococcal surface protein, PAM, was determined and refined to 2.3 A resolution. (rcsb.org)
  • The results from these two modalities have a good agreement, suggesting that PAM could provide an unbiased quantification of microvascular density for objective evaluation of anti-angiogenesis medication. (osapublishing.org)